Aerobic metabolism monitoring device
The aerobic metabolism monitoring device, which combines transmission tubes and optical fibers, solves the problem that existing equipment cannot continuously monitor aerobic metabolism in non-vital organs of the human body for a long period of time. It realizes dynamic detection of NADH and improves the stability and continuity of detection.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-30
- Publication Date
- 2026-04-07
AI Technical Summary
Existing medical equipment cannot continuously monitor the aerobic metabolism of non-vital organs in the human body for long periods of time, especially the detection of NADH, and cannot provide stable dynamic monitoring.
By employing a combination of transmission tube, transmitting device, detection device and receiving device, detection light and reflected light are transmitted through optical fiber, and signal conversion is performed using photoelectric module to obtain parameter information of the target detection position.
It enables long-term continuous aerobic metabolism monitoring of non-critical organs in the human body, especially dynamic detection of NADH, improving the stability and sustainability of the detection.
Smart Images
Figure CN224085324U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of medical device technology, and more particularly to an aerobic metabolism monitoring device. Background Technology
[0002] Currently, cellular respiration capacity is a fundamental indicator of human aerobic metabolism. In clinical practice, many critically ill patients experience severe impairment of their metabolic capacity. When the body's overall oxygen supply is insufficient, it prioritizes oxygen delivery to vital organs, such as the brain and heart. Oxygen supply to non-vital organs decreases rapidly. Therefore, when metabolism is insufficient, detecting aerobic metabolism in non-vital organs is more sensitive than in vital organs.
[0003] Reduced coenzyme I (NADH, Nicotinamide adenine dinucleotide) is an important metabolic substance that can be widely detected in mitochondrial cells throughout the human body. NADH is produced from the citric acid cycle in glycolysis and cellular respiration. The NADH molecule is an important marker in the energy production chain of mitochondria.
[0004] Current medical research offers limited testing for metabolic capacity, particularly for NADH, which is virtually nonexistent. Existing medical equipment for NADH detection only measures NADH on the epidermal tissue, allowing only resting-state measurements and lacking the capacity for long-term continuous monitoring or stable dynamic monitoring.
[0005] In conclusion, improving the detection effectiveness of medical equipment is an urgent problem to be solved. Utility Model Content
[0006] The aerobic metabolism monitoring device provided in this application embodiment can improve the detection effect of the aerobic metabolism monitoring device.
[0007] A first aspect of this application provides an aerobic metabolism monitoring device, comprising:
[0008] Transmission tube;
[0009] The transmitting device includes a first optical fiber connected to a first port of a transmission tube, and the first optical fiber is used to transmit detection light into the transmission tube.
[0010] The detection device is located at the opening of the transmission tube. The detection device includes a second optical fiber, which is used to transmit the detection light to the target detection position and transmit the reflected light into the transmission tube. The light output direction of the second optical fiber intersects with the light propagation direction of the second optical fiber.
[0011] The receiving device includes a third optical fiber connected to the transmission tube, and the third optical fiber is used to receive reflected light transmitted inside the transmission tube.
[0012] Among them, the detection light is reflected after it shines on the target detection position.
[0013] In some embodiments, the second optical fiber includes multiple first sub-optical fibers and multiple second sub-optical fibers, the multiple first sub-optical fibers and the multiple second sub-optical fibers extending in the same direction, the multiple second sub-optical fibers wrapping around the multiple first sub-optical fibers, the first sub-optical fibers being used to propagate detection light to the target detection position, and the second sub-optical fibers being used to propagate reflected light to the receiving device.
[0014] In some embodiments, the second optical fiber includes a first space and a second space, the first space being used to accommodate the first sub-optical fiber, the second space being used to accommodate the second sub-optical fiber, and the second sub-optical fiber surrounding the first sub-optical fiber.
[0015] The second space surrounds the first space.
[0016] In some implementations, the outer walls of adjacent sub-fibers are tangent to each other.
[0017] In some embodiments, at least a portion of the second optical fiber is bent in its axial cross-section, the second optical fiber including a bend angle less than or equal to 120°.
[0018] In some embodiments, the aerobic metabolism monitoring device further includes:
[0019] The optoelectronic module includes a light source and a photomultiplier tube. The light source is connected to the transmitting device and is used to emit detection light into the first optical fiber. The photomultiplier tube is connected to the receiving device and is used to receive reflected light.
[0020] In some implementations, the light source is a light-emitting diode (LED) light source;
[0021] The wavelengths of light detected include the near-infrared band.
[0022] In some implementations, the wavelength of the detected light is 365 nm; the wavelength of the reflected light is 435 nm.
