A cross-linked sodium hyaluronate gel dialysis device

Abstract

The utility model relates to a kind of crosslinked sodium hyaluronate gel dialysis devices, including reaction cylinder, the sliding seat of evenly distributed is fixedly connected in the reaction cylinder inner wall, the first silica gel hose of two groups is fixedly connected in the reaction cylinder inner wall, the one end of the first silica gel hose away from reaction cylinder is fixedly connected with valve.The utility model in the present application, the rotating of the sliding block and spring telescopic rod in the steel frame inner wall is driven by the setting rotating sleeve, the special structure of its sliding block rotation is clamped into the recess when rotating to the recess of clamping seat by guide plate, to realize the position fixing of L-shaped plate, the rotation angle is all flat angle, to facilitate the position of the position of L-shaped plate rotation to the position limiting of steel frame, even after carrying dialysis membrane bag and being hung in reaction cylinder, the problem of the gel quantity of dialysis in prior art is solved, dialysis membrane bag is not inconvenient to put in and take out.

Description

Technical Field

[0001] This utility model relates to the field of biomedical material manufacturing equipment technology, and in particular to a cross-linked sodium hyaluronate gel dialysis device. Background Technology

[0002] Cross-linked sodium hyaluronate gel is a sodium hyaluronate (HA) hydrogel prepared through a cross-linking reaction. Sodium hyaluronate is a natural polysaccharide widely found in living organisms, especially in connective tissue, skin, and synovial fluid. Due to its good biocompatibility and biodegradability, sodium hyaluronate is widely used in the medical and cosmetic fields. During the preparation of cross-linked sodium hyaluronate gel, dialysis is typically required to remove unreacted chemical reagents, cross-linking agents, salts, and other small molecule impurities.

[0003] A search revealed Chinese patent application number CN211754034U, which discloses a cross-linked sodium hyaluronate gel dialysis device, comprising a reaction cylinder, a shelf, hook sleeves, and a circulation system; the reaction cylinder is made of stainless steel; the shelf is installed on the top of the reaction cylinder; the hook sleeves include those with hooks and those without hooks; the circulation system includes a peristaltic pump; the hook sleeves and those without hooks are used to cover the dialysis membrane bags at both ends, and the hooks of the hook sleeves can be hung on the shelf;

[0004] Although the aforementioned patent uses a drain port and a peristaltic pump to directly replace the dialysate without removing the gel products, and uses a peristaltic pump for circulation to ensure effective circulation of the dialysate, and adds hook-and-clip sleeves and hookless-and-clip sleeves to effectively fix the dialysis membrane bags, the following shortcomings still exist in use: 1. The device uses hooks and sleeves to clamp the dialysis membrane bags and place them on a steel frame, which is prone to shaking and even contact between adjacent dialysis membrane bags, resulting in insufficient space for the dialysis membrane bags to react and affecting the dialysis quality; 2. The device dialyzes a large amount of gel at a time, making it inconvenient to insert and remove the dialysis membrane bags.

[0005] Therefore, there is an urgent need for a cross-linked sodium hyaluronate gel dialysis device to solve the above problems. Utility Model Content

[0006] The purpose of this invention is to overcome the above-mentioned shortcomings and provide a cross-linked sodium hyaluronate gel dialysis device to solve the problems mentioned in the background art.

[0007] The purpose of this utility model is achieved as follows:

[0008] A cross-linked sodium hyaluronate gel dialysis device includes a reaction cylinder, wherein uniformly distributed sliding seats are fixedly connected to the inner wall of the reaction cylinder, and two sets of first silicone tubing are fixedly connected to the inner wall of the reaction cylinder. A valve is fixedly connected to the end of each first silicone tubing away from the reaction cylinder. The device also includes:

[0009] A steel frame is slidably connected to the inner wall of a sliding seat. A card seat is fixedly connected to the inner wall of the steel frame. A guide plate is fixedly connected to the outer wall of the card seat, and the guide plate is fixedly connected to the steel frame. Evenly distributed arc-shaped plates are fixedly connected to the outer wall of the steel frame.

[0010] The positioning component includes a rotating sleeve rotatably connected to the outer wall of a steel frame. Symmetrically distributed spring telescopic rods are fixedly connected to the inner wall of the rotating sleeve. A locking block is fixedly connected to the end of the spring telescopic rod away from the rotating sleeve, and the locking block is slidably connected to the rotating sleeve. The locking block is nested with a locking seat. The outer wall of the locking block abuts against the outer wall of the guide plate. An L-shaped locking plate is fixedly connected to the outer wall of the rotating sleeve.

