Mouse endurance testing device

Abstract

The utility model discloses a mouse endurance testing device, which relates to the technical field of testing devices and comprises a glass box, the top of the glass box is movably connected with a positioning frame, the outer wall, close to one side, of the positioning frame is fixedly connected with a pressure-sensitive sensor, and the top end of the pressure-sensitive sensor is movably connected with a metal hanging net. The metal hanging net is located above the glass box, a micro-current metal net is fixedly connected to the inner wall of the glass box, a controller is fixedly connected to the outer wall of the glass box, and a micro-current driving assembly is arranged on one side of the controller. According to the utility model, the four symmetrically distributed pressure-sensitive sensors are used for monitoring the change of weight borne by the metal hanging net in real time, accurately capturing the hanging, moving, falling and other states of the mouse, and accurately recording the upside-down hanging duration in cooperation with the timer, so that the endurance of the mouse can be effectively tested, and accurate data can be obtained no matter for scientific research experiments; and a reliable means is provided for evaluating the physical energy change of the mouse under the scenes of drug research and development and the like.

Description

Technical Field

[0001] This utility model relates to the field of testing device technology, specifically to a mouse endurance testing device. Background Technology

[0002] In biomedical research, drug development, and many other fields, accurate testing of mouse endurance is a critical requirement. The inverted screen test is a classic behavioral experiment used to assess mouse muscle endurance, but in practice, it is often plagued by significant errors and insufficient precision, affecting the accurate evaluation of the target. For example, manually observing the time a mouse is suspended inverted is not only prone to errors but also fails to capture the various state changes of the mouse during the inverted process in real time and accurately. Furthermore, in conventional testing devices, mice actively try to escape to the ground to release the inverted posture, severely impacting the repeatability of experimental data. In addition, traditional testing methods lack effective real-time monitoring tools, making it difficult to accurately record changes in weight distribution caused by the mouse's exploratory behavior during the inverted process. This poses a significant obstacle to in-depth research on mouse endurance characteristics and the effects of related drugs on mouse endurance. Utility Model Content

[0003] The purpose of this invention is to provide a mouse endurance testing device to solve the problems mentioned in the background art.

[0004] To solve the above-mentioned technical problems, the technical solution adopted by this utility model is as follows:

[0005] A mouse endurance testing device includes a glass box, a positioning frame movably connected to the top of the glass box, a pressure-sensitive sensor fixedly connected to the outer wall of the positioning frame near one side, and a metal mesh movably connected to the top of the pressure-sensitive sensor, with the metal mesh located above the glass box.

[0006] A micro-current metal mesh is fixedly connected to the inner wall of the glass box, and a controller is fixedly connected to the outer wall of the glass box. A micro-current driving component is provided on one side of the controller, and a timer is provided above the controller. A height adjustment component for adjusting the height of the metal mesh is provided on the bottom surface near one end.

[0007] A further improvement of the present invention is that the height adjustment component includes a positioning collar, which is fixedly sleeved on the outer wall of the glass box. An adjustment frame is fixedly connected to the outer wall of the positioning collar. A position adjustment rod is movably inserted into the inner wall of the adjustment frame. A threaded hole is opened on the outer wall of the adjustment frame, and a fastening knob is threadedly connected to the inner wall of the threaded hole.

[0008] A further improvement of this utility model is that the number of pressure-sensitive sensors is four, and the four pressure-sensitive sensors are symmetrically distributed on both sides of the positioning frame.

[0009] A further improvement of this utility model is that: a separation groove is provided on the side of the glass box near the bottom, and a collection separation box is movably inserted into the inner wall of the separation groove, and the collection separation box is located below the micro-current metal mesh.

[0010] A further improvement of this utility model is that an insulating sleeve is fitted onto the outer wall of the microcurrent metal mesh.

[0011] A further improvement of this utility model is that the inner wall of the positioning collar is provided with adhesive. The inner wall of the positioning collar is fixedly attached to the outer wall of the glass box by the adhesive.

[0012] Due to the adoption of the above technical solution, the technological progress achieved by this utility model compared to the prior art is as follows:

[0013] 1. This utility model provides a mouse endurance testing device, which uses four symmetrically distributed pressure-sensitive sensors to monitor the weight changes borne by the metal net in real time, accurately capturing the state of the mouse hanging on the net, moving, falling, etc., and accurately recording the duration of hanging upside down with a timer. It can effectively test the endurance of mice and provides a reliable means for obtaining accurate data in scientific research experiments or for evaluating changes in the physical performance of mice in drug development and other scenarios.