[0023] In some implementations, the maximum distance between one end of the first optical fiber and one end of the third optical fiber is 2 mm.
[0024] The beneficial effects of this application are as follows:
[0025] The aerobic metabolism monitoring device of this application can adjust the emission angle of the detection light through the second optical fiber in the detection device, so that the detection light is deflected and emitted to the target detection position. The reflected light reflected from the target detection position is received through the third optical fiber. Based on the reflected light received by the receiving device, the parameter information of the target detection position can be obtained. Attached Figure Description
[0026] Figure 1 A schematic partial structural diagram of an aerobic metabolism monitoring device provided in this application embodiment;
[0027] Figure 2 A schematic partial structural diagram of another aerobic metabolism monitoring device provided in the embodiments of this application;
[0028] Figure 3 A schematic partial structural diagram of another aerobic metabolism monitoring device provided in the embodiments of this application;
[0029] Figure 4 This is a schematic partial structural diagram of an aerobic metabolism monitoring device provided in an embodiment of this application.
[0030] The reference numerals in the figure represent:
[0031] 100, Transmission tube; 200, Transmitting device; 210, First optical fiber; 211, Detection beam; 300, Detection device; 310, Second optical fiber; 311, First sub-optical fiber; 312, Second sub-optical fiber; 400, Receiving device; 410, Third optical fiber; 411, Reflected beam; 510, Power supply; 520, Photomultiplier tube; α, Tilt angle; θ, Bending angle. Detailed Implementation
[0032] To better understand the technical solutions provided in the embodiments of this specification, the technical solutions of the embodiments of this specification will be described in detail below with reference to the accompanying drawings and specific embodiments. It should be understood that the embodiments of this specification and the specific features in the embodiments are detailed descriptions of the technical solutions of the embodiments of this specification, rather than limitations on the technical solutions of this specification. In the absence of conflict, the embodiments of this specification and the technical features in the embodiments can be combined with each other.
[0033] In this document, relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, without necessarily requiring or implying any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element. The term "two or more" includes two or more cases.
[0034] The aerobic metabolism monitoring device provided in this application embodiment can improve the detection effect of the aerobic metabolism monitoring device.
[0035] The first aspect of this application, Figure 1 This is a schematic partial structural diagram of an aerobic metabolism monitoring device provided in an embodiment of this application, with reference to... Figure 1 An aerobic metabolism monitoring device is provided, comprising: a transmission tube 100, a transmitting device 200, a detection device 300, and a receiving device 400. The transmission tube 100 provides a light propagation channel and may include at least two openings. The transmitting device 200 includes a first optical fiber 210 connected to one of the openings of the transmission tube 100. Detection light 211 propagating in the first optical fiber 210 can propagate into the transmission tube 100. The detection device 300 may be disposed at one of the openings of the transmission tube 100. The detection device 300 includes a second optical fiber 310 disposed in the optical path of the detection light 211. The light emission direction of the second optical fiber 310 intersects with the light propagation direction of the second optical fiber 310. After the detection light 211 is transmitted to the second optical fiber 310, it is deflected, thus exiting to the target detection position and transmitting reflected light 411 into the transmission tube 100. The reflected light 411 is the light reflected after the detection light 211 illuminates the target detection position. The receiving device 400 includes a third optical fiber 410, which is connected to the transmission tube 100 and is used to receive the reflected light 411 transmitted within the transmission tube 100.
[0036] In a schematic manner, the detection light emitted from the first optical fiber in the transmitting device is a collimated light. The detection light can be deflected by adjusting the emission position of the second optical fiber, thereby illuminating the target detection position. After the detection light illuminates the target detection position, it forms a reflected light. The reflected light passes through the detection device and is emitted to the receiving device, so as to obtain the parameter information of the target detection position through the receiving device.
[0037] For example, the propagation direction of the second optical fiber is the same as the propagation direction of the light from the transmission tube, and the emission direction of the second optical fiber is the direction from which the emission end of the reflected light points to the target detection position. The emission direction and the propagation direction of the second optical fiber intersect, meaning that the target detection position is not located on the optical path or the extension line of the optical path of the first optical fiber. The detection light can be emitted obliquely to the target detection position through the second optical fiber.
[0038] In some examples, the target detection location mentioned above can also be the target area, which is not limited in this application.
[0039] The aerobic metabolism monitoring device of this application adjusts the emission angle of the detection light through the second optical fiber in the detection device, so that the detection light is deflected and emitted to the target detection position. The reflected light reflected from the target detection position is received through the third optical fiber. Based on the reflected light received by the receiving device, the parameter information of the target detection position can be obtained.
