Microneedle patch mold for multistage drug release delivery

Abstract

The utility model belongs to the field of microneedle patch mould, especially a kind of microneedle patch mould for multistage drug release delivery, to the microneedle of current high polymer material needs to pour polymer solution and medicament into mould then again put into drying oven or vacuum device to make solvent in solution volatilize, after its solidification, it is taken out, need to replace different equipment, not only cumbersome process, and cannot take out the shortcoming of the problem of the microneedle patch after forming automatically, present and propose following scheme, including sealed box and second box, the bottom inner wall of sealed box is fixedly connected with first box, in the utility model, first box and second box can be extracted into vacuum, and the gas extracted is stored in first box, when check valve opens, microneedle patch can be automatically blown out, it is very convenient, not only can the microneedle patch be made but also it can be dried, two-step procedure is fused together, save time and cost.

Description

Technical Field

[0001] This utility model relates to the field of microneedle patch mold technology, and in particular to a microneedle patch mold for multi-stage drug release and delivery. Background Technology

[0002] Multi-stage drug release and delivery microneedle patches are a novel drug delivery system. They combine microneedle technology with a multi-stage drug release mechanism, using microneedles to penetrate the stratum corneum of the skin to establish drug delivery channels and release drugs in a variety of pre-designed ways. Microneedle patches are mainly divided into metal microneedles and polymer microneedles in terms of materials.

[0003] In existing technologies, polymer microneedles are made by pouring polymer solutions and drugs into a mold and then placing it in a drying oven or vacuum device to evaporate the solvent in the solution. After solidification, the microneedles are removed. This process requires changing different equipment, which is not only cumbersome, but also cannot automatically remove the molded microneedle patches. Therefore, a microneedle patch mold for multi-stage drug release and delivery is proposed. Utility Model Content

[0004] The purpose of this invention is to address the shortcomings of existing technologies where polymer material microneedles require pouring polymer solutions and drugs into a mold and then placing it in a drying oven or vacuum device to evaporate the solvent in the solution, and then removing it after solidification. This process is cumbersome and cannot automatically remove the molded microneedle patch. Therefore, this invention proposes a microneedle patch mold for multi-stage drug release and delivery.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A microneedle patch mold for multi-stage drug release delivery, comprising:

[0007] The sealed box comprises a sealed box and a second box. The bottom inner wall of the sealed box is fixedly connected to the first box. The surface of the first box is provided with multiple micro-needle forming mold grooves. The bottom of the micro-needle forming mold grooves is provided with multiple micro-needle holes. The surface of the micro-needle forming mold grooves is provided with air holes, and a one-way valve is fixedly connected to the air holes. The interior of the first box is provided with a cavity, and the air holes communicate with the cavity. One side inner wall of the sealed box is fixedly connected to an air pump. The exhaust port of the air pump is fixedly connected to a first ventilation pipe. The other end of the first ventilation pipe is fixedly connected to the first box and communicates with the cavity. One end of the air pump inlet is fixedly connected to a second ventilation pipe.

[0008] A pressing component is located above the first housing and is used to control the height of the second housing.

[0009] The feeding assembly, located on the surface of the second housing, is used to supply the solution required for microneedle patch molding.

[0010] In one possible design, the pressing assembly includes a plurality of first hydraulic rods, which are fixedly connected inside the sealed box. One end of the output shaft of the plurality of first hydraulic rods is fixedly connected to a second box body. A plurality of forming blocks are fixedly connected to the bottom surface of the second box body. The plurality of forming blocks are used in conjunction with a plurality of microneedle forming mold grooves.

[0011] In one possible design, the feeding assembly includes a protective cover with an opening on its surface. A second hydraulic rod is fixedly connected to the inner wall of the protective cover. A piston rod is fixedly connected to one end of the output shaft of the second hydraulic rod. A storage tank is slidably connected to the outer circumference of the piston rod. A flow channel is fixedly connected to one side of the storage tank. The flow channel has multiple discharge ports, which are respectively located at the center of the corresponding molding block. The storage tank contains a polymer solution for molding microneedle patches, which is discharged into the corresponding microneedle molding mold groove through the discharge ports.

