Heat exchange system for targeted hypothermia therapy of stroke

Abstract

The utility model relates to the technical field of targeted hypothermia treatment, particularly provides a heat exchange system for targeted hypothermia treatment of stroke, and aims to solve one of the problems of high cost, high risk and complicated operation of the conventional hypothermia treatment scheme. The heat exchange system provided by the utility model comprises a heat exchange host which can cool blood input into the heat exchange host to a target temperature and then output the blood; the first end of the intravascular catheter extends to a targeted low-temperature treatment area of the human body; the extracorporeal circulation pipe set comprises a blood leading-out pipeline and a blood leading-in pipeline, and the second end of the blood leading-in pipeline can be connected with the second end of the intravascular catheter so that the autologous blood cooled to the target temperature can be transfused back to the targeted low-temperature treatment area of the human body. The heat exchange system provided by the utility model provides an efficient, safe and economical low-temperature treatment scheme.

Description

Technical Field

[0001] This utility model relates to the field of targeted cryotherapy technology, specifically providing a heat exchange system for targeted cryotherapy of stroke. Background Technology

[0002] Acute ischemic stroke (CIS), also known as cerebral infarction (CI), is a serious vascular event of the central nervous system and a leading cause of death and disability in humans, placing a huge burden on the healthcare system and socio-economic development. Unfortunately, current treatment options for CIS are relatively limited, and most fail to reduce mortality or improve neurological outcomes. Furthermore, due to the narrow treatment window and strict criteria, very few patients can receive effective treatment clinically. Even with effective revascularization therapy, the mortality rate remains high. This is due to reperfusion injury after revascularization, which can lead to cerebral edema and even cerebral hemorrhage, endangering patient safety.

[0003] Hypothermia, as a treatment for human diseases, is believed to primarily achieve its neuroprotective mechanism by reducing the brain's metabolic rate. Specifically, for every 1°C decrease in body temperature, the brain's metabolic rate decreases by 7% to 10%. This reduction in metabolic rate is reflected in decreased oxygen consumption, glucose utilization, and lactate levels, indirectly indicating a slowdown in brain metabolic activity under hypothermic conditions. Hypothermia can effectively reduce the metabolic rate of nerve cells, thereby reducing the brain tissue's demand for energy and oxygen, inhibiting the inflammatory response after brain injury, alleviating cerebral edema, and reducing intracranial pressure, thus protecting damaged neurons.

[0004] Existing hypothermia treatments are mainly divided into three categories based on the treatment method: pharmacological cooling, surface cooling, and intracavitary cooling. While pharmacological cooling is simple to perform, it involves pharmacological effects in addition to its cooling effect, potentially adversely affecting cardiac activity, blood glucose levels, respiratory function, and level of consciousness, thus posing risks to patients. Surface cooling commonly uses devices such as ice blankets and ice caps; however, these devices suffer from slow temperature conduction, difficulty in precise temperature control, and significant side effects, easily causing shivering, arrhythmia, and even frostbite. In contrast, intracavitary cooling exhibits more significant advantages, being more efficient, faster, and easier to precisely target and control the cooling area. Intracavitary cooling is further subdivided into invasive cooling and intravascular cooling. Invasive cooling methods, such as epidural cooling, intradural cooling, and subarachnoid cooling, although clinically proven feasible, require additional surgery for patients, increasing pain, infection risks, and surgical difficulty for doctors, hindering the rapid induction of hypothermia treatment. Intravascular cooling, through the channel of mechanical thrombectomy, rapidly places the catheter in the cooling target area (the damaged brain tissue region, especially the area damaged due to ischemia), which is superior to invasive cooling. Intravascular cooling specifically includes ice-cold saline infusion cooling technology and intravascular closed-tube balloon heat exchange technology. While ice-cold saline infusion cooling technology can rapidly induce cooling, it is difficult to maintain the target temperature for a long time, and the temperature control precision is insufficient, posing a risk of dropping below the target temperature, potentially inducing pulmonary edema, heart failure, or recurrence of cardiac arrest. Intravascular closed-tube balloon heat exchange technology, on the other hand, allows cryogenic fluid to circulate within a closed catheter to the balloon for heat exchange with the blood. However, the heat exchange efficiency is limited by the balloon material, the temperature control depth is affected by the balloon volume, making it difficult to reach the target location, and the high cost of balloon catheter consumables hinders widespread engineering application.

