Auxiliary nuclear magnetic sample batch preparation device

Abstract

The utility model belongs to the technical field of experimental instruments, and particularly relates to an auxiliary nuclear magnetic sample batch preparation device which comprises a supporting frame, a plurality of nuclear magnetic tubes are inserted into the supporting frame, a flow guide plate is connected to the top of the supporting frame, and a plurality of flow guide holes corresponding to the nuclear magnetic tubes are formed in the upper surface of the flow guide plate. The bottom of the flow guide plate is connected with a plurality of flow guide pipes communicated with the flow guide holes, and the flow guide pipes are arranged at pipe openings of the nuclear magnetic tubes. According to the auxiliary nuclear magnetic sample batch preparation device, in the nuclear magnetic sample preparation process, an experimenter does not need to hold the nuclear magnetic tube by hand to add a solution into the nuclear magnetic tube one by one, and the effects that the nuclear magnetic samples can be prepared in batches, and the efficiency is improved are achieved.

Description

Technical Field

[0001] This utility model belongs to the field of experimental instrument technology, specifically an auxiliary nuclear magnetic resonance sample batch preparation device. Background Technology

[0002] Nuclear magnetic resonance (NMR) is a technique used to analyze the properties of atomic nuclei, and it has wide applications in many fields such as chemistry, physics, and medicine. Information about molecular structure can be obtained from NMR spectra. Due to its high sensitivity, small sample requirements, and high speed, NMR spectroscopy has been widely used in scientific research and production in disciplines such as chemical engineering, pharmaceuticals, biology, and materials science.

[0003] NMR tubes are containers used to hold sample solutions. In experiments, a large number of NMR samples often need to be prepared. The diameter of NMR tubes is generally between 3-5 mm. Due to the small diameter of the NMR tubes, the experimenter needs to hold the NMR tubes and add the solution one by one to the corresponding NMR tubes. During the process of adding the solution to the NMR tubes, it is difficult for the experimenter to quickly align the tubes because of the small diameter. The solution may flow outside the NMR tubes, resulting in a relatively low efficiency. Utility Model Content

[0004] To address the problems mentioned above, this invention provides an auxiliary NMR sample batch preparation device. During the NMR sample preparation process, the experimenter does not need to manually add the solution to each NMR tube one by one, thus enabling batch production of NMR samples and improving efficiency.

[0005] This utility model provides an auxiliary NMR sample batch preparation device, including a support frame, a plurality of NMR tubes inserted into the support frame, a flow guide plate connected to the top of the support frame, a plurality of flow guide holes corresponding to the NMR tubes on the upper surface of the flow guide plate, and a plurality of flow guide tubes communicating with the flow guide holes connected to the bottom of the flow guide plate, the flow guide tubes being placed at the inlet of the NMR tubes.

[0006] Furthermore, a positioning frame is provided on the top of the support frame, and a positioning plate is fixedly connected to the positioning frame and abuts against the top of the support frame. The upper surface of the positioning plate is provided with a positioning hole for inserting the flow guide tube, and the lower surface of the positioning plate is provided with a fixing hole for inserting the nuclear magnetic tube. The flow guide plate abuts against the upper surface of the positioning frame.

[0007] Furthermore, the outer diameter of the guide tube is smaller than the diameter of the positioning hole, and the side wall of the positioning frame is fixedly connected to an air extraction tube.

[0008] Furthermore, a fixed frame abuts against the upper surface of the guide plate, and a support frame is provided inside the fixed frame. A filter plate is integrally formed on the inner wall of the support frame. The upper surface of the filter plate is provided with several liquid inlet holes corresponding to the guide holes. Several fixed blocks corresponding to the liquid inlet holes are integrally formed at the bottom of the filter plate. A filter groove communicating with the liquid inlet hole is provided on the upper surface of the fixed block. A filter layer is inserted into the filter groove. A discharge pipe communicating with the filter groove is integrally formed at the bottom of the fixed block. The discharge pipe is placed inside the guide hole.

[0009] Furthermore, a first sealing gasket is provided between the guide plate and the positioning frame, and the fixing frame, guide plate and positioning frame are connected by connecting bolts.

[0010] Furthermore, the lower surface of the fixed frame is provided with a connecting groove, the upper surface of the guide plate abuts against a second sealing gasket that is inserted into the connecting groove, and the support frame abuts against the upper surface of the second sealing gasket.

