Polypeptide cracking and drying kettle with filter screen

By designing a combination of scrapers and inclined blocks in the peptide lysis drying vessel, and combining it with the vibration transmission of cams and bevel gears, the problem of long filtration time for large peptide chains was solved, and the filtration efficiency was significantly improved.

CN223717075UActive Publication Date: 2025-12-26JIANGYIN YUYUN PHARMACEUTICAL EQUIPMENT CO LTD
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Patent Information

Application Number
CN202422879869.X
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-11-25
Publication Date
2025-12-26
Estimated Expiration
2034-11-25

AI Technical Summary

Technical Problem

Existing peptide lysis drying kettles have long filtration times when encountering large peptide chains during the filtration process, which affects work efficiency.

Method used

A peptide lysis drying vessel with a filter screen was designed. The combination of gear 1, gear 2, scraper and inclined block realizes the scraping and rotation of the material adhering to the filter screen. Combined with the vibration transmission of cam and bevel gear, the filtration efficiency is improved.

Benefits of technology

The product adhering to the inner wall of the drying vessel is scraped off by the rotation of the scraper and the inclined block. The vibration of the cam accelerates the filtration, which significantly improves the filtration efficiency of the filter screen, shortens the filtration time, and improves the work efficiency.

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Abstract

The utility model relates to the technical field of polypeptide cracking drying kettles, and discloses a polypeptide cracking drying kettle with a filter screen, which comprises a movable frame, a mounting block is movably mounted above the movable frame, and a drying kettle is fixedly mounted in the mounting block. Through the design of the first gear, the second gear, the scraping plate and the inclined block, during working, the motor drives the output shaft to rotate, the output shaft drives the first gear to rotate, meshing transmission of the first gear and the second gear drives the second gear to rotate, the second gear drives the rotating shaft to rotate, and the rotating shaft drives the scraping plate and the inclined block to rotate; the scraper blade rotates to scrape off products adhered to the inner wall of the drying kettle and decompose the products again, the inclined block can rotate the products on the upper surface of the filter screen and decompose the products again, too much small products are accumulated on the filter screen, the inclined block can quickly filter the small products through the filter screen, and the working efficiency is improved.
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Description

TECHNICAL FIELD

[0001] The utility model relates to polypeptide cleavage dry still technical field, more specifically, the utility model relates to a polypeptide cleavage dry still with filter screen. BACKGROUND

[0002] The polypeptide cleavage dry still with filter screen is a reactor specially designed for polypeptide cleavage and drying process. The device combines multiple functions such as cleavage, filtration and drying in one, and realizes effective separation and purification of polypeptide products through the built-in filter screen. Polypeptide cleavage is usually based on acid hydrolysis reaction, and the polypeptide chain is broken through specific cleavage conditions. This step is usually completed by the built-in cleavage system in the polypeptide cleavage dry still, ensuring that the polypeptide chain can be cleaved into smaller peptide segments in a predetermined manner. However, when the cleaved peptide chain passes through the filter screen, it is not limited, and when encountering a very large peptide chain, it needs to take a long time to filter, affecting the subsequent work and reducing the work efficiency. SUMMARY

[0003] In order to overcome the shortcomings of the prior art, the utility model provides a polypeptide cleavage dry still with filter screen, which has the advantages of improving the filtering time.

[0004] In order to achieve the above purpose, the utility model provides the following technical scheme: a polypeptide cleavage dry still with filter screen, comprising a movable frame, a mounting block movably mounted above the movable frame, a dry still fixedly installed inside the mounting block, a protection frame fixedly installed on the top of the dry still, a motor fixedly installed on the top of the protection frame, an output shaft fixedly connected to the output end of the motor and located inside the dry still, a first gear fixedly installed on the surface of the output shaft and located inside the protection frame, a second gear rotatably installed inside the protection frame, the second gear and the first gear being gear meshing transmission, a rotating shaft fixedly installed inside the second gear, a scraper fixedly installed on the surface of the rotating shaft, an inclined block fixedly installed on the bottom surface of the rotating shaft, a filter screen slidably installed on the bottom of the output shaft, and an installation plate fixedly installed inside the filter screen.

