Preparation device of platelet-rich plasma and hydrogel compound

Abstract

The embodiment of the utility model provides a platelet-rich plasma and hydrogel compound preparation device which comprises a platelet-rich plasma preparation device which comprises a centrifugal assembly with an inner cavity and an extraction assembly arranged in the inner cavity of the centrifugal assembly in a sleeved mode. The hydrogel injector comprises an injector barrel with an inner cavity and a piston assembly arranged in the inner cavity of the injector barrel in a sleeved mode. The centrifugal assembly comprises a centrifugal tube, and the centrifugal tube comprises a tube body and a conical head detachably arranged at the first end of the tube body; the syringe barrel comprises a barrel body and a barrel opening formed in the first end of the barrel body, and the outer diameter of the barrel opening is smaller than the inner diameter of the tube body; the hydrogel injector injects hydrogel in the cylinder into the centrifugal tube through the cylinder opening and the conical head, and the hydrogel is mixed with the platelet-rich plasma to form a platelet-rich plasma and hydrogel compound. According to the embodiment of the utility model, the preparation function is realized through a reasonable assembly design and a reasonable connection mode, and a certain cost advantage is achieved.

Description

TECHNICAL FIELD

[0001] The embodiment of the utility model relates to the technical field of separation and mixing, and particularly relates to a preparation device for platelet-rich plasma and hydrogel compound. BACKGROUND

[0002] Platelet-rich plasma (PRP) is a concentrated solution of platelets extracted from whole blood by centrifugation, containing high concentrations of platelets, white blood cells and fibrin. It is widely used in surgical operations to provide crawling scaffolds and growth factors for postoperative cell repair, promote bone tissue regeneration, accelerate soft tissue repair and wound healing, and reduce wound pain. It is used for chronic skin ulcers to accelerate skin growth and reduce the chance of infection. However, during clinical application, it often faces the problem of flowing away with gravity on the wound surface and cannot stay for a long time, which leads to the failure to achieve the desired therapeutic effect.

[0003] Hydrogel belongs to chitosan derivatives and has temperature sensitivity. At low temperature, it is in a flowable solution state, and when the temperature is higher than the gelation temperature, it changes into a non-flowing gel state. When it has flowability, it can be applied to the wound surface and spread fully on the wound surface of various shapes, including flat, wrinkled and slotted types. After contacting the human body, the temperature gradually rises, and the product changes into a gel and adheres to the wound surface, and will not flow away due to body position change.

[0004] Platelet-rich plasma and hydrogel compound can solve the problem of easy loss of platelet-rich plasma and accelerate wound healing, but the existing related equipment is expensive and has high cost. UTILITY MODEL CONTENT

[0005] The technical problem to be solved by the embodiment of the utility model is to provide a preparation device for platelet-rich plasma and hydrogel compound, which realizes the preparation function through reasonable component design and connection mode, meets the demand, and has certain cost advantage.

[0006] To solve the above technical problem, the technical scheme of the embodiment of the utility model is as follows:

[0007] A preparation device for platelet-rich plasma and hydrogel compound comprises:

[0008] The platelet-rich plasma preparation device comprises a centrifugal component with an inner cavity and an extraction component sleeved in the inner cavity of the centrifugal component;

[0009] The hydrogel syringe comprises a syringe barrel with an inner cavity and a piston assembly sleeved in the inner cavity of the syringe barrel;

[0010] The centrifugal component comprises a centrifugal tube, and the centrifugal tube comprises a tube body and a tapered head detachably arranged at the first end of the tube body.

[0011] The syringe barrel comprises a barrel body and a barrel mouth arranged at the first end of the barrel body, the outer diameter of the barrel mouth is smaller than the inner diameter of the tube body;

[0012] The hydrogel syringe injects the hydrogel in the barrel through the barrel mouth into the centrifuge tube via the cone head, and mixes with the platelet-rich plasma to form a platelet-rich plasma and hydrogel compound.

[0013] Optionally, the centrifuge assembly further comprises:

[0014] A centrifuge tube extraction rod connected to the centrifuge tube sealing piston through the centrifuge tube piston connector;

[0015] The extraction assembly comprises:

[0016] An inner suction tube;

[0017] The inner suction tube is internally provided with an inner suction tube sealing piston;

[0018] The inner suction tube sealing piston is connected with an inner suction tube core rod at one end.

[0019] Optionally, a first luer connector is arranged on the second end of the cone head;

[0020] A first double-wing handle is arranged on the second end of the tube body.

