Circulating pipeline system for hyperthermic perfusion chemotherapy

Abstract

A circulation pipeline system used for hyperthermic perfusion chemotherapy comprises a perfusion fluid power pipeline, which is provided with a fluid injection end, a fluid outlet end and a fluid return end; the crossed access body pipeline comprises a first pipeline, a second pipeline, a third pipeline and a fourth pipeline, the first pipeline and the second pipeline are provided with opposite access ends and connecting ends, the connecting end of the first pipeline is communicated with the liquid return end, and the connecting end of the second pipeline is communicated with the liquid outlet end; the connecting-in end of the first pipeline and the connecting-in end of the second pipeline are used for being connected into a patient body cavity, the third pipeline is communicated with the fourth pipeline in a crossed mode, the two ends of the third pipeline are communicated with the first pipeline and the second pipeline respectively, and the two ends of the fourth pipeline are communicated with the first pipeline and the second pipeline respectively. According to the device, sediments on the pipe wall can be stripped through impact of in-out body reverse fluid, deposition and blockage are avoided, meanwhile, by means of the flow dividing, cross mixing and reverse rotational flow effects generated by water flow, a medicament can be rapidly and evenly spread over the whole water body, and continuity of medicament perfusion is guaranteed.

Description

Technical Field

[0001] This application relates to the field of medical device technology, specifically to a circulation tubing system for hyperthermic perfusion chemotherapy. Background Technology

[0002] Hyperthermic perfusion therapy for tumors is an innovative treatment based on the synergistic effect of hyperthermia and chemotherapy, primarily used clinically as adjuvant therapy after surgery or palliative tumor resection. Its core principle is as follows: A saline solution containing anticancer drugs (such as mitomycin C, gemcitabine, etc.) is heated to an effective temperature (usually 42℃~45℃) using an external heating device. This solution is then continuously injected into the patient's body cavities (such as the pleural cavity, abdominal cavity, or bladder) via a fluid circulation system. This allows the hyperthermic chemotherapy solution to directly target residual lesions and free cancer cells, enhancing the tumor cell killing effect while reducing the risk of postoperative recurrence.

[0003] Currently, hyperthermic perfusion chemotherapy is typically performed using specialized hyperthermic perfusion equipment in conjunction with infusion devices and tubing. However, in practical applications, existing perfusion tubing systems are prone to deposits and blockages due to the potential crystallization of chemotherapy drugs (such as mitomycin C) and the resulting turbid and viscous fluid in some patients, affecting the continuity of perfusion. Utility Model Content

[0004] This application provides a circulating tubing system for hyperthermic perfusion chemotherapy, which can reduce the deposition and blockage of chemotherapy drugs in the tubing and ensure the continuity of drug perfusion.

[0005] According to one aspect of this application, one embodiment provides a circulating tubing system for hyperthermic perfusion chemotherapy, comprising:

[0006] The injection fluid power pipeline has an injection end, an outlet end, and a return end; and

[0007] The cross-access tubing includes a first tubing, a second tubing, a third tubing, and a fourth tubing. The first tubing and the second tubing have access ends and connection ends opposite each other along their respective lengths. The connection end of the first tubing communicates with the return fluid end, and the connection end of the second tubing communicates with the outlet fluid end. The access ends of the first tubing and the second tubing are used to connect to the patient's body cavity.

[0008] The third pipeline and the fourth pipeline are intersecting and connected, and the third pipeline is connected to the first pipeline and the second pipeline at opposite ends in its length direction, and the fourth pipeline is connected to the first pipeline and the second pipeline at opposite ends in its length direction.

[0009] In another embodiment, the intersection angle between the third and fourth pipes is between 60° and 80°, and / or, the diameter of the third and fourth pipes is 7 mm; and / or, in the length direction of the first pipe, the distance between the intersection of the third and fourth pipes and the access end of the first pipe is 15 cm; in the length direction of the second pipe, the distance between the intersection of the third and fourth pipes and the access end of the second pipe is 15 cm.

[0010] In another embodiment, the cross-inlet / outlet pipeline further includes a fifth pipeline, one end of which is connected to the connection end of the first pipeline or the return end, and the other end of which is connected to the connection end of the second pipeline or the outlet end; and a fifth check valve is provided on the fifth pipeline to control the flow rate of the injection fluid in the fifth pipeline.

