Linear emulsification tank and emulsification system

Abstract

The utility model discloses a linear emulsification tank and emulsification system, including: tank body, stirring mechanism, first pipeline, second pipeline, tank body is equipped with along the horizontal flow channel, stirring mechanism includes: driving piece, stirring shaft and stirring blade, driving piece is connected with tank body, stirring shaft is connected with driving piece, stirring shaft is arranged along the horizontal direction and extends into the flow channel, stirring blade is equipped with stirring blade. The stirring blades are sequentially arranged in the length direction of the stirring shaft rod and used for stirring emulsion and conveying the emulsion along the flow channel, the first pipeline is connected to one end of the tank body and forms a feeding port, and the second pipeline is connected to the other end of the tank body and forms a discharging port. The stirring shaft is used for stirring the emulsion in the flow channel, so that all the emulsion can be fully stirred, the emulsion can gradually move towards the outlet direction in the stirring process, and the problems that the stirred emulsion is repeatedly stirred and the unstirred emulsion cannot be stirred are solved, so that the stirring effect and efficiency of the emulsion are improved.

Description

Technical Field

[0001] This utility model relates to the field of vaccine preparation technology, and in particular to a linear emulsifying tank and emulsification system. Background Technology

[0002] Vaccine emulsification is the process of mixing antigens and oil adjuvants with an emulsifier to form a stable water-in-oil (W / O) or oil-in-water (O / W) emulsion. Its core function is to significantly enhance the immunogenicity of vaccines, prolong the protection period, and improve stability through physical mixing technology.

[0003] Emulsification tanks are commonly used equipment for vaccine emulsification. However, existing emulsification tanks have the following drawbacks: the emulsification method usually involves long-term, large-volume emulsification by an agitator inside the tank. This design takes up a lot of workshop space, and the agitator is usually located at 1 / 3 of the tank's volume. This results in the emulsification volume being at least 1 / 3 of the tank's capacity, which is very wasteful for pilot-scale or small-scale products. Furthermore, because large emulsification tanks have large agitator volumes, the linear velocity difference between the blade tips and the tail tips is significant, resulting in noticeable differences in emulsification effects. The agitation speed is generally only around 3000 rpm. In contrast, high-speed, low-volume emulsification heads, such as intermittent high-shear dispersion emulsification heads, high-flow high-shear dispersion mixing heads, and bottom-mounted emulsification heads, share the common characteristic of high speed and small volume. Although they have high speeds, they also generate a lot of heat. Within the large-volume emulsification tank, it's impossible for the entire volume to pass through the emulsification head in a specific order. Instead, eddies are often formed, which carry the un-emulsified portion into the core component for emulsification. This process can lead to the inability to perfectly isolate the already emulsified components and may also result in some vaccines not being fully emulsified. Utility Model Content

[0004] This application provides a linear emulsifying tank to address the technical problem of poor emulsification effect in traditional emulsifying tanks. This application also provides an emulsification system.

[0005] The first aspect of this application provides a linear emulsifying tank, comprising:

[0006] The tank body is equipped with flow channels arranged laterally;

[0007] The stirring mechanism includes:

[0008] A drive unit is connected to the tank body;

[0009] A stirring shaft is connected to the drive component, and the stirring shaft is arranged laterally and extends into the flow channel;

[0010] The stirring blades are arranged sequentially along the length of the stirring shaft and are used to stir the emulsion and transport the emulsion along the flow channel;

[0011] A first pipe is connected to one end of the tank body, and the first pipe forms a feed inlet;

[0012] A second pipe is connected to the other end of the tank, and the second pipe forms a discharge port.

[0013] The beneficial effects of the above embodiments are as follows: through the transversely configured flow channel and stirring shaft, the stirring shaft stirs the emulsion in the flow channel, so that all the emulsion can be fully stirred, and the emulsion will gradually move towards the outlet during the stirring process. There will be no problem of repeated stirring of the stirred emulsion and no stirring of the unstirred emulsion, thus improving the effect and efficiency of emulsion stirring.

[0014] Based on the above embodiments, the embodiments of this application can be further improved as follows:

[0015] In one embodiment of this application: the tank has a jacket for channeling coolant. The beneficial effect of this step is that the temperature of the emulsion is controlled by the coolant.

