Automatic filtering device for high performance liquid chromatography sample

Abstract

The utility model relates to the technical field of liquid chromatography, and discloses an automatic filtering device for high performance liquid chromatography samples, which comprises a liquid suction component, a liquid outlet component and a liquid outlet component, the liquid suction component comprises a horizontal liquid suction plate, the horizontal liquid suction plate is provided with at least one vertical liquid suction cylinder used for being sleeved with a disposable suction head, and the vertical liquid suction cylinders are connected with a vacuum pump through liquid suction and drainage pipelines; the liquid suction assembly is arranged at the moving end of the movement mechanism, and the movement mechanism can drive the liquid suction assembly to ascend and descend in the vertical direction; the discarding assembly comprises a discarding part used for making contact with the upper edge of the disposable suction head and a discarding movement mechanism used for driving the discarding part to ascend and descend in the vertical direction; and the vacuum pump, the movement mechanism and the waste movement mechanism are all in signal connection with the control device. The automation degree of the sample pretreatment filtering link is improved, the manual operation is reduced, the personal harm to operators is reduced, and the sample filtering efficiency is remarkably improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to liquid chromatography technical field more specifically, relate to a kind of high performance liquid chromatography sample automatic filtering device. BACKGROUND

[0002] High performance liquid chromatography (High Performance Liquid Chromatography, for short HPLC) has the advantages of fast analysis speed, high separation efficiency, high sensitivity, small sample capacity, easy recovery, and is widely used in biological, chemical, medical and other fields.

[0003] The sample used in high performance liquid chromatography needs to be pretreated, and in the prior art, a disposable syringe is used to manually filter the sample, which is tedious and time-consuming, and is prone to cross-infection of the sample. And once the operation is not proper, it is easy to cause the operator to be injured and the precious sample to be lost, and the sample with biological hazard can cause biological infection and environmental pollution.

[0004] In summary, how to conveniently and safely pretreat the high performance liquid chromatography sample is a problem that needs to be solved by the technical personnel in the field at present. UTILITY MODEL CONTENT

[0005] Therefore, the utility model aims at providing a kind of high performance liquid chromatography sample automatic filtering device, improve the automation degree of sample pretreatment filtration link, reduce manual operation, both beneficial to reduce the personal harm to operator, and significantly improve sample filtration efficiency.

[0006] In order to achieve the above-mentioned purpose, the utility model provides the following technical scheme:

[0007] A kind of high performance liquid chromatography sample automatic filtering device, comprising:

[0008] Liquid suction assembly, including horizontal liquid suction plate, the horizontal liquid suction plate is equipped with at least one vertical liquid suction cylinder for being sleeved with disposable suction head, the vertical liquid suction cylinder is connected with vacuum pump by suction and drainage pipeline;

[0009] Movement mechanism, the liquid suction assembly is located in the mobile end of the movement mechanism, the movement mechanism can drive the liquid suction assembly to lift along vertical direction;

[0010] Waste component, including the waste part for being contacted with the upper edge of the disposable suction head and the waste movement mechanism for driving the waste part to lift along vertical direction;

[0011] Control device, the vacuum pump, the movement mechanism and the waste movement mechanism are all connected with the control device signal.

[0012] Preferably, the waste part comprises a push ring sleeved outside the vertical liquid suction cylinder, the inner diameter of the push ring is greater than the outer diameter of the vertical liquid suction cylinder, and the inner diameter of the push ring is less than the outer diameter of the upper end surface of the disposable suction head.

[0013] Preferably, the outer peripheral part of the disposable suction head is provided with a positioning part for abutting against the push ring so as to increase the contact area between the waste part and the disposable suction head.

[0014] Preferably, the waste part comprises a push plate provided with a relief hole for the vertical liquid suction cylinder to pass through, both ends of the push plate are connected with a pressing plate above the horizontal liquid suction plate through guide rods, and a return spring is sleeved between the pressing plate and the horizontal liquid suction plate through the guide rods.

[0015] When the pressing plate is pressed, the pressing plate drives the push plate to descend through the guide rods, and when the pressure of the pressing plate is removed, the pressing plate is reset under the action of the return spring.

[0016] Preferably, the motion mechanism comprises a horizontal connecting rod and a length-adjustable vertical telescopic rod, one end of the horizontal connecting rod is connected with the top of the vertical telescopic rod perpendicularly, and the other end of the horizontal connecting rod is connected with the horizontal liquid suction plate.