[0011] Anti-rotation component, installed on the outer wall of the steel frame.

[0012] Furthermore, the anti-rotation assembly includes an anti-rotation block that is uniformly slidably connected to the outer wall of the steel frame. The inner wall of the anti-rotation block is fixedly connected to symmetrically distributed positioning blocks, and the outer wall of the positioning blocks abuts against the outer wall of the arc-shaped plate. The outer wall of the anti-rotation block is fixedly connected to a connecting rod. The end of the connecting rod away from the anti-rotation block is rotatably connected to a screw. The end of the screw away from the connecting rod is fixedly connected to a jacket. The inner wall of the jacket is provided with a dialysis membrane bag.

[0013] Furthermore, the inner wall of the reaction cylinder is fixedly connected with uniformly distributed L-shaped tubes, the inner wall of the L-shaped tubes is slidably connected with extrusion blocks, the top wall of the extrusion blocks is fixedly connected with extrusion rods, and the extrusion rods are fixedly connected to the steel frame. The top wall of the L-shaped tubes is fixedly connected with a breathable plate.

[0014] Furthermore, a positioning plate is fixedly connected to the top wall of the reaction cylinder, and the top wall of the positioning plate is provided with evenly distributed positioning grooves, with the L-shaped clamping plate located on the inner wall of the positioning groove.

[0015] Furthermore, a second silicone hose is fixedly connected to the end of the valve away from the first silicone hose, and a peristaltic pump is fixedly connected to the end of the second silicone hose away from the valve.

[0016] Compared with the prior art, this utility model provides a cross-linked sodium hyaluronate gel dialysis device, which has the following beneficial effects:

[0017] (1) The present invention uses an arc plate that automatically deforms when squeezed by the positioning block on the anti-rotation block, and the arc plate returns to its original position when the positioning block moves between adjacent arc plates, so that the anti-rotation block is squeezed and positioned by the arc plate, thereby preventing the anti-rotation block from performing anti-rotation operation on the dialysis membrane bag connected to the connecting rod, screw and jacket, avoiding contact between the dialysis membrane bag after rotation and affecting the dialysis quality. This solves the problem in the prior art where the device uses a hook and jacket to clamp the dialysis membrane bag and place it on the steel frame, which is prone to shaking, or even contact between adjacent dialysis membrane bags, resulting in insufficient space for the dialysis membrane bag to react and affecting the dialysis quality.

[0018] (2) This utility model uses a rotating sleeve to drive the card block and spring telescopic rod to rotate on the inner wall of the steel frame. When the card block rotates, it will be inserted into the groove of the card seat through the special structure of the guide plate, thereby realizing the limiting and fixing of the L-shaped card plate. The rotation angles are all flat angles, which makes it easy to limit the position of the steel frame by the rotation position of the L-shaped plate. Even after the dialysis membrane bag is hung on the steel frame, it is easy to carry the dialysis membrane bag into the reaction cylinder. This solves the problem in the prior art that the amount of gel dialyzed at one time is large and it is inconvenient to put in and take out the dialysis membrane bag. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0020] Figure 2 This is a schematic diagram of the L-shaped tube part of this utility model.

[0021] Figure 3 This is a schematic diagram of the sliding seat part of this utility model.

[0022] Figure 4 This is a cross-sectional view of the reaction cylinder of this utility model.

[0023] Figure 5 This is a schematic diagram of the positioning block part of this utility model.

[0024] Figure 6 This is a schematic diagram of the screw part of this utility model.

[0025] Figure 7 This is a schematic diagram of the arc-shaped plate part of this utility model.

[0026] Figure 8 This is a cross-sectional view of the L-shaped tube of this utility model.

[0027] Figure 9 This is a schematic diagram of the card holder part of this utility model.

[0028] Figure 10 This is a schematic diagram of the card block structure of this utility model.

