Magnetic resonance imaging auxiliary device for bearing specimen slice

Abstract

The utility model provides a magnetic resonance imaging auxiliary device for bearing a specimen slice, and belongs to the technical field of magnetic resonance imaging of specimen slices. The magnetic resonance imaging auxiliary device for bearing the specimen slice comprises a coil adaptation platform which is a semi-cylinder filled with perfluoropolyether ester, and the outer diameter of the coil adaptation platform is matched with the inner diameter of a mouse coil; the object carrying box is arranged on the plane side wall of the semi-cylinder of the coil adaptation platform, and the interior of the object carrying box is filled with perfluoropolyether ester; and the box cover and the plane side wall can be opened and closed. According to the magnetic resonance imaging auxiliary device for bearing the specimen slice, the specimen slice can be flatly placed in an effective detection range of a magnetic field center of a mouse coil, magnetic sensitive artifacts generated at the junction of air and the specimen slice are eliminated, and the detection efficiency and the image quality of magnetic resonance imaging of an experimental in-vitro specimen slice are improved.

Description

Technical Field

[0001] This utility model belongs to the field of magnetic resonance imaging technology for specimen slices, and specifically relates to a magnetic resonance imaging auxiliary device for carrying specimen slices. Background Technology

[0002] In experiments involving ex vivo specimens of human lesions using magnetic resonance imaging (MRI), the size of the excised human specimen is significantly smaller than the inner diameter of the large in vivo scanning coil suitable for human use, yet larger than... Figure 2 The inner diameter of the MRI mouse coil 200 is shown. Therefore, it is often necessary to slice the excised specimen again to make its size conform to the inner diameter of the MRI mouse coil 200 before using the MRI mouse coil 200 to perform magnetic resonance imaging on the specimen slices, achieving refined imaging. Furthermore, the slices are cut according to pathological standards, allowing for precise registration of the scanned MRI images with the pathological images.

[0003] However, during magnetic resonance imaging of specimen slices using MRI mouse coil 200, three factors affected the image quality of the magnetic resonance scans:

[0004] 1. Thin specimen sections have a large surface area exposed to air, resulting in significant differences at the air-tissue interface, which can cause magnetic susceptibility artifacts during magnetic resonance imaging.

[0005] 2. The specimen slices are relatively thin, and there is currently a lack of a good support system to ensure that the slices are not centered on the coil. This results in uneven magnetic field signals, which affects the imaging quality in some areas.

[0006] 3. Currently, centrifuge tubes filled with perfluoropolyether ester are commonly used for loading. However, these esters are unstable when floating in oil solutions and are prone to motion artifacts during magnetic resonance imaging, affecting image quality. If a fixation material is used in the centrifuge tube, the slices cannot be made flat, the images cannot be located on the same scanning plane, and the slices cannot be registered with the pathological slide images.

[0007] Therefore, how to provide a carrier device suitable for magnetic resonance scanning specimen slices, adapted to experimental mouse coils, to improve the magnetic resonance imaging quality of ex vivo specimen slices is a technical problem that urgently needs to be solved by those skilled in the art. Utility Model Content

[0008] This invention was developed to solve the above-mentioned problems, and its purpose is to provide a magnetic resonance imaging auxiliary device for carrying specimen slices.

[0009] This invention provides a magnetic resonance imaging auxiliary device for carrying specimen slides, which is used to install in a mouse coil. It includes: a coil adapter platform, which is a semi-cylinder filled with perfluoropolyether resin, the outer diameter of which matches the inner diameter of the mouse coil; a specimen container, disposed on the planar sidewall of the semi-cylinder of the coil adapter platform, for placing the specimen slide flat within it, the container being filled with perfluoropolyether resin; and a lid, which is designed to open and close with the planar sidewall, such that when the lid is closed, the air above the perfluoropolyether resin in the container is compressed and expelled.

[0010] The magnetic resonance imaging auxiliary device for carrying specimen slices provided by this utility model may also have the following features: the semi-cylinder has a diameter of 2.5cm and a height of 6cm.

