Supporting device for antigen purification and concentration

Abstract

The utility model relates to the technical field of biological purification and filtration devices, in particular to an antigen purification and concentration supporting device which comprises a base, limiting rods are symmetrically and fixedly connected to the top of the base, and two sets of movable sleeves are symmetrically and slidably connected to the outer portions of the limiting rods. A transverse rod is fixedly connected between the two sets of moving sleeves, a guide sleeve is fixedly connected to the outer portion of the transverse rod, a liquid inlet end and a backflow end are slidably connected to the interior of the guide sleeve, two sets of connecting blocks are fixedly connected to one end of the liquid inlet end, and a rotating shaft is rotatably connected between the two sets of connecting blocks; an arc-shaped plate is fixedly connected outside the rotating shaft, the movable sleeve is composed of a first semi-arc sleeve and a second semi-arc sleeve, compared with an existing supporting device for antigen purification and concentration, through the design of the movable sleeve and the arc-shaped plate, disassembly and assembly of the hollow fiber column can be rapidly completed, and the overall practicability is greatly improved.

Description

Technical Field

[0001] This utility model relates to the technical field of biological purification and filtration devices, specifically to a support device for antigen purification and concentration. Background Technology

[0002] Antigen purification and concentration is a technical method used to extract, purify, and concentrate target antigens from complex mixtures.

[0003] When using hollow fiber columns for antigen purification and concentration, without a fixed hollow fiber column mounting fixture, operators cannot secure the hollow fiber columns during operation. Furthermore, since a single specification of hollow fiber column is typically fixed to a support, disassembly is cumbersome when other types or sizes of hollow fiber columns are needed, leading to inconvenience and hindering rapid installation. In addition, during small-scale laboratory trials, current technology typically concentrates one set of samples. When multiple sets of samples are needed for comparative experiments, rapid purification and concentration of different samples cannot be achieved, resulting in wasted time and effort.

[0004] Therefore, it is particularly important to improve existing antigen purification and concentration support devices, design a new type of support device to address the aforementioned technical deficiencies, and enhance the overall practicality of the antigen purification and concentration support device. Utility Model Content

[0005] The purpose of this invention is to provide a support device for antigen purification and concentration. Through the overall design, the height of the movable sleeve is controlled and adjusted, while the arc-shaped plates move closer to each other to install and disassemble the hollow fiber tube, thereby solving the problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution:

[0007] A support device for antigen purification and concentration includes a base. A limiting rod is symmetrically fixedly connected to the top of the base. A movable sleeve is symmetrically slidably connected to the outside of the limiting rod. Two sets of movable sleeves are provided, and a crossbar is fixedly connected between the two sets of movable sleeves. A guide sleeve is fixedly connected to the outside of the crossbar. An inlet end and a reflux end are slidably connected inside the guide sleeve. A connecting block is fixedly connected to one end of the inlet end. Two sets of connecting blocks are provided, and a rotating shaft is rotatably connected between the two sets of connecting blocks. An arc-shaped plate is fixedly connected to the outside of the rotating shaft.

[0008] As a preferred embodiment of this utility model, the movable sleeve is composed of a first semi-circular sleeve and a second semi-circular sleeve. The first semi-circular sleeve and the second semi-circular sleeve are symmetrically fixedly connected to the outside of a clamping plate, and the clamping plate is internally threaded with a bolt.

[0009] As a preferred embodiment of this utility model, the arc-shaped plate is provided in two sets, and an extension block is fixedly connected to the end of each set of arc-shaped plates away from the rotation axis. A lead screw is threadedly connected to the inside of the extension block, and an auxiliary plate is fixedly connected to the outside of the lead screw.

[0010] As a preferred embodiment of this utility model, a protrusion is fixedly connected to one end of the reflux end near the liquid inlet end, a hollow fiber column is plugged into the outside of the protrusion, and a permeable end is fixedly connected to the outside of the reflux end.

[0011] As a preferred embodiment of this utility model, a peristaltic pump is provided at the end of the liquid inlet that is away from the arc plate, and a connecting pipe is plugged into and disconnected between the liquid inlet and the peristaltic pump. A concentration bottle is provided on the outside of the peristaltic pump.

