Drug synthesis reaction kettle

Abstract

The utility model provides a medicine synthesis reaction kettle. The medicine synthesis reaction kettle comprises a kettle body; the jacket is arranged on the outer wall of the kettle body; the stirring temperature adjusting component comprises a motor, a first bevel gear, a second bevel gear, an inner shaft, an outer shaft and a stirring frame, the motor is arranged at the top of the outer side of the kettle body, the first bevel gear is connected with the output end of the motor through a rotating rod, the first bevel gear is in vertical meshing connection with the second bevel gear, and the outer side of the outer shaft is sleeved with the second bevel gear; the outer shaft extends into the kettle body in the vertical direction, the inner shaft and the outer shaft are coaxially arranged, and the inner shaft penetrates through the outer shaft; one end of the stirring frame communicates with the outer shaft, and the other end of the stirring frame communicates with one end, away from the second bevel gear, of the inner shaft; the interiors of the inner shaft, the outer shaft and the stirring frame are of hollow structures, the end, close to the second bevel gear, of the outer shaft communicates with a heat exchange medium pipeline, and the end, close to the second bevel gear, of the inner shaft communicates with a heat exchange medium recovery pipeline. According to the invention, efficient synthesis of drugs is realized.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of pharmaceutical equipment, and particularly relates to a drug synthesis reaction kettle. BACKGROUND

[0002] The drug synthesis reaction kettle is a common device in the pharmaceutical industry. Raw materials for drug synthesis are usually added to the reaction kettle, and the temperature, pressure and stirring speed of the reaction kettle are adjusted to carry out the reaction, so as to realize efficient production of drugs. The drug synthesis reaction kettle plays a crucial role in the process of drug research and production.

[0003] During the reaction process, when the reaction is a stage reaction, that is, after the end of the previous step reaction, the reaction temperature needs to be reduced or the reaction temperature needs to be accurately controlled, the reaction needs to be quickly cooled to the preset temperature, and then the next step reaction is carried out. However, in the prior art, external jackets or coils are usually used for cooling. However, when the volume of the reaction kettle is large, the cooling rate is slow, and it is difficult to meet the temperature requirements of the reaction, resulting in reduced production efficiency or affecting the quality of the product drug. CONTENT OF THE UTILITY MODEL

[0004] The present application provides a drug synthesis reaction kettle to solve the above problems mentioned in the background art.

[0005] The present application provides a drug synthesis reaction kettle, comprising: a kettle body;

[0006] a jacket, the jacket is arranged on the outer wall of the kettle body; and

[0007] a stirring and temperature adjusting component, the stirring and temperature adjusting component comprises a motor, a first bevel gear, a second bevel gear, an inner shaft, an outer shaft and a stirring frame, the motor is arranged at the top of the outer side of the kettle body, the first bevel gear is connected with the output end of the motor through a rotating rod, the first bevel gear is vertically meshed and connected with the second bevel gear, the second bevel gear is sleeved on the outer side of the outer shaft, the outer shaft vertically extends into the kettle body, the inner shaft is coaxially arranged with the outer shaft and penetrates through the outer shaft;

[0008] one end of the stirring frame is communicated with the outer shaft, and the other end of the stirring frame is communicated with the end of the inner shaft away from the second bevel gear;

[0009] the inner shaft, the outer shaft and the stirring frame are all hollow structures, one end of the outer shaft close to the second bevel gear is communicated with a heat exchange medium pipeline, and one end of the inner shaft close to the second bevel gear is communicated with a heat exchange medium recovery pipeline.

[0010] Optionally, a reinforcing rib is connected between the stirring frame and the outer shaft.

[0011] Optionally, the reinforcing rib is a hollow structure, one end of the reinforcing rib is communicated with the outer shaft, and the other end of the reinforcing rib is communicated with the stirring frame.

[0012] Optionally, the stirring frame is rectangular or arc-shaped.

[0013] Optionally, the reaction kettle is further provided with an aeration component, the aeration component comprising a gas cabinet, a gas pump and an aeration pipe, the outlet end of the gas cabinet being connected with one end of the aeration pipe, the other end of the aeration pipe extending into the kettle body, and the gas pump being arranged on the aeration pipe.