[0011] In another embodiment, a first stop valve is provided on the first pipeline, and the first stop valve is located between the connection point of the first pipeline and the third pipeline and the connection point of the first pipeline and the fourth pipeline; a second stop valve is provided on each of the second pipelines, and the second stop valve is located between the connection point of the second pipeline and the third pipeline and the connection point of the second pipeline and the fourth pipeline.

[0012] In another embodiment, both the inlet and outlet valves are provided at the inlet end of the first pipeline and the inlet end of the second pipeline, and the inlet and outlet valves are used to adjust the opening and closing of the first pipeline and the second pipeline; a third stop valve is provided on the third pipeline, and a fourth stop valve is provided on the fourth pipeline.

[0013] In another embodiment, the injection fluid power line further includes a temperature measuring element, which is disposed at the outlet end and the return end.

[0014] In another embodiment, the injection fluid power line includes an injection line, a collection container having the return end, a circulation pump, and a heating line connected in sequence. The end of the injection line away from the collection container in its length direction is the injection end, and the end of the heating line away from the circulation pump in its length direction is the outlet end.

[0015] In another embodiment, the heating conduit includes a heating tube that is bent and extended.

[0016] In another embodiment, the heating tube is a U-shaped tube, and the heating length of the heating tube is between 30-50cm.

[0017] In another embodiment, the heating tube is a metal tube with a polished inner surface, and the heating tube is heated by an external heating unit.

[0018] According to the above embodiment of the circulating tubing system for hyperthermic perfusion chemotherapy, the chemotherapy drug enters the cross-inlet / outlet tubing from the outlet end. The hyperthermic perfusion fluid containing the chemotherapy drug is diverted through the cross-inlet / outlet tubing composed of the first, second, third, and fourth tubings, and finally enters the human body for treatment along the inlet end of the second tubing. At the same time, the inlet end of the first tubing is simultaneously aspirated and returned to the hyperthermic perfusion fluid circulation tubing through the return end, forming a dynamic circulation. Through the cross channel, the reverse fluid impact of the inlet and outlet can be used to remove deposits from the tube wall, avoiding deposition and blockage. At the same time, the diversion, cross mixing, and reverse swirling effect generated by the water flow can enable the drug to be rapidly and evenly distributed throughout the water body, ensuring the continuity of drug perfusion. Attached Figure Description

[0019] Figure 1 This is an overall schematic diagram of a circulating tubing system used for hyperthermic perfusion chemotherapy;

[0020] Figure 2 This is a schematic diagram of the overall structure of the cross-inlet / outlet pipes in one embodiment;

[0021] Figure 3 This is a schematic diagram of the overall structure of the injection fluid power pipeline in one embodiment;

[0022] Figure 4 This is a schematic diagram of the overall structure of the injection pipeline in one embodiment.

[0023] Figure label:

[0024] 1. Power pipeline for injection fluid;

[0025] 11. Injection pipeline; 111. Injection pipe; 112. Injection connector; 113. Injection check valve; 114. Three-way dosing connector; 115. Protective cap;

[0026] 12. Liquid collection container; 121. Liquid collection bag; 122. Liquid collection tube;

[0027] 13. Circulating pump; 131. Pump pipe;

[0028] 14. Heating pipe; 141. Heating pipe; 142. Connecting pipe;

[0029] 15. Temperature measuring element;

[0030] 16. Liquid injection end; 17. Liquid return end; 18. Liquid outlet end;

[0031] 19. Pressure testing component; 191. Pressure testing tube; 192. Pressure testing connector; 193. Pressure testing check valve; 194. Three-way pressure testing connector;

[0032] 2. Cross-flow / outlet pipes;

[0033] 21. First pipeline; 211. T-junction; 212. Tapered connector; 213. Protective cap; 214. First check valve;

[0034] 22. Second pipeline; 221. Tee-joint; 222. Tapered joint; 223. Protective cap; 224. Second check valve;

[0035] 23. Third pipeline; 231. Third check valve;

[0036] 24. Fourth pipeline; 241. Fourth check valve;

[0037] 25. Fifth pipeline; 251. Fifth check valve;

[0038] 26. Inlet / outlet valves;

[0039] 27. T-type tee connector;

[0040] 28. Access terminal;

[0041] 29. Connection end. Detailed Implementation

[0042] The present application will now be described in further detail with reference to the accompanying drawings and specific embodiments. Similar elements in different embodiments are referred to by related similar element reference numerals. In the following embodiments, many details are described to facilitate a better understanding of the present application. However, those skilled in the art will readily recognize that some features may be omitted in different situations, or may be replaced by other elements, materials, or methods. In some cases, certain operations related to the present application are not shown or described in the specification. This is to avoid obscuring the core parts of the present application with excessive description. For those skilled in the art, detailed description of these related operations is not necessary; they can fully understand the related operations based on the description in the specification and general technical knowledge in the art.