[0011] Furthermore, the inner wall of the fixing hole is provided with a fixing groove that communicates with the fixing hole, and a sealing ring is inserted into the fixing groove for the nuclear magnetic tube to pass through and abut against.

[0012] Furthermore, a threaded rod is threadedly connected to the top of the fixed frame, and a clamping block that abuts against the upper surface of the support frame is fixedly connected to the top of the threaded rod.

[0013] Furthermore, the upper surface of the filter plate is provided with a number of first labels along the width direction of the filter plate and a number of second labels along the length direction of the filter plate. The support frame is also provided with the same and corresponding first and second labels as the upper surface of the filter plate.

[0014] Furthermore, the bottom of the guide hole is funnel-shaped.

[0015] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0016] (1) The experimenter drips the solution into the corresponding inlet hole. After passing through the filter layer, the solution flows into the feed tube. The solution in the feed tube flows into the guide hole. The solution in the guide hole flows into the guide tube. Then the solution in the guide tube flows into the corresponding NMR tube, thus completing the batch preparation of NMR samples. During the preparation of NMR samples, the solution can flow into the NMR tube. The experimenter does not need to hold the NMR tube and add the solution into the NMR tube one by one. It has the effect of batch preparation of NMR samples, improving efficiency, and reducing the possibility that the experimenter may have difficulty aligning the NMR tube and causing the solution to flow outside the NMR tube.

[0017] (2) The air pump extracts the gas between the positioning plate and the guide plate through the air extraction pipe, so that a negative pressure environment is formed in the area between the positioning plate and the guide plate. The space of the fixed hole at the end of the guide pipe is also a negative pressure environment, and the guide hole is also a negative pressure environment. This can quickly draw the solution in the inlet hole into the guide hole, and then quickly draw the solution in the guide hole into the NMR tube through the guide pipe, thereby improving the working efficiency. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1 This is a schematic diagram of the structure of an embodiment of this application;

[0020] Figure 2 This is a schematic diagram illustrating the flow guide holes in this embodiment;

[0021] Figure 3 This is a schematic diagram illustrating the connecting bolts in this embodiment;

[0022] Figure 4 This is a schematic diagram illustrating the liquid inlet hole in this embodiment;

[0023] Figure 5 This is a schematic diagram illustrating the fixed block in this embodiment;

[0024] Figure 6 This is a schematic diagram illustrating the sealing ring in this embodiment;

[0025] Figure 7 This is a schematic diagram illustrating the first and second labels connected to the filter plate in this embodiment;

[0026] Figure 8 This is a schematic diagram illustrating the first and second labels connected to the support frame in this embodiment.

[0027] Explanation of reference numerals in the attached drawings: 1. Support frame; 11. MRI tube; 12. Reserved groove; 2. Positioning frame; 21. First sealing gasket; 22. Evacuation pipe; 3. Positioning plate; 31. Positioning hole; 32. Fixing hole; 33. Fixing groove; 331. Sealing ring; 4. Guide plate; 41. Guide hole; 42. Guide pipe; 5. Fixing frame; 51. Connecting bolt; 52. Connecting groove; 521. Second sealing gasket; 53. Threaded rod; 531. Clamping block; 6. Support frame; 7. Filter plate; 71. Liquid inlet; 72. Fixing block; 721. Filter tank; 722. Filter layer; 723. Discharge pipe; 8. First label; 9. Second label. Detailed Implementation

[0028] The technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0029] The following is in conjunction with the appendix Figure 1 To be continued Figure 8 The present invention will be described in detail with specific embodiments.

[0030] like Figures 1 to 4 As shown, the present invention provides an auxiliary NMR sample batch preparation device, including a support frame 1, in which multiple NMR tubes 11 are inserted. The NMR tubes 11 are inserted into the support frame 1 from top to bottom, and the support frame 1 supports the NMR tubes 11.

[0031] A positioning frame 2 is connected to the top of the support frame 1. A positioning plate 3 is integrally formed on the inner wall of the positioning frame 2. The upper surface of the positioning plate 3 has several downward-facing positioning holes 31, which correspond one-to-one with the NMR tube 11. The lower surface of the positioning plate 3 has several fixing holes 32 that communicate with the positioning holes 31. The lower surface of the positioning plate 3 abuts against the upper surface of the support frame 1, and the support frame 1 abuts against the inner wall of the positioning frame 2. The support frame 1 supports the positioning frame 2 and the positioning plate 3. The NMR tube 11 is inserted into the fixing holes 32, and the top end of the NMR tube 11 is placed in the fixing hole 32.