[0005] As a preferred technical scheme of the utility model, a fixed rod is fixedly installed inside the bottom of the dry still, a work tank is fixedly installed below the installation plate between the fixed rods, a first bevel gear is fixedly installed on the surface of the output shaft and located inside the work tank, a transmission shaft is rotatably installed on the inner wall of the work tank, a cam is fixedly installed on the surface of the transmission shaft and located inside the work tank, the cam is in contact with the bottom end of the filter screen, a second bevel gear is fixedly installed on the surface of the transmission shaft and located inside the cam, and the second bevel gear and the first bevel gear are bevel gear meshing transmission.

[0006] As a preferred technical scheme of the utility model, the inside of the drying kettle is fixedly installed with a drying kettle inner tank, and the outside of the drying kettle inner tank is fixedly installed with a jacket inside the drying kettle.

[0007] As a preferred technical scheme of the utility model, the middle part of the movable frame is fixedly installed with a first pneumatic diaphragm pump, and the output end of the first pneumatic diaphragm pump is fixedly connected with a cleaning liquid inlet above the drying kettle.

[0008] As a preferred technical scheme of the utility model, the bottom of the movable frame is fixedly installed with a second pneumatic diaphragm pump, the output end of the second pneumatic diaphragm pump is fixedly connected with a nitrogen auxiliary device, the output end of the nitrogen auxiliary device is fixedly connected with a nitrogen inlet, and the nitrogen inlet is fixedly connected with the drying kettle.

[0009] As a preferred technical scheme of the utility model, the top of the drying kettle is fixedly installed with a feeding port with a sight glass and a sight lamp, and the top of the drying kettle is fixedly installed with a pressure gauge port away from one end of the feeding port with a sight glass and a sight lamp.

[0010] As a preferred technical scheme of the utility model, the bottom side of the drying kettle is fixedly installed with a tank bottom discharge port, the bottom side of the drying kettle is fixedly installed with a bottom liquid discharge port above the tank bottom discharge port, the side of the drying kettle is fixedly installed with a side liquid discharge port above the bottom liquid discharge port, the bottom side of the drying kettle is fixedly installed with a settling kettle liquid transfer port, and the middle side of the drying kettle is fixedly installed with a jacket inlet and outlet.

[0011] Compared with the prior art, the utility model has the advantages that:

[0012] 1、 the utility model discloses a drying kettle, which comprises a movable frame, a drying kettle, a jacket, a first pneumatic diaphragm pump, a second pneumatic diaphragm pump, a nitrogen auxiliary device, a nitrogen inlet, a feeding port with a sight glass and a sight lamp, a pressure gauge port, a tank bottom discharge port, a bottom liquid discharge port, a side liquid discharge port, a settling kettle liquid transfer port and a jacket inlet and outlet.

[0013] 2. The utility model discloses a cam design, in the work, output shaft drives primary bevel gear rotation, and primary bevel gear and second bevel gear bevel gear meshing drive second bevel gear rotation, and second bevel gear drives transmission shaft rotation, and transmission shaft drives cam rotation, because the big end surface and small end surface of cam will contact with the bottom end of filter screen respectively through rotation, will form the up-and-down movement of second bevel gear, and will form vibration under continuous rotation, convenient to the accelerated filtration of the pyrolysis product on the upper end surface of filter screen, improve work efficiency. BRIEF DESCRIPTION OF DRAWINGS

[0014] Figure 1 It is the structure schematic drawing of the utility model;

[0015] Figure 2 It is the structure schematic drawing of the drying kettle of the utility model;

[0016] Figure 3 It is the structure schematic drawing of the inside section of the drying kettle of the utility model;

[0017] Figure 4 It is the structure schematic drawing of the inside stirring device of the drying kettle of the utility model;

[0018] Figure 5 It is the structure schematic drawing of the movement principle of the stirring device of the utility model;

[0019] Figure 6 It is the structure schematic drawing of the filter device of the utility model;

[0020] Figure 7 It is the structure schematic drawing of the inside of the filter device of the utility model;

[0021] Figure 8 It is the structure schematic drawing of the movement principle of the filter device of the utility model.