[0005] Therefore, a new hypothermia treatment plan is urgently needed. Utility Model Content

[0006] The present invention aims to solve the above-mentioned technical problems, namely, to solve at least one of the problems of high cost, high risk and complicated operation of existing hypothermia treatment programs.

[0007] To address the above problems, this utility model provides a heat exchange system for targeted cryotherapy of stroke, the heat exchange system comprising:

[0008] A heat exchange host that can cool the blood input into it to a target temperature and then output it, the heat exchange host including a blood-side input end and a blood-side output end;

[0009] An intravascular catheter is inserted through a channel during the mechanical thrombectomy phase, with the first end of the intravascular catheter extending to the targeted hypothermic treatment area of ​​the body.

[0010] An extracorporeal circulation tube set comprising a blood outlet tube and a blood inlet tube, a first end of the blood outlet tube being connectable to a blood taking vessel of a human body, a second end of the blood outlet tube being connected to the blood side input end, a first end of the blood inlet tube being connected to the blood side output end, and a second end of the blood inlet tube being connectable to a second end of the intravascular catheter to return the autologous blood cooled to the target temperature to the target hypothermia treatment area of the human body.

[0011] In some possible embodiments of the heat exchange system for stroke targeted hypothermia treatment, the heat exchange host further comprises a monitoring unit, and the monitoring unit comprises a human body physiological parameter monitoring subunit configured to acquire a core temperature of the human body and a target area temperature.

[0012] In some possible embodiments of the heat exchange system for stroke targeted hypothermia treatment, the core temperature of the human body comprises one of a rectal temperature, an esophageal temperature, and a bladder temperature; and / or

[0013] The target area temperature comprises one of a left ear canal temperature and a right ear canal temperature difference, a brain parenchyma temperature, a ventricle temperature, and a subdural temperature.

[0014] It should be noted that the left ear canal temperature and the right ear canal temperature difference is a difference between a left ear canal temperature and a right ear canal temperature.

[0015] In some possible embodiments of the heat exchange system for stroke targeted hypothermia treatment, the human body physiological parameter monitoring subunit is further configured to acquire at least one of a body surface temperature, a blood pressure, a blood oxygen, and an electrocardiogram.

[0016] In some possible embodiments of the heat exchange system for stroke targeted hypothermia treatment, the monitoring unit further comprises an extracorporeal circulation tube set parameter monitoring subunit configured to acquire at least one of a pre-pump arterial pressure, a post-pump arterial pressure, a blood temperature, a bubble detection, a liquid level, and a blood flow.

[0017] In some possible embodiments of the heat exchange system for stroke targeted hypothermia treatment, a power pump is further connected to the blood outlet tube.

[0018] In some possible embodiments of the heat exchange system for stroke targeted hypothermia treatment, the power pump is a magnetic suspension pump or a peristaltic pump.

[0019] In some possible embodiments of the heat exchange system for stroke targeted hypothermia treatment, a filter is arranged on the blood outlet tube and the blood inlet tube.

[0020] In some possible implementation forms of the heat exchange system for stroke targeted hypothermia treatment, the heat exchange host further comprises a refrigerant side connected with a water chiller.

[0021] In some possible implementation forms of the heat exchange system for stroke targeted hypothermia treatment, the heat exchange host further comprises a display unit configured to display the parameters measured by the monitoring unit.

[0022] The heat exchange system for stroke targeted hypothermia treatment provided by the utility model, through the setting up of the intravascular catheter, the intravascular catheter is formed by the mechanical thrombectomy stage and is auxiliary to be put into the channel, the patient's autologous arterial blood is extracted and cooled by the heat exchange host, and the pre-cooled autologous blood is selectively transfused to the targeted hypothermia treatment area through the intravascular catheter, so that the targeted hypothermia treatment area can be maintained at low temperature for a long time without increasing the liquid load (the total amount of liquid in the patient's body) in the patient's body, and the rapid and gentle treatment effect is realized. The system not only significantly reduces the treatment cost, because it does not need to use additional refrigerants or replacement liquids, and the intravascular catheter does not need to use a specially designed catheter, but also is simple to operate, greatly reducing the operation burden of medical staff. In addition, by accurately controlling the cooling process and selectively transfusing, the system can effectively avoid complications that may occur in traditional hypothermia treatment methods, such as liquid overload, electrolyte disorder, and immune reactions that may be caused by the use of external cooling media. It can be seen that the utility model provides an efficient, safe and economical solution for targeted hypothermia treatment of stroke patients, not only improves the treatment effect, but also optimizes the overall treatment experience of the patient.

