Syringe dispensing system for radiopharmaceuticals

Abstract

The utility model provides an injector subpackage system for radiopharmaceuticals, which comprises a stock solution bottle, a diluent bottle, a stock solution branch, a diluent branch and a driving device, one end of the stock solution branch and one end of the diluent branch are respectively connected with the stock solution bottle and the diluent bottle, and the other end of the stock solution branch and the other end of the diluent branch are both connected with one end of a main pipeline. The other end of the main pipeline is provided with a volume variable device interface and an exhaust interface, and the volume variable device interface is detachably connected with an injector; an exhaust pipeline is arranged on the exhaust interface; a first control valve is arranged on the stock solution branch, and a second control valve is arranged on the diluent branch; the driving device is used for driving liquid to flow in the stock solution branch and the diluent branch; and a hydrophobic filter is arranged on the exhaust pipeline. When the radiopharmaceuticals are diluted and subpackaged, air can be effectively prevented from being mixed into the injector.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical packaging technology, and in particular to a syringe packaging system for radioactive pharmaceuticals. Background Technology

[0002] The process of manually preparing radiopharmaceuticals using syringes must be carried out in strict accordance with safety operating procedures to protect operators from radiation damage.

[0003] First, the operator uses a syringe with a lead protective sleeve to draw a specific volume of radiopharmaceutical solution. Next, the drawn radiopharmaceutical is injected into a reagent bottle, shaken, and then labeled. During the extraction, the operator holds a small lead container filled with developer and capped with a perforation seal in one hand and the syringe with a lead protective sleeve in the other, performing the extraction behind a labeled protective screen. Furthermore, to minimize exposure time to radioactivity, the operator quickly completes the extraction and injection process, and after the injection solution is prepared, the radioactivity is measured before a specific amount is drawn for the patient. The entire process requires the operator to perform the procedure under protective equipment to ensure safety.

[0004] The hazards of radiopharmaceuticals to operators mainly include two forms: external radiation and internal radiation. External radiation primarily comes from X-rays, gamma rays, and beta rays generated during the preparation, labeling, and processing of radiopharmaceuticals. Internal radiation can enter the body through skin absorption, inhalation of radioactive aerosols, or through contaminated food and water. This radiation can cause cell damage and increase the risk of malignant tumors and gene mutations. Furthermore, the volatilization and diffusion of radiopharmaceuticals can contaminate workplace floors, walls, and equipment with radioactive materials, increasing the risk of operator exposure. Therefore, operators must take strict protective measures, such as wearing personal protective equipment and operating in fume hoods, to reduce radiation hazards.

[0005] Currently, there are products on the market that are suitable for automatic syringe dispensing. They are generally placed inside a lead shield to operate, so as to achieve syringe dispensing operations while avoiding radiation hazards.

[0006] However, in actual dispensing processes, these devices all face a common problem: air cannot be completely expelled from the syringe. The presence of air in the syringe poses the following hazards: if air is not completely removed, it can cause air embolism during injection, a serious medical accident. Air entering the bloodstream can obstruct blood circulation, leading to organ ischemia and even cardiac arrest. Furthermore, air entering tissues can cause local pain, swelling, or infection. During intramuscular or subcutaneous injections, the presence of air can also lead to uneven drug distribution, affecting efficacy. Therefore, medical professionals must ensure that the syringe is free of air before injection to guarantee patient safety and treatment effectiveness.

[0007] Therefore, there is an urgent need to provide a radiopharmaceutical dispensing system that can completely remove air from the syringe. Summary of the Invention

[0008] The purpose of this invention is to address the shortcomings of existing technologies and provide a syringe dispensing system for radiopharmaceuticals.

[0009] The objective of this invention is achieved through the following technical solution: a syringe dispensing system for radiopharmaceuticals, comprising a raw liquid branch, a diluent branch, a main pipeline, and a driving device. One end of the raw liquid branch and the diluent branch are respectively connected to a raw liquid bottle and a diluent bottle, and the other end of the raw liquid branch and the diluent branch are connected to one end of the main pipeline. The other end of the main pipeline is provided with a variable volume device interface and an exhaust interface. A variable volume device is detachably connected to the variable volume device interface. An exhaust pipe is provided on the exhaust interface, and a hydrophobic filter is provided on the exhaust pipe. A first control valve is provided on the raw liquid branch, and a second control valve is provided on the diluent branch. The driving device is used to drive the liquid to flow in the raw liquid branch and the diluent branch.