[0012] As a preferred embodiment of this utility model, a collar is slidably connected to the outer side of the liquid inlet end away from the arc plate. The collar has a C-shaped structure design, and a threaded post is slidably connected inside the collar. A threaded sleeve is threadedly connected to the outer side of the threaded post.

[0013] As a preferred embodiment of this utility model, the end of the threaded post away from the threaded sleeve is rotatably connected to a handle, the handle has an arc-shaped structure design, and an anti-slip pad is fixedly connected inside the collar.

[0014] Compared with the prior art, the beneficial effects of this utility model are:

[0015] 1. In this utility model, by placing the first semi-circular sleeve and the second semi-circular sleeve outside the limiting rod, and then inserting bolts between the clamping plates, the bolts are rotated and a thread reaction occurs between them and the clamping plates. Subsequently, the clamping plates move closer to each other, so as to realize the flexible adjustment of the movable sleeve and realize that the crossbar provides support for the guide sleeve, thereby positioning hollow fiber columns of different heights.

[0016] 2. In this utility model, hollow fiber columns are inserted between arc-shaped plates. By rotating the two sets of arc-shaped plates, the arc-shaped plates are brought closer together under the action of the rotating shaft. The distance between them is adjusted, and the lead screw is rotated to bring the arc-shaped plates closer together and then limit them, thereby wrapping the hollow fiber columns and fixing their bottom ends for easy disassembly.

[0017] 3. In this utility model, the peristaltic pump connection point has replaceable concentration bottles of different specifications. When different material samples need to be purified and concentrated, and hollow fiber columns of the same specification are used, only the limiting rod needs to be thoroughly rinsed, which greatly saves time. The base is designed to be small, which facilitates the disassembly of the peristaltic pump, reduces the space occupied, and makes it easy to move. Attached Figure Description

[0018] Figure 1This is a schematic diagram of the overall structure of this utility model;

[0019] Figure 2 This is a schematic diagram of the movable sleeve structure of this utility model;

[0020] Figure 3 This is a schematic diagram of the liquid inlet and return ends of this utility model;

[0021] Figure 4 This is a schematic diagram of the semi-arc plate structure of this utility model;

[0022] Figure 5 This is a schematic diagram of the collar structure of this utility model.

[0023] In the diagram: 1. Base; 2. Limiting rod; 3. Moving sleeve; 301. First semi-circular sleeve; 302. Second semi-circular sleeve; 303. Clamping plate; 4. Crossbar; 5. Guide sleeve; 6. Inlet end; 7. Return end; 8. Connecting block; 9. Rotating shaft; 10. Arc plate; 11. Lead screw; 12. Protrusion; 13. Hollow fiber column; 14. Permeable end; 15. Peristaltic pump; 16. Connecting pipe; 17. Concentrating bottle; 18. Collar; 19. Threaded column; 20. Threaded sleeve; 21. Handle. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model without creative effort are within the protection scope of the present utility model.

[0025] Example: Please refer to Figures 1-5 This utility model provides a technical solution:

[0026] A support device for antigen purification and concentration includes a base 1. A limiting rod 2 is symmetrically fixedly connected to the top of the base 1. A movable sleeve 3 is symmetrically slidably connected to the outside of the limiting rod 2. Two sets of movable sleeves 3 are provided, and a crossbar 4 is fixedly connected between the two sets of movable sleeves 3. A guide sleeve 5 is fixedly connected to the outside of the crossbar 4. An inlet end 6 and a reflux end 7 are slidably connected inside the guide sleeve 5. A connecting block 8 is fixedly connected to one end of the inlet end 6. Two sets of connecting blocks 8 are provided, and a rotating shaft 9 is rotatably connected between the two sets of connecting blocks 8. An arc-shaped... Plate 10 is constructed by placing base 1 in a designated position, then inserting two sets of limiting rods 2 into the top of base 1 to ensure they are always perpendicular to the top of base 1. Simultaneously, a movable sleeve 3 is fitted over the limiting rods 2 and its height is adjusted. This allows the crossbar 4 to provide support for the guide sleeve 5. The inlet end 6 and the return end 7 are inserted into the guide sleeve 5 respectively. Hollow fiber columns 13 are inserted between the arc plates 10. By rotating the two sets of arc plates 10, and then under the action of the rotating shaft 9, the arc plates 10 are brought closer together, and the distance between them is adjusted.