[0012] In one possible design, a feed inlet is fixedly connected to the circumferential surface of the storage box, and a cover is threaded onto the feed inlet.

[0013] In one possible design, the first housing has an internal pipe with a heating wire inside, the surface of the first housing has a mounting groove with a temperature sensor inside, a temperature controller is fixedly connected to one side of the sealed housing, the temperature sensor is electrically connected to the temperature controller, and one end of the heating wire is connected to the temperature controller.

[0014] In one possible design, the surface of the first housing is provided with a protruding plate, and the bottom surface of the second housing is provided with a groove, with the protruding plate engaging with the groove.

[0015] In one possible design, the surface of the storage tank is provided with a feed inlet, and the feed inlet is threadedly connected to a threaded cap.

[0016] In this application, during use, the solution is first injected into the storage tank. Then, the second hydraulic rod pushes the piston rod to make the solution flow out from the flow channel and fall into the corresponding microneedle forming mold groove below. Then, the heating wire is activated to control a suitable temperature, which can help the solvent in the solution evaporate faster. Then, the first hydraulic rod retracts to move the second box down to the position where the forming block just contacts the solution, so as to dry the solution. At the same time, the forming block presses down to prevent the four corners of the formed microneedle patch from curling and deforming due to shrinkage.

[0017] Beneficial effects: In this utility model, the microneedle patch mold for multi-stage drug release and delivery can be filled with air by means of a pump and a one-way valve. When the one-way valve is opened, the microneedle patch can be automatically blown out, which is very convenient.

[0018] In this utility model, the microneedle patch mold for multi-stage drug release and delivery, through devices such as a first box, a second box and a sealed box, can not only produce microneedle patches but also dry them, integrating the two processes together to save time and cost.

[0019] In this invention, the solvent in the microneedle patch can be quickly evaporated by using devices such as heating wire and air pump, saving time. Attached Figure Description

[0020] Figure 1 This is a three-dimensional structural schematic diagram of a microneedle patch mold for multi-stage drug release and delivery proposed in this utility model.

[0021] Figure 2 This is a partial cross-sectional view of a microneedle patch mold for multi-stage drug release and delivery proposed in this utility model.

[0022] Figure 3 This is a schematic diagram of the first box structure of a microneedle patch mold for multi-stage drug release and delivery proposed in this utility model;

[0023] Figure 4 This is a schematic diagram of the second box structure of a microneedle patch mold for multi-stage drug release and delivery proposed in this utility model.

[0024] In the diagram: 1. Sealed box; 2. Protective cover; 3. Temperature controller; 4. Air pump; 5. First box body; 6. First hydraulic rod; 7. Microneedle forming mold groove; 8. Second box body; 9. Flow channel; 10. Storage box; 11. Second hydraulic rod; 12. Piston rod; 13. First ventilation pipe; 14. Second ventilation pipe; 15. Cavity; 16. Heating wire; 17. One-way valve; 18. Protruding plate; 19. Forming block; 20. Groove. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0026] Example 1, referring to Figures 1-4 A microneedle patch mold, comprising:

[0027] The sealed box 1 and the second box 8 are coated with grease to reduce friction and improve sealing, creating a vacuum between the second box 8 and the first box 5. This vacuum facilitates solvent evaporation. The bottom inner wall of the sealed box 1 is fixedly connected to the first box 5. The surface of the first box 5 has multiple microneedle forming mold grooves 7, the bottom of which has multiple microneedle holes. The surface of the microneedle forming mold grooves 7 has air holes, and a one-way valve 17 is fixedly connected to each air hole. The one-way valve 17 is connected to the microneedle forming mold. The bottom of the groove 7 is flush with the micro-pin hole and does not occupy the position. The first box 5 has a cavity 15 inside. The air hole is connected to the cavity 15. The cavity 15 is sealed. It is connected to the one-way valve 17 with a rubber ring to prevent air leakage. An air pump 4 is fixedly connected to one side of the inner wall of the sealed box 1. The exhaust port of the air pump 4 is fixedly connected to the first ventilation pipe 13. The other end of the first ventilation pipe 13 is fixedly connected to the first box 5. The first ventilation pipe 13 is connected to the cavity 15. One end of the air inlet of the air pump 4 is fixedly connected to the second ventilation pipe 14. The second ventilation pipe 14 is used for air intake.

[0028] A pressing component is located above the first housing 5 and is used to control the height of the second housing 8.

[0029] The feeding assembly is located on the surface of the second housing 8 and is used to supply the solution required for microneedle patch molding.

[0030] This application can be used in the field of microneedle patch molds, or in other fields applicable to this application.

[0031] Example 2, refer to Figures 1-4 An improvement on Example 1: a microneedle patch mold for multi-stage drug release and delivery, which is applied to the field of microneedle patch molds.

[0032] In another aspect of this embodiment, the pressing assembly includes a plurality of first hydraulic rods 6, which are fixedly connected inside the sealed box 1. One end of the output shaft of the plurality of first hydraulic rods 6 is fixedly connected to the second box 8. A plurality of molding blocks 19 are fixedly connected to the bottom surface of the second box 8. The plurality of molding blocks 19 are used in conjunction with a plurality of microneedle molding mold grooves 7. When it is necessary to dry the microneedle patch, the plurality of first hydraulic rods 6 lower the second box 8 to a suitable height and press the molding blocks 19 onto the microneedle patch to prevent the microneedle patch from curling around its edges due to drying shrinkage.

[0033] In another aspect of this embodiment, the feeding assembly includes a protective cover 2. The surface of the protective cover 2 is provided with an opening to facilitate feeding into the feeding port. A second hydraulic rod 11 is fixedly connected to the inner wall of the protective cover 2. A piston rod 12 is fixedly connected to one end of the output shaft of the second hydraulic rod 11. A storage tank 10 is slidably connected to the outer circumference of the piston rod 12. A flow channel 9 is fixedly connected to one side of the storage tank 10. The flow channel 9 has multiple discharge ports, which are respectively located at the center of the corresponding molding block 19. The storage tank 10 is provided with a polymer solution for molding microneedle patches. The solution is discharged into the corresponding microneedle molding mold groove 7 through the discharge port. When the solution before microneedle patch molding flows out, it can accurately fall into the microneedle molding mold groove 7 below each molding block 19 and corresponding to each molding block 19.

[0034] In another aspect of this embodiment, a feed inlet is fixedly connected to the circumferential surface of the storage tank 10, and a cover is threaded onto the feed inlet to facilitate the storage of the solution and prevent the solution from evaporating.

[0035] In another aspect of this embodiment, the first housing 5 has a pipe inside, and a heating wire 16 is installed inside the pipe. The surface of the first housing 5 has a mounting groove, and a temperature sensor is installed inside the mounting groove. A temperature controller 3 is fixedly connected to one side of the sealed housing 1. The temperature sensor is electrically connected to the temperature controller. One end of the heating wire 16 is connected to the temperature controller 3. The temperature controller 3 can adjust the temperature of the surface of the first housing and control the speed of microneedle patch forming.

[0036] In another aspect of this embodiment, the surface of the first housing 5 is provided with a protruding plate 18, and the bottom surface of the second housing 8 is provided with a groove 20. The protruding plate 18 is engaged with the groove 20, and the surface of the protruding plate 18 is covered with a sealing rubber layer, which can fit tightly with the groove 20 to prevent air leakage.