[0010] Preferably, a first liquid sensor is provided on the original liquid branch, a second liquid sensor is provided on the diluent branch, and a third liquid sensor is provided on the main liquid branch.

[0011] Preferably, the variable volume device is a syringe.

[0012] Preferably, it also includes an activity meter, with a variable volume device placed inside the activity meter.

[0013] Preferably, the driving device is a peristaltic pump.

[0014] Preferably, the original solution branch, the diluent branch, and the main branch are connected by a T-connector A.

[0015] Preferably, a T-connector B is connected to the end of the main pipeline away from the original liquid branch. One of the interfaces on the T-connector B is connected to the main pipeline, and the other two interfaces are the variable volume device interface and the exhaust interface, respectively.

[0016] Preferably, both the tee connector A and the tee connector B are pagoda connectors.

[0017] Preferably, the end of the stock solution branch near the stock solution bottle is connected to a first puncture needle, which is connected to the stock solution branch via a connector; the end of the diluent branch near the diluent bottle is connected to a second puncture needle, which is connected to the stock solution branch via a connector.

[0018] Preferably, both the first control valve and the second control valve are pinch valves.

[0019] The beneficial effects of this utility model are:

[0020] 1. This utility model can effectively prevent air from entering the syringe when diluting and dispensing radiopharmaceuticals, and eliminates the need for operators to manually vent the syringe, thus avoiding liquid loss caused by venting operations.

[0021] 2. This utility model is easy to operate and has high operating efficiency.

[0022] 3. This invention can effectively prevent air from mixing into the medicine in the syringe, which can effectively improve the accuracy of medicine dispensing and improve the safety of medicine use.

[0023] 4. The pipeline consumables used in this utility model (such as the original liquid branch pipe, the diluent branch pipe, the main pipeline, the tee connector A, the tee connector B, etc.) are disposable and can be quickly disassembled and replaced. The closed pipeline system ensures the sterility of the medicine solution during the dispensing process. Attached Figure Description

[0024] Figure 1 This is a schematic diagram of the structure of this utility model.

[0025] Figure 2 This is a schematic diagram of the connection of each pipeline in this utility model.

[0026] In the diagram: 1. Stock solution bottle, 2. Diluent bottle, 3-1. First liquid sensor, 3-2. Second liquid sensor, 3-3. Third liquid sensor, 4. Drive device, 5-1. First shut-off valve, 5-2. Second shut-off valve, 6. Hydrophobic filter, 7. T-connector B, 8. Syringe, 9. T-connector A, 10. Activity meter, 11. Stock solution branch, 12. Diluent branch, 13. Main pipeline, 14. Exhaust pipeline, 15. First puncture needle, 16. Second puncture needle. Detailed Implementation

[0027] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model are within the protection scope of the present utility model.

[0028] like Figures 1 to 2 As shown, a syringe dispensing system for radiopharmaceuticals includes a stock solution bottle 1, a diluent bottle 2, a stock solution branch 11, a diluent branch 12, a drive device 4, and an activity meter 10. One end of the stock solution branch 11 and the diluent branch 12 are connected to the stock solution bottle 1 and the diluent bottle 2, respectively. The other end of the stock solution branch 11 and the diluent branch 12 are both connected to one end of the main pipeline 13. The other end of the main pipeline 13 is provided with a variable volume device interface and an exhaust port. A syringe 8 is detachably connected to the variable volume device interface. During dispensing, the syringe 8 is located in the activity meter 10. An exhaust pipe 14 is provided on the exhaust port. A first shut-off valve 5-1 is provided on the stock solution branch 11, and a second shut-off valve 5-2 is provided on the diluent branch 12. The drive device 4 is used to drive the liquid to flow in the stock solution branch 11 and the diluent branch 12. A hydrophobic filter 6 is provided on the exhaust pipe 14.

[0029] The hydrophobic filter 6 installed on the exhaust pipe 14 has the hydrophobicity of the filter and its hydrophobic pressure resistance value. It can discharge the air in the pipeline during the liquid filling process through the bypass, while preventing water from being discharged outward, and the liquid does not leak out at all.