[0023] Further, by monitoring the patient's physiological parameters such as the core temperature (such as rectal temperature, esophageal temperature, bladder temperature, etc.) and the target area temperature (such as the temperature difference between the left and right ear canals, brain parenchyma temperature, ventricle temperature, subdural temperature, etc.) in real time, the target area temperature is changed under the premise of ensuring that the core temperature is not lost, the temperature is finely controlled, and the low temperature state in the treatment process can be limited to a specific brain tissue area, i.e. the lesion area of stroke, and unnecessary cooling of other important organs of the whole body is avoided. At the same time, according to the real-time feedback of the real-time monitoring data, medical staff can dynamically adjust the infusion rate and temperature of the cooled autologous blood, so as to ensure the treatment effect while minimizing the impact on the patient's normal physiological state. In addition, the combination of real-time monitoring and dynamic adjustment also makes the treatment process more personalized, allowing customized treatment according to the specific circumstances (such as age, weight, underlying diseases, etc.) of different patients, further improving the accuracy and safety of treatment.

[0024] It should be noted that the core temperature of the human body refers to the relatively stable temperature inside the human body, which reflects the heat state inside the human body. Under normal circumstances, i.e. when the human body is in a healthy state, the core temperature of the human body can be characterized by rectal temperature, esophageal temperature, bladder temperature, etc., i.e. the temperature measured at the corresponding position is stable and close to the theoretical value. The target zone temperature (abbreviation of the target low-temperature treatment zone) refers to the temperature of the stroke lesion area and the surrounding tissue, which is characterized by the temperature difference between the left and right ear canals (the temperature difference between the left and right ear canals as one of the reference indicators reflecting the change of brain temperature, not directly measuring the intracranial temperature), brain parenchyma temperature, ventricle temperature or subdural temperature, etc.

[0025] Further, by using a magnetic suspension pump to replace the conventional peristaltic pump, the crushing and damage to blood cells can be significantly reduced, thereby avoiding the wear and shear force caused by mechanical contact of traditional blood pumps, which is of great significance for protecting blood cells and reducing the risk of hemolysis. The use of a magnetic suspension pump not only maintains the integrity and biological activity of autologous blood during extracorporeal circulation, but also further enhances the safety and reliability of the system. During the process of pumping out the patient's autologous arterial blood and cooling it through the heat exchange host, the magnetic suspension pump can smoothly and efficiently push the blood flow, ensuring the cooling effect while reducing the inflammation or immune response that may be caused by blood cell damage. In addition, the low noise and low vibration characteristics of the magnetic suspension pump also provide a more comfortable treatment experience for the patient, which helps to reduce anxiety and discomfort during treatment. BRIEF DESCRIPTION OF DRAWINGS

[0026] The preferred embodiments of the present utility model will be described below in conjunction with the accompanying drawings, in which:

[0027] Figure 1 is a schematic diagram of the heat exchange system for stroke targeted hypothermia treatment provided by the embodiments of the present utility model.

[0028] LIST OF REFERENCE NUMERALS

[0029] 1, first temperature sensor; 2, first pressure sensor; 3, first filter; 4, power pump; 5, blood export pipeline; 6, blood import pipeline; 7, second pressure sensor; 8, second filter; 9, flow sensor; 10, second temperature sensor; 11, heat exchange host; 12, water chiller; 13, water pump. DETAILED DESCRIPTION

[0030] The preferred embodiments of the present utility model will be described below in conjunction with the accompanying drawings. Those skilled in the art should understand that these embodiments are only used to explain the technical principles of the present utility model, and are not intended to limit the protection scope of the present utility model.

