Membrane filtering device

Abstract

The utility model provides a membrane filtering device and relates to the technical field of pharmacy. The membrane filtration device comprises a stock solution tank, a clarification pipeline, a flow supply pipeline, a backflow pipeline and at least two membrane pipe assemblies which are connected in parallel. It needs to be explained that the total filtering area is remarkably increased through the at least two membrane tube assemblies, and the membrane flux is improved. And any two membrane tube assemblies are independent from each other based on the parallel arrangement of the membrane tube assemblies. Therefore, when the production demand changes, the membrane tube assemblies with the corresponding number can be started or stopped to quickly adapt to different filtering capacity requirements, and the flexibility of the device is enhanced. Besides, the flow supply pipeline is provided with a pre-filtering assembly for filtering particle impurities in series, so that large particle impurities can be removed in advance, the membrane tube assembly is protected from being blocked or damaged, the membrane flux is ensured, and the stability and efficiency of the clarification and concentration process are improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of pharmaceutical technology, and particularly relates to a membrane filtration device. BACKGROUND

[0002] Hollow fiber filtration technology, as a tangential flow filtration separation method, has been widely used in biotechnology and pharmaceutical industries. Through the selective permeation characteristics of hollow fiber membranes, it can effectively achieve the clarification and concentration of the liquid, ensuring the effective separation and recovery of target components during production. The hollow fiber filtration device currently used in the industry is designed with a single membrane tube channel.

[0003] However, the inventors have found that a single membrane tube channel has poor flexibility and poor product yield. On the one hand, during the repeated circulation through the single channel, solid substances in the liquid will accumulate on the inner surface of the membrane tube and gradually deposit, causing membrane hole blockage and a decrease in membrane flux. On the other hand, the filtration performance of the single-channel hollow fiber filtration device cannot be flexibly adjusted when facing changes in production batch size. SUMMARY

[0004] The purpose of the utility model includes providing a membrane filtration device that can significantly improve the stability and efficiency of the clarification and concentration process, while being flexible to adapt to changes in production batch size.

[0005] Embodiments of the utility model can be implemented as follows:

[0006] In a first aspect, the utility model provides a membrane filtration device, comprising a stock solution tank, a clarification pipeline, a flow supply pipeline, a reflux pipeline, and at least two parallel membrane tube assemblies;

[0007] Each membrane tube assembly is used to filter the stock solution and is in communication with the flow supply pipeline, the reflux pipeline, and the clarification pipeline. The flow supply pipeline is used to supply liquid to the membrane tube assembly and is in communication with the liquid outlet of the stock solution tank, and a pre-filtration assembly for filtering particulate impurities is serially arranged. The reflux pipeline is used to return the concentrated liquid after filtration and is in communication with the liquid inlet of the stock solution tank. The clarification pipeline is used to discharge the clarified liquid after filtration.

[0008] In an optional embodiment, each membrane tube assembly comprises at least two parallel hollow fiber membrane tubes, each of which is in communication with the flow supply pipeline, the reflux pipeline, and the clarification pipeline.

[0009] In an optional embodiment, each membrane tube assembly further comprises a first connecting pipe, a second connecting pipe, and a third connecting pipe corresponding to each hollow fiber membrane tube. Each hollow fiber membrane tube is in communication with the flow supply pipeline, the reflux pipeline, and the clarification pipeline through the corresponding first connecting pipe, second connecting pipe, and third connecting pipe.

[0010] In an optional embodiment, each first connecting pipe is provided with a feed valve in series, each second connecting pipe is provided with a backflow valve in series, and each third connecting pipe is provided with a permeation valve in series.

[0011] In an optional embodiment, the membrane filtration device further comprises a discharge pipeline, and each hollow fiber membrane tube is in communication with the discharge pipeline.

[0012] In an optional embodiment, each membrane tube assembly further comprises a fourth connecting pipe corresponding to each hollow fiber membrane tube, each fourth connecting pipe is provided with a discharge valve in series, and each hollow fiber membrane tube is in communication with the discharge pipeline through the corresponding fourth connecting pipe.

[0013] In an optional embodiment, the pre-filtering assembly comprises a cylinder, a first filter screen and a second filter screen, wherein both ends of the cylinder are open, and the first filter screen and the second filter screen are connected to the two ends of the cylinder respectively.