[0022] In the drawing: 1, mobile frame, 2, mounting block, 3, drying kettle, 4, protection frame, 5, motor, 6, nitrogen auxiliary device, 7, primary pneumatic diaphragm pump, 8, secondary pneumatic diaphragm pump, 9, cleaning liquid inlet, 10, with sight glass sight lamp feeding port, 11, pressure gauge port, 12, nitrogen inlet, 13, tank bottom discharge port, 14, bottom liquid discharge port, 15, side liquid discharge port, 16, settling kettle rotation liquid port, 17, jacket inlet and outlet, 18, jacket, 19, drying kettle inner tank, 20, output shaft, 21, filter screen, 22, rotating shaft, 23, scraper, 24, inclined block, 25, primary gear, 26, secondary gear, 27, mounting plate, 28, work tank, 29, fixed rod, 30, primary bevel gear, 31, second bevel gear, 32, cam, 33, transmission shaft. DETAILED DESCRIPTION

[0023] Clearly, the described embodiments are merely a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the protection scope of the present application.

[0024] As shown in Figures 1 to 8 The utility model provides a polypeptide cleavage dry still with filter screen, including mobile frame 1, mobile frame 1 top swingly installed have installed block 2, installed block 2's inside fixed mounting has dry still 3, dry still 3's top fixed mounting has protection frame 4, protection frame 4's top fixed mounting has motor 5, motor 5's output fixed connection has located dry still 3 inside output shaft 20, output shaft 20 surface sleeve installation has located protection frame 4 inside no. One gear 25, protection frame 4's inside rotationally installed have no. Two gear 26, no. Two gear 26 and no. One gear 25 are gear meshing transmission, no. Two gear 26's inside sleeve installation has rotating shaft 22, rotating shaft 22's surface fixed mounting has scraper 23, rotating shaft 22's bottom surface fixed mounting has inclined block 24, output shaft 20's bottom sliding installation has filter screen 21, filter screen 21's inside fixed mounting has mounting plate 27.

[0025] The staff opens motor 5, and motor 5 drives output shaft 20 to rotate, and output shaft 20 drives no. One gear 25 to rotate, and the meshing transmission of no. One gear 25 and no. Two gear 26 drives no. Two gear 26 to rotate, and no. Two gear 26 drives rotating shaft 22 to rotate, and rotating shaft 22 drives scraper 23 and inclined block 24 to rotate, when the product passes through filter screen 21, output shaft 20 drives no. One bevel gear 30 to rotate, and the bevel gear meshing transmission of no. One bevel gear 30 and no. Two bevel gear 31 drives no. Two bevel gear 31 to rotate, and no. Two bevel gear 31 drives transmission shaft 33 to rotate, and transmission shaft 33 drives cam 32 to rotate, because the big end surface and small end surface of cam 32 will pass through rotation and contact the bottom end of filter screen 21 respectively, will form the up and down movement of no. Two bevel gear 31, and the continuous rotation will form vibration, improve the filtering effect, control no. One pneumatic diaphragm pump 7 and wash solution are hit into selected dry still 3 by the way of leaching, by setting the hit volume, after reaching the set value, the diaphragm pump is automatically stopped, and the nitrogen purging function is started to blow the residual solution in the pipeline into the dry still 3, control no. Two pneumatic diaphragm pump 8 and MTBE solution are hit into dry still 3, by setting the hit volume, after reaching the set value, no. Two pneumatic diaphragm pump 8 is automatically stopped, and the nitrogen purging function is started to blow the residual solution in the pipeline into the still.