[0040] Figure 2 A schematic partial structural diagram of another aerobic metabolism monitoring device provided in an embodiment of this application. In some examples, reference is made to... Figure 2 The second optical fiber 310 includes multiple first sub-optical fibers 311 and multiple second sub-optical fibers 312. The multiple first sub-optical fibers 311 and multiple second sub-optical fibers 312 extend in the same direction. The multiple second sub-optical fibers 312 are wrapped around the multiple first sub-optical fibers 311. The first sub-optical fibers 311 are used to propagate the detection light 211 to the target detection position, and the second sub-optical fibers 312 are used to propagate the reflected light 411 to the receiving device 400.
[0041] For example, the first sub-optical fiber can propagate detection light to emit deflected detection light, and the second sub-optical fiber receives the reflected light and propagates it to the receiving device.
[0042] For example, the reflected light includes multiple sub-fibers, the number of which can be set according to the actual situation, and the diameter of the sub-fibers is 50 micrometers.
[0043] In some examples, the second optical fiber may further include a first space and a second space, with the second space surrounding the first space. The first space is used to house the first sub-optical fiber, and the second space is used to house the second sub-optical fiber. The second sub-optical fiber surrounds the first sub-optical fiber. Detection light can be received and transmitted through the first sub-optical fiber, and reflected light can be received and propagated through the second sub-optical fiber, thereby propagating the detection light to the target detection position and receiving the reflected light propagated from the target detection position to achieve the detection of the target detection position.
[0044] In some examples, the outer walls of adjacent sub-fibers are set tangentially.
[0045] Figure 3 This is a schematic partial structural diagram of another aerobic metabolism monitoring device provided in an embodiment of this application. For example, refer to... Figure 3Due to material limitations, optical fibers cannot be completely bent; they will break if the bending angle θ exceeds 120°, preventing light from propagating further. The second optical fiber 310 of this application includes multiple sub-fibers. The first sub-fiber 311 can consist of seven bundles, with the remaining second sub-fibers 312 surrounding the first sub-fiber 311. The circular cross-sections of adjacent sub-fibers are connected, thereby reducing the interaction force between them and allowing the second optical fiber 310 to bend at larger angles, such as exceeding 120°.
[0046] In some examples, the second optical fiber is bent in the axial section, and the second optical fiber includes a bend angle less than or equal to 120°.
[0047] For example, the circular cross-sections of adjacent sub-fibers in the second optical fiber are connected to ensure the structural stability of the second optical fiber, thereby enabling a larger bending angle for the second optical fiber.
[0048] In some examples, because the reflected light can be bent, the exit direction of the detection light in the second fiber is tilted or perpendicular to the propagation direction.
[0049] For example, refer to Figure 3 The angle between the emission direction and the propagation direction of the detection light 211 is the tilt angle α, and the tilt angle α can be 30°.
[0050] Figure 4 This is a schematic partial structural diagram of an aerobic metabolism monitoring device provided in an embodiment of this application. In some examples, reference is made to... Figure 4 The aerobic metabolism monitoring device also includes a photoelectric module. The photoelectric module includes a light source and a photomultiplier tube 520. The light source is connected to the transmitting device 200 and is used to emit the detection light 211 to the first optical fiber 210. The photomultiplier tube 520 is connected to the receiving device 400 and is used to receive the reflected light 411.
[0051] For example, the light source can emit detection light into the first optical fiber. The photomultiplier tube can convert weak light signals into electrical signals and amplify the signals. The photomultiplier tube can operate in the near-infrared, visible, and near-infrared spectral regions.
[0052] In some examples, the light source is a light-emitting diode (LED) light source, and the wavelength of the detected light can include the near-infrared light band.
[0053] For example, the wavelength range of the detected light can be 320-380nm, such as 320nm, 350nm or 380nm.
[0054] In some examples, the wavelength of the light being detected is 320 nm.
[0055] In some examples, the wavelength of the detected light is 365nm.
[0056] In some examples, the wavelength of the emitted light is 365 nm, and the wavelength of the received light is 435 nm.
[0057] For example, near-infrared light reflects different wavelengths to different substances. Reduced coenzyme I (NADH, Nicotinamide adenine dinucleotide) reflects wavelengths of 420-480 nm after receiving light in the 320-380 nm range. The detection light can be near-infrared light to detect NADH, while the wavelength range of the reflected light corresponds to 420-480 nm.
[0058] In some examples, the first and third optical fibers are located at the same port of the transmission tube.
[0059] For example, the second sub-fiber in the second optical fiber corresponds to the first sub-fiber in the same optical path. The incident angle and exit angle of the detection light can correspond to the exit angle and incident angle of the reflected light. Setting the first optical fiber and the second optical fiber adjacent to each other can save the cost of the transmission tube and also prevent the second optical fiber from blocking the propagation of the detection light.