[0016] In one embodiment of this application, it further includes a delivery pump connected to the first pipeline.

[0017] In one embodiment of this application, it further includes a pressure regulating valve and a hydraulic sensor, wherein the detection end of the hydraulic sensor extends into the flow channel, and the pressure regulating valve is connected to the second pipe. The beneficial effect of this step is that it facilitates the control of the pressure in the tank according to requirements, thereby controlling the emulsification effect of the emulsion.

[0018] A second aspect of this application provides an emulsification system including the linear emulsification tanks, wherein the second conduit of a later linear emulsification tank is connected to the first conduit of a previous linear emulsification tank.

[0019] The beneficial effects of the above embodiments are that connecting multiple linear emulsifying tanks in series facilitates emulsification in stages, which can adapt to the emulsification requirements of different products and improve the emulsification effect. Attached Figure Description

[0020] To more clearly illustrate the specific embodiments of this utility model or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, the elements or parts are not necessarily drawn to scale.

[0021] Figure 1 This is a schematic diagram of the structure of a linear emulsification tank;

[0022] Figure 2 for Figure 1 A magnified view of part A in the image.

[0023] The components include: 1. Tank body, 101. Flow channel, 102. Jacket, 103. Liquid inlet, 104. Liquid outlet, 2. Stirring mechanism, 201. Drive component, 202. Stirring shaft, 203. Stirring blade, 204. Support, 205. Coupling, 206. Bearing, 207. Sealing ring, 3. First pipe, 301. Feed inlet, 4. Second pipe, 401. Discharge outlet, 5. Conveying pump, and 6. Pressure regulating valve. Detailed Implementation

[0024] In this application, unless otherwise expressly specified and limited, the terms used should be interpreted broadly. For example, a connection can be a fixed connection, a detachable connection, or an integral part; it can be a direct connection or an indirect connection through an intermediate medium. If electrical or electronic equipment is involved, it can also refer to an electrical connection or a communication signal connection, etc. For those skilled in the art, the specific meaning of different terms in this utility model can be understood according to the specific circumstances, and the scope of the specific meaning should be limited to achieving the function of this application.

[0025] In the description of this application, it should be understood that the directional terms or positional relationships described are based on the orientation or positional relationships shown in the accompanying drawings, or based on the orientation or positional relationships in actual use, and are only for the purpose of facilitating the description of the contents of this application and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0026] Example 1

[0027] A linear emulsifying tank includes: a tank body 1, a stirring mechanism 2, a first pipe 3, and a second pipe 4. The tank body 1 is provided with a transversely arranged flow channel 101. The stirring mechanism 2 includes: a driving component 201, a stirring shaft 202, and stirring blades 203. The driving component 201 is connected to the tank body 1, and the stirring shaft 202 is connected to the driving component 201. The stirring shaft 202 is arranged transversely and extends into the flow channel 101. The stirring blades 203 are arranged sequentially along the length of the stirring shaft 202 and are used to stir the emulsion and transport the emulsion along the flow channel 101. The first pipe 3 is connected to one end of the tank body 1 and forms an inlet 301. The second pipe 4 is connected to the other end of the tank body 1 and forms an outlet 401.

[0028] Specifically, the drive component 201 is a motor, which is mounted on a bracket 204. The bracket 204 is connected to the end of the tank body 1. The motor output shaft is fixed to the end of the stirring shaft 202 through a coupling 205. The stirring shaft 202 passes through the end of the tank body 1 and enters the flow channel 101. A bearing 206 and a sealing ring 207 are arranged between the stirring shaft 202 and the tank body 1. The bearing 206 ensures the stirring efficiency of the stirring shaft 202, and the sealing ring 207 prevents leakage.

[0029] Specifically, the stirring shaft 202 has four evenly distributed stirring blades 203 at the same radial position. The stirring blades 203 are arranged at an angle relative to the axis of the stirring shaft 202. The stirring blades 203 can stir the emulsion on the one hand, and on the other hand, make the emulsion move forward by rotating the emulsion, thereby preventing the stirred emulsion from staying in the same position in the flow channel 101 for a long time.

[0030] Specifically, the linear emulsifying tank also includes a transfer pump 5, which is connected to the first pipeline 3. The transfer pump 5 is a pipeline emulsifying pump, and the first pipeline 3 is externally connected to the pre-emulsifying tank. The transfer pump 5 is used to pump the liquid in the pre-emulsifying tank into the flow channel 101.

