Interpretation equipment of chemiluminescence immunoassay analyzer

Abstract

The utility model discloses a chemiluminescence immunoassay analyzer interpretation device which comprises a conveying module, an interpretation module and a liquid suction module, the conveying module comprises a rotating disc and a rotation driving mechanism, the rotating disc is provided with a plurality of reaction cup placing positions which are annularly and uniformly distributed at intervals around the central axis of the rotating disc; the rotation driving mechanism is used for driving the turntable to rotate around the central axis of the turntable, and the plurality of reaction cup placing positions are sequentially provided with a taking and placing station, an interpretation station and a liquid suction station on a rotation track; the interpretation module is arranged at the interpretation station and comprises a photon reader; the liquid suction module is arranged at the liquid suction station and used for sucking reactants in the reaction containers, the multiple reaction containers are driven by the rotating disc to sequentially pass through the taking and placing station, the interpretation station and the liquid suction station, continuous cyclic interpretation is achieved, the interpretation efficiency is improved, the liquid suction module is integrated on the interpretation equipment, the number of movement steps of the reaction containers is reduced, and the interpretation efficiency is improved. And equipment cost is saved. The utility model is suitable for the technical field of analysis equipment.

Description

Technical Field

[0001] This utility model relates to the technical field of chemiluminescence immunoassay analyzers, specifically a chemiluminescence immunoassay analyzer interpretation device. Background Technology

[0002] Chemiluminescence immunoassay is a technique that combines highly sensitive chemiluminescence assay with highly specific immunoreaction to detect and analyze various antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins, and drugs.

[0003] Currently, the reading mechanism of existing chemiluminescence immunoassay analyzers only performs photon readings of the reaction results in the reaction vessel and has only one reading position. This means that when one reaction vessel is being read, the next reaction vessel cannot be placed in the reading mechanism; the previous vessel must be removed after the previous reading is completed before the next vessel can be placed. This reduces reading efficiency and requires manual removal, preventing automated container handling. Furthermore, reactant residue remains in the reaction vessel after reading. The usual method is to use a dedicated liquid aspiration mechanism to move the reaction vessel to a designated location and remove the residue. This requires additional liquid aspiration, increases the number of reaction vessel movement steps, and raises equipment costs. Utility Model Content

[0004] This invention aims to solve at least one of the technical problems existing in the prior art. To this end, this invention provides a chemiluminescence immunoassay analyzer reading device, which solves the problems of long reading waiting time and the need for a dedicated liquid aspiration module.

[0005] A chemiluminescence immunoassay analyzer reading device according to a first aspect of the present invention includes:

[0006] The conveying module includes a turntable and a rotation drive mechanism. The turntable has multiple reaction cup placement positions that are evenly spaced in a ring around the central axis of the turntable. The multiple reaction cup placement positions are used to load reaction containers. The rotation drive mechanism is used to drive the turntable to rotate around the central axis of the turntable. The multiple reaction cup placement positions are sequentially provided with a pick-up and place station, a reading station and a liquid aspiration station on the rotation trajectory.

[0007] An interpretation module is located at the interpretation station. The interpretation module includes a photon reader, which is used to interpret the reactants in the reaction vessel.

[0008] A liquid suction module is provided at the liquid suction station, and the liquid suction module is used to suction the reactants in the reaction vessel.

[0009] A chemiluminescence immunoassay analyzer reading device according to an embodiment of the present invention has at least the following features:

[0010] Beneficial effects:

[0011] This invention utilizes a turntable to enable continuous cyclic reading of reaction cups placed on it. After the reaction container is placed into the reading module, the turntable rotates the container, allowing new reaction cups to be placed in for reading without waiting for the reading to finish. This reduces the pressure of transferring reaction cups and improves reading efficiency. Furthermore, this invention integrates a liquid suction module into the reading device, allowing waste liquid to be suctioned away on-site. This saves on the steps of moving reaction cups during the reading process, reducing space requirements and equipment costs.

[0012] According to some embodiments of the present invention, the liquid suction module includes a liquid suction needle and a vacuum mechanism connected to each other. The liquid suction needle is located at the liquid suction station and is adjustable in a vertical direction.

[0013] According to some embodiments of the present invention, the liquid aspiration module further includes an up-and-down driving mechanism, which is connected to the liquid aspiration needle and is used to drive the liquid aspiration needle to move up and down.

[0014] According to some embodiments of the present invention, the liquid aspiration module includes a mounting block and a bracket, the liquid aspiration needle is mounted on the mounting block, and the mounting block is slidably mounted on the bracket.

