Carbon dioxide chemotherapeutic drug aerosol generating device

Abstract

The utility model relates to a carbon dioxide chemotherapeutic drug aerosol generating device which comprises a drug delivery pipeline, a drug atomizer and an abdominal cavity, one end of the drug delivery pipeline is connected with the drug atomizer, and the other end of the drug delivery pipeline is connected with the abdominal cavity through a first drug delivery branch and a second drug delivery branch; and the second dosing branch is connected with a carbon dioxide pneumoperitoneum machine through a bypass pipeline. The novel carbon dioxide chemotherapy drug aerosol generating device can provide carbon dioxide chemotherapy drug aerosol with smaller mist particles and uniform distribution, a small amount of anti-cancer drugs can be more effectively conveyed to cancer cells, the dosage of the chemotherapy drugs is only 10-30% of that of traditional intraperitoneal hyperthermic perfusion chemotherapy (HIPEC), the aerosol is high in tissue penetrating power, pharmacokinetics can be improved, and the effect of treating cancer cells is achieved. The dosage of chemotherapeutic drugs is greatly reduced, toxic and side effects are reduced, the treatment cost is reduced, and high efficiency, convenience and safety are achieved.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of medical facilities, in particular to a carbon dioxide chemotherapy drug aerosol generating device. BACKGROUND

[0002] The traditional way to inhibit peritoneal cancer and peritoneal free cancer cells is hyperthermic intraperitoneal chemotherapy (HIPEC), which means that the perfusion liquid containing chemotherapy drugs is precisely constant temperature, circulating perfusion, filling the abdominal cavity and maintaining for a period of time to treat primary and secondary peritoneal cancer or prevent peritoneal metastatic cancer. The disadvantage of this chemotherapy method is that the penetration depth of the chemotherapy drug into the tissue is limited, the amount of drug used is large, the side effects are large, the treatment cost is high, and the efficacy is still controversial. CONTENT OF THE INVENTION

[0003] Therefore, the purpose of the present application is to provide a carbon dioxide chemotherapy drug aerosol generating device, which greatly reduces the amount of chemotherapy drugs used, reduces side effects and reduces treatment costs.

[0004] The present application adopts the following scheme: a carbon dioxide chemotherapy drug aerosol generating device, comprising a drug delivery pipeline, a drug atomizer, a peritoneal cavity and a carbon dioxide pneumoperitoneum machine, one end of the drug delivery pipeline is connected with the drug atomizer, and the other end is connected with the peritoneal cavity; a first gas supply pipeline is connected between the carbon dioxide pneumoperitoneum machine and the drug delivery pipeline, and a second gas supply pipeline is connected between the carbon dioxide pneumoperitoneum machine and the peritoneal cavity.

[0005] Further, a one-way valve A, a ball valve A and a heater are arranged on the drug delivery pipeline.

[0006] Further, a ball valve B and a one-way valve C are arranged on the first gas supply pipeline; a ball valve C and a one-way valve B are arranged on the second gas supply pipeline, and the first gas supply pipeline is connected with the pipeline section between the one-way valve A and the ball valve A on the drug delivery pipeline.

[0007] Further, a vortex generator is arranged on the drug delivery pipeline.

[0008] Further, the vortex generator comprises a cylinder, a spiral channel is arranged in the cylinder, an air inlet chamber is arranged at the rear end of the cylinder and communicates with the rear end of the spiral channel, an air outlet chamber is arranged at the front end of the cylinder and communicates with the front end of the spiral channel, a main inlet is arranged at the rear end of the cylinder and communicates with the air inlet chamber, and a main outlet is arranged at the front end of the cylinder and communicates with the air outlet chamber.

[0009] Further, the rear end side of the cylinder of the vortex generator is provided with a first circulation inlet communicated with the air inlet chamber, the front end side is provided with a circulation outlet communicated with the air outlet chamber, a circulation pipe is connected between the circulation outlet and the circulation inlet, and a ball valve D, a circulation pump and a one-way valve D are arranged on the circulation pipe.

[0010] Further, the drug delivery pipeline and the first gas supply pipeline are connected through a buffer bin, the upper part of the buffer bin is provided with a bin cover, the bin cover is rotationally connected with a stirring shaft extending into the buffer bin, and a stirring impeller is connected to the lower end of the stirring shaft; a suction pipe and a pressure gauge are also connected to the bin cover of the buffer bin, a valve is arranged on the suction pipe, and a heater is arranged on the outer side of the buffer bin.