[0029] in:

[0030] 1. Reaction cylinder; 2. First silicone tubing; 3. Valve; 4. Second silicone tubing; 5. Peristaltic pump; 6. L-shaped tube; 7. Ventilation plate; 8. Positioning plate; 9. Positioning groove; 10. Sliding seat; 11. Steel frame; 12. Anti-rotation block; 13. Positioning block; 14. Connecting rod; 15. Screw; 16. Jacket; 17. Dialysis membrane bag; 18. Arc plate; 19. Squeezing rod; 20. Rotating sleeve; 21. L-shaped clamping plate; 22. Clamping seat; 23. Squeezing block; 24. Guide plate; 25. Spring telescopic rod; 26. Clamping block. Detailed Implementation

[0031] To better understand the technical solution of this utility model, a detailed description will be provided below in conjunction with relevant illustrations. It should be understood that the specific embodiments described below are not intended to limit the specific implementation of the technical solution of this utility model, but are merely possible implementations of the technical solution of this utility model. It should be noted that the descriptions of the positional relationships of the components herein, such as component A being located above component B, are based on the relative positions of the components in the illustrations and are not intended to limit the actual positional relationships of the components. Example

[0032] See Figures 1-10 , Figure 1 A schematic diagram of a cross-linked sodium hyaluronate gel dialysis device is shown. As shown, this cross-linked sodium hyaluronate gel dialysis device includes a reaction cylinder 1, with uniformly distributed sliding seats 10 fixedly connected to the inner wall of the reaction cylinder 1. Two sets of first silicone tubing 2 are fixedly connected to the inner wall of the reaction cylinder 1, and a valve 3 is fixedly connected to the end of the first silicone tubing 2 away from the reaction cylinder 1. The device also includes:

[0033] A steel frame 11 is slidably connected to the inner wall of the sliding seat 10. A card seat 22 is fixedly connected to the inner wall of the steel frame 11. A guide plate 24 is fixedly connected to the outer wall of the card seat 22 and is fixedly connected to the steel frame 11. A uniformly distributed arc-shaped plate 18 is fixedly connected to the outer wall of the steel frame 11. The arc-shaped plate 18 guides the card block 26, making it easier for the card block 26 to move out of the card seat 22.

[0034] The positioning assembly includes a rotating sleeve 20 rotatably connected to the outer wall of the steel frame 11. Symmetrically distributed spring telescopic rods 25 are fixedly connected to the inner wall of the rotating sleeve 20. A locking block 26 is fixedly connected to the end of each spring telescopic rod 25 away from the rotating sleeve 20, and the locking block 26 is slidably connected to the rotating sleeve 20. The locking block 26 is nested within a locking seat 22, and the outer wall of the locking block 26 abuts against the outer wall of the guide plate 24. An L-shaped locking plate 21 is fixedly connected to the outer wall of the rotating sleeve 20. By rotating the L-shaped locking plate 21, the rotating sleeve 20 is rotated, thereby raising the rotating sleeve 20 above the outer wall. At the top of the L-shaped clamping plate 21, during the rotation of the L-shaped clamping plate 21, the arc structure of the guide plate 24 guides the clamping block 26 to slide within the rotating sleeve 20, and the spring telescopic rod 25 stores elastic force. When the clamping block 26 rotates to the groove of the clamping seat 22 (not shown in the figure), the spring telescopic rod 25 releases the stored elastic energy, thereby pushing the clamping block 26 into the groove, thus achieving the limiting and fixing of the clamping block 26, that is, the limiting and fixing of the rotating sleeve 20 and the L-shaped clamping plate 21. At this time, it is only necessary to loosen the L-shaped clamping plate 21.

[0035] An anti-rotation component is installed on the outer wall of the steel frame 11.

[0036] See Figure 4-7 The anti-rotation assembly includes an anti-rotation block 12 that is uniformly slidably connected to the outer wall of the steel frame 11. A symmetrically distributed positioning block 13 is fixedly connected to the inner wall of the anti-rotation block 12, and the outer wall of the positioning block 13 abuts against the outer wall of the arc-shaped plate 18. A connecting rod 14 is fixedly connected to the outer wall of the anti-rotation block 12. A screw 15 is rotatably connected to the end of the connecting rod 14 away from the anti-rotation block 12. A jacket 16 is fixedly connected to the end of the screw 15 away from the connecting rod 14. A dialysis membrane bag 17 is provided on the inner wall of the jacket 16. The dialysis membrane bag 17 is installed through the jacket 16, and further slids on the steel frame 11 via the anti-rotation block 12. During installation, the anti-rotation block 12 slides and is pressed against the arc plate 18 by the positioning block 13. The arc plate 18 is deformed by the pressure. When the anti-rotation block 12 and the positioning block 13 are between the arc plate 18, the arc plate 18 returns to its original shape and is pressed against the positioning block 13 and the anti-rotation block 12 by the arc plate 18, so that the anti-rotation block 12 is positioned. In this way, all the anti-rotation blocks 12 and dialysis membrane bags 17 are installed. If the jacket 16 needs to be replaced, the jacket 16 can be rotated to drive the screw 15 and the connecting rod 14 to engage in threaded connection, thereby contacting the threaded connection between the screw 15 and the connecting rod 14.