[0043] Furthermore, the features, operations, or characteristics described in the specification can be combined in any suitable manner to form various embodiments, and the operational steps involved in each embodiment can also be rearranged or adjusted in a manner that is obvious to those skilled in the art. Therefore, the specification and drawings are only for clearly describing a particular embodiment and do not imply that they represent the necessary components and / or order.

[0044] The serial numbers assigned to components in this document, such as "first" and "second," are used only to distinguish the described objects and have no sequential or technical meaning. The terms "connection" and "linkage" used in this application, unless otherwise specified, include both direct and indirect connections (linkages).

[0045] Hyperthermic perfusion therapy for tumors is an innovative treatment based on the synergistic effect of hyperthermia and chemotherapy, primarily used clinically as adjuvant therapy after surgery or palliative tumor resection. Its core principle is as follows: A saline solution containing anticancer drugs (such as mitomycin C, gemcitabine, etc.) is heated to an effective temperature (usually 42℃~45℃) using an external heating device. This solution is then continuously injected into the patient's body cavities (such as the pleural cavity, abdominal cavity, or bladder) via a fluid circulation system. This allows the hyperthermic chemotherapy solution to directly target residual lesions and free cancer cells, enhancing the tumor cell killing effect while reducing the risk of postoperative recurrence.

[0046] In practical applications, existing perfusion tubing systems are prone to deposition and blockage due to the potential crystallization of chemotherapy drugs (such as mitomycin C) and the resulting turbid and viscous fluid after perfusion in some patients, which affects the continuity of perfusion.

[0047] This application provides a circulating tubing system for hyperthermic perfusion chemotherapy, applicable to bladder hyperthermic perfusion scenarios. It connects to a catheter placed in the bladder to form a circulating tubing system. By using cross-flow tubing, it reduces the deposition and blockage of chemotherapy drugs within the tubing, ensuring continuous drug perfusion. This achieves the killing effect of chemotherapy drugs and hyperthermia on superficial bladder tumors. In other embodiments, it can also be applied to the pleural cavity, abdominal cavity, and rectum for treatment.

[0048] Please refer to Figure 1 , Figure 2 and Figure 3 A circulating tubing system for hyperthermic perfusion chemotherapy includes: a perfusion fluid dynamic tubing 1 having an injection end 16, an outlet end 18, and a return end 17; and a cross-entry / exit tubing 2 including a first tubing 21, a second tubing 22, a third tubing 23, and a fourth tubing 24. The first tubing 21 and the second tubing 22 have an access end 28 and a connection end 29 opposite to each other in their respective length directions. The connection end 29 of the first tubing 21 is connected to the return end 17, and the connection end 29 of the second tubing 22 is connected to the outlet end 18. The access end 28 of the first tubing 21 and the access end 28 of the second tubing 22 are used to access the patient's body cavity. The third tubing 23 and the fourth tubing 24 are cross-connected, and the two opposite ends of the third tubing 23 are respectively connected to the first tubing 21 and the second tubing 22 in their respective length directions. The two opposite ends of the fourth tubing 24 are respectively connected to the first tubing 21 and the second tubing 22 in their respective length directions.

[0049] In this embodiment, the injection fluid power line 1 is used to provide heated injection fluid and power to the injection fluid. Please refer to [reference needed]. Figure 1 and Figure 3 The perfusion fluid power line 1 includes a perfusion line 11, a collection container 12 with a return end 17, a circulation pump 13, and a heating line 14 connected in sequence. The end of the perfusion line 11 away from the collection container 12 in its length direction is the perfusion end 16, which is used to inject chemotherapy drugs. The perfusion line 11 is used to deliver chemotherapy drugs into the collection container 12. The circulation pump 13 is used to provide the flow power for the liquid in the line, pumping the perfusion fluid in the collection container 12 into the heating line 14 and heating it. The end of the heating line 14 away from the circulation pump 13 in its length direction is the outlet end 18, and the heated perfusion fluid is discharged from the outlet end 18.