[0011] Further, the buffer bin is provided with a first drug outlet and a second drug outlet at the bottom, and the bin cover of the buffer bin is provided with a first drug inlet and a second drug inlet, the first drug inlet and the first drug outlet are used for series connection of the drug delivery pipeline, the second drug inlet is connected with the first gas supply pipeline, and the second drug outlet is connected with a drug outlet pipe provided with a ball valve E.

[0012] Further, the drug atomizer adopts a compression type atomizer, a carbon dioxide high-pressure gas pipe is connected to the compression gas inlet of the compression type atomizer, and a first drug inlet is arranged on the side of the compression type atomizer, the first drug inlet is connected with a drug storage tank through a drug supply pipe, and a peristaltic pump and a one-way valve E are arranged on the drug supply pipe.

[0013] Further, the abdominal cavity is connected with an exhaust pipeline, and an exhaust safety valve and a waste gas treatment system are connected to the exhaust pipeline.

[0014] Compared with the prior art, the carbon dioxide chemotherapy drug aerosol generating device can provide carbon dioxide chemotherapy drug aerosol with smaller and more uniform mist particles, more effectively deliver a small amount of anticancer drugs to cancer cells, use only 10-30% of the amount of traditional hyperthermic intraperitoneal chemotherapy (HIPEC) drugs, have strong aerosol tissue penetration, improve pharmacokinetics, greatly reduce the use amount of chemotherapy drugs, reduce toxic side effects, and reduce treatment costs, and is efficient, convenient and safe.

[0015] In order to make the purpose, technical scheme and advantages of the present application clearer, the present application will be further described in detail below with reference to specific embodiments and related drawings. BRIEF DESCRIPTION OF DRAWINGS

[0016] Figure 1 is a structural schematic view of the present application embodiment one;

[0017] Figure 2 is a structural schematic view of the present application embodiment two;

[0018] Figure 3is a schematic diagram of the structure of the third embodiment of the present application;

[0019] Figure 4 is a schematic diagram of the structure of the fourth embodiment of the present application;

[0020] Figure Label Explanation: 1 - administration pipeline, 2 - drug atomizer, 3 - abdominal cavity, 4 - first gas supply pipeline, 5 - second gas supply pipeline, 6 - exhaust pipeline, 7 - ball valve A, 8 - heater, 9 - ball valve B, 10 - one-way valve C, 11 - ball valve C, 12 - one-way valve B, 13 - one-way valve A, 14 - vortex generator, 15 - spiral channel, 16 - air inlet chamber, 17 - air outlet chamber, 18 - circulation pipe, 19 - ball valve D, 20 - circulation pump, 21 - one-way valve D, 22 - valve, 23 - buffer bin, 24 - stirring shaft, 25 - stirring impeller, 26 - stirring motor, 27 - air extraction pipe, 28 - pressure gauge, 29 - drug outlet pipe, 30 - ball valve E, 31 - peristaltic pump, 32 - one-way valve E, 33 - exhaust safety valve, 34 - waste gas treatment system, 35 - drug storage tank, 36 - vacuum extraction device. DETAILED DESCRIPTION

[0021] It should be noted that the following detailed description is exemplary in nature and is intended to provide further description of the application. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

[0022] It is to be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments consistent with the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and / or "comprising," when used in this specification, specify the presence of stated features, steps, operations, devices, components and / or combinations thereof, but do not preclude the presence or addition of one or more other features, steps, operations, devices, components and / or combinations thereof.

