Volume tracing device with electric shock function

Abstract

The utility model discloses a plethysmography device with an electric shock function. The device comprises a breathing tank, a plethysmography module and an electric shock control module, wherein a breathing detection sensor is arranged on the wall of the breathing tank, and the breathing detection sensor is used for collecting breathing data of an experimental subject in the breathing tank and transmitting the breathing data to the plethysmography module; an electric shock electrode is arranged at the bottom of the breathing tank, and the electric shock control module is used for transmitting an electric shock control signal to the electric shock electrode. According to the technical scheme, respiratory function detection and electric shock stimulation can be completed in the same space in the breathing tank, researchers do not need to switch operation among different devices, the experiment operation process is simplified, the experiment operation time is shortened, the experiment efficiency is improved, meanwhile, the state change risk of an experiment object is reduced, and the experiment efficiency is improved. The data relevance and accuracy are improved, and the occupied space of equipment can be reduced.

Description

Technical Field

[0001] This utility model relates to the field of biomedical research technology, and in particular to a volumetric recording device with an electric shock function. Background Technology

[0002] In biomedical research, studying the physiological indicators and behavioral responses of laboratory animals is a crucial means of gaining a deeper understanding of life phenomena and disease mechanisms. Respiratory function is one of the key indicators reflecting an animal's physiological state. It can often be measured using a WBP plethysmography device while the animal is awake and freely moving, avoiding interference from anesthesia and invasive procedures. This method is widely used in research fields such as asthma, respiratory disease drug development, and toxicology. On the other hand, plantar electroconvulsive therapy (PCPT), as a commonly used stimulation method, is used in neuroscience and behavioral science research to study behavioral mechanisms such as fear, learned helplessness, learning and memory, and stress responses in animals. It is typically implemented using specialized PCPT devices.

[0003] In existing technologies, the WBP plethysmography (WBP) system and the plantar electroconvulsive therapy (PET) device are independent of each other. When studying respiratory function and behavioral responses simultaneously, researchers must operate two separate sets of equipment, increasing the difficulty and time cost of experiments. For example, when studying changes in animal respiration under stress, respiratory data must first be recorded using the WBP system before transferring the data to the PET device for stimulation. Moreover, experiments need to be conducted in different spaces, making it difficult to simultaneously acquire respiratory data and behavioral data under PET stimulation in the same environment. This hinders the analysis of the intrinsic relationship between the two, and the transfer process can easily alter the state of the experimental animals, affecting the accuracy of the experiment and thus impeding in-depth research on the comprehensive physiological and behavioral changes of animals under specific stimuli. In addition, using two separate sets of equipment also occupies a large amount of placement and operating space, increasing the difficulty of equipment placement and experimentation in space-constrained laboratories. Utility Model Content

[0004] This invention provides a volumetric recording device with an electric shock function, enabling respiratory function detection and electric shock stimulation to be performed in the same space, thereby simplifying the experimental operation process, improving data correlation and accuracy, and reducing the space occupied by the equipment.

[0005] This utility model embodiment provides a volumetric recording device with electric shock function. The device includes: a breathing canister, a volumetric recording module, and an electric shock control module; wherein...

[0006] A respiratory detection sensor is installed on the wall of the breathing chamber. The respiratory detection sensor is used to collect the respiratory data of the experimental subject inside the breathing chamber and transmit the respiratory data to the volume recording module.

[0007] An electric shock electrode is provided at the bottom of the breathing canister, and the electric shock control module is used to transmit electric shock control signals to the electric shock electrode.

[0008] Optionally, the electric shock electrode is a grid electrode.

[0009] Optionally, the electric shock electrode is a conductive metal electrode or a conductive rubber electrode.

[0010] Optionally, the breathing detection sensor includes a flow sensor disposed on the top of the breathing canister and a pressure sensor disposed on the side of the breathing canister. The flow sensor is used to detect changes in airflow inside the canister caused by the breathing of the experimental subject, and the pressure sensor is used to detect fluctuations in air pressure inside the canister caused by the breathing of the experimental subject.

[0011] Optionally, the respiratory detection sensor includes an airflow sensor based on the laser Doppler effect.

[0012] Optionally, the volumetric recording module includes a temperature sensor and a humidity sensor, which are used to detect temperature data and humidity data in the experimental environment, respectively.

[0013] Optionally, the electric shock control module includes a control panel for setting electric shock control parameters.

[0014] Optionally, the electric shock control parameters include electric shock voltage, electric shock current, stimulation time, and stimulation mode.

[0015] Optionally, the electric shock control module includes a safety protection unit, which is used for at least one of overvoltage protection, overcurrent protection, and leakage protection.

[0016] Optionally, the device further includes a data acquisition and processing module for synchronously acquiring respiratory function parameters obtained in real time by the volume plethysmography module, as well as electric shock control parameters used in real time by the electric shock control module.