[0014] 2. This invention provides a mouse endurance testing device. Firstly, it features a height adjustment component, allowing for flexible adjustment of the metal mesh height to suit mice of varying sizes and ensure suitable experimental conditions. Secondly, when a mouse attempts to leave the metal mesh and exhibits exploratory behavior, its tail or hind limbs will first contact the microcurrent mesh before it fully jumps down. Mice receiving electrical stimulation tend to remain hanging upside down on the mesh until their endurance reaches its limit, ensuring accurate and stable data. A collection and extraction box is also included for easy cleaning, comprehensively improving the device's practicality and ease of use, reducing experimental complexity, increasing efficiency, and enhancing data stability. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the structure of this utility model;

[0016] Figure 2 This is a schematic diagram of the metal mesh structure of this utility model;

[0017] Figure 3 This is a schematic diagram showing the structural details of this utility model;

[0018] Figure 4This is a top view of the glass box structure of this utility model.

[0019] In the diagram: 1. Glass box; 2. Metal mesh; 3. Timer; 4. Controller; 5. Microcurrent drive assembly; 6. Positioning frame; 7. Pressure sensor; 8. Positioning collar; 9. Position adjustment rod; 10. Adjustment frame; 11. Fastening knob; 12. Microcurrent metal mesh; 13. Collection and extraction box; 14. Extraction slot. Detailed Implementation

[0020] In the description of this utility model, it should also be noted that, unless otherwise explicitly specified and limited, the terms "set," "install," "connect," and "link" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0021] The present invention will be further described in detail below with reference to embodiments:

[0022] Example 1

[0023] like Figure 1-4 As shown, this utility model provides a mouse endurance testing device, including a glass box 1, a positioning frame 6 movably connected to the top of the glass box 1, a pressure sensor 7 fixedly connected to the outer wall of the positioning frame 6 near one side, and a metal mesh 2 movably connected to the top of the pressure sensor 7, with the metal mesh 2 located above the glass box 1.

[0024] A microcurrent metal mesh 12 is fixedly connected to the inner wall of the glass box 1, and a controller 4 is fixedly connected to the outer wall of the glass box 1. A microcurrent drive component 5 is provided on one side of the controller 4, and a timer 3 is provided above the controller 4. A height adjustment component for adjusting the height is provided on the bottom surface of the metal mesh 2 near one end. There are four pressure sensors 7, which are symmetrically distributed on both sides of the positioning frame 6.

[0025] Example 2

[0026] like Figure 1-4 As shown, based on Embodiment 1, this utility model provides a technical solution: Preferably, the height adjustment component includes a positioning collar 8, which is fixedly sleeved on the outer wall of the glass box 1. An adjustment frame 10 is fixedly connected to the outer wall of the positioning collar 8. A position adjustment rod 9 is movably inserted into the inner wall of the adjustment frame 10. A threaded hole is opened on the outer wall of the adjustment frame 10, and a fastening knob 11 is threadedly connected to the inner wall of the threaded hole.

[0027] A collection slot 14 is provided on one side of the glass box 1 near the bottom. A collection box 13 is movably inserted into the inner wall of the collection slot 14 and is located below the microcurrent metal mesh 12. The collection box 13 is used to collect the feces and urine of the mice for convenient subsequent processing.

[0028] An insulating sleeve is fitted onto the outer wall of the microcurrent metal mesh 12, and adhesive is applied to the inner wall of the positioning ring 8. The inner wall of the positioning ring 8 is fixed to the outer wall of the glass box 1 by the adhesive. The adhesive can be a UV-curable adhesive. The metal mesh 2 and the top of the pressure sensor 7 can be connected via a clamping structure.

[0029] The working principle of this mouse endurance testing device will be explained in detail below.

[0030] like Figure 1-4 As shown, the mouse hanging on the mesh and the timing begins: When the mouse is placed in the glass box 1, it can be lured with food to hang on the mesh plate. At this time, the weight of the mouse is transferred to the pressure sensor 7 through the metal mesh 2. The piezoelectric material in the pressure sensor 7 deforms under external pressure, thereby generating an electric charge. This change in charge can be converted into an electrical signal to represent the magnitude of the pressure. After receiving the electrical signal, the controller 4 determines that the mouse has hung on the mesh plate and triggers the timer 3 to start timing.