[0014] In an optional embodiment, the feed pipeline is provided with a total feed valve in series, and the backflow pipeline is provided with a total backflow valve in series.

[0015] In an optional embodiment, the feed pipeline is provided with a rotor pump in series, and the rotor pump is located downstream of the pre-filtering assembly.

[0016] In an optional embodiment, the membrane filtration device further comprises a liquid storage tank, and the liquid storage tank is in communication with one end of the clarification pipeline away from the membrane tube assemblies.

[0017] The membrane filtration device provided by the embodiment of the present application has the following beneficial effects:

[0018] The present application provides a membrane filtration device. The membrane filtration device comprises a stock solution tank, a clarification pipeline, a feed pipeline, a backflow pipeline and at least two parallel membrane tube assemblies. It should be noted that the at least two membrane tube assemblies significantly increase the total filtration area and improve the membrane flux. Moreover, based on the parallel arrangement between each other, any two membrane tube assemblies are independent of each other. Therefore, when the production demand changes, the different filtration requirements can be quickly adapted by enabling or disabling the corresponding number of membrane tube assemblies, thereby enhancing the flexibility of the device. In addition, the feed pipeline is provided with a pre-filtering assembly for filtering particulate impurities, which can remove larger particulate impurities in advance, protect the membrane tube assemblies from being blocked or damaged, ensure the membrane flux, and improve the stability and efficiency of the clarification and concentration process. BRIEF DESCRIPTION OF DRAWINGS

[0019] In order to more clearly illustrate the technical scheme of the embodiments of the present application, the drawings needed to be used in the embodiments will be briefly introduced as follows. Obviously, the following drawings only show some of the embodiments of the present application, and should not be considered as limiting the scope. The components of the embodiments of the present application described and shown in the drawings can be arranged and designed in various different configurations.

[0020] Figure 1 The structural schematic diagram of the membrane filtration device provided for the embodiment is shown in the figure.

[0021] Figure 2 The structural schematic diagram of the pre-filtering assembly in the membrane filtration device provided for the embodiment is shown in the figure.

[0022] Figure 3 The structural schematic diagram of the membrane tube assembly in the membrane filtration device provided for the embodiment is shown in the figure.

[0023] Icon: 10-membrane filtration device; 100-raw liquid tank; 200-clearing pipeline; 300-feed pipeline; 310-pre-filtering assembly; 311-cylinder; 313-first filter screen; 315-second filter screen; 330-total feed valve; 350-rotary pump; 400-backflow pipeline; 410-total backflow valve; 500-membrane tube assembly; 510-hollow fiber membrane tube; 520-first connecting pipe; 521-feed valve; 530-second connecting pipe; 531-backflow valve; 540-third connecting pipe; 541-permeate valve; 550-fourth connecting pipe; 551-evacuation valve; 600-evacuation pipeline; 700-liquid storage tank. DETAILED DESCRIPTION

[0024] In the related art, the hollow fiber filtering device is a single membrane tube channel, which has the problems of poor flexibility and poor product yield.

[0025] In view of the above problems, the present application provides a membrane filtration device, which can significantly improve the stability and efficiency of the clarification and concentration process, and can be flexibly adapted to production batch changes.

[0026] In order to make the purpose, technical scheme and advantages of the embodiments of the present application more clear, the technical scheme of the embodiments of the present application will be described clearly and completely in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, not all the embodiments. The components of the embodiments of the present application described and shown in the drawings can be arranged and designed in various different configurations.

[0027] Therefore, the following detailed description of the embodiments of the application provided in the drawings is not intended to limit the scope of the claimed application, but merely represents selected embodiments of the application. Based on the embodiments in the application, all other embodiments obtained by those of ordinary skill in the art without creative labor fall within the scope of protection of the application.

[0028] It should be noted that: similar numbers and letters represent similar items in the following drawings, therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0029] In the description of the application, it should be noted that if the terms "upper", "lower", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship of the product of the application when it is usually placed, only for the convenience of describing the application and simplifying the description, and it does not indicate or imply that the device or element must have a particular orientation, be constructed and operated in a particular orientation, therefore, it cannot be understood as a limitation on the application.

[0030] In addition, if the terms "first", "second" and the like appear, they are only used to distinguish the description, and cannot be understood as indicating or implying relative importance.