[0026] Through the design of the first gear 25, the second gear 26, the scraper 23 and the inclined block 24, in work, the motor 5 drives the output shaft 20 to rotate, the output shaft 20 drives the first gear 25 to rotate, the meshing transmission of the first gear 25 and the second gear 26 drives the second gear 26 to rotate, the second gear 26 drives the rotating shaft 22 to rotate, the rotating shaft 22 drives the scraper 23 and the inclined block 24 to rotate, the rotation of the scraper 23 can scrape the product adhered to the inner wall of the drying kettle 3 for decomposition again, the inclined block 24 can rotate the product on the upper surface of the filter screen 21, and then the product is decomposed again. The smaller product is accumulated on the filter screen 21, and the inclined block 24 can quickly filter the product through the filter screen 21, thereby improving the working efficiency.

[0027] The bottom of the drying kettle 3 is internally fixedly provided with a fixed rod 29, the fixed rod 29 is fixedly provided with a working box 28 below the mounting plate 27, the output shaft 20 is externally and telescopically provided with a first bevel gear 30 in the working box 28, the working box 28 is internally and rotatably provided with a transmission shaft 33, the transmission shaft 33 is externally and telescopically provided with a cam 32, the cam 32 is in contact with the bottom end of the filter screen 21, the transmission shaft 33 is externally and telescopically provided with a second bevel gear 31 on the inner side of the cam 32, and the first bevel gear 30 and the second bevel gear 31 are in meshing transmission.

[0028] Through the design of the cam 32, in work, the output shaft 20 drives the first bevel gear 30 to rotate, the meshing transmission of the first bevel gear 30 and the second bevel gear 31 drives the second bevel gear 31 to rotate, the second bevel gear 31 drives the transmission shaft 33 to rotate, and the transmission shaft 33 drives the cam 32 to rotate. Since the large end surface and the small end surface of the cam 32 are in contact with the bottom end of the filter screen 21 through rotation respectively, the up-and-down movement of the second bevel gear 31 is formed, vibration is formed through continuous rotation, the accelerated filtration of the cracking product on the upper surface of the filter screen 21 through the filter screen 21 is facilitated, and the working efficiency is improved.

[0029] The inside of the drying kettle 3 is fixedly provided with a drying kettle inner tank 19, and the outside of the drying kettle inner tank 19 is fixedly provided with a jacket 18 in the inside of the drying kettle 3.

[0030] Through the design of the jacket 18, during the polypeptide cleavage process, heating medium can be introduced into the jacket 18 to transfer heat to the material in the drying kettle 3 through heat exchange, thereby achieving the purpose of heating the reaction. In the drying process, in order to control the temperature of the material, cooling medium can be introduced into the jacket to take away the heat in the drying kettle 3 through heat exchange, achieving the effect of cooling and temperature reduction. The use of the jacket 18 can realize accurate control of the temperature of the material in the drying kettle 3. By adjusting the temperature and flow of the medium in the jacket, the temperature in the reaction kettle can be flexibly adjusted to meet the different requirements of the polypeptide cleavage and drying processes for temperature. The design of the drying kettle 3 can optimize the heat exchange process and improve the thermal efficiency. By increasing the heat transfer area and optimizing the heat transfer path, the drying kettle 3 can more effectively transfer heat, thereby reducing energy consumption and improving production efficiency.

[0031] The middle part of the mobile frame 1 is fixedly installed with a first pneumatic diaphragm pump 7, and the output end of the first pneumatic diaphragm pump 7 is fixedly connected with a cleaning liquid inlet 9 located above the drying kettle 3.

[0032] Through the design of the first pneumatic diaphragm pump 7 and the cleaning liquid inlet 9, the first pneumatic diaphragm pump 7 is controlled to spray cleaning solution into the selected drying kettle 3 through the spray method. When the set value is reached, the diaphragm pump automatically stops working, and the nitrogen blowing function is started to blow the residual solution in the pipeline into the drying kettle 3.