[0023] Example 1: As Figure 1As shown, a carbon dioxide chemotherapeutic drug aerosol generating device includes a drug administration pipeline 1, a drug atomizer 2, an abdominal cavity 3, and a carbon dioxide pneumoperitoneum machine. One end of the drug administration pipeline 1 is connected with the drug atomizer, and the other end is connected with the abdominal cavity 3. A first gas supply pipeline 4 is connected between the carbon dioxide pneumoperitoneum machine and the drug administration pipeline. A second gas supply pipeline 5 is connected between the carbon dioxide pneumoperitoneum machine and the abdominal cavity. The device can be used for actual treatment and experimental research. During surgery, carbon dioxide from the carbon dioxide pneumoperitoneum machine directly enters the abdominal cavity through the second gas supply pipeline 5 and maintains a pressure of 12-15 mmHg. For intraperitoneal chemotherapy, high-pressure carbon dioxide passes through a compression-type atomizer to generate carbon dioxide and chemotherapeutic drug mixed aerosol, which directly enters the abdominal cavity through the drug administration pipeline 1. The carbon dioxide pneumoperitoneum machine appropriately supplements gas through the second gas supply pipeline 5 to maintain the working pressure of the aerosol in the abdominal cavity at 12-15 mmHg. The abdominal cavity 3 can be a human abdominal cavity or an extracorporeal simulated abdominal cavity. The device can perform warm carbon dioxide chemotherapeutic drug aerosol administration in the abdominal cavity. The device provides carbon dioxide chemotherapeutic drug aerosol with smaller and more uniformly distributed mist particles. According to different use scenarios, a small amount of anticancer drug can be more effectively delivered to cancer cells, thereby maximizing the inhibition of free cancer cells in the abdominal cavity and peritoneal cancer. The use amount of the chemotherapeutic drug is only 10-30% of that of traditional hyperthermic intraperitoneal chemotherapy (HIPEC). The aerosol has strong tissue penetration and can improve pharmacokinetics, greatly reduce the use amount of the chemotherapeutic drug, reduce treatment costs, and reduce side effects. In addition, the smaller the mist particles, the better the laparoscopic vision, which enables intraperitoneal pressurized aerosol chemotherapy during laparoscopic tumor resection surgery, inhibits the possible generation of free cancer cells in the abdominal cavity during the surgery, prevents postoperative tumor implantation, and is efficient, convenient, and safe.

[0024] In this embodiment, a one-way valve A13, a ball valve A7, and a heater 8 are arranged on the drug administration pipeline 1. The heater can adjust the temperature of the carbon dioxide chemotherapeutic drug aerosol entering the abdominal cavity to 37-43℃.

[0025] In this embodiment, a ball valve B9 and a one-way valve C10 are arranged on the first gas supply pipeline. A ball valve C11 and a one-way valve B12 are arranged on the second gas supply pipeline. The first gas supply pipeline is connected with the pipeline segment between the one-way valve A and the ball valve A on the drug administration pipeline.

[0026] In this embodiment, the drug nebulizer is a compression nebulizer, and the compressed gas inlet of the compression nebulizer is connected to a high-pressure carbon dioxide tube. A first drug inlet is provided on the side of the compression nebulizer for adding liquid chemotherapy drugs. The first drug inlet is connected to a drug storage tank 35 via a drug supply pipe, which is equipped with a peristaltic pump 31 and a one-way valve E32. The compression nebulizer uses high-pressure carbon dioxide gas instead of air. According to the Venturi jet principle, compressed carbon dioxide forms a high-speed airflow through a narrow tube, and the resulting negative pressure drives liquid or other fluids to be sprayed onto a diaphragm or baffle. Under high-speed impact, the liquid splashes outwards, turning droplets into an extremely fine mist that is sprayed outwards. Larger droplets liquefy and return to the liquid storage tank for recycling.

[0027] In this embodiment, the abdominal cavity is connected to an exhaust pipe, and the exhaust pipe is connected to an exhaust safety valve 33 and an exhaust gas treatment system 34. After the drug is administered, the gas in the abdominal cavity is discharged through the exhaust pipe after treatment. The exhaust gas treatment system 34 is in the prior art, and its structure and principle will not be described in detail here.

[0028] In this embodiment, the abdominal cavity is connected to the drug delivery line and the second gas supply line via an inlet cannula, and the abdominal cavity is connected to the exhaust line via an outlet cannula; the inlet and outlet cannulas are equipped with valves for controlling their opening and closing.

[0029] In this embodiment, the drug delivery line 1 and the first air supply line 4 are connected by a three-way pipe A; the first air supply line 4 and the second air supply line 5 are also connected to the carbon dioxide pneumoperitoneum machine by a three-way pipe B.

[0030] Example 2: Figure 2 As shown, this embodiment adds a vortex generator 14 to the first embodiment. In this embodiment, a vortex generator 14 is provided on the drug delivery pipeline, and the vortex generator 14 is located between the one-way valve A13 and the three-way pipe A.