[0011] The magnetic resonance imaging auxiliary device for carrying specimen slices provided by this utility model may also have the following feature: the specimen container is integrally formed and recessed on the planar side wall.

[0012] The magnetic resonance imaging auxiliary device for carrying specimen slices provided by this utility model may also have the following feature: the size of the container is 0.4cm×2.3cm×6cm.

[0013] The magnetic resonance imaging auxiliary device for carrying specimen slices provided by this utility model may also have the following feature: the container has a snap-fit ​​component inside, which is used to fix the specimen slices thereon.

[0014] The magnetic resonance imaging auxiliary device for carrying specimen slices provided by this utility model may also have the following feature: wherein the snap-fit ​​component is a pair of flat and facing U-shaped protrusions, and the pair of U-shaped protrusions cooperate with each other to snap-fit ​​the specimen slice.

[0015] The magnetic resonance imaging auxiliary device for carrying specimen slices provided by this utility model may also have the following features: the planar shape and size of the lid match the planar sidewall, one side of the lid is hinged to one side of the planar sidewall along its length, and the other side is locked together.

[0016] The magnetic resonance imaging auxiliary device for carrying specimen slices provided by this utility model may also have the following features: the box cover has a female latch on the side that is locked to the planar side wall, and the coil adapter platform has a male latch on the same side, with the female latch and the male latch being matched and locked together.

[0017] The magnetic resonance imaging auxiliary device for carrying specimen slices provided by this utility model may also have the following feature: the box cover has a number of protruding posts distributed on one side near the coil adapter platform. The position of the protruding posts corresponds to the area where the specimen slice is fixed by the snap fastener. When the box cover is closed with the planar side wall, the protruding posts abut against the specimen slice fixed by the snap fastener and press it against the inner bottom of the container.

[0018] The magnetic resonance imaging auxiliary device for carrying specimen slices provided by this utility model may also have the following feature: the protrusion height of the protruding stake is not greater than the depth of the container.

[0019] Functions and effects of utility models

[0020] The magnetic resonance imaging auxiliary device for carrying specimen slides according to this utility model includes: a coil adapter platform, which is a semi-cylinder filled with perfluoropolyether ester, the outer diameter of the coil adapter platform matching the inner diameter of the mouse coil; a container, disposed on the planar side wall of the semi-cylinder of the coil adapter platform, for placing the specimen slide flat therein, the container being filled with perfluoropolyether ester; and a lid, which is designed to open and close with the planar side wall, so that when the lid is closed with the planar side wall, the air above the perfluoropolyether ester in the container is compressed and discharged.

[0021] Therefore, the magnetic resonance imaging auxiliary device for carrying specimen slices of this utility model has the following advantages compared with the prior art:

[0022] (1) The outer diameter of the semi-cylindrical coil adapter platform matches the inner diameter of the mouse coil, and the specimen slice is placed flat in the carrier box so that the specimen slice is located within the effective detection range of the magnetic field center of the mouse coil during magnetic resonance imaging, thus ensuring the uniformity of the local magnetic field and improving the efficiency of magnetic resonance imaging.

[0023] (2) The coil adapter platform and the container filled with perfluoropolyether grease can eliminate the contact interface between air and specimen slices, thereby eliminating the magnetic susceptibility artifacts generated at the interface between air and specimen slices; the magnetic resonance imaging signal of perfluoropolyether grease is a uniform extremely low signal, which forms a natural signal contrast with the specimen slices, and can improve the magnetic resonance image quality of the specimen slices.

[0024] (3) When the lid is closed, the air above the perfluoropolyether ester in the container is compressed and discharged, which improves the flatness of the specimen slice and eliminates the magnetic susceptibility artifacts generated at the interface between the air and the specimen slice, thereby further improving the detection efficiency and image quality of magnetic resonance imaging of the ex vivo specimen slice. Attached Figure Description

[0025] Figure 1 This is a schematic diagram of the structure of the magnetic resonance imaging auxiliary device carrying the specimen slice in an embodiment of this utility model;

[0026] Figure 2 This is a schematic diagram of the structure of an MRI mouse coil under existing technology. Detailed Implementation

[0027] To make the technical means, creative features, objectives and effects of this utility model easy to understand, the following embodiments, in conjunction with the accompanying drawings, will specifically describe the magnetic resonance imaging auxiliary device for carrying specimen slices of this utility model.