[0033] The bottom of the mobile frame 1 is fixedly installed with a second pneumatic diaphragm pump 8, the output end of the second pneumatic diaphragm pump 8 is fixedly connected with a nitrogen auxiliary device 6, the output end of the nitrogen auxiliary device 6 is fixedly connected with a nitrogen inlet 12, and the nitrogen inlet 12 is fixedly connected with the drying kettle 3.

[0034] Through the installation of the nitrogen auxiliary device 6, the second pneumatic diaphragm pump 8 is controlled to spray MTBE solution into the drying kettle 3. When the set value is reached, the second pneumatic diaphragm pump 8 automatically stops working, and the nitrogen blowing function is started to blow the residual solution in the pipeline into the kettle.

[0035] The top of the drying kettle 3 is fixedly installed with a feeding port 10 with a sight glass and a sight lamp, and the top of the drying kettle 3 is fixedly installed with a pressure gauge port 11 away from one end of the feeding port 10 with a sight glass and a sight lamp.

[0036] Through the installation of the feeding port 10 with a sight glass and a sight lamp and the pressure gauge port 11, when the raw material is fed into the drying kettle 3 through the feeding port 10 with a sight glass and a sight lamp, the pressure gauge port 11 can observe the pressure condition in the drying kettle 3 at any time, which effectively protects the working equipment and improves the service life of the equipment.

[0037] The bottom side of the drying kettle 3 is fixedly provided with a tank bottom discharge port 13, the bottom side of the drying kettle 3 is fixedly provided with a bottom liquid discharge port 14 above the tank bottom discharge port 13, the side of the drying kettle 3 is fixedly provided with a side liquid discharge port 15 above the bottom liquid discharge port 14, the bottom side of the drying kettle 3 is fixedly provided with a settling kettle liquid transfer port 16, and the middle side of the drying kettle 3 is fixedly provided with a jacket inlet and outlet 17.

[0038] Through the installation of the tank bottom discharge port 13, the bottom liquid discharge port 14, the side liquid discharge port 15 and the settling kettle liquid transfer port 16, and the installation of various pipe mouths, the subsequent work requirements are met, and the practicality of the polypeptide cracking drying kettle is improved.

[0039] The working principle and use process of the utility model are as follows:

[0040] The staff opens the motor 5, the motor 5 drives the output shaft 20 to rotate, the output shaft 20 drives the first gear 25 to rotate, the meshing transmission of the first gear 25 and the second gear 26 drives the second gear 26 to rotate, the second gear 26 drives the rotating shaft 22 to rotate, the rotating shaft 22 drives the scraper 23 and the inclined block 24 to rotate, when the product passes through the filter screen 21, the output shaft 20 drives the first bevel gear 30 to rotate, the bevel gear meshing transmission of the first bevel gear 30 and the second bevel gear 31 drives the second bevel gear 31 to rotate, the second bevel gear 31 drives the transmission shaft 33 to rotate, the transmission shaft 33 drives the cam 32 to rotate, because the large end face and the small end face of the cam 32 will be in contact with the bottom end of the filter screen 21 through rotation respectively, the up and down movement of the second bevel gear 31 will be formed, and vibration will be formed under continuous rotation, the filtering effect is improved, the first pneumatic diaphragm pump 7 is controlled to spray the cleaning solution into the selected drying kettle 3 in a spraying mode, the spraying volume is set, the diaphragm pump is automatically stopped after reaching the set value, the nitrogen purging function is started to blow the residual solution in the pipeline into the drying kettle 3, the second pneumatic diaphragm pump 8 is controlled to spray the MTBE solution into the drying kettle 3, the spraying volume is set, the second pneumatic diaphragm pump 8 is automatically stopped after reaching the set value, and the nitrogen purging function is started to blow the residual solution in the pipeline into the kettle.

[0041] It should be noted that, in the present document, relational terms such as first and second and the like can be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises", "comprising", or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but can include other elements not expressly listed or inherent to such process, method, article, or apparatus.