[0021] Optionally, a plurality of flow guide grooves are arranged on the inner wall of the cone head;

[0022] A groove is arranged at the connection between the cone head and the first luer connector, the curvature of the groove is 3 to 8 degrees, and one end of the flow guide groove is connected with the groove;

[0023] The included angle between the side wall of the cone head and the central axis of the groove is 35 to 55 degrees.

[0024] Optionally, a first thread is arranged at the first end of the centrifuge tube piston connector, and a second thread is arranged at the second end of the centrifuge tube piston connector; wherein the first thread is arranged as a transverse thread, and the second thread is arranged as an inclined thread;

[0025] A first through hole is arranged at the center of the centrifuge tube piston connector;

[0026] An inner sealing cap is arranged on the centrifuge tube piston connector, and a second luer connector and a third luer connector are respectively arranged at the two ends of the inner sealing cap;

[0027] The threads of the second luer connector and the third luer connector are in opposite directions.

[0028] Optionally, the centrifugal tube sealing piston is a cylindrical structure, the first end of the centrifugal tube sealing piston is a cavity structure, an internal thread is arranged on the inner wall of the cavity of the centrifugal tube sealing piston, and the internal thread is connected with the centrifugal tube piston connector.

[0029] The second end of the centrifugal tube sealing piston is a concave structure, the side wall of the concave structure is at an angle of 120 to 140 degrees, and a second through hole is arranged at the center of the concave structure and can communicate with the first through hole of the centrifugal tube piston connector.

[0030] Optionally, one end of the inner suction pipe is provided with a fourth luer joint.

[0031] The other end is provided with a third double-wing handle, and the third double-wing handle is provided with a decorative sheet.

[0032] The outer wall of the inner suction pipe is provided with a first scale mark.

[0033] Optionally, a second scale mark is arranged on the outer wall of the pipe body.

[0034] Optionally, the platelet-rich plasma preparation device further comprises an upper sealing cap which is detachably connected with the taper head of the centrifugal tube, the centrifugal tube is sealed by the upper sealing cap, and the centrifugal tube is vertically placed.

[0035] Optionally, the platelet-rich plasma preparation device further comprises an inner sealing cap locking rod which is detachably connected with the inner sealing cap.

[0036] The above-mentioned scheme of the embodiment of the utility model has at least the following beneficial effects:

[0037] The taper head of the centrifugal tube is detachably connected with the pipe body through threads, and the outer diameter of the barrel mouth is smaller than the inner diameter of the pipe body, so that the hydrogel syringe can be closely connected with the centrifugal tube, the hydrogel can be easily injected into the centrifugal tube to mix with the platelet-rich plasma, and the connection is convenient and stable.

[0038] The hydrogel can be injected into the centrifugal tube to mix with the platelet-rich plasma in a closed state, that is, the taper head is unscrewed to inject the hydrogel, and then the taper head is screwed on, and the mixture is further mixed uniformly at 2-8 DEG C, so that the opportunity of external pollution is reduced, and the quality and safety of the compound are ensured.

[0039] The platelet-rich plasma and hydrogel compound can solve the problems that the platelet-rich plasma is easy to flow away with gravity and cannot stay on the wound for a long time in clinical application, the temperature sensitivity of the hydrogel is utilized, the hydrogel is in a flowable state at low temperature, the hydrogel is convenient for mixing and application to the wound, the hydrogel is transformed into a gel to adhere to the wound after contacting with the human body, and the hydrogel will not flow away due to body position change, so that the wound healing is better promoted.

[0040] The preparation device has relatively simple structure, realizes the preparation function through reasonable component design and connection mode, and has lower cost compared with existing expensive equipment, and has certain cost advantage. BRIEF DESCRIPTION OF DRAWINGS

[0041] Figure 1 is a perspective view of a platelet-rich plasma preparation device provided by an embodiment of the present application;

[0042] Figure 2 is an exploded view of the platelet-rich plasma preparation device provided by an embodiment of the present application;

[0043] Figure 3 is a structural schematic view of a hydrogel syringe provided by an embodiment of the present application;

[0044] Figure 4 is a structural schematic view of a centrifugal component provided by an embodiment of the present application;

[0045] Figure 5 is a structural schematic view of an extraction component provided by an embodiment of the present application;

[0046] Figure 6 is a structural schematic view of a centrifugal tube provided by an embodiment of the present application;

[0047] Figure 7 is a structural schematic view of a centrifugal tube sealing piston provided by an embodiment of the present application;

[0048] Figure 8 is a sectional view of the centrifugal tube sealing piston provided by an embodiment of the present application;

[0049] Figure 9 is a perspective view of the centrifugal tube sealing piston provided by an embodiment of the present application;

