Local directional hyperthermic perfusion chemotherapy device for abdominal cavity

Abstract

The local directional hyperthermic perfusion chemotherapy device comprises a liquid medicine tube, a heating tube, a liquid medicine release body and a drainage tube, the liquid medicine release body comprises a heating cavity and a release cavity which are arranged in an overlapped mode, a permeable membrane is arranged on the release face of the release cavity, one end of the liquid medicine tube is communicated with an external liquid medicine bag, and the other end of the liquid medicine tube is communicated with the release cavity of the liquid medicine release body; the heating pipe comprises an input section heating pipe and an output section heating pipe, the input section heating pipe and the output section heating pipe wrap the liquid medicine pipe in the middle, the input section heating pipe, the liquid medicine releaser heating cavity and the output section heating pipe are sequentially communicated to form a heating channel, the heating channel is communicated with an external heat supply device, and a heating medium flows in the heating channel; the drainage tube is used for draining the liquid medicine in the abdominal cavity out of the abdominal cavity; according to the utility model, the local focus of the abdominal cavity is directionally perfused, the whole abdominal cavity is prevented from being filled with liquid medicine, the toxic effect on normal cell tissues in the abdominal cavity is small, the occurrence of chemotherapy complications is reduced, and the chemotherapy quality is improved.

Description

Technical Field

[0001] This utility model relates to a device for localized directional hyperthermic perfusion chemotherapy in the peritoneum, belonging to the field of medical device technology. Background Technology

[0002] Hyperthermic intraperitoneal chemotherapy (HIPEC) is an adjuvant therapy for peritoneal malignancies. Normal cells can tolerate temperatures of 47°C for about one hour, while tumor cells will suffer irreversible damage at around 43°C. HIPEC utilizes the difference in temperature tolerance between tumor cells and normal cells. By heating the perfusion fluid containing chemotherapy drugs to a certain temperature (generally 43-45°C) and continuously circulating it into the peritoneal cavity, the tumor cells in the peritoneal cavity are killed under the dual effects of heat and chemotherapy drugs.

[0003] Currently, there are many problems in the implementation of hyperthermic intraperitoneal chemotherapy (HIPEC). When infusing chemotherapy-containing perfusion fluid into the peritoneal cavity, chemotherapy is often carried out by filling the entire peritoneal cavity. This method makes it difficult to target chemotherapy to local lesions in the peritoneal cavity, causing the chemotherapy drugs in the perfusion fluid to have a significant toxic effect on other normal cells and tissues in the peritoneal cavity, thus leading to many clinical complications. In addition, each peritoneal perfusion can only be maintained for about one hour, which cannot continuously release chemotherapy drugs to local lesions in the peritoneal cavity for a long time. Moreover, each perfusion must be completed with the help of a hyperthermic perfusion device, which is not only time-consuming and labor-intensive, but also accompanied by high treatment costs. Utility Model Content

[0004] To address the shortcomings of existing technologies, this invention provides a device for localized directional hyperthermic perfusion chemotherapy in the peritoneum.

[0005] The technical solution adopted in this utility model is as follows:

[0006] A localized hyperthermic perfusion chemotherapy device for the peritoneum includes a drug solution tube, a heating tube, a drug solution release body, and a drainage tube. The drug solution release body includes a heating chamber and a release chamber stacked together. The release surface of the release chamber is provided with a permeable membrane. One end of the drug solution tube is connected to an external drug solution bag, and the other end is connected to the release chamber of the drug solution release body. The heating tube includes an input section heating tube and an output section heating tube, which enclose the drug solution tube in the middle. The input section heating tube, the heating chamber of the drug solution release body, and the output section heating tube are sequentially connected to form a heating channel. The heating channel is connected to an external heating device, and a heating medium flows in the heating channel. The drainage tube is used to drain the drug solution in the peritoneum to the outside of the peritoneum.

[0007] As a preferred embodiment of this invention, the cross-sectional shape of the input heating tube and the output heating tube, which enclose the liquid tube in the middle, is elliptical.

[0008] As a preferred embodiment of the present invention, the drug release body is a groove-shaped structure, and the release cavity is located on the concave surface of the groove-shaped drug release body.

[0009] As a preferred embodiment of this invention, the input section heating tube and the output section heating tube each have a free end that is separate from the liquid medicine tube, and the input section heating tube and the output section heating tube are connected to an external heating device through their respective free ends.