[0030] Furthermore, a first liquid sensor 3-1 is installed on the raw liquid branch 11, a second liquid sensor 3-2 is installed on the diluent branch 12, and a third liquid sensor 3-3 is installed on the main pipe 13. The function of the first liquid sensor 3-1 is to sense whether liquid is flowing through the raw liquid branch 11, the function of the second liquid sensor 3-2 is to sense whether liquid is flowing through the diluent branch 12, and the function of the third liquid sensor 3-3 is to sense whether liquid is flowing through the main pipe 13. The liquid sensors can be ultrasonic sensors, photoelectric sensors, etc.

[0031] The raw liquid branch 11, the diluent branch 12, and the main pipe 13 are connected by a tee connector A9.

[0032] A tee connector B7 is connected to the end of the main pipeline 13 away from the original liquid branch pipeline 11. One of the interfaces on the tee connector B7 is connected to the main pipeline 13, and the other two interfaces are the variable volume device interface and the exhaust interface, respectively.

[0033] The end of the stock solution branch 11 near the stock solution bottle 1 is connected to a first puncture needle 15, which is connected to the stock solution branch 11 via a connector. The end of the diluent branch 12 near the diluent bottle 2 is connected to a second puncture needle 16, which is connected to the stock solution branch 11 via a connector. Considering that the stock solution bottle 1 and the diluent bottle 2 are mostly vials, the puncture needles on the stock solution branch 11 and the diluent branch 12 allow for easy insertion into the vials.

[0034] In this embodiment, the driving device 4 is a peristaltic pump.

[0035] All consumables used in this invention, such as the original liquid branch pipe, diluent branch pipe, main pipe 13, tee connector A9, and tee connector B7, are replaceable.

[0036] In this embodiment, the T-connector A, T-connector B, puncture needle, hydrophobic filter, and tubing are all connected using pagoda-shaped connectors. This type of tubing connection eliminates the so-called "dead volume," meaning there are no dead zones where liquid cannot be extracted or drained. Furthermore, because there is no "dead volume," the liquid volume set by the system for filling the syringe can be fully input into the syringe. For radiopharmaceuticals, since the syringe needs to be tested for activity, the final radiation dose of the liquid obtained is consistent with the system's set value.

[0037] The present invention discloses the following method for dispensing radiopharmaceuticals:

[0038] The liquid medicine to be dispensed and the diluent are respectively put into the original liquid bottle 1 and the diluent bottle 2, and the pipeline is installed manually; the syringe 8 is connected to the variable volume device interface, the syringe 8 is in the empty state, and the syringe 8 is placed in the activity meter 10.

[0039] The process begins with filling the liquid. The system starts, the first shut-off valve 5-1 opens, the second shut-off valve 5-2 closes, and the drive device 4 rotates forward. The liquid in the original liquid bottle 1 flows through the pipeline, sequentially passing through the first liquid sensor 3-1, the first shut-off valve 5-1, and the third liquid sensor 3-3, before being filled into the syringe 8 through the main pipeline 13. During this filling process, there will be air between the syringe 8 and the liquid. Because the piston in the syringe 8 requires a certain starting pressure to move, the air between the syringe 8 and the liquid will first move towards the exhaust pipeline 14 and be discharged by the hydrophobic filter 6. Once all the air between the syringe 8 and the liquid is discharged, the hydrophobic filter 6... As the filter 6 gradually fills with liquid, the hydrophobic filter 6 prevents the liquid from draining out, allowing the medication to enter the syringe 8, which pushes the piston in the syringe 8. At this time, the total activity of the medication is detected by the activity meter 10. When the total activity value reaches the set value, the drive device 4 stops, and the medication stops entering the syringe 8. Subsequently, the drive device 4 reverses, and the medication in the pipeline is drawn back into the original liquid bottle 1 along the original liquid branch 11. During this process, external air enters the original liquid branch 11 and the main pipeline 13 through the hydrophobic filter 6, continuously purging the pipeline. When the first liquid sensor 3-1 can no longer detect the presence of liquid, the drive device 4 stops.

