Integrated fixing device for rodent pathological section manufacturing
By designing an integrated fixing device with a closed fixing groove and a rotating hinge connection, the problems of formaldehyde volatilization and brain tissue damage in existing technologies are solved, achieving stable fixing and efficient material extraction while protecting the health of operators.
Patent Information
- Application Number
- CN202520389556.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-07
- Publication Date
- 2026-02-13
- Estimated Expiration
- 2035-03-07
AI Technical Summary
Existing fixation devices pose health risks to operators due to the volatilization of formaldehyde when fixing brain tissue. They are also cumbersome, inefficient, and prone to damage during transfer, resulting in unstable fixation effects and low sampling accuracy.
An integrated fixation device was designed, which uses a closed fixation slot to integrate brain tissue fixation and sampling functions. The brain card slot is matched with different parts, and the fixation device housing and cover are connected by a rotating hinge to reduce formalin volatilization and simplify the operation process.
It achieves stable fixation of brain tissue, reduces formalin volatilization, protects the health of operators, improves the efficiency and accuracy of fixation and material collection, and simplifies the operation process.
Smart Images
Figure CN223910529U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to the technical field of fixing device, concretely relates to a kind of integrated fixing device for rodent pathological section production. BACKGROUND
[0002] The fixing device for pathological section production refers to the fixation and sampling or block of brain tissue in the steps of formalin fixation, dehydration, embedding, sectioning and staining.
[0003] The above-mentioned fixing includes two meanings. One is the fixation of tissues in pathological experiments (formalin), which prevents tissue corruption and autolysis. The other is the fixation of the position of tissues, which ensures that the tissues do not move and are stably fixed in the device.
[0004] However, the existing fixing device has the following problems to be improved. The existing fixing device usually uses formalin for fixation to prevent tissue autolysis and corruption during tissue fixation. However, brain tissue is relatively soft and needs to be placed in a special device. The volatilization of formalin can cause harm to the operator. The traditional method needs to fix and sample each part of the brain tissue separately, which is complicated and inefficient. During the transfer of brain tissue, mechanical damage to the brain tissue can occur, the fixing effect is unstable, and manual fixing cannot ensure uniform fixing effect, low sampling accuracy, and difficulty in ensuring the flatness and positioning accuracy of the section during manual sampling. UTILITY MODEL CONTENT
[0005] To solve the above-mentioned problems in the prior art, the utility model provides an integrated fixing device for rodent pathological section production, which can use a closed fixing groove to reduce the volatilization of formalin and integrate the functions of brain tissue fixation and sampling into one, simplifying the operation process.
[0006] The purpose of the utility model can be achieved through the following technical solutions.
[0007] An integrated fixing device for rodent pathological section production includes a fixing device housing and a fixing device cover plate. The fixing device housing and the fixing device cover plate are rotationally connected.
[0008] A plurality of brain cutting clamping grooves are formed around the fixing device housing. A brain clamping groove is formed at the bottom of the fixing device housing. The brain clamping groove includes a cerebellum fixing groove, a cerebral cortex fixing groove and an olfactory bulb fixing groove. The cerebellum fixing groove, the cerebral cortex fixing groove and the olfactory bulb fixing groove are integrated.
[0009] Further, the plurality of brain cutting clamping grooves are parallel to each other.
[0010] Further, the cerebellum is arranged in the cerebellum fixing groove, the brain is arranged in the brain fixing groove, and the olfactory bulb is arranged in the olfactory bulb fixing groove.
[0011] Further, two cover plate fixing grooves are arranged on the inner side of the end of the fixing device cover plate away from the fixing device shell.
[0012] Further, two cover plate buckles are arranged on the inner side of the end of the fixing device cover plate away from the fixing device shell.
[0013] Further, the two cover plate fixing grooves and the two cover plate buckles are matched.
[0014] Further, the plurality of brain cutting clamping grooves are matched with the cutter.
[0015] Further, the fixing device shell and the fixing device cover plate are connected through a rotating hinge.
[0016] The fixing device has the advantages that:
[0017] (1) The brain clamping groove is arranged, the cerebellum is arranged in the cerebellum fixing groove, the brain is arranged in the brain fixing groove, and the olfactory bulb is arranged in the olfactory bulb fixing groove.
[0018] (2) The fixing device shell and the fixing device cover plate are arranged, the fixing device shell and the fixing device cover plate are connected through a rotating hinge, the fixing device shell and the fixing device cover plate are closed fixing grooves, the volatilization of formalin is reduced, and the health of the operator is protected. BRIEF DESCRIPTION OF DRAWINGS
[0019] In order to facilitate the understanding of those skilled in the art, the fixing device will be further described below with reference to the drawings.
[0020] Figure 1 It is the first perspective view of the fixing device.
[0021] Figure 2 It is the second perspective view of the fixing device.
[0022] Figure 3 It is the third perspective view of the fixing device.
[0023] Figure 4 It is the fourth perspective view of the fixing device.
[0024] Figure 5 Figure 5 is a fifth perspective view of the present application;
[0025] Mark explanation:
[0026] In the figure: 1, cover plate fixed groove; 2, brain cutting card slot; 3, brain card slot; 4, fixed device shell; 5, fixed device cover plate; 6, cover plate buckle; 7, cerebellum fixed groove; 8, brain fixed groove; 9, olfactory bulb fixed groove. Specific implementation
[0027] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application; obviously, the described embodiments are only some of the embodiments of the present application, not all the embodiments, and all other embodiments obtained by those skilled in the art without creative labor based on the embodiments in the present application are within the scope of protection of the present application.
[0028] In the description of the present application, it should be noted that the terms "upper", "lower", "inner", "outer", "top / bottom end" and the like indicate the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application. In addition, the terms "first", "second" are only for descriptive purposes and cannot be understood as indicating or implying relative importance.