[0050] Figure 10 is a structural schematic view of a centrifugal tube piston connecting piece provided by an embodiment of the present application;

[0051] Figure 11 is a perspective view of the centrifugal tube piston connecting piece provided by an embodiment of the present application;

[0052] Figure 12 is a sectional view of the centrifugal tube piston connecting piece provided by an embodiment of the present application;

[0053] Figure 13 is a structural schematic view of an inner sealing cap provided by an embodiment of the present application

[0054] Figure 14 is a sectional view of the inner sealing cap provided by an embodiment of the present application;

[0055] Figure 15 is a structure schematic view of the centrifugal tube pull rod provided by the embodiment of the utility model;

[0056] Figure 16 is a structure schematic view of the inner sealing cap locking rod provided by the embodiment of the utility model;

[0057] Figure 17 is a structure schematic view of the inner suction pipe provided by the embodiment of the utility model;

[0058] Figure 18 is a structure schematic view of the decorative sheet provided by the embodiment of the utility model;

[0059] Figure 19 is a structure schematic view of the inner suction pipe sealing piston provided by the embodiment of the utility model;

[0060] Figure 20 is a structure schematic view of the inner suction pipe core rod provided by the embodiment of the utility model;

[0061] Figure 21 is a sectional view of the flow guide groove provided by the embodiment of the utility model;

[0062] Figure 22 is a top view of the flow guide groove provided by the embodiment of the utility model;

[0063] Figure 23 is a structure schematic view of the upper sealing cap provided by the embodiment of the utility model.

[0064] Mark explanation:

[0065] 1, centrifugal assembly; 11, centrifugal tube; 111, tube body; 112, cone head; 113, first luer joint; 114, flow guide groove; 115, groove; 116, first double-wing handle; 117, second scale mark; 12, centrifugal tube sealing piston; 121, internal thread; 122, second through hole; 13, centrifugal tube piston connecting piece; 131, first thread; 132, second thread; 133, first through hole; 14, centrifugal tube pull rod; 141, second double-wing handle; 15, inner sealing cap; 151, second luer joint; 152, third luer joint; 2, extraction assembly; 21, inner suction pipe; 211, fourth luer joint; 212, third double-wing handle; 213, first scale mark; 22, inner suction pipe sealing piston; 23, inner suction pipe core rod; 24, decorative sheet; 3, upper sealing cap; 4, inner sealing cap locking rod; 41, third thread; 5, syringe barrel; 51, barrel body; 52, barrel mouth; 6, piston assembly. Specific implementation

[0066] Exemplary embodiments of the present application will be described in greater detail below with reference to the accompanying drawings. While exemplary embodiments of the present application are shown in the drawings, it is understood that the present application can be embodied in various forms without being limited by the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the present application to those skilled in the art.

[0067] As shown in Figures 1 to 5 the present application provides a preparation device for platelet-rich plasma and hydrogel complex, comprising:

[0068] The platelet-rich plasma preparation device comprises a centrifugal assembly 1 having an inner cavity and an extraction assembly 2 sleeved in the inner cavity of the centrifugal assembly 1.

[0069] The hydrogel syringe comprises a syringe barrel 5 having an inner cavity and a piston assembly 6 sleeved in the inner cavity of the syringe barrel 5.

[0070] The centrifugal assembly 1 comprises a centrifugal tube 11, and the centrifugal tube 11 comprises a tube body 111 and a tapered head 112 detachably arranged at a first end of the tube body 111.

[0071] The syringe barrel 5 comprises a barrel body 51 and a barrel mouth 52 arranged at a first end of the barrel body 51, and the outer diameter of the barrel mouth 52 is smaller than the inner diameter of the tube body 111.

[0072] The hydrogel syringe injects the hydrogel in the barrel body 51 into the centrifugal tube 11 through the tapered head 112 via the barrel mouth 52, and mixes with the platelet-rich plasma to form a platelet-rich plasma and hydrogel complex.

[0073] Specifically, the tapered head 112 is detachably connected with the tube body 111 by screw thread, and the hydrogel syringe can be a glass syringe or a plastic syringe. The hydrogel can be an anionic group or a hydroxybutyl chitosan derivative, an osmotic pressure regulator and water.

[0074] In specific work, first, platelet-rich plasma is prepared by the platelet-rich plasma preparation device, and the hydrogel is pre-sealed in the barrel body 51 of the hydrogel syringe; then the hydrogel in the barrel body 51 becomes a sterile product after moist heat sterilization; then the tapered head 112 is unscrewed, the hydrogel syringe injects the hydrogel in the barrel body 51 into the centrifugal tube 11 through the tapered head 112 via the barrel mouth 52, and mixes with the platelet-rich plasma to form a platelet-rich plasma and hydrogel complex; finally, the tapered head 112 is screwed, and the platelet-rich plasma and hydrogel complex is further mixed uniformly at 2-8℃.