[0040] Then, the diluent filling process is carried out, which is similar to the drug filling process. The second shut-off valve 5-2 is opened, the first shut-off valve 5-1 is closed, the drive device 4 rotates forward, and the liquid in the diluent bottle 2 flows through the pipeline, passing sequentially through the second liquid sensor 3-2, the second shut-off valve 5-2, and the third liquid sensor 3-3, and then through the main pipeline 13 into the syringe 8. During this entire filling process, there will be a section of air between the syringe 8 and the liquid. Since the piston in the syringe 8 requires a certain starting pressure when moving, the air between the syringe 8 and the liquid will first move towards the exhaust pipeline 14 and be discharged by the hydrophobic filter 6. After all the air between the syringe 8 and the liquid is discharged, the hydrophobic filter 6 is gradually filled with liquid, the diluent enters the syringe 8, and the piston in the syringe 8 is pushed. When the injection volume of the diluent reaches the set amount, the drive device 4 stops, and the diluent stops entering the syringe 8, thus completing the filling process.

[0041] This utility model has the following advantages:

[0042] 1. When diluting and dispensing radiopharmaceuticals, this utility model can effectively prevent air from entering the syringe 8, and eliminates the need for operators to manually vent the syringe 8, thus avoiding liquid loss caused by venting operations.

[0043] 2. This utility model is easy to operate and has high operating efficiency.

[0044] 3. This invention can effectively prevent air from mixing into the medicine in the syringe 8, which can effectively improve the accuracy of medicine dispensing and improve the safety of medicine use.

[0045] 4. The pipeline consumables used in this utility model (such as the original liquid branch pipe, the diluent branch pipe, the main pipeline 13, the tee connector A9, the tee connector B7, etc.) are disposable and can be quickly disassembled and replaced. The closed pipeline system ensures the sterility of the medicine during the dispensing process.

[0046] This utility model is not limited to the above-described preferred embodiments. Anyone can derive other forms of products under the guidance of this utility model. However, regardless of any changes made in their shape or structure, any technical solution that is the same as or similar to this application falls within the protection scope of this utility model.

Claims

1. A syringe dispensing system for radiopharmaceuticals, characterized in that, The device comprises a stock solution branch, a diluent solution branch, a main pipeline and a driving device. One end of the stock solution branch and the diluent solution branch is connected with a stock solution bottle and a diluent solution bottle respectively. The other end of the stock solution branch and the diluent solution branch is connected with one end of the main pipeline. The other end of the main pipeline is provided with a volume-variable device interface and an exhaust interface. The volume-variable device interface is detachably connected with a volume-variable device. An exhaust pipeline is arranged on the exhaust interface. A drain filter is arranged on the exhaust pipeline. A first control valve is arranged on the stock solution branch. A second control valve is arranged on the diluent solution branch. The driving device is used to drive the liquid to flow in the stock solution branch and the diluent solution branch.

2. The syringe sub-packing system for radiopharmaceuticals according to claim 1, characterized in that, A first liquid sensor is arranged on the stock solution branch. A second liquid sensor is arranged on the diluent solution branch. A third liquid sensor is arranged on the main pipeline.

3. The syringe sub-packing system for radiopharmaceuticals according to claim 1, characterized in that, The volume-variable device is a syringe.

4. The syringe sub-packing system for radiopharmaceuticals according to claim 1, characterized in that, The device further comprises a radioactivity meter. The volume-variable device is arranged in the radioactivity meter.

5. The syringe sub-packing system for radiopharmaceutical according to claim 1, characterized by, The driving device is a peristaltic pump.

6. The syringe sub-packing system for radiopharmaceuticals according to claim 1, characterized in that, The stock solution branch, the diluent solution branch and the main pipeline are connected through a tee joint A.

7. The syringe sub-packing system for radiopharmaceuticals according to claim 6, characterized in that, A tee joint B is connected with the other end of the main pipeline away from the stock solution branch. One interface of the tee joint B is connected with the main pipeline. The other two interfaces are a volume-variable device interface and an exhaust interface respectively.

8. The syringe sub-packing system for radiopharmaceuticals according to claim 7, characterized in that, The tee joint A and the tee joint B are both pagoda joints.

9. The syringe sub-packing system for radiopharmaceuticals according to claim 1, characterized in that, A first puncture needle is connected with one end of the stock solution branch close to the stock solution bottle. The first puncture needle is connected with the stock solution branch through a pipe joint. A second puncture needle is connected with one end of the diluent solution branch close to the diluent solution bottle. The second puncture needle is connected with the stock solution branch through a pipe joint.

10. The syringe sub-packing system for radiopharmaceuticals according to claim 1, characterized in that, The first control valve and the second control valve are both pinch valves.

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