[0017] This invention provides a plethysmography device with electric shock function, including a breathing chamber, a plethysmography module, and an electric shock control module. A breathing detection sensor is installed on the wall of the breathing chamber to collect breathing data from the experimental subject inside the chamber and transmit the collected breathing data to the plethysmography module for processing. Electric shock electrodes are installed at the bottom of the breathing chamber to provide electric shock stimulation to the experimental subject inside. The electric shock control module transmits electric shock control signals to the electric shock electrodes to control the stimulation mode. This plethysmography device with electric shock function, by integrating the electric stimulation function into the breathing chamber, enables respiratory function detection and electric shock stimulation to be performed in the same space within the breathing chamber. Researchers do not need to switch between different devices, simplifying the experimental procedure, reducing experimental time, and improving experimental efficiency. Furthermore, it allows for simultaneous monitoring of respiratory function data and behavioral response data under electric shock stimulation in the same environment, reducing the risk of changes in the experimental subject's state, improving data correlation and accuracy, and reducing the space occupied by the equipment. This facilitates equipment placement and experimental implementation, optimizes laboratory resource allocation, and provides an efficient and comprehensive experimental tool for biomedical research. Attached Figure Description

[0018] Figure 1 A schematic diagram of a volumetric tracing device with an electric shock function provided for an embodiment of this utility model;

[0019] Figure 2 This is a schematic diagram illustrating the signal transmission and data interaction relationship between modules provided in an embodiment of the present invention. Detailed Implementation

[0020] The present invention will now be described in further detail with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present invention and not intended to limit it. Furthermore, it should be noted that, for ease of description, the accompanying drawings show only the parts relevant to the present invention, not the entire structure.

[0021] Figure 1 This is a schematic diagram of a volumetric plethysmography device with an electric shock function, provided as an embodiment of the present invention. This embodiment is applicable to situations in biomedical research where respiratory function and behavioral responses to electric shock stimulation of experimental subjects are monitored simultaneously. Figure 1As shown, the device includes: a breathing chamber 100, a volumetric recording module 200, and an electric shock control module 300; wherein, a breathing detection sensor 110 is provided on the wall of the breathing chamber 100, the breathing detection sensor 110 is used to collect the breathing data of the experimental subject inside the breathing chamber 100, and transmit the breathing data to the volumetric recording module 200; an electric shock electrode 120 is provided at the bottom of the breathing chamber 100, and the electric shock control module 300 is used to transmit electric shock control signals to the electric shock electrode 120.

[0022] Specifically, during the experiment, the experimental subject (such as a mouse) can be placed inside the breathing chamber 100, which is then sealed. The breathing chamber 100 can be made of transparent, high-strength engineering plastic to facilitate observation of the subject's behavior. The size of the chamber can be adapted to the specific experimental subject; for example, for mice, the dimensions can be designed to be 310mm long, 210mm wide, and 200mm high. A good seal on the chamber walls ensures accurate respiratory detection. The subject's breathing causes changes in air pressure and airflow within the breathing chamber 100. These changes can be detected by the respiratory detection sensor 110 and converted into corresponding electrical signals, which are then transmitted to the volumetric recording module 200. The entire device can employ whole-body volumetric plethysmography (WBP), and the breathing chamber 100 provides the experimental subject with relatively free movement space. The volumetric recording module 200 incorporates a dedicated algorithm. After acquiring respiratory data output from the respiratory detection sensor 110 in real time, it can analyze and process the data through a high-performance microprocessor to obtain corresponding respiratory function parameters, such as tidal volume, respiratory rate, inspiratory time, expiratory time, peak expiratory flow rate, peak inspiratory flow rate, etc. The volumetric recording module 200 may also include a display screen, which can display the processed respiratory function parameters in real time for researchers to observe.

[0023] Among them, optional, such as Figure 1 As shown, the respiratory detection sensor 110 includes a flow sensor 111 disposed on the top of the breathing tank 100 and a pressure sensor 112 disposed on the side of the breathing tank 100. The flow sensor 111 is used to detect changes in airflow within the tank caused by the breathing of the experimental subject, and the pressure sensor 112 is used to detect fluctuations in air pressure within the tank caused by the breathing of the experimental subject. This facilitates the volumetric recording module 200 in calculating various respiratory function parameters. For example, the tidal volume can be calculated based on the gas flow rate change detected by the flow sensor 111 per unit time, combined with the volume of the breathing tank 100. Furthermore, the pressure sensor 112 can monitor and analyze pressure changes during the respiratory cycle to determine the inhalation and exhalation times, and thus calculate the respiratory rate, etc.

[0024] In another optional embodiment, the respiratory detection sensor 110 includes an airflow sensor based on the laser Doppler effect, which is more sensitive to airflow changes and can accurately measure minute airflow changes in animal respiration, thereby improving the accuracy of respiratory function parameter detection.