[0075] In the example, the taper head 112 of the centrifugal tube 11 is detachably connected with the tube body 111 through threads, and the outer diameter of the barrel mouth 52 is smaller than the inner diameter of the tube body 111, so that the hydrogel injector can be tightly connected with the centrifugal tube 11, and the hydrogel can be injected into the centrifugal tube 11 to mix with the platelet-rich plasma, which is convenient and stable.

[0076] The hydrogel can be injected into the centrifugal tube 11 to mix with the platelet-rich plasma in a closed state, that is, the taper head 112 is screwed off to inject the hydrogel, and then the taper head 112 is screwed on, and the mixture is further mixed uniformly at 2-8 DEG C, which reduces the opportunity of external pollution and guarantees the quality and safety of the compound.

[0077] The platelet-rich plasma and hydrogel compound can solve the problem that the platelet-rich plasma is easy to flow away with gravity and cannot stay on the wound for a long time in clinical application, and the temperature sensitivity of the hydrogel is utilized, so that the hydrogel is in a flowable state at low temperature, which is convenient for mixing and application to the wound, and the hydrogel is transformed into a gel to adhere to the wound after contacting with the human body, and will not flow away due to body position change, so that the wound healing is better promoted.

[0078] In addition, the taper head 112 and the tube body 111 can also be integrally formed, the inner diameter of the end of the taper head 112 can be increased, and the inner diameter of the end of the taper head 112 is greater than the outer diameter of the barrel mouth 52, so that the hydrogel in the barrel body 51 can be injected into the centrifugal tube 11 through the barrel mouth 52 and the taper head 112.

[0079] The preparation device has a relatively simple structure, and the preparation function is realized through reasonable component design and connection mode, so that the cost is lower than that of the existing expensive equipment, and the cost advantage is achieved.

[0080] In an optional embodiment of the utility model, as shown in Figures 4 to 5 The centrifugal assembly 1 further comprises:

[0081] The centrifugal tube extraction rod 14 connected with the centrifugal tube sealing piston 12 through the centrifugal tube piston connecting piece 13;

[0082] The extraction assembly 2 comprises:

[0083] The inner suction pipe 21;

[0084] The inner suction pipe 21 is internally provided with an inner suction pipe sealing piston 22;

[0085] One end of the inner suction pipe sealing piston 22 is connected with an inner suction pipe core rod 23.

[0086] In an optional embodiment of the utility model, as shown in Figure 6 The centrifugal tube 11 comprises a tube body 111 and a taper head 112;

[0087] The conical head 112 is fixedly connected with one end of the tube body 111, and a first luer joint 113 is fixedly connected with the other end of the tube body 111.

[0088] One end of the tube body 111 is provided with a first double-wing handle 116, so that the centrifugal tube 11 can be hooked or held.

[0089] In an optional embodiment of the utility model, Figure 21 and Figure 22 As shown in the figure, the inner wall of the conical head 112 is provided with a plurality of flow guide grooves 114.

[0090] The conical head 112 is provided with a groove 115 at the connection position of the first luer joint 113, the groove 115 has an arc of 3 to 8 degrees, and one end of the flow guide groove 114 is connected with the groove 115.

[0091] The included angle between the side wall of the conical head 112 and the central axis of the groove 115 is 35 to 55 degrees.

[0092] In the embodiment, the flow guide groove 114 is provided with 6 to 8 flow guide grooves, the flow guide grooves 114 converge towards the center and are located at the groove 115, the groove 115 has an arc of 3 to 8 degrees, and the included angle between the side wall of the conical head 112 and the central axis of the groove 115 is 35 to 55 degrees, so that the liquid can flow more easily and the centrifugal operation is more accurate.

[0093] In an optional embodiment of the utility model, Figure 10 and Figure 12 As shown in the figure, the first end of the centrifugal tube piston connecting piece 13 is provided with a first thread 131, and the second end is provided with a second thread 132; wherein the first thread 131 is provided as a horizontal thread, and the second thread 132 is provided as an inclined thread.

[0094] The second through hole 122 is provided at the center of the centrifugal tube piston connecting piece 13, and the included angle between the side wall of the second through hole 122 and the central axis of the through hole is 8 degrees, so that the second through hole 122 of the centrifugal tube sealing piston 12 can be in communication.

[0095] In an optional embodiment of the utility model, Figure 15 As shown in the figure, the pipe wall of the centrifugal tube pull rod 14 is provided with a hollow groove.