[0014] Optionally, a heat exchanger is arranged between the gas cabinet and the gas pump.

[0015] Optionally, a linear module is arranged on the upper portion of the inner wall of the kettle body, one side of the linear module being fixedly connected with the inner wall of the kettle body, and the sliding block of the linear module being connected with the aeration pipe.

[0016] Optionally, a temperature sensor is arranged in the kettle body.

[0017] The drug synthesis reaction kettle provided by the present application realizes efficient synthesis of drugs, and has the following beneficial effects compared with the prior art:

[0018] (1) By arranging the jacket and the stirring temperature adjusting component, the heat exchange medium is introduced into the jacket to cool (or heat) the reactants in the kettle body, the motor provides power to make the stirring frame stir the reaction materials, thereby accelerating the interaction between the materials in the kettle body, and thus facilitating efficient reaction, thereby facilitating the synthesis of drugs. At the same time, the heat exchange medium is introduced into the cavity between the inner shaft and the outer shaft through the heat exchange medium pipeline, the heat exchange medium enters the stirring frame through the outer shaft, so that the stirring frame can simultaneously stir the reaction materials in the kettle body and cooperatively adjust the temperature with the external jacket, thereby improving the cooling efficiency of the reaction materials in the kettle body, facilitating efficient and stable reaction, and thus improving the efficiency and quality of drug synthesis.

[0019] (2) By arranging the aeration component, the gas in the gas cabinet is pressurized by the gas pump and then introduced into the kettle body through the aeration pipe to stir the reaction materials, thereby further stirring the reaction materials, improving the material exchange between the reaction materials, and improving the reaction efficiency.

[0020] (3) By arranging the linear module on the inner wall of the kettle body in the vertical direction, and fixing one side of the housing of the linear module to the inner wall of the kettle body 1 and connecting the sliding block of the linear module with the aeration pipe, the sliding block of the linear module moves in the vertical direction to drive the aeration pipe to move in the vertical direction, thereby improving the stirring of the reaction materials and improving the reaction efficiency.

[0021] (4) The drug synthesis reaction kettle provided by the present application has simple structure and convenient operation, and is suitable for large-scale promotion and application in the industry. BRIEF DESCRIPTION OF DRAWINGS

[0022] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or prior art description. Obviously, the drawings described below are some embodiments of the present application, and the drawings can also be obtained by those skilled in the art without creative effort on the basis of these drawings.

[0023] Figure 1 The structural schematic diagram of the drug synthesis reaction kettle provided by an embodiment of the present application is shown in the figure.

[0024] Figure 2 The structural schematic diagram of the drug synthesis reaction kettle provided by another embodiment of the present application is shown in the figure.

[0025] Figure 3 The structural schematic diagram of the drug synthesis reaction kettle provided by another embodiment of the present application is shown in the figure.

[0026] Explanation of reference signs:

[0027] 1: kettle body, 2: jacket, 5: heat exchanger, 6: linear module, 7: temperature sensor, 110: feed inlet, 120: discharge outlet, 310: motor, 311: rotating rod, 320: first bevel gear, 330: second bevel gear, 340: inner shaft, 341: negative pressure pump, 350: outer shaft, 351: heat exchange medium pump, 360: stirring frame, 370: reinforcing rib, 410: gas tank, 420: gas pump, 430: aeration pipe, 810: first valve, 820: second valve. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions in the embodiments of the present application will be described clearly and completely below. Obviously, the described embodiments are some embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative effort also belong to the scope of protection of the present application.