[0017] Preferably, the length of the horizontal connecting rod is adjustable, and the vertical telescopic rod and the horizontal connecting rod both comprise an electric telescopic rod.

[0018] Preferably, a rotating platform is arranged between the horizontal connecting rod and the vertical telescopic rod, or the vertical telescopic rod is arranged on the rotating platform, and the rotating platform can rotate in a horizontal plane so as to drive the liquid suction assembly to rotate in the horizontal plane.

[0019] Preferably, a suction head holder for containing the disposable suction head is further arranged, a plurality of suction head containing grooves for containing the disposable suction head are arranged in the suction head holder, and the distribution of the suction head containing grooves in the suction head holder is the same as the distribution of the vertical liquid suction cylinders in the horizontal liquid suction plate.

[0020] Preferably, contour lights are arranged at the four corners of the horizontal liquid suction plate, the contour lights are used for emitting light downward to form light point coordinates so as to accurately align the suction head holder and the horizontal liquid suction plate.

[0021] Preferably, the control device comprises a controller, the controller and the vacuum pump are both arranged in a control box, the control box is provided with control buttons for signal connection with the controller and pipe holes for mounting the liquid suction and discharge pipeline.

[0022] The automatic filtering device for high performance liquid chromatography samples provided by the utility model has the advantages of loading and discarding the disposable suction head by the movement mechanism and the discarded movement mechanism, simultaneously sucking or discharging liquid for the multiple suction heads by the vacuum pump, improving the automation degree of the sample pretreatment filtering link, reducing manual operation, being beneficial to reducing the personal harm to the operator, and significantly improving the sample filtering efficiency. BRIEF DESCRIPTION OF DRAWINGS

[0023] In order to more clearly illustrate the technical scheme in the embodiments of the utility model or the prior art, the drawings needed to be used in the embodiment or the prior art description will be briefly introduced below, and obviously, the drawings in the following description are only the embodiments of the utility model, and other drawings can be obtained according to the provided drawings without the creative labor for the ordinary skilled in the art.

[0024] Figure 1 It is a structure schematic view of the specific embodiment one of the automatic filtering device for high performance liquid chromatography samples provided by the utility model.

[0025] Figure 2 It is a structure schematic view of the specific embodiment two of the automatic filtering device for high performance liquid chromatography samples provided by the utility model.

[0026] Figure 3 It is a structure schematic view of the specific embodiment two of the automatic filtering device for high performance liquid chromatography samples provided by the utility model. Figure 2 It is a structure schematic view in another direction.

[0027] Figure 4 It is a structure schematic view of the discarded part of the automatic filtering device for high performance liquid chromatography samples provided by the utility model. Figure 2 It is a structure schematic view of the discarded part of the automatic filtering device for high performance liquid chromatography samples provided by the utility model.

[0028] Figure 5 It is a structure schematic view of the suction head supporting plate.

[0029] Figure 6 It is a structure schematic view of the disposable suction head.

[0030] Figures 1-6 In the embodiment:

[0031] 01-disposable suction head; 1-suction assembly; 11-horizontal suction plate; 12-vertical suction cylinder; 13-contour lamp; a-light point coordinate; 211-push ring; 212-electric push rod; 221-push plate; 222-guide rod; 2221-return spring; 223-pressing plate; 224-pressing handle; 31-vertical telescopic rod; 32-horizontal connecting rod; 33-rotary platform; 4-suction and discharge pipeline; 5-control box; 51-power key; 52-suction key; 53-discharge key; 54-up key; 55-down key; 56-discarding key; 6-suction head support; 61-suction head containing groove; 7-filter; 8-collection bottle. DETAILED DESCRIPTION

[0032] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all the other embodiments obtained by the ordinary skilled in the art without creative labor belong to the scope of protection of the utility model.

[0033] The core of the utility model provides a kind of high performance liquid chromatography sample automatic filtering device, improve the automation degree of sample pretreatment filtration link, reduce manual operation, both beneficial to reduce the personal harm to operator, and significantly improve sample filtration efficiency.