[0096] The first end of the centrifugal tube pull rod 14 is provided with a through hole, and the inner sealing cap 15 can pass through the through hole to be connected with the centrifugal tube pull rod 14 and the centrifugal tube piston connecting piece 13.

[0097] The first end of the centrifugal tube pull rod 14 is also provided with a thread, which can be connected with the centrifugal tube piston connecting piece 13.

[0098] The second end of the centrifugal tube pull rod 14 is provided with a second double-wing handle 141.

[0099] In an optional embodiment of the utility model, as shown in the figure, Figures 13 to 14 The inner sealing cap 15 is provided with a second luer joint 151 and a third luer joint 152 at two ends respectively;

[0100] The screw thread directions of the second luer joint 151 and the third luer joint 152 are opposite.

[0101] In the embodiment, the inner sealing cap 15 is provided with a second luer joint 151 and a third luer joint 152 at two ends respectively, the screw thread directions of the second luer joint 151 and the third luer joint 152 are opposite, and the second luer joint 151 and the third luer joint 152 are connected with the centrifugal tube piston connecting piece 13 and the centrifugal tube pull rod 14 respectively, so that the sealing effect in the centrifugal tube 11 is improved.

[0102] The luer joint on the inner sealing cap 15 can cooperate with the inner sealing cap locking rod 4 to disassemble the inner sealing cap 15.

[0103] In an optional embodiment of the utility model, as shown in the figure, Figures 7 to 9 The centrifugal tube sealing piston 12 is a cylindrical structure, the first end of the centrifugal tube sealing piston 12 is a cavity structure, the inner thread 121 is arranged on the inner wall of the cavity of the centrifugal tube sealing piston 12, and the centrifugal tube sealing piston 12 is connected with the centrifugal tube piston connecting piece 13 through the inner thread 121;

[0104] The second end of the centrifugal tube sealing piston 12 is a concave structure, the radian is 120 to 140 degrees, the second through hole 122 is arranged at the center of the concave structure, and the included angle between the side wall of the second through hole 122 and the central axis of the through hole is 8 degrees.

[0105] In the embodiment, the concave structure at the bottom of the centrifugal tube sealing piston 12 can improve the pressure of the piston on the tube, and the liquid flows from the peripheral wall to the center during the movement of the centrifugal tube sealing piston 12.

[0106] In an optional embodiment of the utility model, as shown in the figure, Figure 17 One end of the inner suction pipe 21 is provided with a fourth luer joint 211;

[0107] The other end is provided with a third double-wing handle 212, and the third double-wing handle 212 is provided with a decorative sheet 24;

[0108] The outer wall of the inner suction pipe 21 is provided with a first scale mark 213.

[0109] In the embodiment, the inner suction pipe 21 is provided with a fourth luer joint 211 at one end, which is convenient for connecting with the centrifugal tube piston connecting piece 13.

[0110] The third double-wing handle 212 is convenient for pressing operation of the inner suction pipe 21.

[0111] As shown in the drawings, the surface of the decorative sheet 24 can be coated with a color different from other structures, which is convenient for distinguishing components and preventing operation errors. Figure 17 In an optional embodiment of the utility model, the outer wall of the pipe body 111 is provided with a second scale mark 117, so that the amount of extracted blood can be clearly identified.

[0112] In an optional embodiment of the utility model, as shown in the drawings, the platelet-rich plasma preparation device further comprises an upper sealing cap 3 which is detachably connected with the taper head 112 of the centrifugal tube 11.

[0113] Figure 23 In an optional embodiment of the utility model, as shown in the drawings, the platelet-rich plasma preparation device further comprises an inner sealing cap locking rod 4 which is detachably connected with the inner sealing cap 15.

[0114] In an optional embodiment of the utility model, as shown in the drawings, the platelet-rich plasma preparation device further comprises an inner sealing cap locking rod 4 which is detachably connected with the inner sealing cap 15. Figure 16

[0115] In the embodiment, the end of the inner sealing cap locking rod 4 is provided with a third thread 41 which can be inserted into the centrifugal tube extraction rod 14, and the inner sealing cap 15 is detached through the third thread 41 matched with the luer joint of the inner sealing cap 15, so that the centrifugal assembly 1 and the extraction assembly 2 are communicated, and pollution caused in the process of disassembly and assembly can be completely avoided.