[0031] It should be noted that the features in the embodiments of the application can be combined with each other without conflict.

[0032] The overall structure, working principle and technical effects of the membrane filtration device 10 provided by the application will be described in detail below through embodiments and in conjunction with the drawings.

[0033] Figure 1 For the structure diagram of the membrane filtration device 10 provided in this embodiment, please refer to Figure 1The utility model provides a membrane filtration device 10, apply to pharmaceutical technical field, specifically, can apply to the clarification filtration of raw material medicine lumbrokinase ultrafiltration concentrate liquid or other biological protein solution, in order to impurity in solution. The membrane filtration device 10 includes the liquid tank 100, clarification pipeline 200, supply flow pipeline 300, backflow pipeline 400 and at least two parallel membrane tube assemblies 500. It needs to be explained that at least two membrane tube assemblies 500 significantly increase the total filtration area, and improve the membrane flux. Again based on parallel setting between each other, the mutual independence between any two membrane tube assemblies 500. Therefore, when production demand changes, the different filtration amount requirements can be quickly adapted by enabling or disabling the corresponding number of membrane tube assemblies 500, and the flexibility of the device is enhanced. In addition, the pre-filtering assembly 310 for filtering particulate impurities is serially arranged in the supply flow pipeline 300, which can remove larger particulate impurities in advance, protect the membrane tube assembly 500 from being blocked or damaged, ensure the membrane flux, and improve the stability and efficiency of the clarification and concentration process.

[0034] On the basis, the membrane tube assembly 500 is communicated with the supply flow pipeline 300, the backflow pipeline 400 and the clarification pipeline 200. The supply flow pipeline 300 is communicated with the liquid outlet of the liquid tank 100. The backflow pipeline 400 is communicated with the liquid inlet of the liquid tank 100. Again, since the supply flow pipeline 300 is used to supply liquid to the membrane tube assembly 500, each membrane tube assembly 500 is used to filter the raw liquid, the backflow pipeline 400 is used to return the filtered concentrate liquid, and the clarification pipeline 200 is used to discharge the filtered clarified liquid. That is to say, in practical scenarios, the raw liquid flowing out of the liquid tank 100 is guided to the membrane tube assembly 500 by the supply flow pipeline 300, and is filtered and differentiated into clarified liquid and concentrate liquid under the filtering action of the membrane tube assembly 500. Among them, the clarified liquid is guided to be discharged through the clarification pipeline 200, and the concentrate liquid is guided to be returned to the liquid tank 100 through the backflow pipeline 400.

[0035] As an optional embodiment, a stable storage environment is provided for the clarified liquid, and the membrane filtration device 10 further includes a liquid storage tank 700, which is communicated with one end of the clarification pipeline 200 away from the membrane tube assembly 500. Optionally, a monitoring device can be arranged in the liquid storage tank 700 to monitor the quality parameters of the clarified liquid in real time and timely discover and handle abnormal situations. Exemplarily, the liquid storage tank 700 is provided with a pH value detection sensor or an electrical conductivity detection sensor.

[0036] Furthermore, the supply pipeline 300 is equipped with a main feed valve 330. It is understood that the main feed valve 330 controls the flow rate of the feed solution entering the membrane assembly 500. That is, the main feed valve 330 can precisely adjust the flow rate of the feed solution entering the membrane assembly 500 according to actual production needs, ensuring that each membrane assembly 500 operates under optimal working conditions, thereby improving filtration efficiency and product quality. Correspondingly, the return pipeline 400 is equipped with a main return valve 410. Similar to the above, the main return valve 410 controls the speed and pressure of the concentrate returning to the feed tank 100. That is, the main return valve 410 can adjust the return speed to ensure stable system pressure and prevent damage to the membrane assembly 500 due to excessively high return pressure.

[0037] Furthermore, a rotary pump 350 is connected in series in the supply conduit 300. It is easy to understand that the rotary pump 350 provides a stable delivery pressure, ensuring that the feed solution enters the membrane assembly 500 at a constant rate, avoiding a decrease in filtration efficiency or damage to the membrane tubes due to pressure fluctuations. To prevent particulate impurities from damaging the rotary pump 350, the rotary pump 350 is located downstream of the pre-filtration assembly 310.

