Restraining device for mouse eye injection

Abstract

The utility model relates to the technical field of animal eye injection, in particular to a fixing device for mouse eye injection, which comprises a base provided with a first linear transmission mechanism; the first sliding table is arranged above the base and connected to the first linear transmission mechanism, and the first sliding table is provided with a second linear transmission mechanism; and the second sliding table is arranged above the first sliding table and is connected to the second linear transmission mechanism. According to the eye injection fixing device, a user can operate the slide to be in a proper spatial position and angle with one hand, so that the slide can be attached to the surface of an eyeball, the eyeball is limited through tension of water of the eyeball and the slide, the position of the slide is stable and reliable, an operator does not need to worry about displacement of the slide, and operation is convenient. The original slide fixing process needing assistance of an assistant becomes simple, and an operator can complete the eye injection task more independently and efficiently.

Description

Technical Field

[0001] This utility model relates to the field of animal ocular injection technology, and more specifically to a restraint device for ocular injection in mice. Background Technology

[0002] Animal ocular injection is a commonly used technique in ophthalmic research, primarily for drug delivery, disease model establishment, or local treatment. Animal ocular injections are mainly divided into two types: subretinal injection and intravitreal injection.

[0003] Taking ocular injection in mice as an example, the procedure includes animal anesthesia, pupil dilation, scleral incision, and injection. Specifically, the scleral incision involves using forceps to slide between the upper and lower eyelids, causing the eyeball to protrude from the eye socket and exposing the sclera. Then, a small pre-incision is made behind the limbus using a suitable needle. The injection process, depending on the type of injection (subretinal or intravitreal), involves inserting the needle containing the injection solution into the appropriate site. The injection must be performed slowly to prevent backflow of the fluid.

[0004] During the aforementioned injection process, the eyeball is prone to rotation when the needle comes into contact with it, causing positional deviation. Therefore, how to restrain the eye to assist in the injection process is an urgent problem to be solved. Utility Model Content

[0005] To address the technical problems existing in mouse ocular injection in the prior art, the first aspect of this utility model proposes a restraint device for mouse ocular injection, comprising:

[0006] A base, wherein the base is provided with a first linear transmission mechanism;

[0007] A first slide is disposed above the base and connected to the first linear transmission mechanism; the first slide is provided with a second linear transmission mechanism.

[0008] The second slide is disposed above the first slide and connected to the second linear transmission mechanism; the second slide is provided with a third linear transmission mechanism.

[0009] The glass slide is connected to the third linear drive mechanism;

[0010] The first linear transmission mechanism is arranged along the X-axis, the second linear transmission mechanism is arranged along the Y-axis, and the third linear transmission mechanism is arranged along the Z-axis. The first slide can move relative to the base along the X-axis, the second slide can move relative to the first slide along the Y-axis, the glass slide can move relative to the second slide along the Z-axis, and the glass slide can rotate relative to the second slide around the X-axis.

[0011] Preferably, the glass slide is configured as a strip of transparent glass.

[0012] Preferably, the surface of the glass slide is smooth.

[0013] Preferably, the third linear transmission mechanism includes a Z-axis connector, the Z-axis connector is provided with an insertion hole, and a clamping component is connected to one end of the glass slide along its long axis. The clamping component is provided with an insertion shaft that extends into the insertion hole.

[0014] Preferably, the insert shaft is an elastic structure, and the outer diameter of the insert shaft is larger than the inner diameter of the insertion hole.

[0015] Preferably, the clamping component is an elastic structure, and the clamping component is provided with a slot, the height of which is less than the thickness of the glass slide.

[0016] Preferably, the first linear transmission mechanism, the second linear transmission mechanism, and the third linear transmission mechanism are all lead screw transmission mechanisms.

[0017] Preferably, the first linear transmission mechanism includes a first lead screw rotatably connected to the base, one end of the first lead screw being connected to a first knob, and a first slide being threadedly connected to the first lead screw. The second linear transmission mechanism includes a second lead screw rotatably connected to the first slide, one end of the second lead screw being connected to a second knob, and the second slide being connected to the second lead screw. The third linear transmission mechanism includes a third lead screw rotatably connected to the second slide, one end of the third lead screw being connected to a third knob, and the third lead screw being connected to the Z-axis connecting seat.

[0018] Preferably, the second slide is disposed on the side of the first slide near the glass slide.

[0019] Preferably, the clamping component and the insert shaft are made of integrally molded rubber material.