[0027] Furthermore, in this embodiment, the movable sleeve 3 is composed of a first semi-circular sleeve 301 and a second semi-circular sleeve 302. The first semi-circular sleeve 301 and the second semi-circular sleeve 302 are symmetrically fixedly connected to the outside of a clamping plate 303. The clamping plate 303 is internally threaded with a bolt. When it is necessary to adjust the hollow fiber column 13 of different heights, the first semi-circular sleeve 301 and the second semi-circular sleeve 302 are sleeved on the outside of the limiting rod 2, and then the bolt is inserted between the clamping plates 303. By controlling the bolt to rotate, a thread reaction occurs between the bolt and the clamping plate 303, and then the clamping plates 303 move closer to each other, so as to realize the flexible adjustment of the movable sleeve 3.

[0028] Furthermore, in this embodiment, there are two sets of arc-shaped plates 10. Each set of arc-shaped plates 10 has an extension block fixedly connected to the end away from the rotating shaft 9. The extension block is internally threaded with a lead screw 11, and the lead screw 11 is externally fixedly connected with an auxiliary plate. By inserting the lead screw 11 into the extension block and rotating the lead screw 11, the arc-shaped plates 10 are brought closer to each other and then limited, thereby wrapping the hollow fiber column 13.

[0029] Furthermore, in this embodiment, a protrusion 12 is fixedly connected to one end of the return end 7 near the liquid inlet end 6. A hollow fiber column 13 is plugged into the outside of the protrusion 12. A through end 14 is fixedly connected to the outside of the return end 7. After the arc plate 10 fixes the bottom end of the hollow fiber column 13, the height of the return end 7 is adjusted by adjusting the other side of the moving sleeve 3, so that the protrusion 12 is inserted into the top of the inner side of the hollow fiber column 13, thus completing the fixation and facilitating disassembly.

[0030] Furthermore, in this embodiment, a peristaltic pump 15 is provided at the end of the inlet end 6 away from the arc plate 10. A connecting pipe 16 is plugged and plugged between the inlet end 6 and the peristaltic pump 15. A concentration bottle 17 is provided on the outside of the peristaltic pump 15. Different specifications of concentration bottles 17 can be replaced at the connection position of the peristaltic pump 15. When different material samples need to be purified and concentrated, when using hollow fiber columns 13 of the same specifications, only the limit rod 2 needs to be thoroughly rinsed, which greatly saves time. The base 1 is designed to be small, which facilitates the disassembly of the peristaltic pump 15, reduces the space occupied, and facilitates movement.

[0031] Furthermore, in this embodiment, a collar 18 is slidably connected to the outer side of the inlet end 6 away from the arc plate 10. The collar 18 has a C-shaped structure design. A threaded post 19 is slidably connected inside the collar 18. A threaded sleeve 20 is threadedly connected to the outer side of the threaded post 19. A handle 21 is rotatably connected to the end of the threaded post 19 away from the threaded sleeve 20. The handle 21 has an arc-shaped structure design. An anti-slip pad is fixedly connected inside the collar 18. When the connecting tube 16 needs to be replaced, the operator turns the handle 21 by controlling it. Then the handle 21 moves away from the collar 18 and contacts the collar 18 to squeeze it. At the same time, the threaded post 19 is rotated to release the squeeze at the notch of the collar 18 and release the fixation between the connecting tube 16 and the inlet end 6.