[0015] According to some embodiments of the present invention, a plurality of reaction cup placement positions are provided with grooves extending vertically, and the outer peripheral wall of the turntable is provided with a plurality of detection holes, the plurality of detection holes being connected to the ends of the plurality of grooves.

[0016] According to some embodiments of the present invention, the photon reader is disposed on the outer periphery of the turntable and is arranged opposite to the detection hole.

[0017] According to some embodiments of the present invention, the interpretation module further includes a light-shielding block, which is attached to the outer periphery of the turntable and at least covers the outer periphery of the detection hole located at the interpretation station. The light-shielding block is used to shield the detection hole from light.

[0018] According to some embodiments of the present invention, a protective cover is also included, which is fitted over the outside of the turntable and the reading mechanism.

[0019] According to some embodiments of the present invention, the protective cover is provided with a liquid suction hole and a pick-up and drop-out hole, the liquid suction hole being located at the liquid suction station and the pick-up and drop-out hole being located at the pick-up and drop-out station.

[0020] According to some embodiments of the present invention, it further includes a pick-and-place module, which is disposed at the pick-and-place station and is used to transfer the reaction vessel on the reaction cup placement position.

[0021] Other features and advantages of this invention will be set forth in the description which follows, and will be apparent in part from the description, or may be learned by practicing the invention. Attached Figure Description

[0022] The present invention will be further described below with reference to the accompanying drawings and embodiments, wherein:

[0023] Figure 1 This is a schematic diagram of the structure of a chemiluminescence immunoassay analyzer reading device according to one embodiment of the present invention;

[0024] Figure 2 This is a schematic diagram of the structure of a chemiluminescence immunoassay analyzer reading device according to another perspective of one embodiment of the present invention;

[0025] Figure 3 This is a schematic diagram of the structure of a chemiluminescence immunoassay analyzer reading device according to the present invention after the protective cover is installed in one embodiment;

[0026] Figure 4 This is a top view schematic diagram of an embodiment of a chemiluminescence immunoassay analyzer interpretation device of the present invention.

[0027] Icon labels:

[0028] Conveying module 100; Pick-up and drop-off station 101; Liquid suction station 102; Interpretation station 103; Turntable 110; Reaction cup placement station 111; Detection hole 112; Rotation drive mechanism 120; Protective cover 130; Liquid suction hole 131; Pick-up and drop-off hole 132;

[0029] Interpretation module 200; photon reader 210; fixing plate 211; light shield 220;

[0030] Liquid suction module 300; liquid suction needle 310; up and down drive mechanism 320; mounting block 331; bracket 332;

[0031] Base plate 400; support column 410. Detailed Implementation

[0032] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this utility model, and should not be construed as limiting this utility model.

[0033] In the description of this utility model, it should be understood that the orientation descriptions, such as up, down, etc., are based on the orientation or positional relationship shown in the drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0034] In the description of this utility model, "several" refers to two or more. The use of "first" and "second" is for distinguishing technical features only and should not be construed as indicating or implying relative importance, or implicitly indicating the number of technical features or their sequential relationship.

[0035] In the description of this utility model, unless otherwise explicitly defined, terms such as "setting," "installation," and "connection" should be interpreted broadly, and those skilled in the art can reasonably determine the specific meaning of the above terms in this utility model in conjunction with the specific content of the technical solution.

[0036] The technical solution of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the embodiments described below are some embodiments of this utility model, not all embodiments.

[0037] Chemiluminescence immunoassay is a technique that combines highly sensitive chemiluminescence assay with highly specific immunoreaction to detect and analyze various antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins, and drugs.

[0038] Currently, the reading mechanism of existing chemiluminescence immunoassay analyzers only performs photon readings of the reaction results in the reaction vessel and has only one reading position. This means that when one reaction vessel is being read, the next reaction vessel cannot be placed in the reading mechanism; the previous vessel must be removed after the previous reading is completed before the next vessel can be placed. This reduces reading efficiency and requires manual removal, preventing automated container handling. Furthermore, reactant residue remains in the reaction vessel after reading. The usual method is to use a dedicated liquid aspiration mechanism to move the reaction vessel to a designated location and remove the residue, adding the need for a dedicated aspiration mechanism and reaction vessel movement steps, thus increasing equipment costs.

[0039] To address the aforementioned issues, this invention proposes a chemiluminescence immunoassay analyzer reading device, which effectively solves the problems of long reading waiting time and the need for a dedicated liquid aspiration module 300.