[0050] Please refer to Figure 1 , Figure 2 and Figure 3 According to the circulation pipeline system of the above embodiment, the inlet 28 of the first pipeline 21 and the second pipeline 22 are both connected to a catheter and inserted into the human body cavity, so that the human body cavity, the cross-inlet / outlet pipeline 2 and the cross-inlet / outlet pipeline 2 form a closed pipeline. Under the action of the circulation pump 13, the infusion fluid circulates between the circulation pipeline system and the human body cavity. In this application, the circulation pump 13 circulates the infusion fluid. The heating pipeline 14 and the second pipeline 22 are downstream of the circulation pump 13, and the collection container 12 and the first pipeline 21 are upstream of the circulation pump 13. The infusion fluid is delivered from the inlet 28 of the second pipeline 22 and returned from the inlet 28 of the first pipeline 21. In other embodiments, by changing the pumping direction of the circulation pump 13, the flow direction of the liquid can be changed, and the delivery and return positions can be changed.

[0051] Please refer to Figure 1 , Figure 2 and Figure 3 The heated perfusion fluid enters the second pipeline 22 from the outlet 18. The hot perfusion fluid containing chemotherapy drugs is diverted through the third pipeline 23 and the fourth pipeline 24, and finally enters the human body for treatment through the inlet 28 of the second pipeline 22. At the same time, the inlet 28 of the first pipeline 21 is simultaneously aspirated and returned to the collection container 12 through the return end 17, forming a dynamic circulation. Through the cross channels, the reverse fluid impact of the inlet and outlet can be used to remove the deposits on the pipe wall, avoiding deposition and blockage. At the same time, the diversion, cross mixing and reverse swirling effect generated by the water flow can make the drug quickly and evenly distributed throughout the water body, ensuring the continuity of drug perfusion.

[0052] For further details, please refer to... Figure 1 and Figure 2The third pipe 23 and the fourth pipe 24 are arranged in an "X" shape, and the intersection angle between the third pipe 23 and the fourth pipe 24 is between 60° and 80°.

[0053] Please refer to Figure 1 and Figure 2 In this embodiment, the diameter of the third pipe 23 and the fourth pipe 24 is 7mm. The first pipe 21 and the second pipe 22 adopt the conventional hot perfusion pipe diameter, which is smaller than the diameter of the third pipe 23 and the fourth pipe 24. The specific selection is based on different patients or conditions.

[0054] Please refer to Figure 1 and Figure 2 In the length direction of the first conduit 21, the distance between the intersection of the third conduit 23 and the fourth conduit 24 and the access end 28 of the first conduit 21 is 15cm; in the length direction of the second conduit 22, the distance between the intersection of the third conduit 23 and the fourth conduit 24 and the access end 28 of the second conduit 22 is 15cm. Specifically, when the circulation tubing is used for bladder hyperthermic irrigation, both the first conduit 21 and the second conduit 22 are connected to the catheter interface. Therefore, the access end 28 of the first conduit 21 and the access end 28 of the second conduit 22 mentioned in this application are both catheter interfaces, and the distance between the intersection of the third conduit 23 and the fourth conduit 24 and the catheter interface is 15cm.

[0055] During hyperthermic perfusion chemotherapy, chemotherapeutic drugs (such as mitomycin C) may crystallize, leading to turbid and viscous fluid in some patients, which can easily cause tubing deposition and blockage, affecting the continuity of perfusion. In this embodiment, the circulation of fluid through a cross-pipeline offers several advantages: 1. Wide applicability: The X-type cross-pipeline is suitable for handling various fluids, including medium- to high-viscosity liquids (such as perfused chemotherapeutic drugs) in liquid-liquid reactions, mixing, and absorption processes; it can also adapt to various operating conditions, maintaining stable mixing efficiency even under significant temperature variations. 2. High-efficiency mixing: The X-type cross-pipeline effectively reduces the mixing non-uniformity coefficient, thereby achieving a highly efficient mixing effect. 3. Simple structure and low cost: No external force is required; relying on the diversion, cross-mixing, and reverse swirling effects of the water flow, the drug can be rapidly and uniformly distributed throughout the entire water body.