[0031] It should be noted that in the description of the utility model, the terms "upper", "lower", "inner", "outer" and other terms indicating direction or positional relationship are based on the direction or positional relationship shown in the drawings, which is merely for the convenience of description, and does not indicate or imply that the device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the utility model.

[0032] In addition, it should be noted that in the description of the utility model, unless otherwise explicitly specified and limited, the terms "mounting", "connection", "connection" should be understood broadly, for example, it can be fixed connection, or detachable connection, or integrated connection, it can be mechanical connection, it can be direct connection, or indirect connection through intermediate medium, it can be the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the utility model can be understood according to the specific circumstances. In addition, the terms "first", "second" are only for the purpose of description, and cannot be understood as indicating or implying relative importance.

[0033] As shown in Figure 1 The utility model embodiment provides a heat exchange system for stroke targeted low temperature treatment, which comprises a heat exchange host 11, a cold water machine 12, an extracorporeal circulation pipe group, an intravascular catheter and other components arranged on the pipeline.

[0034] Specifically, the heat exchange host 11 comprises a refrigerant side and a blood side, which are isolated from each other inside the host, but can realize effective heat exchange. The refrigerant side maintains a lower temperature than the blood side and is responsible for cooling the blood flowing through the blood side to the target temperature. In order to stably maintain the low temperature of the refrigerant side, the refrigerant side is connected with the cold water machine 12 through a special pipeline to form a complete refrigerant circulation loop. The refrigerant can be a mixture of propylene glycol and deionized water, and of course can also be other liquid substances that can be used as heat exchange medium. The blood side passes through the extracorporeal circulation pipe group, the intravascular catheter and the vascular system of the patient to build a blood circulation loop, ensuring that the blood can be smoothly guided out, cooled and then reinfused into the patient's body. The blood side is provided with a blood side input end and a blood side output end, which are convenient for connecting with the extracorporeal circulation pipe group, and are usually connected through a luer joint, and of course can also be connected through other connection modes. Between the refrigerant side and the blood side, designs such as parallel pipe structure, sleeve structure, etc. can be adopted, and the blood side pipe can also be designed into a coil structure, the refrigerant side is arranged as a tank structure capable of containing liquid, the tank structure contains the propylene glycol and deionized water mixture and the like as described above, and the coil structure is directly immersed in the mixture, and other structures capable of realizing efficient heat exchange can also be adopted.

[0035] The intravascular catheter is usually a catheter commonly used in the operating room. The size and diameter of the catheter are selected by the doctor according to the site of the patient, the position of the catheter, etc. The mechanical thrombectomy is an interventional treatment method, which is mainly used for the treatment of acute ischemic stroke patients. Through the method of intervention, the specific instrument (such as a thrombectomy stent, a suction catheter, etc.) is sent into the arterial blood vessel, and the blood clots in the blood vessel are taken out by mechanical force, so as to make the blood vessel recanalization, rapidly restore the cerebral blood flow, and improve the function of the ischemic penumbra tissue, so as to maximize the improvement of the symptoms and signs of neurological impairment. The intravascular catheter is usually inserted through puncture of the femoral artery. The femoral artery is located at the root of the thigh and is one of the main arteries of the lower extremities. It is relatively superficial and easy to touch, so it is a common puncture point for intravascular interventional surgery.

[0036] The extracorporeal circulation tube set includes a blood outlet tube 5 and a blood inlet tube 6. As shown in Figure 1 , the first end of the blood outlet tube 5 can be connected to the blood vessel of the human body. The blood vessel can be selected from the radial artery, the femoral artery, etc. As shown in Figure 1 , the blood collection site is the femoral artery. The second end of the blood outlet tube 5 is connected to the blood inlet end, the blood outlet end is connected to the first end of the blood inlet tube 6, and the second end of the blood inlet tube 6 can be connected to the second end of the intravascular catheter. The first end of the intravascular catheter extends to the target hypothermia treatment area to return the autologous blood cooled to the target temperature to the target hypothermia treatment area of the human body.

[0037] In addition, other important components are also provided on the paths of the blood outlet tube 5 and the blood inlet tube 6.

