Circular reaction device for preparing medical intermediates

Abstract

The utility model relates to a circular reaction device for preparing medical intermediates, which comprises a reaction kettle body provided with a feed port at the top and a discharge port at the bottom, a stirring component is arranged in the reaction kettle body, and a circular feed port is further arranged at the top of the reaction kettle body. The side part of the discharging port is connected with the circulating feeding port through a circulating conveying pipe, a circulating conveying pump is mounted on the circulating conveying pipe and is used for pumping materials output from the discharging port to the circulating feeding port, and the materials return to the interior of the reaction kettle body through the circulating feeding port. According to the reaction kettle disclosed by the utility model, the circulating feeding hole is formed in the top of the reaction kettle body and is connected with the discharging hole in the bottom of the reaction kettle body through the circulating conveying pipe, so that a material output from the discharging hole is pumped to the circulating feeding hole, and then the material returns to the inside of the reaction kettle body through the circulating feeding hole; the materials are sent back into the reaction kettle body to be circularly stirred and mixed, and the stirring and mixing effect is improved.

Description

Technical fields:

[0001] This utility model relates to a cyclic reaction apparatus for the preparation of pharmaceutical intermediates. Background technology:

[0002] Pharmaceutical intermediates are chemical substances used in the pharmaceutical process to synthesize drugs. They are intermediate steps from active pharmaceutical ingredients (APIs) to the final formulation, transforming into the final drug through a series of chemical reactions. Pharmaceutical intermediates are essentially chemical raw materials or products used in drug synthesis processes. These chemical products do not require a drug production license and can be produced in ordinary chemical plants. As long as they meet certain standards, they can be used in drug synthesis.

[0003] Currently, the preparation of pharmaceutical intermediates typically requires the use of a reaction vessel to stir and mix the raw materials. However, in existing reaction vessels, the material is discharged through the bottom outlet after a period of stirring and mixing. Because the stirring and mixing only occurs once, the mixing is often not uniform enough, affecting the quality. Utility model content:

[0004] This invention addresses the problems existing in the prior art by providing a cyclic reaction apparatus for the preparation of pharmaceutical intermediates.

[0005] To achieve the above objectives, the technical solution adopted by this utility model is: a circulating reaction device for the preparation of pharmaceutical intermediates, comprising a reactor body with a feed inlet at the top and a discharge outlet at the bottom, a stirring assembly inside the reactor body, a circulating feed inlet at the top of the reactor body, a circulating conveying pipe connecting the side of the discharge outlet to the circulating feed inlet, a circulating conveying pump installed on the circulating conveying pipe, the circulating conveying pump being used to pump the material output from the discharge outlet to the circulating feed inlet, and the material then returning to the reactor body through the circulating feed inlet.

[0006] Furthermore, the upper interior of the reactor body is provided with a lifting and moving seat that is arranged around the outside of the stirring assembly. The lifting and moving seat is driven by the lifting assembly to move up and down along the axis of the reactor body. The bottom of the lifting and moving seat is provided with a scraping assembly for contacting the inner peripheral sidewall of the reactor body. Above the scraping assembly is a water spraying assembly for spraying water toward the inner peripheral sidewall of the reactor body.

[0007] Furthermore, the scraping assembly includes a scraper plate in the shape of a frustum, the top of which is fixedly connected to the bottom of the lifting and moving seat, and the lower end of the outer peripheral side of the scraper plate is in contact with the inner peripheral sidewall of the reactor body.

[0008] Furthermore, the water spraying assembly includes an annular conveying pipe arranged around the outer periphery of the lifting and moving seat. The annular conveying pipe is connected to a water inlet pipe. The water inlet pipe slides vertically through the top of the reactor body. Multiple water outlet nozzles are arranged in a circular pattern at the lower end of the outer periphery of the annular conveying pipe. The water outlet nozzles spray water toward the inner periphery of the reactor body.

[0009] Furthermore, the water nozzle is inclined with the inner end higher and the outer end lower.

[0010] Furthermore, the lifting assembly includes a movable plate horizontally positioned directly above the reactor body. The movable plate is driven to move up and down by a lifting cylinder vertically positioned directly below its center. A pair of left-right distributed vertical connecting rods are fixed to the bottom of the movable plate. The pair of vertical connecting rods slide vertically through the top of the reactor body and are fixedly connected to the lifting movable seat. When the cylinder rod of the lifting cylinder extends or retracts, it drives the lifting movable plate to move up and down through the movable plate and the vertical connecting rods.