[0032] A guide plate 4 is connected to the top of the positioning frame 2. A first sealing gasket 21 is provided between the guide plate 4 and the positioning frame 2. The first sealing gasket 21 is arranged around the upper surface of the positioning frame 2. The lower surface of the first sealing gasket 21 abuts against the upper surface of the positioning frame 2. The lower surface of the guide plate 4 abuts against the upper surface of the first sealing gasket 21.

[0033] The upper surface of the guide plate 4 is provided with several guide holes 41, which are corresponding to the positioning holes 31 below. The bottom of the guide plate 4 is integrally formed with several guide tubes 42, which are corresponding to and connected to the guide holes 41. The outer diameter of the guide tubes 42 is smaller than the diameter of the positioning holes 31. When the guide plate 4 abuts against the first sealing gasket 21, the guide tubes 42 pass through the positioning holes 31 and are inserted into the corresponding fixing holes 32, with the guide tubes 42 positioned at the opening of the nuclear magnetic resonance tube 11.

[0034] The upper surface of the deflector plate 4 abuts against the fixing frame 5. Multiple connecting bolts 51 are provided between the fixing frame 5, the deflector plate 4 and the positioning frame 2. The connecting bolts 51 connect and fix the fixing frame 5, the deflector plate 4 and the positioning frame 2.

[0035] The top of the guide plate 4 is provided with a support frame 6, which is placed inside the fixed frame 5 and abuts against the inner wall of the fixed frame 5. The lower surface of the fixed frame 5 is provided with a connecting groove 52, which surrounds the fixed frame 5. The upper surface of the guide plate 4 abuts against a second sealing gasket 521, which surrounds the upper surface of the guide plate 4 and is inserted into the connecting groove 52. The lower surface of the support frame 6 abuts against the upper surface of the second sealing gasket 521.

[0036] like Figure 1 and Figure 5 As shown, a filter plate 7 is integrally formed on the inner wall of the support frame 6. The upper surface of the filter plate 7 has several liquid inlet holes 71 corresponding to the flow guide holes 41. The width of the liquid inlet holes 71 is larger than the inner diameter of the nuclear magnetic resonance tube 11. Several fixing blocks 72 are integrally formed on the bottom of the filter plate 7. The top of each fixing block 72 has a filter groove 721 communicating with the liquid inlet holes 71, and a filter layer 722 is inserted into the filter groove 721. A discharge pipe 723 is integrally formed on the bottom of each fixing block 72, and the discharge pipe 723 communicates with the filter groove 721. When the support frame 6 abuts against the second sealing gasket 521, the discharge pipe 723 is inserted into the corresponding flow guide hole 41.

[0037] The experimenters dripped the solution into the corresponding inlet hole 71. After passing through the filter layer 722, the solution flowed into the feed tube 723. The solution in the feed tube 723 flowed into the guide hole 41. The solution in the guide hole 41 flowed into the guide tube 42. Then the solution in the guide tube 42 flowed into the corresponding NMR tube 11, thus completing the batch preparation of NMR samples.

[0038] During the preparation of NMR samples, the solution can flow into the NMR tube 11, eliminating the need for the experimenter to manually add the solution to each NMR tube one by one. This allows for batch preparation of NMR samples, improving efficiency and reducing the possibility of the solution flowing outside the NMR tube 11 due to the experimenter's difficulty in aligning the tube with the NMR tube.

[0039] The filter layer 722 can filter out undissolved solids in the solution, reducing the possibility of solids clogging the guide tube 42.

[0040] like Figure 4 and Figure 6 As shown, a suction pipe 22 is fixedly connected to the side wall of the positioning frame 2. The suction pipe 22 is connected to the interior of the positioning frame 2 and the end of the suction pipe 22 is positioned above the positioning plate 3. The suction pipe 22 is connected to a suction pump (not shown in the figure). The suction pump extracts the gas between the positioning plate 3 and the guide plate 4 through the suction pipe 22, so that a negative pressure environment is formed in the area between the positioning plate 3 and the guide plate 4.