[0029] As shown in Figure 1 and Figure 3 The present application provides a drug synthesis reaction kettle, which comprises:

[0030] a kettle body 1;

[0031] a jacket 2, which is arranged on the outer wall of the kettle body 1; and

[0032] The stirring and temperature adjusting component comprises a motor 310, a first bevel gear 320, a second bevel gear 330, an inner shaft 340, an outer shaft 350 and a stirring frame 360. The motor 310 is arranged at the top of the kettle body 1 outside. The first bevel gear 320 is connected with the output end of the motor 310 through a rotating rod 311. The first bevel gear 320 is vertically meshed with the second bevel gear 330. The second bevel gear 330 is sleeved outside the outer shaft 350. The outer shaft 350 vertically extends into the kettle body 1. The inner shaft 340 is coaxially arranged with the outer shaft 350, and the inner shaft 340 penetrates through the outer shaft 350.

[0033] One end of the stirring frame 360 is communicated with the outer shaft 350. The other end of the stirring frame 360 is communicated with one end of the inner shaft 340 away from the second bevel gear 330.

[0034] The inner shaft 340, the outer shaft 350 and the stirring frame 360 are all hollow structures. One end of the outer shaft 350 close to the second bevel gear 330 is communicated with the heat exchange medium pipeline. One end of the inner shaft 340 close to the second bevel gear 330 is communicated with the heat exchange medium recovery pipeline.

[0035] Specifically, the top of the kettle body 1 is provided with a feeding port 110. The reaction raw materials are added into the kettle body 1 through the feeding port 110. The inside of the kettle body 1 provides a space for reaction. The heat exchange medium is introduced into the jacket 2 to cool (or heat) the reactants in the kettle body 1, so as to control the temperature in the kettle body 1 and make the reaction proceed smoothly.

[0036] The stirring and temperature adjusting component is used for stirring the materials in the kettle body 1 and adjusting the temperature in the kettle body 1 in cooperation with the jacket 2. The stirring and temperature adjusting component comprises the motor 310, the first bevel gear 320, the second bevel gear 330, the inner shaft 340, the outer shaft 350 and the stirring frame 360. The motor 310 provides power to drive the rotating rod 311 to rotate. The rotating rod 311 drives the first bevel gear 320 to rotate. The first bevel gear 320 drives the second bevel gear 330 vertically meshed therewith to rotate. The second bevel gear 330 drives the outer shaft 350 to rotate. At the same time, the stirring frame 360 rotates with the outer shaft 350 and collides with the materials in the kettle body 1. The materials are stirred to accelerate the interaction between the materials in the kettle body 1, which is conducive to the efficient reaction and the synthesis of the medicine.

[0037] The stirring temperature adjusting component also has the function of temperature adjustment, the inner shaft 340 is coaxially arranged with the outer shaft 350, and the inner shaft 340 penetrates through the outer shaft 350, the inner shaft 340, the outer shaft 350 and the inside of the stirring frame 360 are all hollow structures, one end of the outer shaft 350 close to the second bevel gear 330 is in communication with the heat exchange medium pipeline, and the heat exchange medium is introduced into the cavity between the inner shaft 340 and the outer shaft 350 through the heat exchange medium pipeline, when the kettle body 1 needs to be cooled, the cooling medium flows into the outer shaft 350 from top to bottom through the cavity between the inner shaft 340 and the outer shaft 350, and when the cooling medium passes through the communication part between the outer shaft 350 and the stirring frame 360, part of the cooling medium enters the inside of the stirring frame 360, so that the stirring frame 360 can introduce the cooling medium for cooling while stirring the reaction material in the kettle body 1, and cooperates with the jacket 2 to improve the cooling efficiency of the reaction material in the kettle body 1, which is beneficial to the efficient and stable reaction, and further improves the efficiency and quality of drug synthesis. When the cooling medium flows in the stirring frame 360 to the bottom, it enters the inner shaft 340 and flows from bottom to top and is output from the top outlet of the inner shaft 340, and the cooling medium is recycled through the heat exchange medium recovery pipeline.