[0028] <Example>

[0029] Figure 1 This is a schematic diagram of the magnetic resonance imaging auxiliary device that carries the specimen slice in an embodiment of this utility model.

[0030] like Figure 1 As shown, this embodiment provides a magnetic resonance imaging auxiliary device 100 for carrying specimen slices, which is used to be placed in a mouse coil. The magnetic resonance imaging auxiliary device 100 for carrying specimen slices includes a coil adapter platform 10, a container 20, and a container cover 30.

[0031] The coil adapter platform 10 is a semi-cylinder filled with perfluoropolyether ester, and its outer diameter matches the inner diameter of the mouse coil; the semi-cylinder diameter of the coil adapter platform 10 is 2.5cm and its height is 6cm.

[0032] The coil adapter platform 10 has a male locking buckle 10a at one end of the planar side wall of the semi-cylinder along the length direction.

[0033] The container 20 is integrally recessed into the flat side wall of the semi-cylindrical body of the coil adapter platform 10, and its dimensions are 0.4cm × 2.3cm × 6cm.

[0034] The interior of the container 20 is filled with perfluoropolyether resin.

[0035] The container 20 has several pairs of snap-fit ​​pieces 20a inside. The snap-fit ​​pieces 20a are pairs of flat and facing U-shaped protrusions. The openings of the pairs of U-shaped protrusions face each other and are axially symmetrical about the central axis of the length direction of the container 20. The pairs of U-shaped protrusions are used to cooperate with each other to snap the specimen slices.

[0036] Specifically, in this embodiment, the snap-fit ​​component 20a consists of two pairs of U-shaped protrusions of different sizes (one large and one small).

[0037] As a preferred embodiment, in this embodiment, the larger pair of U-shaped protrusions in the snap-fit ​​component 20a have recessed notches on their sides during the manufacturing process, thereby saving material consumption while ensuring structural strength.

[0038] The cover 30 is plate-shaped, and its planar shape and size match the planar sidewall of the semi-cylindrical coil adapter platform 10.

[0039] One end of the cover 30 along its length is hinged to the end of the planar sidewall of the coil adapter platform 10 away from the male latch 10a.

[0040] The other end of the lid 30 along its length has a female latch 30a that is matched and latched to the male latch 10a.

[0041] The cover 30 has several raised posts 30b distributed on one side near the coil adapter platform 10.

[0042] The position of the protruding post 30b corresponds to the area where the specimen slice is fixed by the snap-fit ​​20a, and the protrusion height of the protruding post 30b is no more than 0.4cm.

[0043] When the lid 30 closes with the planar sidewall of the semi-cylindrical coil adapter platform 10, the protruding post 30b abuts against the specimen slice fixed by the snap-fit ​​20a and presses it against the inner bottom of the container 20.

[0044] As a preferred option, such as Figure 1 As shown, in this embodiment, the number of raised piles 30b is 6:

[0045] (1) Among them, four protruding posts 30b correspond to the larger snap-fit ​​piece 20a. When the cover 30 and the semi-cylindrical sidewall of the coil adapter platform 10 are closed, these four protruding posts 30b are located at the four corners inside the groove formed by a pair of larger U-shaped protrusions in the snap-fit ​​piece 20a.

[0046] When the size of the specimen slice is perfectly matched with the size of the retaining clip 20a, the four protrusions 30b can further press the specimen slice tightly, preventing it from drifting perpendicular to its plane. When the size of the specimen slice is slightly smaller than the size of the retaining clip 20a, since the four protrusions 30b are located at the four corners inside the groove formed by the pair of larger U-shaped protrusions in the retaining clip 20a, the drift space of the specimen slice can be further reduced, thus reducing its drift degree. In extreme cases, when the size of the specimen slice is much smaller than the size of the retaining clip 20a, any one of the four protrusions 30b can press the specimen slice tightly against the inner bottom of the container 20, thereby reducing its drift degree.