[0031] In this embodiment, the vortex generator 14 includes a cylindrical body with a spiral channel 15 inside. An air inlet chamber 16 communicating with the rear end of the cylindrical body is located inside the spiral channel, and an air outlet chamber 17 communicating with the front end of the cylindrical body is located inside the cylindrical body. The rear end of the cylindrical body has a main inlet communicating with the air inlet chamber, and the front end has a main outlet communicating with the air outlet chamber. Because the interior of the vortex generator is a narrow, spirally advancing space, the chemotherapy drug aerosol enters the spiral channel 15 and forms a fully mixed aerosol vortex. Some of the atomized drug liquid liquefies due to impact with the inner wall of the vortex generator, and the high-pressure carbon dioxide can again impact the liquefied drug liquid on the inner wall to reform small droplets of aerosol. During intraperitoneal chemotherapy, the fully mixed aerosol vortex directly enters the abdominal cavity through the drug delivery tubing 1. The carbon dioxide pneumoperitoneum machine maintains the working pressure of the aerosol in the abdominal cavity at 12-15 mmHg by appropriately supplementing air through the second air supply tubing 5.

[0032] In this embodiment, the vortex generator 14 has a first circulation inlet communicating with the air inlet chamber on the rear end side of its cylinder and a circulation outlet communicating with the air outlet chamber on the front end side. A circulation pipe 18 connects the circulation outlet and the circulation inlet. The circulation pipe is equipped with a ball valve D19, a circulation pump 20, and a one-way valve D21. The vortex generator 14 can circulate internally through the circulation pipe 18.

[0033] Example 3: Figure 3 As shown, this embodiment, based on embodiment one, replaces the three-way tube A with a buffer chamber. In this embodiment, the drug delivery line 1 and the first gas supply line 4 are connected through a buffer chamber 23, the volume of which is approximately equal to the volume of the abdominal cavity. The buffer chamber 23 has a cover at its top, and a stirring shaft 24 extending into the buffer chamber is rotatably connected to the cover. A stirring impeller 25 is connected to the lower end of the stirring shaft, and a handle is connected to the upper end, allowing manual control of the stirring shaft's rotation. In practice, a stirring motor 26 can also be installed above the buffer chamber to drive the stirring shaft. A vacuum pipe 27 and a pressure gauge 28 are also connected to the cover of the buffer chamber. A valve 22 is installed on the vacuum pipe, and a heater 8 is installed on the outer side of the buffer chamber, directly on the buffer chamber rather than connected in series with the drug delivery line. The vacuum pipe 27 is connected to a vacuum pump 36, which can be used to remove air from the buffer chamber. The buffer chamber 23 is used to temporarily store carbon dioxide chemotherapy drug aerosols, stabilize the aerosol pressure, and make the carbon dioxide gas and mist mix more evenly through stirring.

[0034] In this embodiment, the buffer chamber has a first drug outlet and a second drug outlet at its bottom. The cover of the buffer chamber has a first drug inlet and a second drug inlet. The first drug inlet and the first drug outlet are connected in series for drug delivery tubing. The second drug inlet is connected to a first gas supply line. The second drug outlet is connected to a drug outlet pipe 29, which is equipped with a ball valve E30. When used for intraperitoneal chemotherapy, high-pressure carbon dioxide is used to generate a carbon dioxide and chemotherapy drug mixed aerosol through a compression nebulizer. This aerosol enters the buffer chamber 23 through the first drug inlet, where it temporarily stores the carbon dioxide chemotherapy drug aerosol. The carbon dioxide pneumoperitoneum machine maintains the aerosol pressure in the buffer chamber 23 at 12-15 mmHg by appropriately supplementing air through the first gas supply line 4 and the second drug inlet. Under the action of the stirring impeller 25, the carbon dioxide gas and chemotherapy drug aerosol in the buffer chamber 23 are mixed more evenly. The mixed aerosol temporarily stored in the buffer chamber 23 enters the peritoneal cavity through the first drug outlet and the drug delivery line 1 to begin chemotherapy. After exhausting the waste gas, the buffer chamber 23 can continuously generate new mixed working aerosols that enter the abdominal cavity. The carbon dioxide pneumoperitoneum machine maintains the working pressure of the aerosol in the abdominal cavity at 12-15 mmHg through the first gas supply line 4, the buffer chamber 23 and the drug delivery line 1, so as to stably, efficiently and uniformly act on the peritoneal cancer tissue, or inhibit free cancer cells in the abdominal cavity during laparoscopic surgery.