[0025] Based on the above technical solution, optionally, the volumetric recording module 200 includes a temperature sensor and a humidity sensor, used to detect temperature and humidity data in the experimental environment, respectively. This allows the volumetric recording module 200 to use the temperature and humidity data in the experimental environment for correction during data analysis and processing, thereby improving the accuracy of respiratory function parameter calculations.

[0026] The bottom of the breathing chamber 100 is equipped with electric shock electrodes 120 for applying foot electric shock stimulation to experimental subjects placed inside the chamber. This integrates the electric shock stimulation function into the breathing chamber 100, allowing simultaneous electric shock stimulation and respiratory monitoring within the same chamber without the need to transfer the animal. Exemplary applications include animal stress respiratory response experiments, where different intensities of foot electric shock stimulation can be set to simultaneously monitor changes in respiratory function, studying the patterns of respiratory function changes in animals under different stress states. Further applications include drug screening research, neurophysiological research, environmental stress research, etc. In drug screening research, for example, studying the effects of drugs on respiratory function and behavioral responses in animals under stress can involve administering different drugs to animals, then applying foot electric shock stimulation to this device and monitoring relevant indicators to evaluate drug efficacy and safety, providing experimental evidence for drug development. In neurophysiological research, combining neurophysiological recording techniques (such as electroencephalography, electromyography, etc.) can be used to study the relationship between neural activity and respiratory function and behavioral responses in animals under foot electric shock stimulation, exploring the neural regulatory mechanisms in depth. Environmental stress research, such as simulating different environmental stressors (e.g., noise, bright light) and combining them with foot electric shock stimulation, can study the physiological and behavioral responses of animals under combined stress conditions, providing experimental models for environmental science and psychology research. Of course, this device can also be used for standalone respiratory monitoring or electric shock stimulation. For example, in asthma research, changes in respiratory function before and after drug intervention can be detected to assess drug efficacy. Similarly, in conditioned fear experiments, foot electric shock stimulation can be administered to animals to establish fear memories of specific stimuli, allowing for the study of related neural circuits and molecular mechanisms.

[0027] Optionally, the electric shock electrode 120 is a grid electrode and can be laid flat on the bottom of the breathing canister 100, so as not to hinder the free movement of the experimental subject. The grid spacing can be set according to the experimental subject to ensure that the soles of the experimental subject's feet can fully contact the electrodes, thereby ensuring the effect of electric shock stimulation. For example, for mice, the grid spacing can be set to 5-20 mm.

[0028] Based on the above technical solution, optionally, the electric shock electrode 120 is a conductive metal electrode or a conductive rubber electrode. Among them, the conductive rubber electrode has better flexibility and comfort, can reduce damage to the animal's foot, and ensures good conductivity, thereby ensuring the electric shock stimulation effect.

[0029] The electric shock control module 300 is connected to the electric shock electrode 120 to transmit electric shock control signals to the electric shock electrode 120, thereby controlling the electric shock electrode 120 to generate electric shock stimulation as needed. Figure 1 As shown, the electric shock control module 300 can be connected to the electric shock electrode 120 via an electrical plug 310 sealed to the wall of the breathing can 100, thereby ensuring the airtightness of the can. In addition, the bottom of the breathing can 100 may also include a detachable rubber sealing base 130 to stabilize the experimental apparatus.

[0030] Optionally, the electric shock control module 300 includes a control panel for setting electric shock control parameters. Specifically, it can be equipped with an easy-to-use control panel, allowing researchers to set the electric shock control parameters via buttons and a display screen. It can also be configured with a power-off memory function, enabling the generation of corresponding electric shock control signals to be provided to the electric shock electrodes 120 during experiments. Further optionally, the electric shock control parameters include electric shock voltage, electric shock current, stimulation time, and stimulation mode. The electric shock voltage range can be 0.1-200V, the electric shock current range can be 0.1-999mA, and the stimulation mode can include various modes such as P1 mode (continuous discharge stimulation after a delay of T1 time) and P2 mode (continuous discharge stimulation after a T2 time, followed by power-off), thereby meeting various experimental needs.

[0031] Based on the above technical solution, optionally, the electric shock control module 300 includes a safety protection unit, which provides at least one of overvoltage protection, overcurrent protection, and leakage protection, thereby preventing equipment malfunctions from injuring experimental subjects and researchers. Furthermore, upon detecting an abnormal situation, it can automatically cut off the electric shock control signal and issue an alarm to ensure experimental safety. Additionally, the electric shock control module 300 can internally employ a constant voltage and constant current control circuit to ensure a stable output of the electric shock control signal under set parameters.