[0060] In some examples, the maximum distance between one end of the first fiber and one end of the third fiber is 2 mm.
[0061] For example, the detection light propagating in the first optical fiber and the second optical fiber propagating in the third optical fiber correspond to different wavelengths, so the receiving position of the reflected light is different from the emitting position of the detection light.
[0062] A second aspect of this application provides a urinary catheter. The urinary catheter of this application includes a tubing body and an aerobic metabolism monitoring device as described in any of the above-mentioned technical solutions, wherein the detection end and a portion of the transmission tube of the aerobic metabolism monitoring device are disposed within the tubing body.
[0063] For example, the urinary catheter of this application can be used for critically ill patients. The urinary catheter can be left in the urethra for a long time. The target detection location of the aerobic metabolism monitoring device can be set to the urethral wall. While the patient is undergoing urinary catheterization and drainage, the urethral wall of the patient can be detected by the aerobic metabolism monitoring device. This allows for long-term monitoring of the patient through the urinary catheter of this application, which solves the drawback of other products that can only monitor the epidermis.
[0064] For example, the urethral wall region selected in this application is a non-critical area of the human body, which is more sensitive to changes in NADH. This allows for early detection of changes in the patient's aerobic metabolic capacity, facilitating timely treatment by doctors.
[0065] It should be noted that the descriptions of each embodiment in the above embodiments have different focuses. For parts that are not described in detail in a certain embodiment, please refer to the relevant descriptions in other embodiments.
[0066] The above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this application.
[0067] Although preferred embodiments have been described in this specification, those skilled in the art, upon learning the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments as well as all changes and modifications falling within the scope of this specification.
[0068] Obviously, those skilled in the art can make various modifications and variations to this specification without departing from its spirit and scope. Therefore, if such modifications and variations fall within the scope of the claims and their equivalents, this specification is also intended to include such modifications and variations.
Claims
1. An aerobic metabolism monitoring device, characterized in that, include: Transmission tube; The transmitting device includes a first optical fiber connected to a first port of the transmission tube, and the first optical fiber is used to transmit detection light into the transmission tube. A detection device is disposed at the opening of the transmission tube. The detection device includes a second optical fiber, which is used to transmit the detection light to the target detection position and transmit the reflected light into the transmission tube. The light output direction of the second optical fiber intersects with the light propagation direction of the second optical fiber. The receiving device includes a third optical fiber connected to the transmission tube, and the third optical fiber is used to receive the reflected light transmitted in the transmission tube; The detected light is reflected after it shines on the target detection position.
2. The aerobic metabolism monitoring device according to claim 1, characterized in that, The second optical fiber includes multiple first sub-optical fibers and multiple second sub-optical fibers. The multiple first sub-optical fibers and multiple second sub-optical fibers extend in the same direction. The multiple second sub-optical fibers wrap around the multiple first sub-optical fibers. The first sub-optical fibers are used to propagate the detection light to the target detection position, and the second sub-optical fibers are used to propagate the reflected light to the receiving device.
3. The aerobic metabolism monitoring device according to claim 2, characterized in that, The second optical fiber includes a first space and a second space, the first space being used to accommodate the first sub-optical fiber, the second space being used to accommodate the second sub-optical fiber, and the second sub-optical fiber surrounding the first sub-optical fiber; The second space surrounds the first space.
4. The aerobic metabolism monitoring device according to claim 3, characterized in that, The outer walls of adjacent sub-fibers are tangent to each other.
5. The aerobic metabolism monitoring device according to claim 4, characterized in that, At least a portion of the second optical fiber is bent, and the second optical fiber includes a bend angle, the angle of which is less than or equal to 120°.
6. The aerobic metabolism monitoring device according to claim 1, characterized in that, The aerobic metabolism monitoring device also includes: The optoelectronic module includes a light source and a photomultiplier tube. The light source is connected to the transmitting device and is used to emit the detection light into the first optical fiber and the second optical fiber. The photomultiplier tube is connected to the receiving device and is used to receive the reflected light.
7. The aerobic metabolism monitoring device according to claim 6, characterized in that, The light source is a light-emitting diode (LED) light source; The wavelength range of the detected light includes the near-infrared band.
8. The aerobic metabolism monitoring device according to claim 7, characterized in that, The wavelength of the detection light is 365nm; the wavelength of the reflected light is 435nm.
9. The aerobic metabolism monitoring device according to claim 7, characterized in that, The maximum distance between one end of the first optical fiber and one end of the third optical fiber is 2mm.