[0038] The bottom of the kettle body 1 is provided with a discharge port 120, and the reaction material is discharged through the discharge port 120 after the reaction is completed. The stirring frame 360 is centrally and symmetrically provided with a plurality of

[0039] Further, the heat exchange medium includes cooling medium or heating medium, when the reaction material needs to be heated, the cooling medium is replaced by the heating medium, and the above-mentioned cooling scheme is used for operation, so as to achieve the purpose of heating the reaction material in the kettle body 1. The heating medium is, for example, water vapor, heat conducting oil, etc., and the cooling medium is, for example, circulating water, refrigerated water, air, etc., which is not limited here and is determined according to the actual working condition. In this way, the stirring of the reaction material is realized, and the temperature of the reaction material is efficiently adjusted through the internal and external temperature adjustment, which further improves the reaction efficiency and is beneficial to improving the production quality and production efficiency of the drug.

[0040] Further, in order to improve the flow of the heat exchange medium in the inner shaft 340 and the outer shaft 350, a heat exchange medium pump 351 is arranged on the heat exchange medium pipeline to pressurize the input of the heat exchange medium and accelerate the flow of the heat exchange medium in the cavity between the inner shaft 340 and the outer shaft 350; and a negative pressure pump 341 is arranged on the heat exchange medium recovery pipeline to improve the movement of the heat exchange medium in the inner shaft 340, improve the output rate of the heat exchange medium, and further improve the heat exchange efficiency.

[0041] The bottom of the inner shaft 340 is connected with the outer shaft 350 in a sealed manner to avoid the mixing of the heat exchange medium and the reaction material. The top of the inner shaft 340 is connected with the outer shaft 350 in a dynamic sealing manner. The connection between the inner shaft 340 and the heat exchange medium recovery pipeline and the connection between the outer shaft 350 and the heat exchange medium pipeline are both rotary sealing connections.

[0042] The present application realizes the efficient synthesis of drugs. The jacket and the stirring temperature adjusting component are arranged, the heat exchange medium is introduced into the jacket to cool (or heat) the reaction material in the kettle body, the motor provides power to make the stirring frame stir the reaction material, the interaction between the materials in the kettle body is accelerated, and thus the efficient reaction is facilitated, thereby helping the synthesis of drugs. Meanwhile, the heat exchange medium is introduced into the cavity between the inner shaft and the outer shaft through the heat exchange medium pipeline, the heat exchange medium enters the inside of the stirring frame through the outer shaft, the stirring frame can be temperature adjusted with the external jacket while stirring the reaction material in the kettle body, the cooling efficiency of the reaction material in the kettle body is improved, the efficient and stable reaction is facilitated, and thus the efficiency and quality of the drug synthesis are improved.

[0043] As shown in Figure 2 Optionally, the stirring frame 360 is connected with the outer shaft 350 through the reinforcing rib 370.

[0044] Specifically, one end of the reinforcing rib 370 is connected with the outer shaft 350, and the other end of the reinforcing rib 370 is connected with the stirring frame 360. The reinforcing rib 370 helps to improve the mechanical strength and resistance of the stirring frame 360, improves the stirring efficiency, and thus improves the stability of the stirring frame 360, and facilitates the stable operation of the reaction kettle.

[0045] Optionally, the reinforcing rib 370 is hollow, one end of the reinforcing rib 370 is connected with the outer shaft 350, and the other end of the reinforcing rib 370 is connected with the stirring frame 360.

[0046] Specifically, the heat exchange medium enters the reinforcing rib 370 from the cavity between the inner shaft 340 and the outer shaft 350, and flows from the reinforcing rib 370 to the lower part of the stirring frame 360, which improves the heat exchange area between the heat exchange medium and the reaction material, improves the temperature adjusting efficiency, and thus improves the synthesis efficiency of the drugs.

[0047] Optionally, the stirring frame 360 is rectangular or arc-shaped. More preferably, the stirring frame 360 is arc-shaped, which can improve the pressure-bearing capacity of the stirring frame 360 while achieving the stirring purpose, and thus facilitates the stable operation of the reaction kettle and prolongs the service life of the reaction kettle.

[0048] As shown in Figure 2As shown, optionally, the reaction kettle is further provided with an aeration component, the aeration component comprising a gas cabinet 410, a gas pump 420 and an aeration pipe 430, the outlet end of the gas cabinet 410 being connected with one end of the aeration pipe 430, the other end of the aeration pipe 430 extending into the kettle body 1, and the gas pump 420 being arranged on the aeration pipe 430.