[0010] As a preferred embodiment of this invention, the heating medium is water.

[0011] As a preferred embodiment of the present invention, the front end of the drainage tube has a flexible portion, and the flexible portion forms a plurality of drainage holes.

[0012] As a preferred embodiment of this invention, the soft part is filled with medical polyurethane foam.

[0013] As a preferred embodiment of this invention, the flexible part is made of silicone rubber.

[0014] The advantages of this utility model are:

[0015] (1) It can achieve targeted perfusion of local lesions in the peritoneum, avoid filling the entire peritoneum with the drug solution, reduce the perfusion pressure of the drug solution in the peritoneum, and have less toxic effects on normal cells and tissues in the peritoneum. This helps to reduce the probability of chemotherapy complications, improve the effect and quality of chemotherapy, and reduce the patient's pain and treatment costs.

[0016] (2) Because of the use of directional perfusion, the time for perfusion of local lesions in the abdominal cavity can be appropriately extended each time;

[0017] (3) It is designed with a heating channel. The heating medium flowing in the heating channel can heat the drug liquid tube and the drug liquid in the release chamber, so that the temperature of the drug liquid increases. At the same time, the temperature of the drug liquid release body will also increase. The drug liquid release body also heats the local lesions in the abdominal cavity, so as to kill the tumor cells in the local lesions in the abdominal cavity by combining high temperature with chemotherapy drugs. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the structure of this utility model.

[0019] Figure 2 yes Figure 1 A cross-sectional view at point A in the diagram.

[0020] Figure 3 yes Figure 1 A cross-sectional view at point B in the diagram.

[0021] Figure 4 yes Figure 1Enlarged diagram of point C in the image.

[0022] Meaning of the reference numerals in the diagram:

[0023] 1-Medicine solution tube.

[0024] 2-Heating tube, 21-Input section heating tube, 22-Output section heating tube, 23-Free end.

[0025] 3-Drug release body, 31-Heating chamber, 32-Release chamber, 33-Permeabilized membrane.

[0026] 4-Drainage tube, 41-Soft part, 42-Drainage hole.

[0027] 5-External medicine bag. Detailed Implementation

[0028] The present invention will now be described in detail with reference to the accompanying drawings and specific embodiments.

[0029] like Figure 1-3 As shown, this embodiment is a localized directional hyperthermic perfusion chemotherapy device for the peritoneum, including a drug solution tube 1, a heating tube 2, a drug solution release body 3, and a drainage tube 4. The drug solution release body 3 includes a heating chamber 31 and a release chamber 32 stacked together. A permeable membrane 33 is provided on the release surface of the release chamber 32. One end of the drug solution tube 1 is connected to an external drug solution bag 5, and the other end is connected to the release chamber 32 of the drug solution release body 3. Figure 3 As shown, in this embodiment, the drug release body 3 has a groove-shaped structure and is circular in shape. The release cavity 32 is located on the concave surface of the groove-shaped drug release body 3. During chemotherapy, the drug release body 3 is placed in the peritoneal cavity, and the permeable membrane 33 is attached to the local lesion in the peritoneal cavity. If necessary, adhesive material is provided at the edge of the permeable membrane 33. The drug solution containing chemotherapy drugs flows into the release cavity 32 through the drug solution tube 1, and then is slowly released to the local lesion in the peritoneal cavity through the permeable membrane 33. This achieves targeted perfusion of the local lesion in the peritoneal cavity, avoids filling the entire peritoneal cavity with the drug solution, reduces the perfusion pressure of the drug solution in the peritoneal cavity, and has less toxicity to normal cells and tissues in the peritoneal cavity. This helps to reduce the probability of chemotherapy complications, improve the effect and quality of chemotherapy, and reduce the patient's pain and treatment costs.

[0030] Heating tube 2 includes an input section heating tube 21 and an output section heating tube 22, which enclose the medicine liquid tube 1 in the middle; for example Figure 2As shown, in this embodiment, the cross-sectional shape of the input section heating pipe 21 and the output section heating pipe 22, which wrap around the drug solution pipe 1, is elliptical to accommodate the surgical incision on the abdominal skin. The input section heating pipe 21, the drug solution release body 3 heating chamber 31, and the output section heating pipe 22 are sequentially connected to form a heating channel. The heating channel is connected to an external heating device, and a heating medium, which is water, flows in the heating channel, ensuring safety and reliability. The external heating device circulates and heats the heating medium. The heating medium flowing in the heating channel heats the drug solution in the drug solution pipe 1 and the release chamber 32, raising the temperature of the drug solution. At the same time, the temperature of the drug solution release body 3 also rises, and the drug solution release body 3 also heats the local lesions in the abdominal cavity, achieving the goal of killing tumor cells in the local lesions of the abdominal cavity by combining high temperature with chemotherapy drugs.