[0032] Based on the above technical solutions, alternatives include, for example... Figure 2As shown, the device also includes a data acquisition and processing module 400, used to synchronously acquire respiratory function parameters processed in real time by the volumetric recording module 200, and electric shock control parameters used in real time by the electric shock control module 300. The data acquisition and processing module 400 can integrate, process, and store the acquired respiratory function parameters and electric shock control parameters according to time, forming a synchronous experimental data record for synchronous monitoring. Furthermore, it can perform correlation analysis on the two data sets to uncover their intrinsic relationship and accurately reveal the comprehensive physiological and behavioral changes in animals during electric shock stimulation, providing more research value than existing technologies. The data processing software in the data acquisition and processing module 400 can be independently developed or further developed using mature commercial data analysis software platforms. This allows for the utilization of its powerful data analysis functions and rich algorithm library, expanding the overall device's data processing and analysis capabilities to meet the personalized needs of different researchers.

[0033] The volumetric plethysmography device with electric shock function provided in this embodiment includes a breathing chamber, a volumetric plethysmography module, and an electric shock control module. A respiratory detection sensor is installed on the wall of the breathing chamber to collect respiratory data from the experimental subject inside the chamber and transmit the collected respiratory data to the volumetric plethysmography module for processing. Electric shock electrodes are installed at the bottom of the breathing chamber to provide electric shock stimulation to the experimental subject inside. The electric shock control module transmits electric shock control signals to the electric shock electrodes to control the stimulation mode. By integrating the electric stimulation function into the breathing chamber, respiratory function detection and electric shock stimulation can be completed in the same space within the chamber. Researchers do not need to switch between different devices, simplifying the experimental procedure, reducing experimental time, and improving experimental efficiency. Furthermore, it allows for simultaneous monitoring of respiratory function data and behavioral response data under electric shock stimulation in the same environment, reducing the risk of changes in the experimental subject's state, improving data correlation and accuracy, and reducing the space occupied by the equipment. This facilitates equipment placement and experimental implementation, optimizes laboratory resource allocation, and provides an efficient and comprehensive experimental tool for biomedical research.

[0034] Note that the above description is merely a preferred embodiment of the present invention and the technical principles employed. Those skilled in the art will understand that the present invention is not limited to the specific embodiments described herein, and various obvious changes, readjustments, and substitutions can be made without departing from the scope of protection of the present invention. Therefore, although the present invention has been described in detail through the above embodiments, the present invention is not limited to the above embodiments, and may include many other equivalent embodiments without departing from the concept of the present invention. The scope of the present invention is determined by the scope of the appended claims.

Claims

1. A volumetric recording device with an electric shock function, characterized in that, include: The device includes a breathing chamber, a plethysmography module, and an electric shock control module; among which, A respiratory detection sensor is installed on the wall of the breathing chamber. The respiratory detection sensor is used to collect the respiratory data of the experimental subject inside the breathing chamber and transmit the respiratory data to the volume recording module. An electric shock electrode is provided at the bottom of the breathing canister, and the electric shock control module is used to transmit electric shock control signals to the electric shock electrode.

2. The volumetric recording device with electric shock function according to claim 1, characterized in that, The electric shock electrode is a grid electrode.

3. The volumetric recording device with electric shock function according to claim 1, characterized in that, The electric shock electrode is a conductive metal electrode or a conductive rubber electrode.

4. The volumetric recording device with electric shock function according to claim 1, characterized in that, The breathing detection sensor includes a flow sensor disposed on the top of the breathing tank and a pressure sensor disposed on the side of the breathing tank. The flow sensor is used to detect changes in airflow inside the tank caused by the breathing of the experimental subject, and the pressure sensor is used to detect fluctuations in air pressure inside the tank caused by the breathing of the experimental subject.

5. The volumetric recording device with electric shock function according to claim 1, characterized in that, The respiratory detection sensor includes an airflow sensor based on the laser Doppler effect.

6. The volumetric recording device with electric shock function according to claim 1, characterized in that, The volumetric recording module includes a temperature sensor and a humidity sensor, which are used to detect temperature and humidity data in the experimental environment, respectively.

7. The volumetric recording device with electric shock function according to claim 1, characterized in that, The electric shock control module includes a control panel for setting electric shock control parameters.

8. The volumetric recording device with electric shock function according to claim 7, characterized in that, The electric shock control parameters include electric shock voltage, electric shock current, stimulation time, and stimulation mode.

9. The volumetric recording device with electric shock function according to claim 1, characterized in that, The electric shock control module includes a safety protection unit, which is used for at least one of overvoltage protection, overcurrent protection, and leakage protection.

10. The volumetric recording device with electric shock function according to claim 1, characterized in that, The device also includes a data acquisition and processing module, used to synchronously acquire respiratory function parameters obtained in real time by the volume plethysmography module, as well as electric shock control parameters used in real time by the electric shock control module.

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