[0041] The outer diameter of the guide tube 42 is smaller than the diameter of the positioning hole 31. Therefore, the space of the fixing hole 32 at the end of the guide tube 42 is also a negative pressure environment. The guide hole 41 is also a negative pressure environment, which can quickly draw the solution in the liquid inlet hole 71 into the guide hole 41, and then quickly draw the solution in the guide hole 41 into the NMR tube 11 through the guide tube 42, thereby improving working efficiency.

[0042] The first sealing gasket 21 seals the guide plate 4 and the positioning frame 2, reducing the possibility of air leakage between the guide plate 4 and the positioning plate 3 and ensuring a negative pressure environment between the guide plate 4 and the positioning plate 3. The second sealing gasket 521 seals the support frame 6 and the guide plate 4, ensuring a negative pressure environment between the support frame 6 and the guide plate 4.

[0043] The filter layer 722 consists of a sieve plate, a filter membrane, and a filter element from top to bottom. The filter membrane and filter element are made of relatively dense materials. While the solution can pass through the filter layer 722, the filter layer 722 can also better maintain the negative pressure environment between the support frame 6 and the guide plate 4.

[0044] The bottom of the flow guide hole 41 is funnel-shaped, which facilitates the automatic downward flow of the solution and ensures that all the solution in the flow guide hole 41 flows into the NMR tube 11.

[0045] Each fixing hole 32 has a fixing groove 33 on its inner wall, which surrounds the axis of the fixing hole 32 and is connected to the fixing hole 32. A sealing ring 331 is inserted into the fixing groove 33, and the nuclear magnetic tube 11 abuts against the sealing ring 331. The sealing ring 331 seals the fixing hole 32, reducing the possibility of air leakage between the nuclear magnetic tube 11 and the fixing hole 32, and ensuring a negative pressure environment between the guide plate 4 and the positioning plate 3.

[0046] like Figure 1 and Figure 3As shown, a pair of threaded rods 53 are threadedly connected to the top of the fixed frame 5. The threaded rods 53 are placed on both sides of the support frame 6, and a clamping block 531 is fixedly connected to the top of each threaded rod 53. After the support frame 6 abuts against the second sealing gasket 521, the clamping block 531 is rotated, and the threaded rods 53 move downward until the lower surface of the clamping block 531 abuts tightly against the upper surface of the support frame 6. The clamping block 531 presses the support frame 6 tightly, thereby making the support frame 6 abut tightly against the second sealing gasket 521, further ensuring the negative pressure environment between the support frame 6 and the guide plate 4.

[0047] The side of the support frame 1 is provided with a pair of reserved slots 12, which allow the experimenter to hold the reserved slots 12 to move the support frame 1. The reserved slots 12 facilitate the experimenter to move the support frame 1.

[0048] like Figure 7 and Figure 8 As shown, the upper surface of the filter plate 7 has several first labels 8 along its width direction. These first labels 8 can be sequentially labeled "1, 2, 3, 4, ...," and the labeling corresponds to the number of liquid inlet holes 71 along the width direction of the filter plate 7. The upper surface of the filter plate 7 also has several second labels 9 along its length direction. These second labels 9 can be sequentially labeled "A, B, C, D, ...," and the labeling corresponds to the number of liquid inlet holes 71 along the length direction of the filter plate 7. The support frame 1 has the same and corresponding first labels 8 and second labels 9 as the upper surface of the filter plate 7.

[0049] First label 8 and second label 9 facilitate quick location and marking of the NMR tube 11 by experimental personnel (see reference). Figure 1 This also makes it easier for researchers to record data and reduces the possibility of NMR samples becoming messy due to labeling.

[0050] The implementation principle of the auxiliary NMR sample batch preparation device provided by this utility model is as follows: Several NMR tubes 11 are inserted into the support frame 1, so that the lower surface of the positioning plate 3 abuts against the upper surface of the support frame 1. The support frame 1 supports the positioning frame 2, and the NMR tubes 11 are inserted into the fixing holes 32. The support frame 6 abuts against the second sealing gasket 521, and the threaded rod 53 is turned so that the clamping block 531 presses the support frame 6 tightly. The evacuation pipe 22 evacuates the inside of the positioning frame 2 to create a negative pressure environment inside the positioning frame 2. The experimenter drips the solution into the corresponding liquid inlet hole 71. After passing through the filter layer 722, the solution flows into the feed pipe 723. The solution in the feed pipe 723 flows into the guide hole 41. The solution in the guide hole 41 flows into the guide pipe 42. Then the solution in the guide pipe 42 flows into the corresponding NMR tube 11, completing the batch preparation of NMR samples.