[0037] See Figure 7-8The inner wall of the reaction cylinder 1 is fixedly connected with uniformly distributed L-shaped tubes 6. The inner wall of the L-shaped tubes 6 is slidably connected with extrusion blocks 23. The top wall of the extrusion blocks 23 is fixedly connected with extrusion rods 19, and the extrusion rods 19 are fixedly connected to the steel frame 11. The top wall of the L-shaped tubes 6 is fixedly connected with a vent plate 7. The steel frame 11 slides in the L-shaped tubes 6 through the extrusion blocks 23 and extrusion rods 19. The extrusion blocks 23 push the air in the L-shaped tubes 6 towards the vent plate 7 and discharge it through the vent plate 7. Since the air extruded by the extrusion blocks 23 is discharged slowly through the vent plate 7, the descent speed of the steel frame 11 is reduced. There is no need to manually put the steel frame 11 in, and the operation is simple and convenient.

[0038] See Figure 1-3 The top wall of the reaction cylinder 1 is fixedly connected to a positioning plate 8. The top wall of the positioning plate 8 is provided with evenly distributed positioning grooves 9. The L-shaped card plate 21 is located on the inner wall of the positioning groove 9. The positioning groove 9 limits and fixes the L-shaped card plate 21, so that the dialysis membrane bag 17 is in a suitable position for dialysis.

[0039] See Figure 1 The valve 3 is fixedly connected to a second silicone hose 4 at the end furthest from the first silicone hose 2. A peristaltic pump 5 is fixedly connected to the end of the second silicone hose 4 furthest from the valve 3. One side of the valve 3 is an inlet valve for draining the dialysate, and the other side is an outlet valve for draining the dialysate. The first silicone hose 2 and the second silicone hose 4, in conjunction with the peristaltic pump 5, enable the circulation and dialysis of the drained dialysate.

[0040] Working principle:

[0041] This invention provides a cross-linked sodium hyaluronate gel dialysis device. First, the rotating sleeve 20 is placed above the top of the L-shaped clamping plate 21, and the L-shaped clamping plate 21 is inserted into the positioning groove 9 to limit and fix its position. At this time, the steel frame 11 is located outside the reaction cylinder 1. Then, the dialysis membrane bag 17 is installed through the clamping sleeve 16. Further installation is achieved by the anti-rotation block 12 sliding on the steel frame 11. During the sliding process, the anti-rotation block 12 presses against the arc-shaped plate 18 through the positioning block 13, causing the arc-shaped plate 18 to deform under pressure. When the anti-rotation block 12 and the positioning block 13 are positioned between the arc-shaped plate 18... The arc-shaped plate 18 returns to its original shape, and the positioning block 13 and anti-rotation block 12 are positioned by the arc-shaped plate 18 pressing them together. All anti-rotation blocks 12 and dialysis membrane bags 17 are then installed. If the jacket 16 needs to be replaced, it can be rotated to drive the screw 15 and connecting rod 14 to engage in threaded connection, thus establishing the threaded connection between the screw 15 and connecting rod 14. Furthermore, by rotating the L-shaped clamping plate 21, the rotating sleeve 20 is rotated, causing the rotating sleeve 20 to rise above the top of the L-shaped clamping plate 21. During the rotation of the L-shaped clamping plate 21, the guide plate 24 guides the rotation. The arc-shaped structure guides the locking block 26 to slide within the rotating sleeve 20, allowing the spring telescopic rod 25 to elastically store energy. When the locking block 26 rotates to the groove of the locking seat 22 (not shown in the figure), the spring telescopic rod 25 releases its stored energy, thereby pushing the locking block 26 into the groove. This achieves the limiting and fixing of the locking block 26, that is, the limiting and fixing of the rotating sleeve 20 and the L-shaped locking plate 21. At this time, it is only necessary to loosen the L-shaped locking plate 21. Its steel frame 11 will slide within the L-shaped tube 6 through the pressing block 23 and the pressing rod 19. The pressing block 23 will push the air in the L-shaped tube 6 towards the vent plate. The air moves in direction 7 and passes through the vent plate 7 to be discharged. Because the air squeezed by the squeezing block 23 is discharged slowly through the vent plate 7, the descent speed of the steel frame 11 is reduced, and there is no need to manually put the steel frame 11 in, thereby further preventing the dialysis membrane bag 17 from shaking when it enters the reaction cylinder 1. At this time, the L-shaped card plate 21 automatically falls into the positioning groove 9 to achieve the limit. One side of its valve 3 is the liquid inlet valve, which is used to discharge the dialysis liquid, and the other side is the discharge valve, which is used to discharge the dialysis liquid. The first silicone hose 2 and the second silicone hose 4 work together with the peristaltic pump 5 to realize the circulation dialysis of the discharged dialysis liquid.