[0049] Specifically, the aeration component is used for aeration into the kettle body 1, further realizing agitation of the reaction materials, improving the material exchange between the reaction materials, and improving the reaction efficiency. The gas in the gas cabinet 410 is introduced into the kettle body 1 through the aeration pipe 430 to agitate the reaction materials, and the gas pump 420 is used for pressurizing the gas to improve the kinetic energy of the collision between the gas and the reaction materials, thereby improving the reaction efficiency.

[0050] Further, the aeration pipe 430 enters the kettle body 1 in the vertical direction, and one side of the aeration pipe 430 is connected with the inner wall of the kettle body 1 to avoid shaking of the aeration pipe 430 during agitation.

[0051] As shown, Figure 3 Optionally, a heat exchanger 5 is arranged between the gas cabinet 410 and the gas pump 420.

[0052] Specifically, the heat exchanger 5 is used for heating or cooling the gas from the gas cabinet 410, and then the heated / cooling gas is input into the kettle body 1 through the aeration pipe 430, so as to disperse the heated / cooling gas in the reaction materials while assisting in agitation, thereby further improving the temperature adjusting efficiency of the reaction materials.

[0053] The gas used for aeration is a gas that does not react with the reaction materials, such as inert gas (e.g. nitrogen) when oxygen is avoided from entering.

[0054] Optionally, a linear module 6 is arranged on the upper part of the inner wall of the kettle body 1, one side of the linear module 6 being fixedly connected with the inner wall of the kettle body 1, and the sliding block of the linear module 6 being connected with the aeration pipe 430.

[0055] Specifically, the linear module 6 is arranged in the vertical direction of the inner wall of the kettle body 1, one side of the shell of the linear module 6 being fixedly connected with the inner wall of the kettle body 1, the sliding block of the linear module 6 being connected with the aeration pipe 430, and the sliding block of the linear module 6 moving in the vertical direction to drive the aeration pipe 430 to also move in the vertical direction, thereby improving the agitation of the reaction materials and further improving the reaction efficiency.

[0056] Further, the linear module 6 is arranged on the upper part of the inner wall of the kettle body 1 to avoid splashing of the reaction materials on the surface of the linear module 6.

[0057] Optionally, a temperature sensor 7 is arranged in the kettle body 1.

[0058] Specifically, the temperature sensor 7 is used to detect the temperature in the kettle body 1 in real time, so that the operator can quickly regulate the temperature in the kettle body 1 according to the reading of the temperature sensor 7. The heat exchange medium inlet of the jacket 2 is provided with a first valve 810, and the heat exchange medium pipeline connected with the outer shaft 350 is provided with a second valve 820. By adjusting the opening degree of the first valve 810 and the second valve 820 and the frequency of the air pump 420, the temperature in the kettle body 1 can be efficiently regulated.

[0059] The technical solutions of the present application will be described in detail below with specific examples.

[0060] The running process of the drug synthesis reaction kettle in the embodiment during actual work is as follows:

[0061] The reaction raw materials are added to the kettle body 1 through the feeding port 110, the motor 310 provides power to drive the rotating rod 311 to rotate, the rotating rod 311 drives the first bevel gear 320 to rotate, the first bevel gear 320 drives the second bevel gear 330 which is vertically engaged with the first bevel gear 320 to rotate, and the second bevel gear 330 drives the outer shaft 350 to rotate. At the same time, the stirring frame 360 rotates with the outer shaft 350 and collides with the materials in the kettle body 1, thereby stirring the reaction materials to make the reaction proceed smoothly.

