Autonomous jump training device for mouse behavioral experiment

Abstract

The utility model relates to the field of animal behavioral experiment equipment, in particular to an autonomous jumping training device for a mouse behavioral experiment. Comprising a conveying belt, a plurality of height-adjustable one-way opening units are arranged on the outer side of the conveying belt in the conveying direction of the conveying belt, the two ends of the conveying belt in the conveying direction are located in two shells respectively, a reward device and a punishment device are installed in the two shells respectively, and the one-way opening units can only be opened towards the punishment device. According to the utility model, by arranging the reward water nozzle and the punishment electrode, an autonomous behavior driving mechanism is constructed, and the mice need to actively jump obstacles to avoid punishment or obtain awards, so that the device is more in line with naturalness and scientificity of behavioral research.

Description

TECHNICAL FIELD

[0001] The utility model relates to an animal behavior experiment equipment field, concretely relates to a kind of for the autonomous jumping training device of mouse behavior experiment. BACKGROUND

[0002] In animal behavior, the research of mouse movement ability, learning and memory ability is an important way to explore nervous system and cognitive function. Mice, as commonly used experimental animals, are similar to humans in genetics and physiology, so they have become ideal objects in neuroscience and psychology research. By observing and analyzing the movement behavior of mice, researchers can obtain important information about neural activity, motor control, perception and other aspects. These information can provide experimental basis for exploring the mechanism of various neurological diseases, cognitive impairment and motor impairment.

[0003] Jumping, as a complex movement behavior, involves mouse coordination, balance ability and strength and other physiological mechanisms. In mouse behavior experiment, jumping ability is not only closely related to mouse movement function, but also reflects its adaptive response to different environments, danger avoidance ability and the agility of neural reflex function. Different types of jumping behavior can reflect the adaptive ability and emotional state of mice in different situations. In addition, the training of jumping ability may also affect the learning and memory ability of mice, especially in experiments involving spatial memory and cognitive flexibility. By training mice to jump in a specific environment, researchers can further study the adaptive behavior of mice in complex environments and provide reference for exploring the mechanism of motor impairment in different nervous system diseases (such as Parkinson's disease, Alzheimer's disease, etc.).

[0004] Currently, the design of mouse behavior experiment device mainly focuses on evaluating the basic movement ability, endurance, anxiety level of mice, such as mouse treadmill, open cage and other equipment. However, these existing devices lack systematic training and testing of mouse jumping ability. Therefore, the device for studying mouse jumping ability not only complements the existing research methods, but also provides a new perspective for in-depth exploration of motor control, nervous system response and learning and memory mechanism. At the same time, this invention can also provide new research tools and ideas for experiments in the fields of behavior, neuroscience and drug development, with important scientific value and application significance.

[0005] The patent document with publication number CN205180037U discloses a mouse jumping motion training device, which comprises a square fixing frame, a mouse cage arranged below the fixing frame, and a fixing rod fixed to the side of the fixing frame and provided with a rope hole at the other end parallel to the ground. A wooden board is arranged on one side of the square fixing frame, and a motor with a power supply is arranged on the wooden board. The output shaft of the motor is connected to the inner ring of a one-way rotating flywheel, and the outer ring of the one-way rotating flywheel is connected to a movable rod. A rope is arranged on the movable rod and connected to the mouse cage 4 through the rope hole. A variable resistor is connected to the power supply and connected to the motor. In use, the mouse is placed in the mouse cage, the power supply is plugged in, and the motor starts to rotate in one direction, driving the movable rod to rotate, rotating the one-way rotating flywheel, reaching the vertical height and continuing to rotate. When the movable rod and the mouse cage naturally fall and hit the ground due to their own weight, the mouse's limbs will form a reaction force to relieve the force, simulate the jumping motion, and the cycle can be repeated.