[0038] like Figure 2 As shown, the pre-filtration assembly 310 includes a cylinder 311, a first filter screen 313, and a second filter screen 315. The cylinder 311 has open ends to ensure smooth inflow and outflow of the raw liquid. The first filter screen 313 and the second filter screen 315 are respectively connected to the two ends of the cylinder 311. For example, the first filter screen 313 is located at the liquid inlet end of the cylinder 311, and can perform preliminary filtration of larger particulate impurities. The second filter screen 315 is located at the liquid outlet end of the cylinder 311, and can perform secondary filtration to further remove fine particulate impurities. Optionally, the cylinder 311, the first filter screen 313, and the second filter screen 315 are all made of stainless steel.

[0039] Please see Figure 3 To improve the efficiency of a single membrane tube assembly 500 in application, each membrane tube assembly 500 includes at least two hollow fiber membrane tubes 510 connected in parallel. Furthermore, each hollow fiber membrane tube 510 is connected to the supply pipe 300, the return pipe 400, and the clarification pipe 200. It is easy to understand that, on the one hand, the parallel design allows more hollow fiber membranes to participate in the filtration process, improving the overall filtration effect and the quality of the clarified liquid; on the other hand, by distributing the filtration task among multiple hollow fiber membrane tubes 510, the risk of clogging of a single hollow fiber membrane tube 510 is reduced, ensuring long-term stable filtration performance.

[0040] It should be further explained that the above setting is to indicate that two or more hollow fiber membrane tubes 510 are integrated in one device, compared with a filtration device using one or more single membrane tube channels in the related art, the membrane filtration device 10 provided by the application also has the beneficial effects of saving equipment manufacturing accessory costs and reducing the area of site use.

[0041] Further, each membrane tube assembly 500 also includes a first connecting pipe 520, a second connecting pipe 530 and a third connecting pipe 540 corresponding to the hollow fiber membrane tube 510. Each hollow fiber membrane tube 510 is in communication with the feed pipe 300, the backflow pipe 400 and the clarification pipe 200 through the corresponding first connecting pipe 520, the second connecting pipe 530 and the third connecting pipe 540. That is to say, each hollow fiber membrane tube 510 has an independent first connecting pipe 520 (feed), a second connecting pipe 530 (backflow) and a third connecting pipe 540 (clarification), so that even if a certain connecting pipe fails, other hollow fiber membrane tubes 510 can still work normally, enhancing the reliability and stability of the device.

[0042] On the basis of the above, in order to independently regulate the flow of each membrane tube and ensure that each membrane tube operates under the best working condition, each first connecting pipe 520 is serially provided with a feed valve 521, each second connecting pipe 530 is serially provided with a backflow valve 531, and each third connecting pipe 540 is serially provided with a permeate valve 541. It is easy to understand that through the independent valve design, each membrane tube can obtain stable feed, backflow and permeate flow, avoiding the problem of excessive load of part of the membrane tubes due to uneven flow.

[0043] In addition, in the optional embodiment, in order to quickly discharge the residual liquid in the hollow fiber membrane tube 510, the membrane filtration device 10 also includes a discharge pipe 600, and each hollow fiber membrane tube 510 is in communication with the discharge pipe 600. Further, each membrane tube assembly 500 also includes a fourth connecting pipe 550 corresponding to the hollow fiber membrane tube 510, and each third connecting pipe 540 is serially provided with a discharge valve 551, and each hollow fiber membrane tube 510 is in communication with the discharge pipe 600 through the corresponding fourth connecting pipe 550. That is to say, each membrane tube can be independently discharged through the fourth connecting pipe 550 and the discharge valve 551, ensuring that each membrane tube can be quickly and completely discharged of residual liquid when needed.