[0056] This application can improve drug mixing efficiency, prevent leakage and blockage, and simplify operation procedures while ensuring temperature stability, thus meeting clinical needs. Through the modular cross-inlet / outlet tubing 2, reverse flushing can be allowed by switching flow directions, utilizing reverse fluid impact to remove deposits from the tubing wall. The multi-stage flow splitting structure enhances fluid turbulence, improves impurity carrying capacity, and reduces the probability of tubing wall adhesion.

[0057] For further details, please refer to... Figure 1 and Figure 2 The first conduit 21 has a tapered connector 212 at its inlet end 28 for easy mating with a catheter. A protective cap 213 is fitted onto the tapered connector 212 to protect it from dust or debris when not in use. The second conduit 22 has the same structure as the first conduit 21. The second conduit 22 also has a tapered connector 222 at its inlet end 28 for easy mating with a catheter. A protective cap 223 is fitted onto the tapered connector 222 to protect it from dust or debris when not in use.

[0058] For further details, please refer to... Figure 1 and Figure 2 Multiple valves are installed on the cross-flow inlet / outlet pipe 2 to block or adjust the flow rate of the corresponding pipes. Specifically, inlet / outlet valves 26 are provided at the inlet / outlet ends 28 of the first pipe 21 and the second pipe 22, respectively, to adjust the flow of the first pipe 21 and the second pipe 22. The third pipe 23 is connected to the first pipe 21 and the second pipe 22 via T-shaped tee joints 27. A first check valve 214 is installed on the first pipe 21, located between the connection point of the first pipe 21 and the third pipe 23 and the connection point of the first pipe 21 and the fourth pipe 24, that is, between the two T-shaped tee joints 27 on the first pipe 21. A second check valve 224 is provided on the second pipeline 22. The second check valve 224 is located between the connection point of the second pipeline 22 and the third pipeline 23 and the connection point of the second pipeline 22 and the fourth pipeline 24, that is, between the two T-shaped tee joints 27 on the second pipeline 22. A third check valve 231 is provided on the third pipeline 23, and a fourth check valve 241 is provided on the fourth pipeline 24. In this embodiment, the third check valve 231 and the fourth check valve 241 are distributed close to the first pipeline 21.

[0059] For further details, please refer to... Figure 1 and Figure 2 The cross-inlet / outlet pipe 2 also includes a fifth pipe 25. One end of the fifth pipe 25 is connected to the connection end 29 or the return end 17 of the first pipe 21 in the length direction, and the other end of the fifth pipe 25 is connected to the connection end 29 or the outlet end 18 of the second pipe 22. A fifth stop valve 251 is provided on the fifth pipe 25 to control the flow rate of the injection fluid in the fifth pipe 25.

[0060] Please refer to Figure 1 and Figure 2The first pipeline 21 is connected to a three-way diverter 211 at its connection end 29, which is connected to and communicates with the first pipeline 21, the fifth pipeline 25 and the return end 17 respectively. The second pipeline 22 is also connected to a three-way diverter 221 at its connection end 29, which is connected to and communicates with the second pipeline 22, the fifth pipeline 25 and the outlet end 18 respectively, so that the fifth pipeline 25 is connected in parallel with the first pipeline 21 and the second pipeline 22.

[0061] In this embodiment, the inlet / outlet valve 26, the first stop valve 214, the second stop valve 224, the third stop valve 231, the fourth stop valve 241, and the fifth stop valve 251 all employ stop clamps. The inlet / outlet valve 26 and the fifth stop valve 251 are generally used to block the flow of the pipeline, while the first stop valve 214, the second stop valve 224, the third stop valve 231, and the fourth stop valve 241 are generally used to adjust the liquid flow rate. In other embodiments, the pipeline may also employ other devices that can adjust the flow rate / flow rate of the pipeline.

[0062] Before treatment via the tubing system, air in the tubing system is purged to prevent inflammation. Specifically, the fifth check valve 251 is opened, and the two inlet and outlet valves 26 are closed. The infusion fluid is drawn from the collection container 12 by the circulation pump 13 and enters the tubing for internal circulation, so that the tubing is filled with infusion fluid. Therefore, air in the tubing system can be purged in advance.