[0006] The technical solution of the above patent document forcibly descends the mouse cage by the motor to force the mouse to passively bear the impact force and produce a jumping reflex, which is essentially a mechanical stress training. The jumping action of the mouse is triggered by external mechanical force, rather than autonomous selection, which cannot simulate the jumping decision-making process in the real environment (such as avoiding natural enemies or obtaining food). Long-term training may cause anxiety or learned helplessness in mice, interfering with the reliability of experimental data. Only the variable resistor is used to adjust the rotating speed of the motor to indirectly control the falling frequency of the mouse cage, but it cannot adjust the jumping height, obstacle complexity and other key parameters. It cannot adjust the jumping difficulty for mice of different weights and ages (such as young mice and old mice), and the experimental universality is poor. Only the repeated training of a single jumping action can be realized, which is difficult to extend to complex motion ability research, and is only suitable for muscle load training of basic jumping action, and cannot be combined with high-level behavior research. Practical new type content

[0007] The main purpose of the present utility model is to provide a mouse behavior experiment autonomous jumping training device which meets the naturalness and scientificness of behavior research. The training device supports multi-dimensional parameter control and can be flexibly adapted to various scenes such as anaerobic exercise training, learning and memory association experiment, etc.

[0008] In order to achieve the above purpose, the technical scheme provided by the present utility model is:

[0009] A kind of autonomous jumping training device for mouse behavior experiment, including conveyor belt, multiple height-adjustable one-way opening units are arranged on the outer side of conveyor belt along its conveying direction, two ends in the conveying direction of conveyor belt are located in two housings respectively, reward device and punishment device are respectively installed in two housings, one-way opening unit can only open to punishment device direction.

[0010] Specifically, the one-way opening unit includes a height-adjustable gantry, and a one-way door is rotatably connected to the side of the gantry facing the punishment device. The one-way door can only be opened in the direction of the punishment device.

[0011] Specifically, the reward device is a reward faucet.

[0012] Specifically, the punishment device is a punishment electrode, which is electrically connected to a power supply and a switch.

[0013] Specifically, the conveyor belt is equipped with a support frame, and two rollers are rotatably connected to both ends of the support frame. The two rollers are driven by the conveyor belt. The shaft of any one roller is concentrically and fixedly connected to the output shaft of the motor. The motor is fixed on the support frame. The motor is a servo motor. The motor, driver, PLC controller and control panel are electrically connected.

[0014] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0015] 1. This utility model constructs an autonomous behavior-driven mechanism by setting up reward water nozzles and punishment electrodes. Mice need to actively jump over obstacles to avoid punishment or obtain rewards, which is more in line with the naturalness and scientific nature of behavioral research.

[0016] 2. This utility model supports multi-dimensional parameter control, including the number and height of unidirectional opening units and the running speed of the conveyor belt, and can be flexibly adapted to various scenarios such as anaerobic exercise training and learning and memory association experiments.

[0017] 3. By combining the conveyor belt's running speed with the one-way door design, the mechanical load of a real jump can be simulated.

[0018] 4. By using reward and punishment mechanisms, we can study the learning and memory abilities and risk decision-making behavior of mice. Attached Figure Description

[0019] Fig. 1 This is a schematic diagram of the present invention.

[0020] Fig. 2 This is a front view of the present invention.

[0021] Fig. 3 This is a side view of a unidirectional opening unit.

[0022] The components in the attached diagram are named as follows: 1. Housing, 2. Support, 3. Conveyor belt, 4. Gantry, 5. One-way door, 6. Mouse, 7. Punishment electrode. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0024] Example 1: Refer to Figs. 1-3 As shown, an autonomous jumping training device for mouse behavioral experiments includes a conveyor belt 3. Multiple height-adjustable one-way opening units are arranged on the outer side of the conveyor belt 3 along its conveying direction. The two ends of the conveyor belt 3 in the conveying direction are respectively located in two housings 1. A reward device and a punishment device are respectively installed in the two housings 1. The one-way opening units can only be opened in the direction of the punishment device.

[0025] The one-way opening unit includes a height-adjustable gantry 4, and a one-way door 5 is rotatably connected to the side of the gantry 4 facing the punishment device. The one-way door 5 can only be opened in the direction of the punishment device.