[0032] In this embodiment, the specific implementation scenario is as follows: The base 1 is placed in a designated position, and then two sets of limiting rods 2 are inserted into the top of the base 1, ensuring they remain perpendicular to the top. The first semi-circular sleeve 301 and the second semi-circular sleeve 302 are fitted over the limiting rods 2. Bolts are then inserted between the clamping plates 303. By controlling the rotation of the bolts, a threaded reaction occurs between the bolts and the clamping plates 303, causing the clamping plates 303 to move closer together. This allows for flexible adjustment of the movable sleeve 3. The crossbar 4 provides support to the guide sleeve 5. The inlet end 6 and the return end 7 are respectively inserted into the guide sleeve 5. Hollow fiber columns 13 are inserted between the arc-shaped plates 10. By rotating the two sets of arc-shaped plates 10, and under the action of the rotating shaft 9, the arc-shaped plates 10 move closer together, adjusting their spacing. Finally, the lead screw 11 is inserted into the extension block and rotated, causing the arc-shaped plates 10 to move closer together and be limited. This encloses the hollow fiber column 13. After the arc plate 10 fixes the bottom of the hollow fiber column 13, the height of the return end 7 is adjusted by adjusting the moving sleeve 3 on the other side, so that the protrusion 12 can be inserted into the top of the inner side of the hollow fiber column 13 to complete the fixation. At the same time, it is easy to disassemble. The peristaltic pump 15 has a replaceable concentration bottle 17 of different specifications. When different material samples need to be purified and concentrated, when using the same specification of hollow fiber column 13, only the limit rod 2 needs to be thoroughly rinsed, which greatly saves time. The base 1 is designed to be small, which facilitates the disassembly of the peristaltic pump 15, reduces the space occupied, and facilitates movement. When it is necessary to replace the connecting tube 16, the operator turns it by controlling the handle 21. Then the handle 21 moves away from the collar 18 and contacts the collar 18 for compression. At the same time, the threaded column 19 is rotated to release the compression at the notch of the collar 18 and release the fixation between the connecting tube 16 and the liquid inlet 6.

[0033] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A support device for the purification and concentration of antigens, comprising a base (1), characterized in that: The top of the base (1) is symmetrically fixedly connected with a limiting rod (2), the outer part of the limiting rod (2) is symmetrically and slidably connected with a moving sleeve (3), the moving sleeve (3) is provided with two groups, the two groups of moving sleeves (3) are fixedly connected with a cross rod (4), the outer part of the cross rod (4) is fixedly connected with a guide sleeve (5), the inner part of the guide sleeve (5) is slidably connected with a liquid inlet end (6) and a return flow end (7), one end of the liquid inlet end (6) is fixedly connected with a connecting block (8), the connecting block (8) is provided with two groups, the two groups of connecting blocks (8) are rotatably connected with a rotating shaft (9), the outer part of the rotating shaft (9) is fixedly connected with an arc-shaped plate (10).

2. An antigen purification and concentration support device according to claim 1, characterized in that: The moving sleeve (3) is composed of a first half-arc sleeve (301) and a second half-arc sleeve (302), the outer part of the first half-arc sleeve (301) and the second half-arc sleeve (302) is symmetrically fixedly connected with a clamping plate (303), the inner part of the clamping plate (303) is threadedly connected with a bolt.

3. An antigen purification and concentration support device according to claim 1, characterized in that: The arc-shaped plate (10) is provided with two groups, one end of the arc-shaped plate (10) away from the rotating shaft (9) is fixedly connected with an extension block, the inner part of the extension block is threadedly connected with a lead screw (11), the outer part of the lead screw (11) is fixedly connected with an auxiliary plate.

4. An antigen purification and concentration support device according to claim 1, characterized in that: One end of the return flow end (7) close to the liquid inlet end (6) is fixedly connected with a protruding block (12), the outer part of the protruding block (12) is plug-connection with a hollow fiber column (13), the outer part of the return flow end (7) is fixedly connected with a permeation end (14).

5. An antigen purification and concentration support device according to claim 1, wherein: One end of the liquid inlet end (6) away from the arc-shaped plate (10) is provided with a peristaltic pump (15), the liquid inlet end (6) and the peristaltic pump (15) are plug-connection with a communication pipe (16), the outer side of the peristaltic pump (15) is provided with a concentration bottle (17).

6. An antigen purification and concentration support device according to claim 1, characterized in that: The outer part of one end of the liquid inlet end (6) away from the arc-shaped plate (10) is slidably connected with a thimble (18), the thimble (18) is designed in a C-shaped structure, the inner part of the thimble (18) is slidably connected with a threaded column (19), the outer part of the threaded column (19) is threadedly connected with a threaded sleeve (20).

7. An antigen purification and concentration support device according to claim 6, characterized in that: One end of the threaded column (19) away from the threaded sleeve (20) is rotatably connected with a handle (21), the handle (21) is designed in an arc-shaped structure, the inner part of the thimble (18) is fixedly connected with an anti-skid pad.

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