[0063] For further details, please refer to... Figure 1 The infusion fluid power line 1 also includes a temperature measuring element 15, which is disposed at the outlet end 18 and the return end 17. In this embodiment, the temperature measuring element 15 can be a temperature measuring tube, fixed to the surface of the pipeline at the outlet end 18 and the return end 17, or it can be an in-cavity thermometer, inserted into the liquid to measure the temperature, thereby measuring the temperature of the liquid at the inlet and outlet ends of the cross-inlet / outlet pipeline 2 in real time and accurately, so as to monitor the true temperature of the liquid entering the bladder.

[0064] For further details, please refer to... Figure 1 , Figure 3 and Figure 4The injection line 11 includes an injection tube 111, an injection connector 112, an injection stop valve 113, and a three-way drug delivery connector 114. One end of the injection tube 111 along its length is connected to the collection container 12, and the other end is the injection connector 112. The injection connector 112 can be a needle, used to insert into a drug bag or other drug storage unit to smoothly introduce the drug from the drug bag into the collection container 12. Optionally, a protective cap 115 can be fitted onto the injection connector 112 to protect it from accidental puncture and the entry of external impurities and dust. The injection stop valve 113 is installed on the injection tube 111 to control the opening and closing of the injection tube 111. The three-way drug delivery connector 114 is connected in series with the injection tube 111 and connects the injection tube 111 and the collection container 12. The remaining connector is used for external tubing or needles for drug delivery.

[0065] When the concentration of chemotherapy drugs in the perfusion fluid decreases or before perfusion treatment, open the infusion stop valve 113, connect the drug storage unit through the infusion connector 112, and inject the chemotherapy drugs into the collection container 12. During treatment, other drugs can also be added through the three-way drug delivery connector 114.

[0066] For further details, please refer to... Figure 1 and Figure 3 The liquid collection container 12 includes a liquid collection bag 121 and three liquid collection tubes 122 on the liquid collection bag 121. The three liquid collection tubes 122 are respectively connected to a three-way diverter 211, a three-way dosing connector 114 and a circulation pump 13. In this embodiment, the capacity of the liquid collection bag 121 is 500-1000mL, and the bag body is marked with volume scale lines (not shown in the figure).

[0067] For further details, please refer to... Figure 1 The circulation pump 13 includes a peristaltic pump and a pump pipe 131. The peristaltic pump drives the wheel assembly to compress the hose and drive the liquid in the pipe to flow. The pump pipe 131 has two joints and is connected to the liquid collection pipe 122 and the heating pipe 14 respectively, to extract the liquid in the liquid collection container 12 and provide power for liquid circulation.

[0068] For further details, please refer to... Figure 1 and Figure 3 The heating pipe 14 includes a heating pipe 141 and connecting pipes 142 connected to both ends of the heating pipe 141 along its length. The heating pipe 141 is bent and extended. Specifically, the heating pipe 141 is a U-shaped pipe, and the heating length of the heating pipe 141 is between 30-50cm. The heating pipe 141 is a metal pipe with a polished inner surface, and the heating pipe 141 is heated by an external heating unit.

[0069] In this embodiment, the heating tube 141 is a U-shaped stainless steel heating tube 141, which, in conjunction with microwave or water bath heating, prolongs the contact time between the liquid and the heating surface. With the help of an external heating device (such as microwave or water bath heating), the overall temperature of the treatment solution can be raised more evenly. Higher heat conduction efficiency can be achieved in a limited space, and the treatment solution can be heated to the target temperature (43°C) quickly and maintained at a constant temperature. The temperature difference can be controlled within ±0.3°C, avoiding damage to normal tissues caused by local overheating or a decrease in efficacy caused by insufficient temperature.

[0070] In this embodiment, the bending radius of the heating pipe 141 is 6 times the pipe diameter, and the wall thickness is 0.5 mm. When the injection fluid passes through the U-shaped pipe, the enhanced turbulence effect is amplified. That is, the turbulence formed at the pipe bend can disrupt the laminar boundary layer of the liquid, accelerate heat transfer, shorten the preheating time, and meet the requirements for rapid start-up. At the same time, the bent pipe structure can absorb the pulse pressure fluctuations generated by the circulating pump 13, preventing damage to the internal organs due to sudden pressure increases.