[0031] Mouse grip strength maintenance and process monitoring: While the mouse grips the metal mesh 2, the pressure sensor 7 continuously monitors the weight borne by the metal mesh 2. If the mouse moves on the metal mesh 2, due to the change in weight distribution, the pressure sensor 7 at different positions will generate different electrical signal changes accordingly. The controller 4 can understand the mouse's activity on the metal mesh 2 based on these signal changes, but the timing continues.

[0032] Mouse Fall and Timing Stop: When the mouse loses its grip on the metal mesh 2 and falls, the weight of the mouse supported by the metal mesh 2 suddenly disappears, and the electrical signal output by the pressure sensor 7 returns to its initial value or close to its initial value. Upon receiving this signal change, the controller 4 determines that the mouse has fallen, immediately stops the timing module, and records the timing data for the entire process.

[0033] Microcurrent stimulation and cycle preparation: After the mouse falls, the microcurrent metal mesh 12 located below the metal hanging mesh 2 begins to operate under the action of the microcurrent driving component 5. The multivibrator circuit composed of the NE555 timer in the microcurrent driving component 5 generates a pulse signal with a specific frequency and duty cycle. After being amplified by the LM358 dual operational amplifier, it provides a suitable microcurrent to the microcurrent metal mesh 12. The microcurrent forms a weak current field through the conductive electrodes on the mesh, which can stimulate the mouse and prompt it to climb back onto the metal hanging mesh 2. If the experiment is set to be repeated cyclically, when the mouse grabs the metal hanging mesh 2 again, the sensor will detect the weight change, and the controller 4 will restart the timing, repeating the above process to test the mouse's maximum endurance value, i.e., the duration of inverted hanging.

[0034] Furthermore, if the microcurrent metal mesh 12 is continuously energized while the mouse is gripping the metal mesh 2, and the mouse extends its tail or limbs to contact the microcurrent metal mesh 12 and detects electrical stimulation below, it will not jump down. Instead, the mouse will continue to grip the metal mesh 2 and hang upside down on it until it is exhausted and jumps down. In this situation, the height of the current mesh should be adjusted appropriately to ensure that the mouse's limbs can contact the electrical stimulation when it attempts to move downwards.

[0035] For mice of different sizes, some with shorter tails and others with longer bodies, the height of the metal mesh 2 can be adjusted to accommodate them. To adjust, lift and press the metal mesh 2 up and down to change the distance between it and the microcurrent metal mesh 12. After adjusting, tighten the fastening knob 11 to fix the position of the metal mesh 2, thus completing the adjustment.

[0036] The present invention has been described in detail above. However, modifications or improvements can be made to it, which will be obvious to those skilled in the art. Therefore, any modifications or improvements that do not depart from the spirit of the present invention are within the protection scope of the present invention.

Claims

1. A mouse endurance test device comprising a glass box (1), characterized in that: A positioning frame (6) is movably connected to the top of the glass box (1). A pressure sensor (7) is fixedly connected to the outer wall of the positioning frame (6) near one side. A metal mesh (2) is movably connected to the top of the pressure sensor (7). The metal mesh (2) is located above the glass box (1). The inner wall of the glass box (1) is fixedly connected to a micro-current metal mesh (12), and the outer wall of the glass box (1) is fixedly connected to a controller (4). A micro-current drive component (5) is provided on one side of the controller (4), and a timer (3) is provided above the controller (4). A height adjustment component for adjusting the height of the metal mesh (2) is provided on the bottom surface near one end.

2. The mouse endurance testing device according to claim 1, wherein: The height adjustment assembly includes a positioning collar (8), which is fixedly sleeved on the outer wall of the glass box (1). An adjustment frame (10) is fixedly connected to the outer wall of the positioning collar (8). A position adjustment rod (9) is movably inserted into the inner wall of the adjustment frame (10). A threaded hole is opened on the outer wall of the adjustment frame (10), and a fastening knob (11) is threadedly connected to the inner wall of the threaded hole.

3. The mouse endurance testing device of claim 1, wherein: The number of pressure-sensitive sensors (7) is four, and the four pressure-sensitive sensors (7) are symmetrically distributed on both sides of the positioning frame (6).

4. The mouse endurance testing device of claim 1, wherein: The glass box (1) has an extraction groove (14) on one side near the bottom. A collection extraction box (13) is movably inserted into the inner wall of the extraction groove (14). The collection extraction box (13) is located below the microcurrent metal mesh (12).

5. The mouse endurance testing device of claim 1, wherein: An insulating sleeve is fitted around the outer wall of the microcurrent metal mesh (12).

6. The mouse endurance testing device of claim 2, wherein: The inner wall of the positioning collar (8) is provided with adhesive.

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