[0038] As shown in Figure 1 , a first filter 3 and a power pump 4 are sequentially provided on the blood outlet tube 5. The first filter 3 is mainly used to filter impurities, air, etc. such as thrombus and gas embolus in the blood. The top of the first filter 3 extends two tube lines in communication with the inside of the filter. One of the tube lines is used to remove air bubbles, and the other tube line is used to connect the first pressure sensor 2 to detect the arterial pressure before the pump through the first pressure sensor 2. The filtered blood is transported to the blood side of the heat exchange host 11 through the action of the power pump 4 from the tube line connected to the bottom of the first filter 3. A first temperature sensor 1 is also provided on the blood outlet tube 5. The first temperature sensor 1 is attached to the tube wall and is used to detect the temperature of the blood before heat exchange. In addition, a liquid level detection device and a tube clamp valve are also provided on the first filter 3. The liquid level detection device is used to monitor the liquid level change of the blood in the first filter 3 in real time. The tube clamp valve is used to control the flow state of the blood.

[0039] In this embodiment, the power pump 4 can adopt a common peristaltic pump, preferably a magnetic suspension pump, which can significantly reduce the crushing and damage to blood cells, thereby avoiding the wear and shear force generated by the traditional blood pump due to mechanical contact, which is of great significance to protect blood cells and reduce the risk of hemolysis.

[0040] When the blood enters the blood side, the relatively high-temperature blood exchanges heat with the relatively low-temperature refrigerant side, so that the autologous blood is cooled to the target temperature, and the cooled blood is returned to the patient's body through the blood introduction pipeline 6.

[0041] With reference to the foregoing Figure 1 A second filter 8 is arranged on the blood introduction pipeline 6, and the structure of the second filter 8 is the same as that of the first filter 3, and the second filter 8 is also used for filtering impurities, air and the like. The top of the second filter 8 also extends two pipelines, one of which is used for removing air bubbles, and the other of which is used for connecting a second pressure sensor 7, which is used for detecting the arterial pressure after the pump. By combining the arterial pressure before the pump, the smoothness of the blood flow in the pipeline can be accurately obtained. Specifically, if the arterial pressure after the pump is relatively high relative to the arterial pressure before the pump, it indicates that there is a blockage in the pipeline; if the arterial pressure after the pump is relatively low relative to the arterial pressure before the pump, it indicates that there is an air leakage in the pipeline.

[0042] In addition, a flow sensor 9 and a second temperature sensor 10 are arranged on the pipeline after the second filter 8. The flow sensor can adopt an ultrasonic flow sensor, which is used for detecting the flow and air bubbles in the pipeline, and is a non-invasive sensor that does not need to contact the blood. The second temperature sensor 10 is used for detecting the temperature of the blood in the pipeline, i.e., the temperature of the blood before being input into the patient's body. The flow sensor 9 and the second temperature sensor 10 are both attached to the wall of the blood introduction pipeline 6. In addition, Robert clamps are arranged at the required positions in the pipeline, and part or all of the pipe interfaces are connected through luer connectors.

[0043] In addition to the blood side and the refrigerant side, the heat exchange host 11 also includes a display unit, a central processing unit, a monitoring unit, a driving unit, a power management and emergency processing unit, etc.

[0044] Specifically, the display unit is responsible for displaying the operating status of the heat exchange host 11, blood temperature, flow rate, human physiological parameters, and other key parameters in an intuitive manner. This helps medical personnel monitor the status of blood extracorporeal circulation in real time and promptly discover and handle abnormal situations. The central processing unit is the core of the heat exchange host 11, responsible for receiving data from various sensors and processing and analyzing it. It controls the operation of other units according to pre-set programs and algorithms to achieve precise regulation of blood temperature and stable operation of blood extracorporeal circulation. The monitoring unit is responsible for monitoring human physiological parameters, related parameters of the extracorporeal circulation tube set, etc. Once an abnormal situation is detected, the monitoring unit will immediately issue an alarm and notify medical personnel to handle it. The drive unit is the part of the heat exchange host 11 responsible for driving key equipment such as pumps and cold water machines 12. It adjusts the speed of the fans in the pump and cold water machine 12 according to the instructions of the central processing unit, thereby controlling the flow rate and temperature of the blood. The power management unit is responsible for providing stable and reliable power supply for the heat exchange host 11. It monitors parameters such as voltage and current of the power supply to ensure that the host operates in a safe power environment. At the same time, the power management unit should also have overvoltage, overcurrent, and other protection functions to prevent equipment damage or safety accidents caused by power problems. The emergency handling unit is an important safety guarantee part of the heat exchange host 11. In the event of an emergency (such as power failure, equipment failure, etc.), the emergency handling unit will immediately start the backup power supply or backup equipment to ensure continuous operation of extracorporeal circulation.