[0071] In this embodiment, the inner surface of the heating tube 141 is electropolished to a roughness Ra≤0.2μm to reduce internal resistance, resulting in a residence time of the infusion fluid of 8-12 seconds and a heating rate of 1℃ / s. The infusion fluid enters the heating tube 141 through the pump tube 131, stays in the heating zone for 8-12 seconds to complete the temperature rise, and after heating, the liquid flows into the bladder through the cross structure, while the first pipeline 21 simultaneously draws back the fluid.

[0072] For further details, please refer to... Figure 1 and Figure 3 Temperature measuring tubes are installed in the connecting pipes 142 at both ends of the heating tube 141 to monitor the temperature of the injection fluid before and after heating in real time. Combined with the liquid temperature at the inlet and outlet of the cross-inlet / outlet pipe 2, the temperature dynamics of the heating tube 141 are adjusted in real time, that is, the overall temperature of the injection fluid is adjusted in real time to maintain the temperature fluctuation ≤ ±0.3℃.

[0073] For further details, please refer to... Figure 1 and Figure 3 The injection fluid power line 1 also includes two sets of pressure measuring elements 19, which are respectively located downstream of the liquid collection container 12 and downstream of the heating line 14, for measuring the inlet pressure and outlet pressure. The pressure measuring element 19 includes a pressure measuring tube 191, a pressure measuring connector 192, and a pressure measuring stop valve 193 installed on the pressure measuring tube 191.

[0074] For details, please refer to Figure 1 and Figure 3The collection bag 121 is connected to the pump tube 131 via a three-way pressure testing connector 194. The other end of the pressure testing tube 191 is connected to one end along its length. The other end of the pressure testing tube 191 is used to connect to an external monitoring device, such as a pressure sensor. A pressure-checking valve 193 is used to adjust the opening and closing of the pressure testing tube 191. The outlet end 18 is configured as one end of an intermediate tube along its length. A three-way pressure testing connector 194 is installed between the other end of the intermediate tube (away from the outlet end 18) and the end of the connecting tube 142 downstream of the heating tube 141. The other end of the three-way pressure testing connector 194 is connected to one end of another pressure testing tube 191 along its length. The other end of the pressure testing tube 191 is used to connect to an external monitoring device, such as a pressure sensor. A pressure-checking valve 193 is used to adjust the opening and closing of the pressure testing tube 191. This monitors the inlet and outlet pressures to prevent excessive pressure from damaging the bladder or insufficient pressure from preventing the infusion fluid from entering the bladder.

[0075] In this embodiment, all pipes in the piping system can be made of flexible hoses, such as medical-grade PVC; regulating valves can be adaptively installed in the pipes in the piping system at the required locations, such as the intermediate pipe position; medical connectors are used for pipe connections as needed.

[0076] The circulating pipeline system disclosed in this application uses a U-shaped stainless steel pipe for heating the heating tube 141. The U-shaped stainless steel structure can increase the heating efficiency of the pipeline by increasing the heating area per square centimeter of the injected liquid during liquid heating. At the same time, increasing the wall thickness can effectively reduce heat loss during injection. Meanwhile, the cross-shaped inlet and outlet structure can effectively avoid the problem of blockage during pipeline injection. The circulating pipeline is an integrated structure, which does not require assembly by medical staff and is convenient and quick to use.

[0077] The circulation piping system in this embodiment requires the following process when in use:

[0078] Piping installation: Connect the U-shaped stainless steel heating tube 141 of the perfusion fluid power pipeline 1 to the patient and place it into the heating tank of the hot perfusion. Connect the injection connector 112 to the drug storage unit and inject the chemotherapy drug into the pipeline. Connect the two cross-entry and exiting access ends 28 to the urinary catheter that is connected to the patient.

[0079] Heating start-up: After pre-filling the pipeline and purging the air, the heating area of ​​the heating tank heats up at a rate of 1℃ / s after power is turned on. When the injection liquid flows through the U-shaped heating tube 141, it stays in the heating zone for 8-12 seconds under the action of spiral turbulence to complete the heating.

[0080] Cross-irrigation: The heated irrigation fluid enters the human body cavity (bladder) through the conical connector 222 of the second pipeline 22 via the catheter. The outflow fluid is simultaneously aspirated and returned through the conical connector 212 of the first pipeline 21 via the catheter. The irrigation fluid is returned to the circulation pipeline through the collection bag 121.