[0042] The above are merely specific application examples of this utility model and do not constitute any limitation on the scope of protection of this utility model. All technical solutions formed by equivalent transformations or equivalent substitutions fall within the scope of protection of this utility model.

Claims

1. A cross-linked sodium hyaluronate gel dialysis device, comprising a reaction chamber (1), characterized in that: The inner wall of the reaction cylinder (1) is fixedly connected with uniformly distributed sliding seats (10), and the inner wall of the reaction cylinder (1) is fixedly connected with two sets of first silicone hoses (2). The end of the first silicone hose (2) away from the reaction cylinder (1) is fixedly connected with a valve (3), and the reaction cylinder (1) also includes: A steel frame (11) is slidably connected to the inner wall of a sliding seat (10). A card seat (22) is fixedly connected to the inner wall of the steel frame (11). A guide plate (24) is fixedly connected to the outer wall of the card seat (22). The guide plate (24) is fixedly connected to the steel frame (11). A uniformly distributed arc plate (18) is fixedly connected to the outer wall of the steel frame (11). The positioning component includes a rotating sleeve (20) rotatably connected to the outer wall of the steel frame (11). The inner wall of the rotating sleeve (20) is fixedly connected with symmetrically distributed spring telescopic rods (25). The end of the spring telescopic rod (25) away from the rotating sleeve (20) is fixedly connected with a locking block (26), and the locking block (26) is slidably connected to the rotating sleeve (20). The locking block (26) is nested with the locking seat (22). The outer wall of the locking block (26) abuts against the outer wall of the guide plate (24). The outer wall of the rotating sleeve (20) is fixedly connected with an L-shaped locking plate (21). An anti-rotation component is installed on the outer wall of the steel frame (11).

2. The cross-linked sodium hyaluronate gel dialysis device according to claim 1, characterized in that, The anti-rotation assembly includes an anti-rotation block (12) that is uniformly slidably connected to the outer wall of the steel frame (11). The inner wall of the anti-rotation block (12) is fixedly connected to symmetrically distributed positioning blocks (13), and the outer wall of the positioning blocks (13) abuts against the outer wall of the arc plate (18). The outer wall of the anti-rotation block (12) is fixedly connected to a connecting rod (14). The end of the connecting rod (14) away from the anti-rotation block (12) is rotatably connected to a screw (15). The end of the screw (15) away from the connecting rod (14) is fixedly connected to a jacket (16). The inner wall of the jacket (16) is provided with a dialysis membrane bag (17).

3. The cross-linked sodium hyaluronate gel dialysis device according to claim 1, characterized in that, The inner wall of the reaction cylinder (1) is fixedly connected with uniformly distributed L-shaped tubes (6), and the inner wall of the L-shaped tubes (6) is slidably connected with extrusion blocks (23). The top wall of the extrusion blocks (23) is fixedly connected with extrusion rods (19), and the extrusion rods (19) are fixedly connected to the steel frame (11). The top wall of the L-shaped tubes (6) is fixedly connected with a breathable plate (7).

4. The cross-linked sodium hyaluronate gel dialysis device according to claim 1, characterized in that, The top wall of the reaction cylinder (1) is fixedly connected to a positioning plate (8), and the top wall of the positioning plate (8) is provided with evenly distributed positioning grooves (9), and the L-shaped card plate (21) is located on the inner wall of the positioning groove (9).

5. The cross-linked sodium hyaluronate gel dialysis device according to claim 1, characterized in that, The valve (3) is fixedly connected to a second silicone hose (4) at the end away from the first silicone hose (2), and a peristaltic pump (5) is fixedly connected to the end of the second silicone hose (4) away from the valve (3).

Images