[0045] The monitoring unit includes a human physiological parameter monitoring subunit and an extracorporeal circulation tube set parameter monitoring subunit. The human physiological parameter monitoring subunit is used to obtain the core body temperature and the target area temperature. The core body temperature includes one of the rectal temperature, esophageal temperature, and bladder temperature, and the rectal temperature is preferably obtained. The target area temperature includes one of the left and right ear canal temperature difference, brain parenchyma temperature, ventricle temperature, and subdural temperature, and the left and right ear canal temperature difference is preferably used to achieve non-invasive detection and avoid risks such as infection. In addition, the human physiological parameter monitoring subunit is also used to obtain at least one of the body surface temperature, blood pressure, blood oxygen, and electrocardiogram.

[0046] The extracorporeal circulation tube set parameter monitoring subunit is used to obtain at least one of the pre-pump arterial pressure (detected by the first pressure sensor 2), post-pump arterial pressure (detected by the second pressure sensor 7), blood temperature (including the temperature of the blood in the blood leading-out pipeline 5 and the temperature of the blood in the blood leading-in pipeline 6), bubble detection (detected by the ultrasonic flow sensor 9), liquid level (including the liquid level in the first filter 3 and the liquid level in the second filter 8), and blood flow rate (detected by the ultrasonic flow sensor 9).

[0047] As Figure 1As shown, the heat exchange host 11 is connected with the water chiller 12 on the refrigerant side to form a liquid circuit circulation, and the water pump 13 is arranged on the path of the liquid circuit circulation. The water chiller 12 is used to provide cold energy to cool the blood on the blood side.

[0048] The working principle of the whole heat exchange system is as follows:

[0049] An incision is made at the femoral artery of the patient, and blood is taken from the femoral artery through the blood leading-out pipeline 5 and led out. The led-out blood first passes through the first filter 3 to filter out impurities and bubbles, and then enters the blood side of the heat exchange host 11 under the action of the power pump 4. After heat exchange and cooling with the refrigerant on the refrigerant side, it is output to the blood leading-in pipeline 6, and then passes through the second filter 8 to filter out impurities and bubbles, and is then led into the intravascular catheter and further delivered to the target hypothermia treatment area, so as to achieve the purpose of cooling the target area by autologous blood. During the blood circulation process, the corresponding parameters are detected by the sensors, and the display unit is used for display.

[0050] It should be noted that the targeted hypothermia treatment can be divided into four stages of induction, maintenance, rewarming and normal temperature control according to the target temperature management of the neural critical illness. During the treatment process, the purpose is to keep the core temperature unchanged and change the target area temperature. In this embodiment, the rectal temperature of the human body is selected as the core temperature, and the temperature difference between the left and right ears is selected as the target area temperature. During the treatment process, the system core temperature is the basis, and the target area temperature is controlled by adjusting the extracorporeal circulation system flow, such as the speed of the power pump 4, the refrigeration temperature set by the water chiller 12, the displacement of the water chiller 12, etc. The greater the extracorporeal circulation flow, the more obvious the change of the target area temperature in the human body; the lower the refrigeration temperature set by the water chiller 12, the greater the extracorporeal heat exchange temperature difference, and the lower the blood return temperature; the greater the displacement of the water chiller 12, the higher the heat exchange efficiency. However, too fast extracorporeal circulation flow will cause discomfort to the human body, and even affect the change of intracranial pressure; and by adjusting the refrigeration temperature set by the water chiller 12 and the displacement of the water chiller 12 to control the target area temperature, the above problems will not occur. Therefore, different weights are given to the three parameters in the process of changing the target area temperature by adjusting the parameters, and the importance of the parameter weight is ranked as follows: the refrigeration temperature set by the water chiller 12 is the highest, followed by the displacement of the water chiller 12, and finally the extracorporeal circulation system flow.