[0011] Compared with the prior art, the present invention has the following advantages: The present invention has a simple and reasonable structural design. By setting a circulating feed port at the top of the reactor body and connecting the circulating feed port to the discharge port at the bottom of the reactor body through a circulating conveying pipe, the material output from the discharge port is pumped to the circulating feed port, and the material is then returned to the reactor body through the circulating feed port, thereby realizing the material being sent back to the reactor body for circulating stirring and mixing, and improving the stirring and mixing effect. Attached image description:

[0012] Figure 1 This is a front view structural schematic diagram of Embodiment 1 of this utility model;

[0013] Figure 2 This is a schematic diagram of the front cross-sectional structure of Embodiment 2 of this utility model;

[0014] Figure 3 yes Figure 2 Enlarged diagram of point A in the diagram. Detailed implementation method:

[0015] The present invention will now be described in further detail with reference to the accompanying drawings and specific embodiments.

[0016] In the description of this utility model, it should be understood that the terms "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0017] Example 1: As Figure 1 As shown, this utility model discloses a circulating reaction device for the preparation of pharmaceutical intermediates, comprising a reactor body 1 with a feed inlet 12 at the top and a discharge outlet 13 at the bottom. A stirring assembly 2 is installed inside the reactor body 1. A circulating feed inlet 14 is also provided at the top of the reactor body 1. The side of the discharge outlet 13 is connected to the circulating feed inlet 14 via a circulating conveying pipe 15. A circulating conveying pump 16 is installed on the circulating conveying pipe 15. The circulating conveying pump 16 is used to pump the material output from the discharge outlet 13 to the circulating feed inlet 14, and the material then returns to the reactor body 1 through the circulating feed inlet 14. By providing a circulating feed inlet at the top of the reactor body, and connecting the circulating feed inlet to the discharge outlet at the bottom of the reactor body via a circulating conveying pipe, the material output from the discharge outlet is pumped to the circulating feed inlet, and then the material returns to the reactor body through the circulating feed inlet, achieving the goal of circulating and mixing the material back into the reactor body, thus improving the mixing effect.

[0018] Example 2: Figures 2-3 As shown, this embodiment further defines a cleaning structure based on embodiment one. This cleaning mechanism is used to remove residual material from the inner peripheral sidewall of the reactor body. Specifically, the upper part of the reactor body 1 is provided with a lifting and moving seat 3 that is arranged around the outside of the stirring assembly 2. The lifting and moving seat is circular. The lifting and moving seat 3 is driven by the lifting assembly to move up and down along the axis of the reactor body 1. The bottom of the lifting and moving seat 3 is provided with a scraping assembly for contacting the inner peripheral sidewall of the reactor body 1. Above the scraping assembly is a water spraying assembly for spraying water toward the inner peripheral sidewall of the reactor body 1. When the lifting and moving seat moves up and down along the axis of the reactor body, the scraping assembly and the water spraying assembly move synchronously with the lifting and moving seat. When the scraping assembly moves synchronously with the lifting and moving seat, it scrapes off the material remaining on the inner wall of the reactor body, while the water spraying assembly sprays water to clean after the scraping assembly scrapes off the residual material. By installing a scraping component and a water spraying component on the lifting and moving seat inside the reactor body, the scraping component scrapes away the material remaining on the inner wall of the reactor body as the lifting and moving seat moves up and down. In conjunction with the water spraying component, water is sprayed for cleaning, which effectively removes the material remaining on the inner wall of the reactor body. The operation is simple and convenient, and the cleaning effect is improved.

[0019] In this embodiment, the scraping assembly includes a scraper 4, which is a frustum-shaped ring with a small upper diameter and a large lower diameter. The top of the scraper 4 is fixedly connected to the bottom of the lifting and moving seat 3. The lower end of the outer peripheral side of the scraper 4 contacts the inner peripheral side wall of the reactor body 1 so as to scrape off the material on the inner peripheral side wall of the reactor body.

[0020] In this embodiment, the scraper 4 is made of rubber material.

[0021] In this embodiment, the water spraying assembly includes an annular conveying pipe 5 arranged around the outer periphery of the lifting and moving seat 3. The annular conveying pipe 5 is connected to a water inlet pipe 6. The water inlet pipe draws water to the annular conveying pipe through a water pump. The water inlet pipe 6 slides vertically through the top of the reactor body 1. A plurality of circumferentially distributed water outlet nozzles 7 are provided at the lower end of the outer periphery of the annular conveying pipe 5. The water outlet nozzles 7 spray water toward the inner periphery of the reactor body 1.

[0022] In this embodiment, the water nozzle 7 is inclined with the inner end higher and the outer end lower, so as to achieve the effect of spraying water downwards for rinsing.