[0116] The specific work of the platelet-rich plasma preparation device for preparing platelet-rich plasma comprises:

[0117] Step 1, the upper sealing cap 3 of the centrifugal assembly 1 is removed, a blood sampling needle is installed at the end of the centrifugal tube 11, after blood is extracted, the upper sealing cap 3 is installed and the centrifugal tube extraction rod 14 is removed, and the centrifugal tube 11 is placed in a centrifugal machine as a whole to centrifuge, so that the blood is stratified, the upper layer is a plasma layer, the middle layer is a platelet layer, and the lower layer is a red blood cell layer.

[0118] ​​Step 2, the centrifuge tube 11 is taken out from the centrifuge, the centrifuge tube pull rod 15 is locked, the upper cap 3 is taken off, the centrifuge tube pull rod 14 double wings are pressed down slowly to the liquid level line, the lower red blood cells are discharged from the centrifuge tube 11 to the related container, the upper cap 3 is locked again, the centrifuge tube pull rod 14 is taken off, and the centrifuge tube 11 is placed in the centrifuge as a whole to be centrifuged, so that the plasma is layered, the upper layer is a poor platelet plasma layer, and the lower layer is a platelet-rich plasma layer;

[0119] Step 3, the centrifuge tube 11 is taken out from the centrifuge, the centrifuge tube pull rod 14 is connected to the centrifuge tube 11, the inner cap 15 is disassembled through the inner cap locking rod 4, the inner suction tube 21 is connected with the centrifuge tube piston connector 13, the centrifuge tube pull rod 14 double wings are pressed down slowly, the inner suction tube core rod 23 is reversely lifted under the action of pressure, the poor platelet plasma is completely entered into the inner suction tube 21, and the remaining liquid is the required platelet-rich plasma.

[0120] In an optional embodiment of the utility model, step 1 can specifically include:

[0121] Step 11, check the package integrity to confirm that all components are complete, undamaged and open the package;

[0122] Step 12, the upper cap 3 of the centrifuge assembly 1 is rotated counterclockwise and taken off, a blood collection needle is installed at the luer joint of the centrifuge tube 11, blood is extracted to the nominal scale, then the upper cap 3 is rotated clockwise and locked, and then the centrifuge tube pull rod 14 is rotated counterclockwise and taken off;

[0123] Step 13, after the above operation is completed, the centrifuge tube 11 is placed in the centrifuge as a whole, 1500G centrifugal force is used to centrifuge for 10 minutes, so that the blood is layered, the upper layer is a plasma layer, the middle layer is a platelet layer, and the lower layer is a red blood cell layer;

[0124] Step 14, the extraction assembly 2 is taken out, the inner suction tube 21 is held with the left hand, the inner suction tube core rod 23 is held with the right thumb and index finger and is repeatedly pulled open for 2-3 times.

[0125] In an optional embodiment of the utility model, step 2 can specifically include:

[0126] Step 21, the centrifuge tube 11 is taken out vertically, the centrifuge tube pull rod 14 is rotated clockwise and locked, the upper cap 3 is rotated counterclockwise and taken off, the fingers of both hands are placed below the centrifuge tube pull rod 14 double wings and clamped to keep the vertical state, the thumbs of both hands press the centrifuge tube pull rod 14 double wings, and the centrifuge tube pull rod 14 double wings are slowly pressed down to the liquid level line, the red blood cells are discharged from the centrifuge tube 11 to the related container, the upper cap 3 is rotated clockwise and locked again, and then the centrifuge tube pull rod 14 is rotated counterclockwise and taken off;

[0127] Step 22, again, the centrifuge tube 11 as a whole is put into the centrifuge, using 1500G centrifugal force centrifugation 10 minutes, so that the plasma is layered, the upper layer is the poor platelet plasma layer, the lower layer is the platelet rich plasma layer.

[0128] In an optional embodiment of the utility model, step 3 can specifically include:

[0129] Step 31, gently take, vertically take out the centrifuge tube 11, rotate the centrifuge tube pull rod 14 clockwise and lock, and detach the inner sealing cap 15 by rotating the inner sealing cap locking rod 4 counterclockwise;

[0130] Step 32, connect the luer joint at one end of the inner suction tube 21 with the luer joint of the centrifuge tube piston connecting piece 13, rotate clockwise and lock, place the index finger of both hands under the double wings of the centrifuge tube 11 and clamp and keep vertical state, press the double wings of the centrifuge tube pull rod 14 with the thumb of both hands, slowly press down, and the inner suction tube core rod 23 reversely rises under the action of pressure until the poor platelet plasma is completely entered into the inner suction tube 21, hold the inner suction tube core rod 23 with the left hand, and take out the extraction assembly 2 by rotating the inner suction tube 32 double wings counterclockwise;