[0051] In addition, it is also necessary to monitor the parameters of the extracorporeal circulation pipeline during the system operation, such as bubble monitoring, which can monitor whether there are bubbles entering the human body in the extracorporeal circulation in real time. The bubbles entering the human body may form gas embolism, thereby causing secondary injury to the human body; the speed and flow of the power pump 4 form a closed loop feedback, and the deviation of the speed and flow can enable medical staff to timely find out whether the extracorporeal circulation pipeline is bent or whether a new thrombus is formed and blocks the extracorporeal circulation pipeline. The change of the pressure sensor can also enable the medical staff to have a full judgment on the air tightness of the pipeline.

[0052] The technical scheme of the utility model has been described in combination with the preferred embodiments shown in the drawings, but the person skilled in the art can easily understand that the protection scope of the utility model is obviously not limited to these specific embodiments. The person skilled in the art can make equivalent changes or replacements to the related technical features without deviating from the principles of the utility model, and the technical schemes after the changes or replacements will all fall within the protection scope of the utility model.

Claims

1. A heat exchange system for targeted cryotherapy of stroke, characterized in that, The heat exchange system includes: a heat exchange host (11) that can cool the blood input into it to a target temperature and then output it, the heat exchange host (11) including a blood-side input end and a blood-side output end; an intravascular catheter that is inserted through a channel during the mechanical thrombectomy stage, the first end of the intravascular catheter extending to the targeted hypothermia treatment area of ​​the human body; and an extracorporeal circulation tubing assembly that includes a blood outlet tubing (5) and a blood inlet tubing (6), the first end of the blood outlet tubing (5) being able to connect to a blood collection vessel of the human body, the second end of the blood outlet tubing (5) being connected to the blood-side input end, the first end of the blood inlet tubing (6) being connected to the blood-side output end, and the second end of the blood inlet tubing (6) being able to connect to the second end of the intravascular catheter, so as to reinfuse the autologous blood cooled to the target temperature to the targeted hypothermia treatment area of ​​the human body.

2. The heat exchange system for targeted cryotherapy of stroke according to claim 1, characterized in that, The heat exchange host (11) also includes a monitoring unit, which includes a human physiological parameter monitoring subunit, which is used to acquire the core temperature and target area temperature of the human body.

3. The heat exchange system for targeted cryotherapy of stroke according to claim 2, characterized in that, The core human body temperature includes one of rectal temperature, esophageal temperature, and bladder temperature; and / or The target area temperature includes one of the following: temperature difference between the left and right ear canals, brain parenchyma temperature, ventricular temperature, and subdural temperature.

4. The heat exchange system for targeted cryotherapy of stroke according to claim 2, characterized in that, The human physiological parameter monitoring subunit is also used to acquire at least one of the following: body surface temperature, blood pressure, blood oxygen, and electrocardiogram.

5. The heat exchange system for targeted cryotherapy of stroke according to claim 2, characterized in that, The monitoring unit also includes an extracorporeal circulation tubing parameter monitoring subunit, which is used to acquire at least one of the following: pre-pump arterial pressure, post-pump arterial pressure, blood temperature, bubble detection, fluid level, and blood flow.

6. The heat exchange system for targeted cryotherapy of stroke according to claim 1, characterized in that, A power pump (4) is also connected to the blood discharge line (5).

7. The heat exchange system for targeted cryotherapy of stroke according to claim 6, characterized in that, The power pump (4) is a magnetic levitation pump or a peristaltic pump.

8. The heat exchange system for targeted cryotherapy of stroke according to claim 1, characterized in that, Filters (3, 8) are installed on both the blood outlet tube (5) and the blood inlet tube (6).

9. The heat exchange system for targeted cryotherapy of stroke according to claim 1, characterized in that, The heat exchange host (11) also includes a refrigerant side, which is connected to a chiller (12).

10. The heat exchange system for targeted cryotherapy of stroke according to claim 2, characterized in that, The heat exchange host (11) also includes a display unit, which is used to display the parameters measured by the monitoring unit.

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