[0040] refer to Figure 1 , Figure 2 , Figure 3 and Figure 4 The present invention provides the following embodiments of a chemiluminescence immunoassay analyzer reading device:

[0041] Reference Figure 1 As shown, the interpretation device of this utility model embodiment includes a conveying module 100, an interpretation module 200, and a liquid suction module 300. The conveying module 100, the interpretation module 200, and the liquid suction module 300 are mounted on the same base plate 400 to integrate the various modules of the interpretation device, facilitating overall movement and handling. The base plate 400 is connected to multiple evenly distributed support columns 410. The base plate 400 and the support columns 410 support and support the interpretation device, while lifting the interpretation device off the ground to facilitate user operation and improve the user experience.

[0042] Specifically, the delivery module 100 is used to drive multiple reaction containers to perform continuous cyclic movement, the interpretation module 200 is used to perform chemiluminescent immunoassay on the reaction containers, and the liquid aspiration module 300 is used to aspirate the reactants in the interpreted reaction containers. In some embodiments, the interpretation device also includes a pick-and-place module, which is used to remove the aspirated reaction containers and place new reaction containers.

[0043] The conveying module 100 includes a turntable 110 and a rotation drive mechanism 120. The turntable 110 is located above the base plate 400. The turntable 110 has a plurality of reaction cup placement positions 111 that are evenly spaced in a ring around the central axis of the turntable 110. The plurality of reaction cup placement positions 111 are used to load reaction containers. The reaction cup placement positions 111 have grooves that connect to the upper surface of the turntable 110 and extend vertically. The reaction containers extend into the grooves from top to bottom to complete the placement and fixation of the reaction containers in the reaction cup placement positions 111.

[0044] In some other embodiments, the reaction cup placement position 111 can fix the reaction vessel by other structures, such as an openable gripping mechanism, as long as the fixation requirements of the reaction vessel are met.

[0045] The rotation drive mechanism 120 is connected to the turntable 110 for transmission. The rotation drive mechanism 120 is used to drive the turntable 110 to rotate around the central axis of the turntable 110 so that the reaction containers in the multiple reaction cup placement positions 111 can rotate continuously in a cycle. By setting multiple reaction cup placement positions 111 and the turntable 110 drive mechanism that enables the reaction cup placement positions 111 to rotate continuously in a cycle, continuous cyclic reading is achieved. The reaction container does not need to wait for its reading to finish before a new reaction container can be placed on the next reaction cup placement position 111, avoiding the waiting time of the reading step and improving the reading efficiency.

[0046] Specifically, the rotation drive mechanism 120 is a rotation motor. To save space and reduce the area occupied on the plane, the rotation drive mechanism 120 is installed on the lower side of the base plate 400.

[0047] In this embodiment, there are four reaction cup placement positions 111. The number of reaction cup placement positions 111 can be adjusted according to the actual demand of the reactants to be analyzed. In other embodiments, the reaction vessel can be continuously moved in a cycle in other ways, such as by a water conveyor line connected end to end.

[0048] Multiple reaction cup placement positions 111 are sequentially provided with a pick-and-place station 101, a reading station 103, and a liquid suction station 102 on the rotational trajectory, so that the reading device performs the following sequentially on the reaction cup placement positions 111 on the rotational trajectory: placing the reaction container containing the reactants, reading the reactants in the reaction container, emptying the reactants in the reaction container, and taking out the empty reaction container.

[0049] The interpretation module 200 is located at the interpretation station 103. The interpretation module 200 includes at least a photon reader 210 for interpreting the reactants in the reactor. It should be noted that in the interpretation of chemiluminescence immunoassay, the photon reader 210 is used to measure the yield of light quantum signals generated by the reactants during the chemiluminescence process. Therefore, it is necessary to avoid ambient light from entering the photon reader 210 as much as possible in order to improve the accuracy of the interpretation by the photon reader 210.

[0050] To reduce the impact of ambient light on the interpretation of chemiluminescence immunoassay, the reaction vessel is placed in the groove of the reaction cup placement position 111. The outer peripheral wall of the turntable 110 is provided with multiple detection holes 112, which are connected to the ends of multiple grooves, so that the detection holes 112 are positioned opposite to the reactants in the reaction vessel. The photon reader 210 is located on the outside of the turntable 110, so that the photon reader 210 can detect the photon signals generated by the reactants through the detection holes 112. At the same time, ambient light can only enter from the other end of the detection holes 112 or the grooves. The other parts of the reaction vessel are surrounded by the turntable 110, which greatly reduces the possibility of ambient light entering the photon reader 210.