[0034] The high performance liquid chromatography sample automatic filtering device provided by the utility model comprises:

[0035] Liquid suction assembly 1, including horizontal liquid suction plate 11, horizontal liquid suction plate 11 is equipped with at least one vertical liquid suction cylinder 12 for being sleeved with disposable suction head 01, vertical liquid suction cylinder 12 is connected with vacuum pump by suction and drainage pipeline 4;

[0036] Movement mechanism, liquid suction assembly 1 is arranged at the moving end of movement mechanism, and movement mechanism can drive liquid suction assembly 1 to lift along vertical direction;

[0037] Waste component, including waste part for being contacted with the upper edge of disposable suction head 01 and waste movement mechanism for driving waste part to lift along vertical direction;

[0038] Control device, vacuum pump, movement mechanism and waste movement mechanism are signal connected with control device.

[0039] Please refer to Figures 1-3 , horizontal liquid suction plate 11 is usually equipped with multiple vertical liquid suction cylinders 12, so as to improve overall filtration efficiency by increasing the flux of liquid suction assembly 1, vertical liquid suction cylinder 12 is evenly arranged along the extension direction of horizontal liquid suction plate 11, the number of vertical liquid suction cylinder 12 is determined according to design flux, and the spacing of adjacent two vertical liquid suction cylinders 12 is determined according to the size of disposable suction head 01 in actual production and the operation space required for manual loading filter 7.

[0040] The top of vertical liquid suction cylinder 12 is connected with vacuum pump by suction and drainage pipeline 4, and vacuum pump can be specifically provided as bidirectional micropump etc.;When vacuum pump is negative pressure, the pressure of vacuum pump is less than the pressure at vertical liquid suction cylinder 12, and suction and drainage pipeline 4 is inwards under the action of pressure gradient, and when vacuum pump is positive pressure, the pressure of vacuum pump is greater than the pressure at vertical liquid suction cylinder 12, and suction and drainage pipeline 4 is outward under the action of pressure gradient.

[0041] The moving mechanism is connected with the liquid suction assembly 1, and is used to drive the liquid suction assembly 1 to move up and down in the vertical direction, so as to complete the loading process of the disposable suction head 01 and the like. The moving mechanism can be specifically provided as an electric push rod, a ball screw mechanism or the like linear motion mechanism.

[0042] After the sample in the disposable suction head 01 is completely discharged to the collection bottle 8 through the filter 7, the disposable suction head 01 needs to be discarded. In order to reduce the personal harm to the operator and improve the discarding efficiency, the sample automatic filtering device is provided with a discarding assembly. The discarding moving mechanism can drive the discarding part to move downward in the vertical direction, so that the discarding part is in contact with the upper edge of the disposable suction head 01, until the disposable suction head 01 is separated from the vertical liquid suction cylinder 12, and the discarding of the disposable suction head 01 is completed.

[0043] The vacuum pump, the moving mechanism and the discarding moving mechanism are all signal-connected with the control device. The control device is used to control the suction and discharge of the vacuum pump and the lifting of the moving mechanism and the discarding moving mechanism.

[0044] The control device can be specifically provided as a controller. The controller and the vacuum pump can be arranged in the control box 5. The control box 5 is provided with control buttons for signal connection with the controller and pipe holes for mounting the liquid suction and discharge pipeline 4.

[0045] Please refer to Figure 1 The control box 5 is provided with a power key 51, a liquid suction key 52 for controlling the vacuum pump to generate negative pressure to suck liquid, a liquid discharge key 53 for controlling the vacuum pump to generate positive pressure to discharge liquid, an ascending key 54 for controlling the moving mechanism to drive the liquid suction assembly 1 to ascend, a descending key 55 for controlling the moving mechanism to drive the liquid suction assembly 1 to descend, and a discarding key 56 for controlling the discarding assembly to complete a discarding operation. The above control buttons can be electrically connected with the controller through a cable, or can be signal-connected with the controller through a wireless communication mode.

[0046] During sample pretreatment, the moving mechanism is first controlled to drive the liquid suction assembly 1 to move downward, so that the vertical liquid suction cylinder 12 is in contact with the unused disposable suction head 01 in the suction head bracket 6, and the disposable suction head 01 is loaded on the vertical liquid suction cylinder 12;

[0047] Then the moving mechanism is controlled to drive the liquid suction assembly 1 to move upward, the suction head bracket 6 for placing the disposable suction head 01 is removed, and the sample container containing sample liquid is moved to the lower side of the liquid suction assembly 1. The moving mechanism is controlled to drive the liquid suction assembly 1 to move downward, so that the disposable suction head 01 is inserted into the sample liquid, and the vacuum pump is controlled to suck liquid, so that the sample liquid enters the disposable suction head 01, and the liquid suction process is completed.