[0026] A support frame 2 is installed inside the conveyor belt 3. Rollers are rotatably connected to both ends of the support frame 2. The two rollers are driven by the conveyor belt 3. The shaft of any one roller is concentrically and fixedly connected to the output shaft of the motor. The motor, a servo motor, is fixed on the support frame 2. The motor, driver, PLC controller, and control panel are electrically connected. After receiving signals from the control panel, the PLC controller outputs corresponding control signals to the driver. The driver controls the motor's speed and direction of rotation based on the frequency and phase of the PLC controller's control signals, thereby adjusting the speed and direction of the conveyor belt 3.

[0027] The end of conveyor belt 3 on one side of the punishment device is the punishment end, and the end of conveyor belt 3 on the other side of the reward device is the reward end. A mouse 6 is placed at the reward end of conveyor belt 3. When the mouse 6 is not running, it is transported from the reward end to the punishment end via conveyor belt 3. During this process, the mouse 6 will sequentially push open multiple one-way doors 5. After the punishment device penalizes the mouse 6, it will run from the punishment end to the reward end on conveyor belt 3. At this point, the one-way doors 5 are closed, and the mouse 6 cannot push open them. The mouse 6 can only jump over the gates 4 and one-way doors 5 to move towards the reward end. By adjusting the number and height of the one-way opening units and the speed of conveyor belt 3, the number of autonomous jumps and the height of the mouse 6 within a certain time can be adjusted.

[0028] This training device supports multi-dimensional parameter control, including the number and height of unidirectional opening units and the operating speed of conveyor belt 3, and can be flexibly adapted to various scenarios such as anaerobic exercise training and learning and memory association experiments. Combining the operating speed of conveyor belt 3 with the design of unidirectional doors 5, the mechanical load of real jumping can be simulated. Through reward and punishment mechanisms, the learning and memory abilities and risk decision-making behavior of mice 6 can be studied.

[0029] Example 2: Based on Example 1, the reward device is a reward faucet. The punishment device is a punishment electrode 7, which is electrically connected to a power source and a switch.

[0030] Before starting the conveyor belt 3, turn on the switch to energize the punishment electrode 7. After the punishment electrode 7 shocks the mouse 6, the mouse 6 will move from the punishment end to the reward end on the conveyor belt 3.

[0031] By setting up reward water nozzles and punishment electrodes 7, an autonomous behavior-driven mechanism was constructed. Mice 6 were required to actively jump over obstacles to avoid punishment or obtain rewards, which is more in line with the naturalness and scientific nature of behavioral research.

[0032] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A self-jumping training device for mouse behavioral experiments, comprising a conveyor belt (3), characterized in that, Multiple height-adjustable one-way opening units are provided on the outer side of the conveyor belt (3) along its conveying direction. The two ends of the conveyor belt (3) in the conveying direction are respectively located in two housings (1). A reward device and a punishment device are respectively installed in the two housings (1). The one-way opening unit can only be opened in the direction of the punishment device.

2. The autonomous jumping training device for mouse behavioral experiments according to claim 1, characterized in that, The one-way opening unit includes a height-adjustable gantry (4), and a one-way door (5) is rotatably connected to the side of the gantry (4) facing the punishment device. The one-way door (5) can only be opened in the direction of the punishment device.

3. The autonomous jumping training device for mouse behavioral experiments according to claim 1, characterized in that, The reward device is a reward faucet.

4. The autonomous jumping training device for mouse behavioral experiments according to claim 1, characterized in that, The punishment device is a punishment electrode (7), which is electrically connected to the power supply and the switch.

5. The autonomous jumping training device for mouse behavioral experiments according to claim 1, characterized in that, The conveyor belt (3) is equipped with a support (2), and both ends of the support (2) are rotatably connected to rollers. The two rollers are driven by the conveyor belt (3). The shaft of any one roller is concentrically and fixedly connected to the output shaft of the motor. The motor is fixed on the support (2). The motor is a servo motor. The motor, driver, PLC controller and control panel are electrically connected.

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