[0042] Although the embodiments of the present application have been shown and described, it is to be understood that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present application, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A polypeptide cleavage dryer with filtering screen, comprising a moving frame (1), characterized in that: The movable frame (1) is movably installed with a mounting block (2), the inside of the mounting block (2) is fixedly installed with a drying kettle (3), the top of the drying kettle (3) is fixedly installed with a protection frame (4), the top of the protection frame (4) is fixedly installed with a motor (5), the output end of the motor (5) is fixedly connected with an output shaft (20) in the inside of the drying kettle (3), the surface of the output shaft (20) is sleevedly installed with a first gear (25) in the inside of the protection frame (4), the inside of the protection frame (4) is rotatably installed with a second gear (26), the second gear (26) and the first gear (25) are gear meshing transmission, the inside of the second gear (26) is sleevedly installed with a rotating shaft (22), the surface of the rotating shaft (22) is fixedly installed with a scraper (23), the bottom surface of the rotating shaft (22) is fixedly installed with an inclined block (24), the bottom of the output shaft (20) is slidably installed with a filter screen (21), the inside of the filter screen (21) is fixedly installed with a mounting plate (27).

2. The polypeptide cleavage dry-kettle according to claim 1, wherein: The bottom inside of the drying kettle (3) is fixedly installed with a fixed rod (29), the fixed rod (29) is fixedly installed with a working box (28) below the mounting plate (27), the surface of the output shaft (20) is sleevedly installed with a first bevel gear (30) in the inside of the working box (28), the inside of the working box (28) is rotatably installed with a transmission shaft (33), the surface of the transmission shaft (33) is sleevedly installed with a cam (32), the cam (32) is in contact with the bottom end of the filter screen (21), the surface of the transmission shaft (33) is sleevedly installed with a second bevel gear (31) inside the cam (32), the second bevel gear (31) and the first bevel gear (30) are bevel gear meshing transmission.

3. The polypeptide cleavage dry reactor with filter screen according to claim 1, characterized in that: The inside of the drying kettle (3) is fixedly installed with a drying kettle inner tank (19), the outside of the drying kettle inner tank (19) is fixedly installed with a jacket (18) in the inside of the drying kettle (3).

4. The polypeptide cleavage dry reactor with filter screen according to claim 1, characterized in that: The middle of the movable frame (1) is fixedly installed with a first pneumatic diaphragm pump (7), the output end of the first pneumatic diaphragm pump (7) is fixedly connected with a cleaning liquid inlet (9) above the drying kettle (3).

5. The polypeptide lysis and drying vessel with a filter screen according to claim 1, characterized in that: The bottom of the movable frame (1) is fixedly installed with a second pneumatic diaphragm pump (8), the output end of the second pneumatic diaphragm pump (8) is fixedly connected with a nitrogen auxiliary device (6), the output end of the nitrogen auxiliary device (6) is fixedly connected with a nitrogen inlet (12), the nitrogen inlet (12) is fixedly connected with the drying kettle (3).

6. The polypeptide lysis and drying vessel with a filter screen according to claim 1, characterized in that: The top of the drying kettle (3) is fixedly installed with a feeding port (10) with a sight glass and a light, the top of the drying kettle (3) is fixedly installed with a pressure gauge port (11) away from one end of the feeding port (10) with a sight glass and a light.

7. The polypeptide-cleaving dry-kettle having a filter screen according to claim 1, wherein: The bottom side of the drying kettle (3) is fixedly installed with a tank bottom discharge port (13), the bottom side of the drying kettle (3) is fixedly installed with a bottom liquid discharge port (14) above the tank bottom discharge port (13), the side of the drying kettle (3) is fixedly installed with a side liquid discharge port (15) above the bottom liquid discharge port (14), the bottom side of the drying kettle (3) is fixedly installed with a settling kettle liquid transfer port (16), and the middle side of the drying kettle (3) is fixedly installed with a jacket inlet and outlet (17).