[0048] Then the control motion mechanism drives the liquid suction assembly 1 to rise, and the filter 7 is manually loaded at the lower end of the disposable suction head 01, and the collection bottle 8 is placed below the liquid suction assembly 1. In order to prevent the collection bottle 8 from shaking during the liquid discharge process, the collection bottle 8 is preferably placed in a cradle or other collection bottle containing container;

[0049] Then the control motion mechanism drives the liquid suction assembly 1 to descend, and the vacuum pump discharges the liquid. The sample in the disposable suction head 01 is discharged to the collection bottle 8 through the filter 7. After the collection of the sample liquid is completed, the control motion mechanism drives the liquid suction assembly 1 to rise, and the collection bottle 8 is removed.

[0050] Finally, the control waste motion mechanism drives the waste part to move down, and the waste part presses the disposable suction head 01 to separate it from the vertical liquid suction cylinder 12. In order to prevent the disposable suction head 01 from contaminating the experiment table, a waste box is preferably provided below the liquid suction assembly 1 to collect the waste disposable suction head 01, and the disposal of the disposable suction head 01 is completed.

[0051] In this embodiment, the loading and disposal of the disposable suction head 01 are completed by the motion mechanism and the waste motion mechanism, and the vacuum pump is used to simultaneously suck or discharge the liquid of multiple suction heads, which improves the automation degree of the sample pretreatment filtration link, reduces manual operation, is beneficial to reducing the personal harm to the operator, and significantly improves the sample filtration efficiency.

[0052] On the basis of the above embodiment, the structure of the waste assembly is limited. Please refer to Figure 1 The waste part includes a push ring 211 sleeved outside the vertical liquid suction cylinder 12. The inner diameter of the push ring 211 is greater than the outer diameter of the vertical liquid suction cylinder 12, and the inner diameter of the push ring 211 is less than the outer diameter of the upper end surface of the disposable suction head 01.

[0053] Therefore, the push ring 211 can partially or fully abut the upper end surface of the disposable suction head 01. When the electric push rod 212 or other waste motion mechanism drives the push ring 211 to move downward in the vertical direction, the push ring 211 can push the disposable suction head 01 to move downward synchronously, so that the disposable suction head 01 is separated from the vertical liquid suction cylinder 12.

[0054] In order to ensure the waste effect of the push ring 211, the outer peripheral part of the disposable suction head 01 is preferably provided with a positioning part. The positioning part can be a positioning ring or a plurality of positioning arc plates uniformly distributed in the circumferential direction. The positioning part is used to abut the push ring 211, so as to increase the contact area between the waste part and the disposable suction head 01, so that the disposable suction head 01 is more stably disposed.

[0055] Preferably, please refer to Figure 2 and Figure 3The waste part can be provided with a push plate 221 provided with a clearance hole for the vertical liquid suction cylinder 12 to pass through. Both ends of the push plate 221 are connected with a pressing plate 223 above the horizontal liquid suction plate 11 through guide rods 222, and the guide rods 222 are sleeved with return springs 2221 between the pressing plate 223 and the horizontal liquid suction plate 11.

[0056] When the pressing plate 223 is pressed, the pressing plate 223 drives the push plate 221 to descend through the guide rods 222. When the pressure of the pressing plate 223 is removed, the pressing plate 223 is reset under the action of the return spring 2221.

[0057] The clearance hole on the push plate 221 is provided in one-to-one correspondence with the vertical liquid suction cylinder 12 on the horizontal liquid suction plate 11. The diameter of the clearance hole is greater than the outer diameter of the vertical liquid suction cylinder 12, so as to avoid scratching between the clearance hole and the vertical liquid suction cylinder 12 during the waste process. In addition, the diameter of the clearance hole is smaller than the outer diameter of the upper end surface of the disposable suction head 01, so as to ensure that the push plate 221 can push the disposable suction head 01 to move downward.

[0058] When the disposable suction head 01 needs to be discarded, the pressing plate 223 is controlled to move downward along the vertical direction, and the push plate 221 connected with the pressing plate 223 is also moved downward, so that the push plate 221 contacts the upper end surface of the disposable suction head 01 and drives the disposable suction head 01 to move downward, and finally the disposable suction head 01 is separated from the vertical liquid suction cylinder 12.

[0059] After the waste is completed, the pressure on the pressing plate 223 is removed, and the pressing plate 223 drives the push plate 221 to move upward along the vertical direction to reset under the elastic restoring force of the return spring 2221.