[0029] In the description of the present application, it should be noted that unless otherwise explicitly specified and limited, the terms "mounting", "provided with", "sleeved / connected", "connected" and the like should be understood broadly, for example, "connected" can be fixedly connected, can be detachably connected, or integrally connected; can be mechanically connected, can be electrically connected; can be directly connected, can be indirectly connected through an intermediate medium, and can be connected inside two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.
[0030] Reference Figures 1 to 5 The utility model discloses a kind of integrated fixing device for rodent pathological section production, including fixed device shell 4 and fixed device cover plate 5, fixed device shell 4 and fixed device cover plate 5 are rotationally connected between them;
[0031] A plurality of brain cutting card slots 2 are formed around the fixed device shell 4, and a brain card slot 3 is formed at the bottom of the fixed device shell 4. The brain card slot 3 includes a cerebellum fixed groove 7, a brain fixed groove 8 and an olfactory bulb fixed groove 9, which are integrated. The plurality of brain cutting card slots 2 are parallel to each other.
[0032] The cerebellum is arranged in the cerebellum fixing groove 7, the cerebrum is arranged in the cerebrum fixing groove 8, and the olfactory bulb is arranged in the olfactory bulb fixing groove 9.
[0033] Two cover plate fixing grooves 1 are fixedly arranged on the inner side of the end of the fixing device shell 4 away from the fixing device cover plate 5.
[0034] Two cover plate buckles 6 are fixedly arranged on the inner side of the end of the fixing device cover plate 5 away from the fixing device shell 4. The two cover plate fixing grooves 1 and the two cover plate buckles 6 are matched. The plurality of brain cutting card slots 2 are matched with the cutter.
[0035] The brain card slot 3 can fix the brain tissue, can more accurately control the formalin concentration, the fixing time and the temperature, ensures the fixing effect stable, is used for rodent brain tissue fixation and material taking, realizes the automatic replacement of fixing fluid and the automation of material taking process, improves the efficiency and the precision.
[0036] The fixing device shell 4 and the fixing device cover plate 5 are connected through a rotating hinge. The fixing device shell 4 and the fixing device cover plate 5 are closed fixing grooves, reduce formalin volatilization, protect the health of the operator. The brain tissue fixing and material taking functions are integrated into one, simplify the operation process, reduce the damage to the brain tissue when the operator takes it out.
[0037] The working principle and the use process of the utility model are as follows: after the dissection of the animal is completed, the brain tissue of the animal is taken out, the brain tissue is placed into the brain card slot 3 of the integrated fixing device, the cerebellum, the cerebrum and the olfactory bulb are respectively placed into the corresponding cerebellum fixing groove 7, cerebrum fixing groove 8 and olfactory bulb fixing groove 9, the fixing device cover plate 5 is rotated to the upper end of the fixing device shell 4, the cover plate buckle 6 is placed into the cover plate fixing groove 1 and buckled, and then the integrated fixing device containing the brain tissue is placed into the formalin solution, the tissue is fixed, and the stability of the brain tissue in the device is ensured.
[0038] After the fixation of the brain tissue is completed, the integrated fixing device is taken out, the cover plate buckle 6 in the cover plate fixing groove 1 is opened, the fixing device cover plate 5 is opened, the cutter is inserted into the brain cutting card slot 2, and the cutting and material taking work of the brain tissue is carried out.
[0039] The above merely describes preferred embodiments of the present application, and is not intended to limit the present application in any form. Although the present application has been disclosed with preferred embodiments, it is not intended to limit the present application. Any person skilled in the art can make minor changes or modifications to the disclosed technical content, or make equivalent embodiments with equivalent changes, without departing from the technical solution of the present application. Any modification, equivalent change or modification of the above embodiments, which does not depart from the technical solution of the present application, is still within the scope of the technical solution of the present application.
Claims
1. An integrated fixation device for rodent pathology slide preparation, comprising: a base; a cover; a plurality of fixation reagents; and a plurality of reagent containers, wherein each reagent container is in fluid communication with a respective one of the plurality of fixation reagents. The fixing device shell and the fixing device cover plate are rotationally connected; A plurality of brain cutting clamping grooves are formed around the fixing device shell, and a brain clamping groove is formed at the bottom of the fixing device shell, wherein the brain clamping groove comprises a cerebellum fixing groove, a cerebral cortex fixing groove and an olfactory bulb fixing groove, and the three fixing grooves are integrated.
2. An integrated fixation device for rodent pathology sectioning according to claim 1, wherein: The plurality of brain cutting clamping grooves are parallel to each other.
3. An integrated fixation device for rodent pathology sectioning according to claim 1, wherein: The cerebellum fixing groove is provided with a cerebellum, the cerebral cortex fixing groove is provided with a cerebral cortex, and the olfactory bulb fixing groove is provided with an olfactory bulb.
4. An integrated fixation device for rodent pathology sectioning according to claim 1, wherein: Two cover plate fixing grooves are fixedly arranged on the inner side of the end of the fixing device shell away from the fixing device cover plate.
5. An integrated fixation device for rodent pathology sectioning according to claim 4, wherein: Two cover plate buckles are fixedly arranged on the inner side of the end of the fixing device cover plate away from the fixing device shell.
6. An integrated fixation device for rodent pathology sectioning according to claim 5, wherein: The two cover plate fixing grooves and the two cover plate buckles are matched.
7. An integrated fixation device for rodent pathology sectioning according to claim 1, wherein: The plurality of brain cutting clamping grooves are matched with a cutter.
8. An integrated fixation device for rodent pathology sectioning according to claim 1, wherein: The fixing device shell and the fixing device cover plate are connected through a rotary hinge.