[0051] The present invention has been further described above with reference to specific embodiments. However, it should be understood that the specific description herein should not be construed as limiting the substance and scope of the present invention. Various modifications made by those skilled in the art to the above embodiments after reading this specification are all within the scope of protection of the present invention.

Claims

1. An apparatus for assisting batch preparation of nuclear magnetic samples, characterized by, The application relates to a nuclear magnetic resonance tube support frame, which comprises a support frame (1) into which a plurality of nuclear magnetic resonance tubes (11) are inserted, a flow guide plate (4) connected to the top of the support frame (1), a plurality of flow guide holes (41) corresponding to the nuclear magnetic resonance tubes (11) arranged on the upper surface of the flow guide plate (4), a plurality of flow guide pipes (42) arranged in communication with the flow guide holes (41) at the bottom of the flow guide plate (4), and the flow guide pipes (42) being arranged at the tube openings of the nuclear magnetic resonance tubes (11). A positioning frame (2) is arranged on the top of the support frame (1), the positioning frame (2) is fixedly connected with a positioning plate (3) abutting against the top end of the support frame (1), the upper surface of the positioning plate (3) is provided with positioning holes (31) for inserting the flow guide pipes (42), the lower surface of the positioning plate (3) is provided with fixing holes (32) for inserting the nuclear magnetic resonance tubes (11), and the flow guide plate (4) abuts against the upper surface of the positioning frame (2). An air exhaust pipe (22) is fixedly and communicatively arranged on the side wall of the positioning frame (2). A fixed frame (5) abuts against the upper surface of the flow guide plate (4). A first sealing gasket (21) is arranged between the flow guide plate (4) and the positioning frame (2), and the fixed frame (5), the flow guide plate (4) and the positioning frame (2) are connected through connecting bolts (51). The bottom of the flow guide hole (41) is funnel-shaped.

2. The apparatus according to claim 1, wherein The outer diameter of the flow guide pipe (42) is smaller than the diameter of the positioning hole (31).

3. The device according to claim 1, wherein, A support frame (6) is arranged in the fixed frame (5), a filter plate (7) is integrally formed on the inner wall of the support frame (6), a plurality of liquid inlet holes (71) corresponding to the flow guide holes (41) are arranged on the upper surface of the filter plate (7), a plurality of fixing blocks (72) corresponding to the liquid inlet holes (71) are integrally formed at the bottom of the filter plate (7), a filter groove (721) in communication with the liquid inlet hole (71) is arranged on the upper surface of the fixing block (72), a filter layer (722) is inserted into the filter groove (721), a discharging pipe (723) in communication with the filter groove (721) is integrally formed at the bottom of the fixing block (72), and the discharging pipe (723) is arranged in the flow guide hole (41).

4. The apparatus according to claim 3, wherein, A connecting groove (52) is arranged on the lower surface of the fixed frame (5), a second sealing gasket (521) is inserted into the connecting groove (52), and the support frame (6) abuts against the upper surface of the second sealing gasket (521).

5. The apparatus according to claim 1, wherein A fixing groove (33) in communication with the fixing hole (32) is arranged inwardly on the inner wall of the fixing hole (32), and a sealing ring (331) is inserted into the fixing groove (33) and abuts against the nuclear magnetic resonance tube (11).

6. The apparatus according to claim 3, wherein A threaded rod (53) is threadedly connected to the top of the fixed frame (5), and a pressing block (531) abutting against the upper surface of the support frame (6) is fixedly connected to the top end of the threaded rod (53).

7. The apparatus according to claim 3, wherein A plurality of first labels (8) are arranged on the upper surface of the filter plate (7) along the width direction of the filter plate (7), and a plurality of second labels (9) are arranged on the upper surface of the filter plate (7) along the length direction of the filter plate (7), and the support frame (1) is also provided with the same first labels (8) and second labels (9) as the upper surface of the filter plate (7).

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