[0051] Furthermore, the interpretation module 200 also includes a light-shielding block 220, which is attached to the outer periphery of the turntable 110 and at least covers the outer periphery of the detection hole 112 located at the interpretation station 103. The light-shielding block 220 is used to prevent ambient light from entering the photon reader 210 between the photon reader 210 and the detection hole 112, which would cause errors in the interpretation result and the actual result, so that the photon reader only receives the photon quantum signal generated by the chemiluminescence of the reactants.

[0052] The interpretation module 200 also includes a fixing plate 211, which is located on the side of the turntable 110 and is used to install and fix the photon reader 210. The fixing plate 211 is fixed to the base plate 400 by screws.

[0053] The liquid suction module 300 is located at the liquid suction station 102 and includes at least a liquid suction needle 310 and a vacuum mechanism (not shown in the figure). The liquid suction needle 310 and the vacuum mechanism are connected to each other. The vacuum mechanism draws a vacuum so that the reactants in the reaction container are sucked into the liquid suction needle 310 under atmospheric pressure, thereby removing the reactants in the reaction container.

[0054] To prevent the aspiration needle 310 from colliding with the reaction vessel during continuous rotation and causing equipment damage, the aspiration module 300 also includes an up-and-down drive mechanism 320, a mounting block 311, and a bracket 332. The up-and-down drive mechanism 320 is connected to the aspiration needle 310 for transmission. The up-and-down drive mechanism 320 is used to drive the aspiration needle 310 to move up and down. The aspiration needle 310 is mounted on the mounting block 311, and the mounting block 311 is slidably mounted on the bracket 332. The bracket 332 and the mounting block 311 guide the movement of the aspiration needle 310. At the same time, the bracket 332 is mounted on the upper side of the base plate 400 to support the aspiration needle 310, so that the aspiration needle 310 is suspended above the turntable 110.

[0055] Regarding the specific structure of the liquid aspiration module 300, the bracket 332 is an L-shaped component, with its bottom end connected to the base plate 400 by screws. The bracket 332 has a protrusion arranged in the vertical direction, and the mounting block 311 has a groove that matches the protrusion. Through the mutual cooperation between the groove and the protrusion, the mounting block 311 can slide in the vertical direction. The vertical drive mechanism 320 is a lead screw motor located next to the bracket 332. The lead screw motor is connected to the mounting block 311. The lead screw motor drives the mounting block 311 to move vertically, thereby controlling the vertical movement of the liquid aspiration needle 310. The mounting block 311 has a fixing part that extends horizontally. The fixing part has a fixing hole that matches the liquid aspiration needle 310. The liquid aspiration needle 310 is installed through the fixing hole with its needle tip facing downward.

[0056] This embodiment integrates the liquid aspiration module 300 into the interpretation device, and the reactants can be removed by the liquid aspiration module 300 during continuous cyclic interpretation, without the need to transfer the reaction container to a dedicated waste liquid removal device. This reduces the movement steps of the reaction container, improves interpretation efficiency, and saves equipment cost and space because there is no need to set up a dedicated waste liquid removal mechanism. At the same time, it enriches the functions of the interpretation device and improves the degree of integration.

[0057] When the turntable 110 rotates, it drives one of the reaction cup placement positions 111 to rotate to the liquid suction position 102. When the liquid suction needle 310 moves downward from the default position to the liquid suction position, the liquid suction needle 310 extends into the liquid surface of the reactants. The vacuum mechanism is activated, and the reactants are sucked into the liquid suction needle 310 under the action of vacuum. The vacuum mechanism stops, and the turntable 110 can only rotate again after the liquid suction needle 310 moves upward from the liquid suction position back to the default position and completes one liquid suction process.

[0058] The interpretation device in this embodiment also includes a protective cover 130, which is sleeved on the outside of the turntable 110 and the interpretation mechanism to protect the internal structure and prevent the reactants in the reaction vessel from being contaminated or the complex structures such as the turntable 110 and the photon reader 210 from being impacted by external forces. At the same time, it can further reduce the amount of ambient light entering the photon reader 210 to improve the interpretation accuracy. The protective cover 130 has a cuboid structure and multiple connection holes on the bottom side. The protective cover 130 is connected to the base plate 400 by bolts installed in the multiple connection holes.