[0035] Example 4; as Figure 4 As shown, based on Example 3, a vortex generator 14 is added. In this example, a vortex generator 14 is provided on the drug delivery line, which is located between the drug nebulizer and the buffer chamber. Two one-way valves A13 are provided on the drug delivery line 1, located at both ends of the vortex generator 14. A stirring motor 26 for driving the stirring shaft to rotate is provided above the buffer chamber. In the specific implementation process, the stirring shaft can also be manually controlled by a handle.

[0036] In the embodiment, the vortex generator 14 comprises a cylinder, a spiral channel 15 is arranged in the cylinder, an air inlet chamber 16 is arranged in the rear end of the cylinder and communicates with the rear end of the spiral channel, an air outlet chamber 17 is arranged in the front end of the cylinder and communicates with the front end of the spiral channel, a main inlet is arranged in the rear end of the cylinder and communicates with the air inlet chamber, and a main outlet is arranged in the front end of the cylinder and communicates with the air outlet chamber. Since the inside of the vortex generator is a narrow spiral space, the chemotherapy drug gas mist forms a fully mixed gas mist vortex after entering the spiral channel 15. Part of the atomized liquid is liquefied by impacting the inner wall of the vortex generator, and the high-pressure carbon dioxide can impact the liquefied liquid on the inner wall again to form a small droplet gas mist. When used for abdominal cavity chemotherapy, the gas mist vortex generated by the vortex generator enters the buffer bin 23 through the first drug inlet, the buffer bin 23 is used for temporarily storing the carbon dioxide chemotherapy drug gas mist. The carbon dioxide pneumoperitoneum machine appropriately supplements the gas through the first gas supply pipeline 4 and the second drug inlet to maintain the pressure of the gas mist in the buffer bin 23 at 12-15 mmHg. The carbon dioxide gas and the chemotherapy drug gas mist in the buffer bin 23 are mixed more uniformly under the action of the stirring impeller 25. The uniformly mixed gas mist temporarily stored in the buffer bin 23 enters the abdominal cavity to start chemotherapy through the first drug outlet and the drug supply pipeline 1. After the exhaust gas is discharged, the buffer bin 23 can continuously generate new uniformly mixed working gas mist into the abdominal cavity. The carbon dioxide pneumoperitoneum machine always maintains the working pressure of the gas mist in the abdominal cavity at 12-15 mmHg through the first gas supply pipeline 4, the buffer bin 23 and the drug supply pipeline 1, and stably, efficiently and uniformly acts on the peritoneal cancer tissue, or inhibits the free cancer cells in the abdominal cavity during the laparoscopic surgery.

[0037] In the embodiment, a second circulating inlet of the spiral channel is arranged in the middle of the cylinder of the vortex generator 14, the drug outlet pipe 29 of the buffer bin is connected to the second circulating inlet of the vortex generator 14, a ball valve D19, a circulating pump 20 and a one-way valve D21 are arranged on the drug outlet pipe 29. During the interval of the abdominal cavity chemotherapy, the gas mist temporarily stored in the buffer bin 23 can also be circulated to the vortex generator for re-mixing. The carbon dioxide pneumoperitoneum machine maintains the pressure of the uniformly mixed gas mist in the buffer bin 23 at 12-15 mmHg through the first gas supply pipeline 4.

[0038] Any technical solution disclosed in the present application, unless otherwise stated, if a numerical range is disclosed, the disclosed numerical range is a preferred numerical range. Any person skilled in the art should understand that the preferred numerical range is only one of the many implementable values with more obvious technical effects or representative values. Since there are too many values, it is impossible to enumerate them all, so the present application only discloses part of the values to illustrate the technical solutions of the present application, and the above-mentioned values should not constitute a limitation on the protection scope of the present application.

[0039] If the present disclosure discloses or involves mutually fixedly connected parts or structural members, unless otherwise stated, the fixed connection can be understood as: detachably fixedly connected (for example, connected by bolts or screws), and can also be understood as: non-detachable fixed connection (for example, riveting, welding), of course, the mutually fixed connection can also be replaced by an integral structure (for example, integrally formed by using a casting process) (except for obvious cases that cannot use an integral forming process).

[0040] In addition, the terms used to represent the positional relationship or shape in any of the technical solutions disclosed in the present disclosure include states or shapes similar, similar or close to them, unless otherwise stated.

[0041] Any component provided by the present disclosure can be assembled from multiple individual components or can be a single component manufactured by an integral forming process.