[0060] It should be noted that the operator can directly manually press the pressing plate 223, or a pressing handle 224 can be hinged on the horizontal connecting rod 32 to apply pressure to the pressing plate 223 by rotating the pressing handle 224, or a linear power mechanism such as an electric push rod can be provided above the pressing plate 223 to realize automatic waste of the disposable suction head 01.

[0061] On the basis of the above embodiment, the structure of the movement mechanism is limited. The movement mechanism can include a horizontal connecting rod 32 and a length-adjustable vertical telescopic rod 31. One end of the horizontal connecting rod 32 is connected with the top of the vertical telescopic rod 31 perpendicularly, and the other end of the horizontal connecting rod 32 is connected with the horizontal liquid suction plate 11.

[0062] Therefore, by adjusting the length of the vertical telescopic rod 31, the height of the horizontal connecting rod 32 can be adjusted, and the height of the liquid suction assembly 1 installed on the horizontal connecting rod 32 can be adjusted. The structure is simple and convenient to adjust.

[0063] But considering the coincidence of the suction head suction position, liquid taking position, liquid discharging position and waste position, the operator needs to frequently take and place the container below the liquid suction assembly 1, in order to further improve the sample filtering efficiency, the length of the horizontal connecting rod 32 can be adjusted, the suction head suction position, liquid taking position, liquid discharging position and waste position are arranged at different positions in the same direction, so as to avoid taking and placing the container below the liquid suction assembly 1.

[0064] At this time, in order to reduce the types of parts and facilitate subsequent maintenance, it is preferred that the types of horizontal connecting rod 32 and vertical telescopic rod 31 are the same, and both can be set as electric telescopic rods.

[0065] Of course, the suction head taking and placing position, liquid taking position, liquid discharging position and waste position can also be arranged at different positions on the same circumference, at this time, the horizontal connecting rod 32 and the vertical telescopic rod 31 of the movement mechanism are provided with a rotating platform 33, or the vertical telescopic rod 31 is arranged on the rotating platform 33, and the rotating platform 33 can rotate in the horizontal plane to drive the liquid suction assembly 1 to rotate in the horizontal plane.

[0066] The rotating platform 33 is usually driven by a rotating motor, which can directly drive the rotating platform 33 to rotate, or can drive the rotating platform 33 to rotate through a gear transmission mechanism, a synchronous belt mechanism or other transmission mechanisms.

[0067] On the basis of the above embodiment, in order to facilitate the loading of the disposable suction head 01, the sample automatic filtering device further comprises a suction head holder 6 for containing the disposable suction head 01, a plurality of suction head containing grooves 61 for containing the disposable suction head 01 are arranged in the suction head holder 6, and the distribution of the suction head containing grooves 61 in the suction head holder 6 is the same as the distribution of the vertical liquid suction cylinders 12 on the horizontal liquid suction plate 11.

[0068] Suppose that the horizontal liquid suction plate 11 is provided with n vertical liquid suction cylinders 12 along the extension direction (n is a positive integer, and n≥2), the distances between the centers of adjacent two vertical liquid suction cylinders 12 are m1, …, m n-1 ;

[0069] Then the suction head holder 6 is also provided with n suction head containing grooves 61 along the extension direction, and the distances between the centers of adjacent two suction head containing grooves 61 are m1, …, m n-1 .

[0070] In order to facilitate the alignment of the vertical liquid suction cylinder 12 and the disposable suction head 01 in the suction head containing groove 61, it is preferred that the vertical liquid suction cylinder 12 is uniformly distributed along the extension direction of the horizontal liquid suction plate 11, and the suction head containing groove 61 is uniformly distributed along the extension direction of the suction head holder 6.

[0071] Preferably, the four corners of the horizontal liquid suction plate 11 are provided with contour lamps 13, which are usually point light sources such as LED lamps, and the contour lamps 13 are used to emit light downward to form a light point coordinate a, so as to accurately align the suction head bracket 6 and the horizontal liquid suction plate 11, and then ensure that the disposable suction head 01 is accurately aligned with the vertical liquid suction cylinder 12.

[0072] The various embodiments are described in a progressive manner in the specification, and each embodiment focuses on the difference from other embodiments, and the same or similar parts between the various embodiments can be referred to each other.

[0073] The above has carried out the detailed introduction to the high performance liquid chromatography sample automatic filter device provided by the utility model. The principle and implementation mode of the utility model are described by applying specific examples in this paper, and the above embodiment is only used for helping to understand the method and core idea of the utility model. It should be pointed out that for ordinary skilled person in the art, without departing from the principle of the utility model, the utility model can be improved and modified in several ways, and these improvements and modifications also fall within the protection scope of the utility model claim.