[0031] To facilitate communication between the input section heating pipe 21 and the output section heating pipe 22 and an external heating device, in this embodiment, the input section heating pipe 21 and the output section heating pipe 22 each have a free end 23 that is separate from the liquid pipe 1, such as... Figure 1 As shown, the input section heating tube 21 and the output section heating tube 22 are connected to the external heating device through their respective free ends 23.

[0032] The medication instilled into the abdominal cavity is drained out of the abdominal cavity through drainage tube 4. The number of drainage tubes 4 can be selected according to the actual situation; if necessary, the drainage tube 4 can be connected to external negative pressure drainage.

[0033] like Figure 1 and 4 As shown, in this embodiment, the front end of the drainage tube 4 has a flexible part 41, and multiple drainage holes 42 are formed on the flexible part 41. The flexible part 41 has a certain degree of flexibility and can bend and deform with the organs in the abdominal cavity. The flexible part 41 is filled with medical polyurethane sponge, which has an attraction effect on the drug solution. At the same time, the medical polyurethane sponge plays a supporting role inside the flexible part 41. The flexible part 41 is made of silicone rubber material. Silicone rubber is safe and non-toxic and is a good medical material.

[0034] In the description of this utility model, it should be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", and "outer" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0035] In the description of this utility model, it should be noted that unless otherwise explicitly specified and limited, the terms "installation", "connection", "setting", and "forming" should be interpreted broadly; for example, they can refer to fixed connection or setting, detachable connection or setting, or an integrated structure; they can refer to direct connection, indirect connection through an intermediate medium, or internal communication between two components; those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0036] The above embodiments are only used to illustrate the technical solutions of this utility model. Those skilled in the art should understand that the above embodiments do not limit this utility model in any way. All technical solutions obtained by equivalent substitution or equivalent transformation fall within the protection scope of this utility model.

Claims

1. A device for localized directional hyperthermic perfusion chemotherapy in the peritoneum, characterized in that: The device includes a medication tube, a heating tube, a medication release body, and a drainage tube. The medication release body includes a heating chamber and a release chamber stacked together. The release surface of the release chamber is provided with a permeable membrane. One end of the medication tube is connected to an external medication bag, and the other end is connected to the release chamber of the medication release body. The heating tube includes an input section heating tube and an output section heating tube, which enclose the medication tube in the middle. The input section heating tube, the heating chamber of the medication release body, and the output section heating tube are sequentially connected to form a heating channel. The heating channel is connected to an external heating device, and a heating medium flows in the heating channel. The drainage tube is used to drain the medication from the abdominal cavity to the outside of the abdominal cavity.

2. The intraperitoneal localized directional hyperthermic perfusion chemotherapy device according to claim 1, characterized in that, The cross-sectional shape of the input section heating tube and the output section heating tube, which enclose the medicine liquid tube in the middle, is elliptical.

3. The intraperitoneal localized directional hyperthermic perfusion chemotherapy device according to claim 1, characterized in that, The drug release body has a groove-shaped structure, and the release cavity is located on the concave surface of the groove-shaped drug release body.

4. The intraperitoneal localized directional hyperthermic perfusion chemotherapy device according to claim 1, characterized in that, The input section heating tube and the output section heating tube each have a free end that is separate from the liquid medicine tube, and the input section heating tube and the output section heating tube are connected to an external heating device through their respective free ends.

5. The intraperitoneal localized directional hyperthermic perfusion chemotherapy device according to claim 1, characterized in that, The heating medium is water.

6. The intraperitoneal localized directional hyperthermic perfusion chemotherapy device according to claim 1, characterized in that, The front end of the drainage tube has a flexible portion, and the flexible portion has multiple drainage holes.

7. The intraperitoneal localized directional hyperthermic perfusion chemotherapy device according to claim 6, characterized in that, The soft part is filled with medical-grade polyurethane foam.

8. The intraperitoneal localized directional hyperthermic perfusion chemotherapy device according to claim 6 or 7, characterized in that, The flexible part is made of silicone rubber.

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