[0062] When the reaction materials in the kettle body 1 need to be cooled, cooling medium is input into the cavity between the inner shaft 340 and the outer shaft 350 through the heat exchange medium pipeline. The cooling medium flows from top to bottom into the outer shaft 350 through the cavity between the inner shaft 340 and the outer shaft 350. During the flow process, part of the cooling medium enters the stirring frame 360, and part of the cooling medium enters the reinforcing rib 370. Therefore, the stirring frame 360 can not only stir the reaction materials in the kettle body 1, but also pass the cooling medium to cool down, and cooperates with the jacket 2 to improve the cooling efficiency of the reaction materials in the kettle body 1. The cooling medium in the reinforcing rib 370 flows to the lower part of the stirring frame 360, enters the inner shaft 340 through the bottom of the stirring frame 360, flows from bottom to top, and is output from the top outlet of the inner shaft 340. The cooling medium is recycled through the heat exchange medium recovery pipeline.

[0063] At the same time, the gas in the gas tank 410 is cooled by the heat exchanger 5, pressurized by the air pump 420, and then input into the kettle body 1 through the aeration pipe 430. The slider of the linear module 6 is connected with the aeration pipe 430, so that the aeration pipe 430 moves vertically and stirs the reaction materials to increase the kinetic energy of the collision between the gas and the reaction materials, thereby improving the reaction efficiency.

[0064] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, and are not limited thereto; although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand; it can still modify the technical solutions recorded in the foregoing embodiments, or make equivalent replacement to part or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present application.

Claims

1. A pharmaceutical synthesis reaction vessel, characterized by, The utility model relates to a reaction kettle, including: The kettle body (1); The jacket (2) is set up on the outer wall of the kettle body (1); And, The stirring temperature adjusting part includes motor (310), first bevel gear (320), second bevel gear (330), inner shaft (340), outer shaft (350) and stirring frame (360), the motor (310) is set up on the top of the kettle body (1) outside, the first bevel gear (320) is connected with the output end of the motor (310) through the rotating rod (311), the first bevel gear (320) is connected with the second bevel gear (330) perpendicularly engaged, the second bevel gear (330) is set up in the outer side of the outer shaft (350), the outer shaft (350) vertically direction goes into the kettle body (1) inside, the inner shaft (340) is coaxial with the outer shaft (350) setting, and the inner shaft (340) passes through the outer shaft (350); One end of the stirring frame (360) is communicated with the outer shaft (350), and the other end of the stirring frame (360) is communicated with one end of the inner shaft (340) away from the second bevel gear (330); The inner shaft (340), the outer shaft (350) and the inside of the stirring frame (360) are all hollow structures, one end of the outer shaft (350) close to the second bevel gear (330) is communicated with the heat exchange medium pipeline, and one end of the inner shaft (340) close to the second bevel gear (330) is communicated with the heat exchange medium recovery pipeline.

2. The pharmaceutical synthesis reaction kettle according to claim 1, characterized in that, The reinforcing rib (370) is connected between the stirring frame (360) and the outer shaft (350).

3. The pharmaceutical synthesis reaction vessel of claim 2, wherein, The reinforcing rib (370) is hollow inside, one end of the reinforcing rib (370) is communicated with the outer shaft (350), and the other end of the reinforcing rib (370) is communicated with the stirring frame (360).

4. The pharmaceutical synthesis reaction vessel of claim 1, wherein, The stirring frame (360) is rectangular or arc-shaped.

5. The pharmaceutical synthesis reaction vessel of claim 1, wherein, The reaction kettle is further provided with aeration components, the aeration components include gas cabinet (410), gas pump (420) and aeration pipe (430), the outlet end of the gas cabinet (410) is connected with one end of the aeration pipe (430), the other end of the aeration pipe (430) goes into the kettle body (1) inside, and the gas pump (420) is set up on the aeration pipe (430).

6. The pharmaceutical synthesis reaction kettle of claim 5, wherein, The heat exchanger (5) is arranged between the gas cabinet (410) and the gas pump (420).

7. The pharmaceutical synthesis reaction kettle of claim 6, wherein, The kettle body (1) is provided with a linear module (6) on the inner wall upper portion, one side of the linear module (6) is fixedly connected with the kettle body (1) inner wall, and the sliding block of the linear module (6) is connected with the aeration pipe (430).

8. The pharmaceutical synthesis reaction kettle according to any one of claims 1-7, characterized in that, The kettle body (1) is provided with a temperature sensor (7).

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