[0131] Step 33, take out a new extraction assembly 2, hold the inner suction tube 21 with the left hand, hold the inner suction tube core rod 23 with the thumb and index finger of the right hand and repeatedly pull apart 2-3 times, connect the luer joint at one end of the inner suction tube 21 with the luer joint of the centrifuge tube piston connecting piece 13, and rotate clockwise and lock;

[0132] Step 34, turn the device over by 180 degrees so that the upper sealing cap 3 of the centrifugal assembly 1 is upward, remove the upper sealing cap 3 by rotating counterclockwise, hold the centrifuge tube 11 with the left hand, hold the inner suction tube core rod 23 with the thumb and index finger of the right hand, and extract the platelet rich plasma in the centrifuge tube 11 into the extraction assembly 2, after installing a needle at the luer joint at one end of the inner suction tube 21, the platelet rich plasma can be used immediately at the treatment site.

[0133] The taper head 112 of the centrifuge tube 11 is detachably connected with the tube body 111 through threads, and the outer diameter of the barrel mouth 52 is smaller than the inner diameter of the tube body 111, so that the hydrogel syringe is tightly connected with the centrifuge tube 11, the hydrogel is conveniently injected and mixed with the platelet rich plasma, the connection operation is simple and stable, and a reliable basis is provided for the subsequent mixing process.

[0134] The mixing of the hydrogel and the platelet rich plasma can be completed in a closed state, the operation of unscrewing and screwing the taper head 112 reduces the opportunity of external pollution, ensures the quality and safety of the compound, reduces the risk caused by pollution, and is beneficial to clinical application.

[0135] The platelet-rich plasma and hydrogel complex utilizes the temperature-sensitive characteristics of the hydrogel, and the hydrogel is in a flowable state at low temperature, facilitating mixing with the platelet-rich plasma and application to the wound surface; after contacting the human body, the temperature rises to change into a gel, firmly adhering to the wound surface and not flowing away due to body position changes, effectively solving the problems that the platelet-rich plasma easily flows away with gravity and cannot stay for a long time in the clinical application, so as to better promote wound healing and improve the treatment effect.

[0136] The device structure is relatively simple, and the preparation function is realized through reasonable component design and connection mode. Compared with existing expensive equipment, the cost is lower while meeting the use requirements, has a cost advantage, is more conducive to popularization and application, and can benefit more medical institutions and patients.

[0137] The centrifugal tube 11 is provided with a first double-wing handle 116, facilitating hooking or holding, and improving operation convenience; the flow guide groove 114 on the inner wall of the tapered head 112, the groove 115 at the connection position of the luer joint, and the specific side wall included angle design make the liquid flow more easily and accurately during centrifugation and operation, which helps to improve the preparation efficiency and quality of platelet-rich plasma.

[0138] The concave structure at the bottom of the centrifugal tube sealing piston 12 can improve the pressure of the piston on the liquid in the tube, and make the liquid flow from the peripheral wall to the center during the movement of the piston, which is conducive to the separation of blood stratification and different components, and improves the scientificity and accuracy of the preparation process.

[0139] The design of the centrifugal tube piston connecting piece 13, the inner sealing cap 15 and other components can improve the sealing effect in the centrifugal tube 11, and completely avoid contamination during disassembly and assembly, thereby ensuring the sterile state and use safety of the device; the luer joint at one end of the inner suction pipe 21 is convenient for connection with the centrifugal tube piston connecting piece 13, the double-wing handle is convenient for pressing operation, and the decorative sheet 24 can distinguish the components by color to prevent operation errors and improve the accuracy and efficiency of operation.

[0140] The scale marks provided on the outer walls of the tube body 111 and the inner suction pipe 21 can clearly identify the amount of extracted blood and other liquid, so that the operator can accurately control the amount of each component, ensure the accurate proportion of the prepared platelet-rich plasma and hydrogel complex, and thus ensure the performance and effect of the product.

[0141] The upper sealing cap 3 can seal the centrifugal tube 11 and enable the centrifugal tube 11 to be placed vertically, facilitating operation and storage, and also ensuring the stability of the device during centrifugation; the cooperation design of the inner sealing cap locking rod 4 and the inner sealing cap 15 can realize contactless disassembly, further avoid contamination, and protect the sterile environment of the device.

[0142] The above is the preferred embodiment of the present application, it should be pointed out that, for those skilled in the ordinary in the art, without departing from the principles described in the present application, can be made several improvements and refinements, these improvements and refinements should also be considered as the scope of protection of the present application.