[0059] To prevent the protective cover 130 from obstructing the handling of the reaction vessel and the removal of reactants, the protective cover 130 is provided with a suction hole 131 and a pick-and-place hole 132. The suction hole 131 is located at the suction station 102, specifically at the projection position of the suction needle 310 in the vertical direction, so that the suction needle 310 can move up and down through the suction hole 131 to draw reactants from the reaction vessel. The pick-and-place hole 132 is located at the pick-and-place station 101, so that the pick-and-place module can pass through the protective cover 130, providing space for the pick-and-place module to transfer the reaction vessel.

[0060] Regarding the usage of the chemiluminescence immunoassay analyzer reading device provided in this embodiment: the reaction containers are placed one by one by the pick-and-place module into the reaction cup placement position 111 of the pick-and-place station 101. The turntable 110 drives the reaction containers to rotate. When they reach the reading station 103, the photon reader 210 reads the reactants in the reaction containers through the detection hole 112. When the reaction containers that have completed the reading reach the liquid aspiration station 102, the liquid aspiration needle 310 removes the reactants from the reaction containers. When the reaction containers that have completed the removal of reactants reach the pick-and-place station 101, the pick-and-place module takes out the reaction containers and places new reaction containers.

[0061] The chemiluminescence immunoassay analyzer reading device provided in this embodiment uses a turntable 110 to drive the reaction cup placement position 111 to rotate continuously in a cycle, thereby achieving continuous reading and improving reading efficiency. By setting a liquid aspiration module 300 in the rotation trajectory, the transfer pressure of the reaction container is reduced, which can reduce the number of transfer steps of the reaction container, further improving the experimental efficiency, saving equipment costs and space. By utilizing the cooperation of the reading module 200, the delivery module 100, the liquid aspiration module 300 and the pick-and-place module, the chemiluminescence immunoassay test can be automated without the need for personnel supervision, which greatly saves labor costs.

[0062] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0063] The embodiments of the present utility model have been described in detail above with reference to the accompanying drawings. However, the present utility model is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present utility model.

Claims

1. A chemiluminescence immunoassay analyzer reading device, characterized in that, include: The conveying module includes a turntable and a rotation drive mechanism. The turntable has multiple reaction cup placement positions that are evenly spaced in a ring around the central axis of the turntable. The multiple reaction cup placement positions are used to load reaction containers. The rotation drive mechanism is used to drive the turntable to rotate around the central axis of the turntable. The multiple reaction cup placement positions are sequentially provided with a pick-up and place station, a reading station and a liquid aspiration station on the rotation trajectory. An interpretation module is located at the interpretation station. The interpretation module includes a photon reader, which is used to interpret the reactants in the reaction vessel. A liquid suction module is provided at the liquid suction station, and the liquid suction module is used to suction the reactants in the reaction vessel.

2. The interpretation device according to claim 1, characterized in that: The liquid suction module includes a liquid suction needle and a vacuum mechanism connected to each other. The liquid suction needle is located at the liquid suction station and is adjustable in height.

3. The interpretation device according to claim 2, characterized in that: The liquid aspiration module also includes an up-and-down driving mechanism, which is connected to the liquid aspiration needle and is used to drive the liquid aspiration needle to move up and down.

4. The interpretation device according to claim 3, characterized in that: The liquid aspiration module includes a mounting block and a bracket. The liquid aspiration needle is mounted on the mounting block, and the mounting block is slidably mounted on the bracket.

5. The interpretation device according to claim 1, characterized in that: The reaction cup placement positions are provided with grooves extending vertically, and the outer peripheral wall of the turntable is provided with multiple detection holes, which are connected to the ends of the multiple grooves.

6. The interpretation device according to claim 5, characterized in that: The photon reader is located on the outer periphery of the turntable and is positioned opposite to the detection hole.

7. The interpretation device according to claim 6, characterized in that: The interpretation module also includes a light-shielding block, which is attached to the outer periphery of the turntable and at least covers the outer periphery of the detection hole located at the interpretation station. The light-shielding block is used to shield the detection hole from light.

8. The interpretation device according to claim 1, characterized in that: It also includes a protective cover, which is fitted over the outside of the turntable and the reading device.

9. The interpretation device according to claim 8, characterized in that: The protective cover is provided with a liquid suction hole and a pick-up and drop-out hole. The liquid suction hole is located at the liquid suction station, and the pick-up and drop-out hole is located at the pick-up and drop-out station.

10. The interpretation device according to claim 1, characterized in that: It also includes a pick-and-place module, which is located at the pick-and-place station and is used to transfer the reaction vessel on the reaction cup placement position.

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