[0047] (2) The other two protrusions 30b correspond to the smaller snap-fit ​​piece 20a. When the box cover 30 is closed with the plane side wall of the semi-cylindrical body of the coil adapter platform 10, these two protrusions 30b are located inside the groove formed by a pair of smaller U-shaped protrusions in the snap-fit ​​piece 20a and abut against the specimen slice fixed by the smaller snap-fit ​​piece 20a, thereby pressing it against the inner bottom of the container 20.

[0048] Because the groove formed by the pair of smaller U-shaped protrusions in the snap fastener 20a has a small internal space, the corresponding small specimen slices are easy to fix. Therefore, the two protruding posts 30b are sufficient to ensure that the specimen is pressed and fixed to the inner bottom of the container 20.

[0049] The process of using the magnetic resonance imaging auxiliary device 100 that carries specimen slices:

[0050] S10, the excised specimen slice is placed flat in the container 20 and held in place by one of the pair of U-shaped protrusions in the snap-fit ​​20a that are adapted to its size.

[0051] S20, fill the container 20 with perfluoropolyether grease (perfluoropolyether grease is an oily liquid at room temperature).

[0052] S30, the cover 30 is closed to the flat side wall of the coil adapter platform 10, and the closed surface is attached to the container 20 to compress and expel the air above the perfluoropolyether grease in the container 20.

[0053] When closed, several protruding posts 30b work together to further flatten the specimen slice fixed by the snap fastener 20a into the container 20.

[0054] S40, the magnetic resonance imaging auxiliary device 100 carrying the specimen slice is placed in the magnetic resonance mouse coil, and the specimen slice is located within the effective detection range of the magnetic field center of the mouse coil, and magnetic resonance imaging of the specimen slice is performed.

[0055] The role and effect of the embodiments

[0056] According to this embodiment, a magnetic resonance imaging auxiliary device for carrying specimen slices is provided and is used to be installed in a mouse coil. It includes: a coil adapter platform, which is a semi-cylinder filled with perfluoropolyether ester, and the outer diameter of the coil adapter platform matches the inner diameter of the mouse coil; a specimen container, which is disposed on the planar side wall of the semi-cylinder of the coil adapter platform for placing specimen slices flat in it, and the interior of the specimen container is filled with perfluoropolyether ester; and a lid, which is designed to be openable and closable with the planar side wall. When the lid is closed with the planar side wall, the air above the perfluoropolyether ester in the specimen container is compressed and discharged.

[0057] Therefore, the magnetic resonance imaging auxiliary device for carrying specimen slices in this embodiment has the following advantages compared with the prior art:

[0058] (1) The outer diameter of the semi-cylindrical coil adapter platform matches the inner diameter of the mouse coil, and the specimen slice is placed flat in the carrier box so that the specimen slice is located within the effective detection range of the magnetic field center of the mouse coil during magnetic resonance imaging, thus ensuring the uniformity of the local magnetic field and improving the efficiency of magnetic resonance imaging.

[0059] (2) The coil adapter platform and the container filled with perfluoropolyether grease can eliminate the contact interface between air and specimen slices, thereby eliminating the magnetic susceptibility artifacts generated at the interface between air and specimen slices; the magnetic resonance imaging signal of perfluoropolyether grease is a uniform extremely low signal, which forms a natural signal contrast with the specimen slices, and can improve the magnetic resonance image quality of the specimen slices.

[0060] (3) When the lid is closed, the air above the perfluoropolyether ester in the container is compressed and discharged, which improves the flatness of the specimen slice and eliminates the magnetic susceptibility artifacts generated at the interface between the air and the specimen slice, thereby further improving the detection efficiency and image quality of magnetic resonance imaging of the ex vivo specimen slice.

[0061] Furthermore, the sample holder is integrally recessed into the planar sidewall. This design further improves the integration of the magnetic resonance imaging auxiliary device that carries the specimen slices, and reduces unnecessary air gaps between parts that could affect the detection efficiency and image quality of magnetic resonance imaging.