[0020] Compared with the prior art, the advantages of this utility model are:

[0021] The ocular injection restraint device proposed in this invention allows the user to operate the slide with one hand, positioning it in a suitable spatial position and angle so that the slide can adhere to the surface of the eyeball. The surface tension of the water between the eyeball and the slide is used to restrain the eyeball, ensuring stable and reliable slide positioning. Operators do not need to worry about slide displacement, simplifying the previously assistant-assisted slide fixation process. This allows operators to complete ocular injection tasks more independently and efficiently, shortening operation time and reducing the time the animal's eyes are exposed to light. This reduces discomfort and potential risks caused by prolonged light exposure and complex procedures, fully demonstrating care and protection for laboratory animals and meeting the ethical requirements of modern animal experiments. Attached Figure Description

[0022] The accompanying drawings are not intended to be drawn to scale. In the drawings, each identical or nearly identical component shown in the various figures may be denoted by the same reference numeral. For clarity, not every component is labeled in each figure. Embodiments of various aspects of the present invention will now be described by way of example and with reference to the accompanying drawings, wherein:

[0023] Figure 1 This is a schematic diagram of the restraint device for ocular injection in mice as shown in this utility model;

[0024] Figure 2 This is a schematic diagram showing the adjustment of the glass slide along the X-axis and Z-axis according to this utility model;

[0025] Figure 3 This is a schematic diagram of the clamping component shown in this utility model. Detailed Implementation

[0026] To better understand the technical content of this utility model, specific embodiments are provided below in conjunction with the accompanying drawings.

[0027] Combination Figure 1 As shown, this utility model proposes a restraint device for ocular injection in mice, including a base 10, a first slide 20, a second slide 30, and a glass slide 40.

[0028] Before injecting the mouse eye, the restraint device is placed on one side of the mouse, that is, the base 10 is in a fixed position, while the second slide 20 and the second slide 30 provide the slide 40 with triaxial displacement capability, that is, the spatial position of the slide 40 can be adjusted along the X-axis, Y-axis and Z-axis, so that the slide 40 can be moved above the mouse eye and kept in contact with the eyeball. The eyeball is kept in a stable position by the tension of the water between the slide 40 and the eyeball.

[0029] Combination Figure 1 As shown, specifically, the base 10 is provided with a first linear transmission mechanism; the first slide 20 is disposed above the base 10 and connected to the first linear transmission mechanism, and the first slide 20 is provided with a second linear transmission mechanism; the second slide 30 is disposed above the first slide 20 and connected to the second linear transmission mechanism, and the second slide 30 is provided with a third linear transmission mechanism; the glass slide 40 is connected to the third linear transmission mechanism.

[0030] The first linear transmission mechanism is arranged along the X-axis, the second linear transmission mechanism is arranged along the Y-axis, and the third linear transmission mechanism is arranged along the Z-axis. The first slide 20 can move relative to the base 10 along the X-axis, the second slide 30 can move relative to the first slide 20 along the Y-axis, and the glass slide 40 can move relative to the second slide 30 along the Z-axis.

[0031] Furthermore, the slide 40 can rotate relative to the second slide 30 around the X-axis. Thus, as needed for shooting, by changing the angle of the slide 40, while keeping the slide 40 in close contact with the surface of the eyeball, reflections from the slide 40 into the camera's field of view can be avoided.

[0032] In an optional embodiment, the slide 40 is configured as a strip of transparent glass. This design of the slide 40 can cover the eyeball and also facilitate the injection of the syringe into the eye from the side.

[0033] Preferably, the surface of the slide 40 is smooth, which facilitates the filling of water between the eyeball and the surface of the slide 40, thereby limiting the position of the eyeball by the surface tension of the water.

[0034] In an optional embodiment, combined with Figure 3 As shown, the third linear transmission mechanism includes a Z-axis connecting seat 32, which has an insertion hole. One end of the glass slide 40 in the long axis direction is connected to a clamping component 41, and the clamping component 41 has an insertion shaft 42 that extends into the insertion hole.

[0035] Thus, the glass slide 40 is connected to the Z-axis connecting seat 32 via the clamping component 41, and the rotation angle of the glass slide 40 can be freely adjusted. During adjustment, the user can manually move the glass slide 40 to rotate it to a suitable angle.

[0036] The insert shaft 42 is an elastic structure, and the outer diameter of the insert shaft 42 is larger than the inner diameter of the insertion hole. In this way, there is a stable connection between the insert shaft 42 and the Z-axis connecting seat 32, that is, when no external force is applied to the slide 40, the slide 40 can be in a stable position and angle.

[0037] In an optional embodiment, the clamping component 41 and the insert shaft 42 are integrally molded from rubber. This ensures the structural flexibility and durability required.

[0038] In an optional embodiment, the clamping member 41 is an elastic structure with a slot, the height of which is less than the thickness of the glass slide 40. Thus, without external force, the clamping member 41 can stably hold the glass slide 40.

[0039] In an optional embodiment, the first linear transmission mechanism, the second linear transmission mechanism, and the third linear transmission mechanism are all lead screw transmission mechanisms. Lead screw transmission mechanisms have good transmission accuracy and stability, meaning that when adjusted to a certain position, they will not change their existing position due to external forces.