[0023] In this embodiment, the annular conveying pipe 5 is located directly above the conical surface of the scraper.

[0024] In this embodiment, the lifting assembly includes a movable plate 8 horizontally positioned directly above the reactor body 1. The movable plate 8 is driven to move up and down by a lifting cylinder 9 vertically positioned directly below its center. The lifting cylinder 9 can be mounted on the top of the reactor body 1 via a cylinder seat 10. A pair of vertically distributed connecting rods 11 are fixed to the bottom of the movable plate 8. The pair of vertical connecting rods 11 slide vertically through the top of the reactor body 1 and are fixedly connected to the lifting movable seat 3. When the cylinder rod of the lifting cylinder 9 extends or retracts, it drives the lifting movable plate 3 to move up and down through the movable plate 8 and the vertical connecting rods 11, thereby realizing the lifting movable plate moving up and down inside the reactor body.

[0025] If this utility model discloses or relates to mutually fixedly connected parts or structural components, then, unless otherwise stated, a fixed connection can be understood as: a detachable fixed connection (e.g., using bolts or screws), or a non-detachable fixed connection (e.g., riveting, welding). Of course, mutually fixed connections can also be replaced by an integral structure (e.g., manufactured using a casting process) (except where it is obviously impossible to use an integral forming process).

[0026] In addition, unless otherwise stated, the terms used to indicate positional relationships or shapes in any of the technical solutions disclosed in this utility model above include states or shapes that are similar to, close to, or approximate with them.

[0027] Any component provided by this utility model can be assembled from multiple individual components, or it can be a single component manufactured by a one-piece molding process.

[0028] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of this utility model and not to limit it; although the utility model has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications can still be made to the specific implementation of this utility model or equivalent substitutions can be made to some technical features without departing from the spirit of the technical solution of this utility model, and all such modifications and substitutions should be covered within the scope of the technical solution claimed by this utility model.

Claims

1. A circulating reaction device for the preparation of medical intermediates, comprising a reaction kettle body provided with a feed inlet at the top and a discharge outlet at the bottom, and a stirring assembly arranged inside the reaction kettle body, characterized in that: The top of the reaction kettle body is also provided with a circulating feeding port, the side of the discharging port is connected with the circulating feeding port through a circulating conveying pipe, a circulating conveying pump is installed on the circulating conveying pipe, and the circulating conveying pump is used to pump the material output from the discharging port to the circulating feeding port, and the material returns to the inside of the reaction kettle body through the circulating feeding port; The inside of the reaction kettle body is provided with a lifting moving seat which is arranged outside the stirring assembly and is arranged at the upper end of the reaction kettle body, the lifting moving seat is driven by a lifting assembly to move up and down along the axis direction of the reaction kettle body, the bottom of the lifting moving seat is provided with a scraping assembly which is used to contact the inner circumferential wall of the reaction kettle body, and the upper portion of the scraping assembly is provided with a water spraying assembly which is used to spray water towards the inner circumferential wall of the reaction kettle body; The scraping assembly comprises a scraping plate which is in the shape of a circular truncated cone ring, the top of the scraping plate is fixedly connected with the bottom of the lifting moving seat, and the outer circumferential side of the lower end of the scraping plate is in contact with the inner circumferential wall of the reaction kettle body. The water spraying assembly comprises a ring-shaped conveying pipe which is arranged outside the circumferential side of the lifting moving seat, the ring-shaped conveying pipe is connected with a water inlet pipe, the water inlet pipe vertically slides through the top of the reaction kettle body, and the outer circumferential side of the lower end of the ring-shaped conveying pipe is provided with a plurality of water outlet nozzles which are circumferentially distributed, the water outlet nozzles spray water towards the inner circumferential wall of the reaction kettle body.

2. A circulating reaction apparatus for the preparation of pharmaceutical intermediates according to claim 1, characterized in that: The water outlet nozzle is in the shape of an inclination with the inner side end being high and the outer side end being low.

3. The cyclic reaction apparatus for the preparation of pharmaceutical intermediates as claimed in claim 1, wherein: The lifting assembly comprises a moving plate which is horizontally arranged above the reaction kettle body, the moving plate is driven by a lifting cylinder which is vertically arranged below the middle portion of the moving plate to move up and down, the bottom of the moving plate is fixedly connected with a pair of vertically arranged connecting rods which are distributed on the left and right sides, the pair of vertically arranged connecting rods vertically slide through the top of the reaction kettle body and are fixedly connected with the lifting moving seat, and when the cylinder rod of the lifting cylinder is retracted and extended, the lifting moving plate is driven by the moving plate and the vertically arranged connecting rods to move up and down.

Images