Claims

1. A device for preparing a platelet-rich plasma and hydrogel complex, characterized by, The application relates to a platelet-rich plasma preparation device and a hydrogel injector. The platelet-rich plasma preparation device comprises a centrifugal assembly (1) with an inner cavity and a drawing assembly (2) sleeved in the inner cavity of the centrifugal assembly (1). The hydrogel injector comprises a hydrogel injector barrel (5) with an inner cavity and a piston assembly (6) sleeved in the inner cavity of the hydrogel injector barrel (5). The centrifugal assembly (1) comprises a centrifugal tube (11) which comprises a tube body (111) and a tapered head (112) detachably arranged at a first end of the tube body (111). The hydrogel injector barrel (5) comprises a barrel body (51) and a barrel mouth (52) arranged at a first end of the barrel body (51), and the outer diameter of the barrel mouth (52) is smaller than the inner diameter of the tube body (111). The hydrogel injector injects hydrogel in the barrel body (51) into the centrifugal tube (11) through the barrel mouth (52) and the tapered head (112), and mixes with the platelet-rich plasma to form a platelet-rich plasma and hydrogel compound.

2. The device for preparing a platelet-rich plasma and hydrogel complex according to claim 1, characterized in that: The centrifugal assembly (1) further comprises: a centrifugal tube drawing rod (14) connected with the centrifugal tube sealing piston (12) through a centrifugal tube piston connecting piece (13). The drawing assembly (2) comprises: an inner suction tube (21); the inner suction tube (21) is internally provided with an inner suction tube sealing piston (22); one end of the inner suction tube sealing piston (22) is connected with an inner suction tube core rod (23).

3. The device for preparing a platelet-rich plasma and hydrogel complex according to claim 1, characterized in that: A first luer joint (113) is arranged at a second end of the tapered head (112); a first double-wing handle (116) is arranged at a second end of the tube body (111).

4. The device for preparing a platelet-rich plasma and hydrogel complex according to claim 3, characterized in that: A plurality of flow guide grooves (114) are arranged on the inner wall of the tapered head (112); a groove (115) is arranged at the connection position of the tapered head (112) and the first luer joint (113), the curvature of the groove (115) is 3-8 degrees, one end of the flow guide groove (114) is connected with the groove (115); and the included angle between the side wall of the tapered head (112) and the central axis of the groove (115) is 35-55 degrees.

5. The device for preparing a platelet-rich plasma and hydrogel complex according to claim 2, characterized in that: The centrifugal tube piston connecting piece (13) is provided with a first thread (131) at a first end and a second thread (132) at a second end; the first thread (131) is arranged as a transverse thread, and the second thread (132) is arranged as an inclined thread; a first through hole (133) is arranged at the center of the centrifugal tube piston connecting piece (13); an inner sealing cap (15) is arranged on the centrifugal tube piston connecting piece (13), and the inner sealing cap (15) is provided with a second luer joint (151) and a third luer joint (152) at two ends respectively; the thread directions of the second luer joint (151) and the third luer joint (152) are opposite.

6. The device for preparing a platelet-rich plasma and hydrogel complex according to claim 5, characterized in that: The centrifugal tube sealing piston (12) is in a cylindrical structure, the first end of the centrifugal tube sealing piston (12) is in a cavity structure, an inner thread (121) is arranged on the inner wall of the cavity of the centrifugal tube sealing piston (12), and the centrifugal tube sealing piston (12) is connected with the centrifugal tube piston connecting piece (13) through the inner thread (121). The second end of the centrifugal tube sealing piston (12) is a concave structure, the side wall of the concave structure is 120-140 degrees, the center of the concave structure is provided with a second through hole (122) which can communicate with the first through hole (133) of the centrifugal tube piston connector (13).

7. The device for preparing a platelet-rich plasma and hydrogel complex according to claim 2, characterized in that: One end of the inner suction pipe (21) is provided with a fourth luer connector (211); The other end is provided with a third double-wing handle (212), and the third double-wing handle (212) is provided with a decorative sheet (24); The inner suction pipe (21) is provided with a first scale mark (213) on the outer wall.

8. The device for preparing a platelet-rich plasma and hydrogel complex according to claim 3, characterized in that: The outer wall of the pipe body (111) is provided with a second scale mark (117).

9. The device for preparing a platelet-rich plasma and hydrogel complex according to claim 1, characterized in that: The platelet-rich plasma preparation device further comprises an upper sealing cap (3) which is detachably connected with the taper head (112) of the centrifugal tube (11), the centrifugal tube (11) is sealed by the upper sealing cap (3), and the centrifugal tube (11) is vertically placed.

10. The device for preparing a platelet-rich plasma and hydrogel complex according to claim 5, characterized in that: The platelet-rich plasma preparation device further comprises an inner sealing cap locking rod (4) which is detachably connected with the inner sealing cap (15).

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