[0044] Taking two membrane tube assemblies 500 arranged in parallel as an example, the working principle and process of the membrane tube filtration device provided by the embodiment of the application are as follows:

[0045] When applied in an environment with a small production batch, the total feed valve 330 and the total backflow valve 410 are opened, and all the feed valves 521, the backflow valves 531 and the permeate valves 541 in only one of the membrane tube assemblies 500 are opened. Based on this, after the raw liquid in the raw liquid tank 100 flows out, the raw liquid is filtered to remove solid particulate impurities by the pre-filter assembly 310, and then enters the membrane tube assembly 500 with the opened valve under the action of the rotor pump 350, is affected by the hollow fiber membrane tube 510, the permeate clear liquid flows to the clear liquid pipeline 200 through the corresponding third connection flow, and finally enters the storage tank 700. The concentrated liquid that is not permeated flows to the raw liquid tank 100 through the corresponding second connection flow of the backflow pipeline 400, and is recycled and filtered. When the membrane flux of the membrane tube assembly 500 decreases to a certain proportion, the feed valves 521, the backflow valves 531 and the permeate valves 541 are closed, and the emptying valve 551 is opened, so that the hollow fiber membrane tube 510 can be quickly and completely emptied of residual liquid. Subsequently, the emptying valve 551 of the module assembly is closed. At this time, all the feed valves 521, the backflow valves 531 and the permeate valves 541 of another module assembly are opened, that is, the module assembly is switched, and the above operation is repeated, so that the remaining raw liquid can continue to be filtered at a higher membrane flux. In addition, after the filtration is completed, the two membrane tube assemblies 500 can be cleaned at the same time. When applied in an environment with a large production batch, all the membrane tube assemblies 500 can be opened at the same time to meet the production demand.

[0046] In summary, the membrane filtration device 10 is provided. The membrane filtration device 10 includes a raw liquid tank 100, a clear liquid pipeline 200, a feed pipeline 300, a backflow pipeline 400 and at least two parallel membrane tube assemblies 500. It should be noted that the at least two membrane tube assemblies 500 significantly increase the total filtration area and improve the membrane flux. Based on the parallel arrangement between each other, any two membrane tube assemblies 500 are independent of each other. Therefore, when the production demand changes, the corresponding number of membrane tube assemblies 500 can be enabled or disabled to quickly adapt to different filtration requirements, thereby enhancing the flexibility of the device. In addition, the pre-filter assembly 310 for filtering particulate impurities is arranged in series in the feed pipeline 300, which can remove larger particulate impurities in advance, protect the membrane tube assembly 500 from being blocked or damaged, ensure the membrane flux, and improve the stability and efficiency of the clarification and concentration process.

[0047] The above is only a specific embodiment of the present application, but the protection scope of the present application is not limited thereto, and any person skilled in the art can easily think of changes or replacements within the technical range disclosed by the present application, which should be covered within the protection scope of the present application.

Claims

1. A membrane filtration device, characterized by, The membrane filtration device comprises a raw liquid tank, a clarification pipeline, a feed pipeline, a backflow pipeline and at least two membrane tube assemblies connected in parallel. Each of the membrane tube assemblies is used for filtering raw liquid and is connected to the feed pipeline, the backflow pipeline and the clarification pipeline.

2. The membrane filtration device of claim 1, wherein, Each of the membrane tube assemblies comprises at least two hollow fiber membrane tubes connected in parallel.

3. The membrane filtration device of claim 2, wherein, Each of the membrane tube assemblies further comprises a first connecting pipe, a second connecting pipe and a third connecting pipe corresponding to each of the hollow fiber membrane tubes.

4. The membrane filtration device of claim 3, wherein, Each of the first connecting pipes is provided with a feed valve, each of the second connecting pipes is provided with a backflow valve, and each of the third connecting pipes is provided with a permeate valve.

5. The membrane filtration device of claim 2, wherein, The membrane filtration device further comprises a discharge pipeline, and each of the hollow fiber membrane tubes is connected to the discharge pipeline.

6. The membrane filtration device of claim 5, wherein, Each of the membrane tube assemblies further comprises a fourth connecting pipe corresponding to each of the hollow fiber membrane tubes.

7. The membrane filtration device of claim 1, wherein, The pre-filtering assembly comprises a cylinder, a first filter screen and a second filter screen.

8. The membrane filtration device of any one of claims 1 to 7, wherein, The feed pipeline is provided with a total feed valve, and the backflow pipeline is provided with a total backflow valve.

9. The membrane filtration device of any one of claims 1 to 7, wherein, The feed pipeline is provided with a rotor pump, and the rotor pump is located downstream of the pre-filtering assembly.

10. The membrane filtration device of any one of claims 1 to 7, wherein, The membrane filtration device further comprises a storage tank connected to one end of the clarification pipeline away from the membrane tube assemblies.

Images