[0081] The above-described specific examples are for illustrative purposes only and are not intended to limit the scope of this invention. Those skilled in the art to which this invention pertains can make various simple deductions, modifications, or substitutions based on the concept of this invention.

Claims

1. A circulating tubing system for hyperthermic perfusion chemotherapy, characterized in that, include: The injection fluid power line (1) has an injection end (16), an outlet end (18) and a return end (17); as well as A cross-connection / exit system (2) includes a first conduit (21), a second conduit (22), a third conduit (23), and a fourth conduit (24). The first conduit (21) and the second conduit (22) have access ends (28) and connection ends (29) opposite each other in their respective length directions. The connection end (29) of the first conduit (21) is connected to the return end (17), and the connection end (29) of the second conduit (22) is connected to the outlet end (18). The access ends (28) of the first conduit (21) and the second conduit (22) are used to connect to the patient's body cavity. The third pipe (23) and the fourth pipe (24) are intersecting and connected, and the third pipe (23) is connected to the first pipe (21) and the second pipe (22) at opposite ends in its length direction, and the fourth pipe (24) is connected to the first pipe (21) and the second pipe (22) at opposite ends in its length direction.

2. The circulation pipeline system as described in claim 1, characterized in that, The intersection angle between the third pipe (23) and the fourth pipe (24) is between 60° and 80°, and / or the diameter of the third pipe (23) and the fourth pipe (24) is 7 mm; and / or, in the length direction of the first pipe (21), the distance between the intersection of the third pipe (23) and the fourth pipe (24) and the access end (28) of the first pipe (21) is 15 cm; in the length direction of the second pipe (22), the distance between the intersection of the third pipe (23) and the fourth pipe (24) and the access end (28) of the second pipe (22) is 15 cm.

3. The circulation pipeline system as described in claim 1, characterized in that, The cross-inlet / outlet pipe (2) also includes a fifth pipe (25), one end of which is connected to the connection end (29) of the first pipe (21) or the return end (17) in the length direction, and the other end of which is connected to the connection end (29) of the second pipe (22) or the outlet end (18); and a fifth stop valve (251) is provided on the fifth pipe (25) to control the flow rate of the injection fluid in the fifth pipe (25).

4. The circulation pipeline system as described in claim 1, characterized in that, A first stop valve (214) is provided on the first pipeline (21), and the first stop valve (214) is located between the connection between the first pipeline (21) and the third pipeline (23) and the connection between the first pipeline (21) and the fourth pipeline (24); a second stop valve (224) is provided on each of the second pipelines (22), and the second stop valve (224) is located between the connection between the second pipeline (22) and the third pipeline (23) and the connection between the second pipeline (22) and the fourth pipeline (24).

5. The circulation pipeline system as described in claim 1, characterized in that, Both the inlet and outlet valves (26) are provided at the inlet end (28) of the first pipeline (21) and the inlet end (28) of the second pipeline (22). The inlet and outlet valves (26) are used to adjust the opening and closing of the first pipeline (21) and the second pipeline (22). A third stop valve (231) is provided on the third pipeline (23), and a fourth stop valve (241) is provided on the fourth pipeline (24).

6. The circulating pipeline system as described in claim 1, characterized in that, The injection fluid power line (1) also includes a temperature measuring element (15), which is disposed at the outlet end (18) and the return end (17).

7. The circulation piping system as described in any one of claims 1-6, characterized in that, The injection fluid power line (1) includes an injection line (11), a collection container (12) with the return end (17), a circulation pump (13), and a heating line (14) connected in sequence. The end of the injection line (11) away from the collection container (12) in its length direction is the injection end (16), and the end of the heating line (14) away from the circulation pump (13) in its length direction is the outlet end (18).

8. The circulation pipeline system as described in claim 7, characterized in that, The heating pipe (14) includes a heating pipe (141), which is bent and extended.

9. The circulation pipeline system as described in claim 8, characterized in that, The heating tube (141) is a U-shaped tube, and the heating length of the heating tube (141) is between 30-50cm.

10. The circulation pipeline system as described in claim 8, characterized in that, The heating tube (141) is a metal tube with a polished inner surface, and the heating tube (141) is heated by an external heating unit.

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