[0040] Specifically, in combination Figure 1 and Figure 2 As shown, the first linear transmission mechanism includes a first lead screw 11, which is rotatably connected to the base 10. One end of the first lead screw 11 is connected to a first knob 12, and a first slide 20 is threadedly connected to the first lead screw 11. The second linear transmission mechanism includes a second lead screw 21, which is rotatably connected to the first slide 20. One end of the second lead screw 21 is connected to a second knob 22, and a second slide 30 is connected to the second lead screw 21. The third linear transmission mechanism includes a third lead screw, which is rotatably connected to the second slide 30. One end of the third lead screw is connected to a third knob 31, and the third lead screw is connected to a Z-axis connecting seat 32.

[0041] Thus, when the slide 40 needs to be moved to the left or right, turn the first knob 12 to adjust the position of the slide 40 in the X-axis direction; when the slide 40 needs to be moved forward or backward, turn the second knob 22 to adjust the position of the slide 40 in the Y-axis direction; and when the slide needs to be moved up or down, turn the third knob 31 to adjust the position of the slide 40 in the Z-axis direction. The adjustment process can be completed with one hand.

[0042] Furthermore, the second slide 30 is positioned on the side of the first slide 20 closest to the slide 40. This positions the slide 40 more closely relative to the mouse's position on the right side of the device, facilitating adjustment of the slide 40 to a suitable location.

[0043] In conjunction with the above embodiments, the ocular injection restraint device proposed by this utility model allows the user to operate the slide with one hand to position it in a suitable spatial position and angle, enabling the slide to adhere to the surface of the eyeball. The surface tension of the water between the eyeball and the slide is used to restrain the eyeball, and the position of the slide is stable and reliable. Operators do not need to worry about slide displacement, simplifying the previously assistant-assisted slide fixation process. This allows operators to complete ocular injection tasks more independently and efficiently, shortening operation time and reducing the time the animal's eyes are exposed to light. This reduces discomfort and potential risks to animals caused by prolonged light exposure and complex operations, fully demonstrating care and protection for laboratory animals and meeting the ethical requirements of modern animal experiments.

[0044] Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Those skilled in the art to which this invention pertains can make various modifications and refinements without departing from the spirit and scope of the present invention. Therefore, the scope of protection of this invention shall be determined by the claims.

Claims

1. A holding device for eye injection of a mouse, characterized by, include: The base (10) is provided with a first linear transmission mechanism; A first slide (20) is disposed above the base (10) and connected to the first linear transmission mechanism. The first slide (20) is provided with a second linear transmission mechanism. The second slide (30) is disposed above the first slide (20) and connected to the second linear transmission mechanism. The second slide (30) is provided with a third linear transmission mechanism. A glass slide (40) is connected to a third linear drive mechanism; The first linear transmission mechanism is arranged along the X-axis, the second linear transmission mechanism is arranged along the Y-axis, and the third linear transmission mechanism is arranged along the Z-axis. The first slide (20) can move relative to the base (10) along the X-axis, the second slide (30) can move relative to the first slide (20) along the Y-axis, the glass slide (40) can move relative to the second slide (30) along the Z-axis, and the glass slide (40) can rotate relative to the second slide (30) around the X-axis.

2. The device for restraining a mouse for eye injection according to claim 1, wherein The glass slide (40) is configured as a strip of transparent glass.

3. The device for restraining a mouse for eye injection according to claim 1, wherein The surface of the glass slide (40) is smooth.

4. The device for restraining a mouse for eye injection according to claim 1, wherein The third linear transmission mechanism includes a Z-axis connecting seat (32), which has an insertion hole. One end of the glass slide (40) in the long axis direction is connected to a clamping component (41), which has an insertion shaft (42) extending into the insertion hole.

5. The restraining device for ocular injection of a mouse according to claim 4, wherein The insert shaft (42) is an elastic structure, and the outer diameter of the insert shaft (42) is larger than the inner diameter of the insertion hole.

6. The restraining device for ocular injection of a mouse according to claim 4, wherein The clamping component (41) is an elastic structure, and the clamping component (41) is provided with a slot, the height of which is less than the thickness of the glass slide (40).

7. The device for restraining a mouse for eye injection according to claim 1, wherein The first linear transmission mechanism, the second linear transmission mechanism, and the third linear transmission mechanism are all lead screw transmission mechanisms.

8. The device for restraining a mouse for eye injection according to claim 4, wherein, The first linear transmission mechanism includes a first lead screw (11), which is rotatably connected to the base (10). One end of the first lead screw (11) is connected to a first knob (12). The first slide (20) is threadedly connected to the first lead screw (11). The second linear transmission mechanism includes a second lead screw (21), which is rotatably connected to the first slide (20). One end of the second lead screw (21) is connected to a second knob (22). The second slide (30) is connected to the second lead screw (21). The third linear transmission mechanism includes a third lead screw, which is rotatably connected to the second slide (30). One end of the third lead screw is connected to a third knob (31). The third lead screw is connected to the Z-axis connecting seat (32).

9. The device for restraining a mouse for eye injection according to claim 1, wherein, The second slide (30) is located on the side of the first slide (20) near the glass slide (40).

10. The device for restraining a mouse for eye injection according to claim 4, wherein The clamping component (41) and the insert shaft (42) are made of one piece of rubber.

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