Claims

1. A high performance liquid chromatography sample auto filtration device, characterized by, The application relates to a liquid suction device, which comprises a liquid suction assembly (1) including a horizontal liquid suction plate (11) provided with at least one vertical liquid suction cylinder (12) for sleeving a disposable suction head (01), wherein the vertical liquid suction cylinder (12) is connected with a vacuum pump through a liquid suction and discharge pipeline (4); a moving mechanism, wherein the liquid suction assembly (1) is arranged at a moving end of the moving mechanism, and the moving mechanism can drive the liquid suction assembly (1) to move up and down along a vertical direction; a waste assembly, which comprises a waste part for contacting an upper edge of the disposable suction head (01) and a waste moving mechanism for driving the waste part to move up and down along a vertical direction; and a control device, wherein the vacuum pump, the moving mechanism and the waste moving mechanism are signal-connected with the control device. The waste part comprises a push ring (211) sleeved outside the vertical liquid suction cylinder (12), the inner diameter of the push ring (211) is larger than the outer diameter of the vertical liquid suction cylinder (12), and the inner diameter of the push ring (211) is smaller than the outer diameter of the upper end surface of the disposable suction head (01). The outer peripheral part of the disposable suction head (01) is provided with a positioning part for abutting against the push ring (211) so as to increase the contact area between the waste part and the disposable suction head (01). The waste part comprises a push plate (221) provided with an avoiding hole for the vertical liquid suction cylinder (12) to pass through, the two ends of the push plate (221) are connected with a pressing plate (223) above the horizontal liquid suction plate (11) through guide rods (222), and a reset spring (2221) is sleeved between the pressing plate (223) and the horizontal liquid suction plate (11) of the guide rod (222). When the pressing plate (223) is pressed, the pressing plate (223) drives the push plate (221) to descend through the guide rod (222), and when the pressing force of the pressing plate (223) is removed, the pressing plate (223) is reset under the action of the reset spring (2221).

2. The high performance liquid chromatography sample auto filtration device according to claim 1, wherein, The moving mechanism comprises a horizontal connecting rod (32) and a length-adjustable vertical telescopic rod (31), one end of the horizontal connecting rod (32) is vertically connected with the top of the vertical telescopic rod (31), and the other end of the horizontal connecting rod (32) is connected with the horizontal liquid suction plate (11).

3. The high performance liquid chromatography sample auto filtration device of claim 2, wherein, The length of the horizontal connecting rod (32) is adjustable, and the vertical telescopic rod (31) and the horizontal connecting rod (32) both comprise an electric telescopic rod.

4. The high performance liquid chromatography sample auto filtration device of claim 1, wherein, A rotating platform (33) is arranged between the horizontal connecting rod (32) and the vertical telescopic rod (31), or the vertical telescopic rod (31) is arranged on the rotating platform (33), and the rotating platform (33) can rotate in a horizontal plane so as to drive the liquid suction assembly (1) to rotate in the horizontal plane. ​ 5. The high performance liquid chromatography sample auto filtration device of claim 1, wherein, ​ 6. The high performance liquid chromatography sample auto filtration device of claim 5, wherein, ​ 7. The high performance liquid chromatography sample auto filtration device of claim 5, wherein, ​ 8. The HPLC sample auto-filtering device according to any one of claims 1-7, wherein, Also included is a tip holder (6) for containing the disposable tips (01), the tip holder (6) is provided with a plurality of tip containing grooves (61) for containing the disposable tips (01), and the distribution of the tip containing grooves (61) in the tip holder (6) is the same as the distribution of the vertical liquid suction cylinders (12) in the horizontal liquid suction plate (11).

9. The high performance liquid chromatography sample auto filtration device of claim 8, wherein, The horizontal liquid suction plate (11) is provided with a contour lamp (13) at each corner, the contour lamp (13) is used to emit light downward to form a light point coordinate (a), so as to accurately align the tip holder (6) and the horizontal liquid suction plate (11).

10. The HPLC sample auto-filtering device according to any one of claims 1-7, wherein, The control device includes a controller, the controller and the vacuum pump are arranged in a control box (5), the control box (5) is provided with control buttons for signal connection with the controller and a pipe hole for installing the liquid suction and discharge pipe (4).

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