[0062] Furthermore, the specimen container contains snap-fit ​​components for securing specimen slides. These snap-fit ​​components are pairs of flat, facing U-shaped protrusions that engage to secure the slides. This design further stabilizes the slides and controls their flatness, ensuring the elimination of motion artifacts during MRI examinations.

[0063] Furthermore, the planar shape and dimensions of the lid match the planar sidewall. One side of the lid is hinged to the other side of the planar sidewall along its length, while the other side is connected by a snap-fit ​​mechanism. The lid has a female snap-fit ​​on the side that is connected to the planar sidewall, and the coil adapter platform has a male snap-fit ​​on the same side. The female and male snap-fit ​​mechanisms are matched and connected in a snap-fit ​​manner. This design allows for quick and easy opening and closing of the container and lid, facilitating experimental operations.

[0064] Furthermore, the lid has several raised posts distributed on one side near the coil adapter platform. The positions of these raised posts correspond to the areas where the specimen slices are fixed by the snap-fit ​​connectors. When the lid is closed with the planar sidewall, the raised posts abut against the specimen slices fixed by the snap-fit ​​connectors and press them against the inner bottom of the container. The protrusion height of the raised posts does not exceed the depth of the container. This design further compresses the specimen slices, preventing them from drifting or curling, improving the flatness of the specimen slices during magnetic resonance imaging, thereby further improving the detection efficiency and image quality of specimen slice magnetic resonance imaging.

[0065] Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A magnetic resonance imaging auxiliary device for carrying specimen slices, used to be installed in a mouse coil, characterized in that, include: The coil adapter platform is a semi-cylinder filled with perfluoropolyether ester, and the outer diameter of the coil adapter platform matches the inner diameter of the mouse coil. A sample container is disposed on the planar side wall of the semi-cylindrical body of the coil adapter platform, and is used to place specimen slides flat in it. The interior of the sample container is filled with perfluoropolyether resin. as well as The lid is designed to open and close with the planar sidewall. When the lid and the planar sidewall are closed, the air above the perfluoropolyether resin in the container is compressed and expelled.

2. The magnetic resonance imaging auxiliary device for carrying specimen slices according to claim 1, characterized in that: in, The semi-cylinder has a diameter of 2.5cm and a height of 6cm.

3. The magnetic resonance imaging auxiliary device for carrying specimen slices according to claim 1, characterized in that: in, The container is integrally formed and recessed into the planar sidewall.

4. The magnetic resonance imaging auxiliary device for carrying specimen slices according to claim 1 or 3, characterized in that: in, The dimensions of the container are 0.4cm × 2.3cm × 6cm.

5. The magnetic resonance imaging auxiliary device for carrying specimen slices according to claim 1, characterized in that: in, The container has snap-fit ​​connectors inside. The snap-fit ​​component is used to fix specimen slices onto it.

6. The magnetic resonance imaging auxiliary device for carrying specimen slices according to claim 5, characterized in that: in, The snap-fit ​​components are pairs of flat, facing U-shaped protrusions. The paired U-shaped protrusions engage with each other to hold the specimen slice in place.

7. The magnetic resonance imaging auxiliary device for carrying specimen slices according to claim 1, characterized in that: in, The planar shape and size of the box lid match the planar sidewall. The lid is hinged to one side of the planar sidewall along its length, and the other side is connected by a snap-fit ​​mechanism.

8. The magnetic resonance imaging auxiliary device for carrying specimen slices according to claim 7, characterized in that: in, The lid has a female latch on the side that is locked to the flat sidewall. The coil adapter platform has a male locking buckle on this side. The female latch and the male latch are matched and locked together.

9. The magnetic resonance imaging auxiliary device for carrying specimen slices according to claim 5 or 6, characterized in that: in, The cover has several raised posts distributed on one side near the coil adapter platform. The position of the protruding post corresponds to the area where the specimen slice is fixed by the snap-fit ​​component. When the lid is closed to the planar sidewall, the protruding post abuts against the specimen slice fixed by the snap-fit ​​and presses it against the inner bottom of the container.

10. The magnetic resonance imaging auxiliary device for carrying specimen slices according to claim 9, characterized in that: in, The protrusion height of the raised post is not greater than the depth of the container.

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