[0031] Specifically, the linear emulsifying tank also includes: a pressure regulating valve 6 and a hydraulic sensor. The detection end of the hydraulic sensor extends into the flow channel 101. The hydraulic sensor is connected to a controller via an electrical control signal. The controller is an industrial computer. The pressure regulating valve 6 is connected to the second pipeline 4. The pressure regulating valve 6 is used to control the pressure of the emulsion in the flow channel 101. The pressure regulating valve 6 is an automatic regulating valve. The controller is electrically connected to the pressure regulating valve 6. The controller controls the automatic regulating valve according to the signal fed back by the hydraulic sensor, thereby realizing the function of automatic hydraulic control.

[0032] Specifically, the tank 1 has a jacket 102 through which coolant is introduced. One end of the tank 1 has an inlet 103, and the other end has an outlet 104. The outlet 104 and the inlet 103 are connected to a radiator via pipes and a water pump. The radiator is a plate-type radiator. A temperature sensor, a thermocouple-type temperature sensor, is also installed in the flow channel. The temperature sensor is connected to the controller's electrical control signal, and the controller is connected to the water pump's electrical control signal. The controller controls the pumping rate of the water pump (by adjusting the output frequency of the frequency converter, changing the pump's rotation speed, and thus adjusting the pumping speed), thereby controlling the flow rate of the coolant. Since stirring generates significant heat, the temperature of the emulsion is controlled by the coolant (such as purified water) to prevent the emulsion temperature from becoming too high.

[0033] When this type of linear emulsifier is in use, the pre-emulsified liquid in the pre-emulsifier is sent into the flow channel 101 through the feed port 301 by the delivery pump 5. The emulsified liquid is stirred and pushed forward by the stirring blades 203. When the emulsified liquid moves out through the discharge port 401, the emulsified liquid has been stirred.

[0034] Example 2

[0035] An emulsification system includes a linear emulsifying tank as disclosed in Embodiment 1. The second pipe 4 of a subsequent linear emulsifying tank is connected to the first pipe 3 of a preceding linear emulsifying tank, allowing the linear emulsifying tanks to be stacked along their height. Connecting multiple linear emulsifying tanks in series facilitates staged emulsification, which can adapt to the emulsification requirements of different products and improve the emulsification effect.

[0036] The above are merely embodiments of this utility model. Commonly known structures and characteristics are not described in detail here. Those skilled in the art are aware of all common technical knowledge in the field prior to the application date or priority date, are aware of all existing technologies in that field, and have the ability to apply conventional experimental methods prior to that date. Those skilled in the art can, based on the guidance provided in this application, improve and implement this solution in combination with their own capabilities. Some typical known structures or methods should not be obstacles for those skilled in the art to implement this application. It should be noted that those skilled in the art can make several modifications and improvements without departing from the structure of this utility model. These should also be considered within the scope of protection of this utility model, and will not affect the effectiveness of the implementation of this utility model or the practicality of the patent.

Claims

1. A linear emulsifying tank, characterized in that, include: The tank body is equipped with flow channels arranged laterally; The stirring mechanism includes: A drive unit is connected to the tank body; A stirring shaft is connected to the drive component, and the stirring shaft is arranged laterally and extends into the flow channel; The stirring blades are arranged sequentially along the length of the stirring shaft and are used to stir the emulsion and transport the emulsion along the flow channel; A first pipe is connected to one end of the tank body, and the first pipe forms a feed inlet; A second pipe is connected to the other end of the tank, and the second pipe forms a discharge port.

2. The linear emulsifying tank according to claim 1, characterized in that, The tank has a jacket for introducing coolant.

3. The linear emulsifying tank according to claim 1, characterized in that, Also includes: A delivery pump, which is connected to the first pipeline.

4. The linear emulsifying tank according to claim 1, characterized in that, Also includes: The pressure regulating valve and the hydraulic sensor are provided, with the detection end of the hydraulic sensor extending into the flow channel and the pressure regulating valve connected to the second pipeline.

5. An emulsification system, characterized in that, The system includes a linear emulsifying tank according to any one of claims 1-4, wherein the second pipe of the later linear emulsifying tank is connected to the first pipe of the earlier linear emulsifying tank.

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