[0037] In another aspect of this embodiment, the surface of the storage tank 10 is provided with a heat insulation layer, which is used to keep the solution warm and prevent the solution from cooling too quickly and failing to reach the required temperature.

[0038] However, as is well known to those skilled in the art, the working principles and wiring methods of the temperature controller 3, the first hydraulic rod 6, the second hydraulic rod, the second hydraulic rod 11, the heating wire 16, and the air pump 4 are commonplace and belong to conventional means or common knowledge. They will not be described in detail here. Those skilled in the art can make any selections according to their needs or convenience.

[0039] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A microneedle patch mold for multi-stage drug release and delivery, comprising a sealed box (1) and a second box body (8), characterized in that, The bottom inner wall of the sealed box (1) is fixedly connected to a first box body (5). The surface of the first box body (5) is provided with multiple micro-needle forming mold grooves (7). Multiple micro-needle holes are opened at the bottom of the micro-needle forming mold grooves (7). Air holes are opened on the surface of the micro-needle forming mold grooves (7), and a one-way valve (17) is fixedly connected inside the air holes. A cavity (15) is opened inside the first box body (5). The air holes are connected to the cavity (15). An air pump (4) is fixedly connected to one side inner wall of the sealed box (1). The exhaust port of the air pump (4) is fixedly connected to a first ventilation pipe (13). The other end of the first ventilation pipe (13) is fixedly connected to the first box body (5). The first ventilation pipe (13) is connected to the cavity (15). A second ventilation pipe (14) is fixedly connected to one end of the air inlet of the air pump (4). A pressing component is positioned above the first housing (5) to control the height of the second housing (8); The feeding assembly is located on the surface of the second housing (8) and is used to supply the solution required for microneedle patch molding.

2. A microneedle patch mold for multi-stage drug release and delivery according to claim 1, characterized in that, The pressing assembly includes multiple first hydraulic rods (6), which are fixedly connected inside the sealed box (1). One end of the output shaft of the multiple first hydraulic rods (6) is fixedly connected to the second box (8). Multiple forming blocks (19) are fixedly connected to the bottom surface of the second box (8). The multiple forming blocks (19) are used in conjunction with multiple microneedle forming mold grooves (7).

3. A microneedle patch mold for multi-stage drug release and delivery according to claim 1, characterized in that, The feeding assembly includes a protective cover (2), the surface of which is provided with an opening. A second hydraulic rod (11) is fixedly connected to the inner wall of the protective cover (2). A piston rod (12) is fixedly connected to one end of the output shaft of the second hydraulic rod (11). A storage box (10) is slidably connected to the outer circumference of the piston rod (12). A flow channel (9) is fixedly connected to one side of the storage box (10). The flow channel (9) is connected to multiple discharge ports, which are respectively located at the center of the corresponding molding block (19). The storage box (10) is provided with a polymer solution and a pharmaceutical solution for molding microneedle patches, which are discharged into the corresponding microneedle molding mold groove (7) through the discharge port.

4. A microneedle patch mold for multi-stage drug release and delivery according to claim 3, characterized in that, The storage box (10) has a feed inlet fixedly connected to its circumferential surface, and a cover is threaded onto the feed inlet.

5. A microneedle patch mold for multi-stage drug release and delivery according to claim 1, characterized in that, The first box (5) has a pipe inside, and an electric heating wire (16) is installed inside the pipe. The surface of the first box (5) has an installation groove, and a temperature sensor is installed in the installation groove. A temperature controller (3) is fixedly connected to one side of the sealed box (1). The temperature sensor is electrically connected to the temperature controller. One end of the electric heating wire (16) is connected to the temperature controller (3).

6. A microneedle patch mold for multi-stage drug release and delivery according to claim 1, characterized in that, The surface of the first box (5) is provided with a protruding plate (18), and the bottom surface of the second box (8) is provided with a groove (20), and the protruding plate (18) and the groove (20) are engaged.

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