[0042] The above is only a preferred embodiment of the present disclosure, and does not limit other forms of the present disclosure. Any person skilled in the art can modify or change the above disclosed technical content to equivalent embodiments. However, any simple modification, equivalent change and modification made to the above embodiments without departing from the technical content of the present disclosure, according to the technical essence of the present disclosure, still belongs to the protection scope of the present technical solution.

Claims

1. A carbon dioxide chemotherapeutic drug aerosol-generating device, characterized by: The application relates to a drug delivery pipeline, a drug atomizer, an abdominal cavity and a carbon dioxide pneumoperitoneum machine, one end of the drug delivery pipeline is connected with the drug atomizer, and the other end is connected with the abdominal cavity; a first gas supply pipeline is connected between the carbon dioxide pneumoperitoneum machine and the drug delivery pipeline, and a second gas supply pipeline is connected between the carbon dioxide pneumoperitoneum machine and the abdominal cavity.

2. The carbon dioxide chemotherapeutic drug aerosol-generating device according to claim 1, characterized by: A one-way valve A, a ball valve A and a heater are arranged on the drug delivery pipeline. 3.The carbon dioxide chemotherapeutic drug aerosol-generating device of claim 2, wherein: A ball valve B and a one-way valve C are arranged on the first gas supply pipeline; a ball valve C and a one-way valve B are arranged on the second gas supply pipeline, and the first gas supply pipeline is connected with a pipeline section between the one-way valve A and the ball valve A on the drug delivery pipeline. 4.The carbon dioxide chemotherapeutic drug aerosol-generating device of claim 1, wherein: A vortex generator is arranged on the drug delivery pipeline. 5.The carbon dioxide chemotherapeutic drug aerosol-generating device of claim 4, wherein: The vortex generator comprises a cylinder, a spiral channel is arranged in the cylinder, an air inlet chamber is arranged in the rear end of the cylinder and communicates with the rear end of the spiral channel, an air outlet chamber is arranged in the front end of the cylinder and communicates with the front end of the spiral channel, a main inlet communicating with the air inlet chamber is arranged on the rear end of the cylinder, and a main outlet communicating with the air outlet chamber is arranged on the front end of the cylinder. 6.The carbon dioxide chemotherapeutic drug aerosol-generating device of claim 5, wherein: A first circulation inlet communicating with the air inlet chamber is arranged on the side of the rear end of the cylinder of the vortex generator, a circulation outlet communicating with the air outlet chamber is arranged on the side of the front end of the cylinder, a circulation pipeline is connected between the circulation outlet and the circulation inlet, a ball valve D, a circulation pump and a one-way valve D are arranged on the circulation pipeline. 7.The carbon dioxide chemotherapeutic drug aerosol-generating device of claim 1, wherein: The drug delivery pipeline and the first gas supply pipeline are connected through a buffer bin, a bin cover is arranged on the upper portion of the buffer bin, a stirring shaft extending into the buffer bin is rotationally connected to the bin cover of the buffer bin, and a stirring impeller is connected to the lower end of the stirring shaft; an air exhaust pipe and a pressure gauge are further connected to the bin cover of the buffer bin, a valve is arranged on the air exhaust pipe, and a heater is arranged on the lateral portion of the buffer bin. 8.The carbon dioxide chemotherapeutic drug aerosol-generating device of claim 7, wherein: First and second medicine outlets are arranged on the bottom of the buffer bin, first and second medicine inlets are arranged on the bin cover of the buffer bin, the first medicine inlet and the first medicine outlet are used for connecting the drug delivery pipeline in series, and the second medicine inlet is connected with the first gas supply pipeline; a medicine outlet pipe is connected with the second medicine outlet, and a ball valve E is arranged on the medicine outlet pipe. 9.The carbon dioxide chemotherapeutic drug aerosol-generating device of claim 1, wherein: The drug atomizer adopts a compression type atomizer, a carbon dioxide high-pressure gas pipe is connected with the compression gas inlet of the compression type atomizer, a first medicine inlet is arranged on the lateral portion of the compression type atomizer, the first medicine inlet is connected with a medicine storage tank through a medicine supply pipe, and a peristaltic pump and a one-way valve E are arranged on the medicine supply pipe. 10.The carbon dioxide chemotherapeutic drug aerosol-generating device of claim 1, wherein: An exhaust pipeline is connected with the abdominal cavity, an exhaust safety valve and a waste gas treatment system are connected with the exhaust pipeline.

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