A wet granulator for oral solid formulations

Abstract

The utility model discloses an oral solid preparation's wet granulator, including the granulator body and the material tank of setting at its top, the inner bottom wall rotation of material tank is connected with the rotation axle rod of by servo motor no.

Description

Technical Field

[0001] This utility model relates to the field of wet granulation machine technology, specifically a wet granulation machine for oral solid dosage forms. Background Technology

[0002] A wet granulation machine is a device used to granulate powders, primarily used in industries such as pharmaceuticals. Its working principle involves adding the main and auxiliary materials to be granulated into a mixer according to a suitable ratio and formula. The powdered materials and binders are thoroughly mixed at high speed by a bottom mixing paddle in a cylindrical container, forming a moist, soft material. This material is then cut into uniform wet granules by a side-mounted high-speed pulverizing paddle, thus achieving the purpose of granulation.

[0003] After a certain period of use, wet granulation machines often need to be cleaned inside the hopper, especially the mixing components, to prevent excessive material from adhering to the hopper and mixing components, which could affect subsequent use.

[0004] In current technology, the mixing components are mostly located on the inner bottom wall of the tank, which undoubtedly hinders the cleaning of the inner bottom wall. Therefore, when cleaning the tank, people often remove the mixing components to better clean the tank and the mixing components separately. However, since the shape of the tank is usually wide at the bottom and narrow at the top, it is inconvenient to remove the long mixing components from the narrow opening, which makes it difficult to remove the mixing components and hinders the thorough cleaning of the inside of the tank. Utility Model Content

[0005] To overcome the shortcomings mentioned above, this utility model aims to provide a technical solution that can solve the above problems.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a wet granulation machine for oral solid dosage forms, comprising a granulation machine body and a material tank disposed on its top, wherein a rotating shaft driven by a servo motor is rotatably connected to the inner bottom wall of the material tank, a positioning rod is welded to the top of the rotating shaft, a threaded rod is welded to the top of the positioning rod, and a stirring assembly is disposed on the rod body of the positioning rod; the stirring assembly comprises a fixed sleeve, a stirring blade one and a stirring blade two, wherein multiple stirring blades one are welded in a ring at equal intervals to the side of the fixed sleeve, and a stirring blade two is connected to one side of the stirring blade one via a hinge, and a permanent magnet one and a permanent magnet two adsorbing each other are respectively disposed on the side of the stirring blade one and the stirring blade two that are close to each other.

[0007] As a further embodiment of this utility model: the positioning rod is a hexagonal rod body, and the inner cavity of the fixing sleeve is provided with a positioning hole that is adapted to the positioning rod and is hexagonal. The fixing sleeve is inserted into the positioning rod through the positioning hole and fits against the top of the rotating shaft. A fastening cap is threadedly connected to the threaded rod, and the fastening cap is tightly pressed against the top of the fixing sleeve.

[0008] As a further embodiment of this utility model: a driven bevel gear is provided at the bottom of the rotating shaft, the second servo motor is installed inside the granulator body, and a driving bevel gear is provided on the power output shaft of the second servo motor, the driving bevel gear meshing with the driven bevel gear.

[0009] As a further embodiment of this utility model: the hinge is installed on the top between stirring blade one and stirring blade two by bolts, and permanent magnet one and permanent magnet two are the same size.

[0010] As a further embodiment of this utility model: a fixing plate is also provided on one side of the top of the pellet mill body, a servo motor is installed on the fixing plate, a power shaft is provided on one side of the servo motor, and the end of the power shaft away from the servo motor extends movably into the interior of the material tank and is fixed with a hexagonal insert rod.

[0011] As a further embodiment of this utility model: a granulation knife assembly is provided on the hexagonal insert rod. The granulation knife assembly includes a drive rod and a granulation blade fixed on the drive rod. The inner cavity of the drive rod is provided with a hexagonal insertion hole adapted to the hexagonal insert rod. The drive rod is inserted into the hexagonal insert rod through the hexagonal insertion hole. A screwing block is also provided on one side of the drive rod. A locking screw is fixed on one side of the screwing block. The locking screw is threaded through the drive rod and threadedly connected to the inside of the hexagonal insert rod.

[0012] As a further embodiment of this utility model: a discharge pipe is connected to the bottom of one side of the material tank, a cover plate is provided on the top of the material tank, and a material inlet is provided on the cover plate.

[0013] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0014] First, in this application, the mixing assembly, which is designed to consist of a fixed sleeve, a first mixing blade, a second mixing blade, and a hinge, allows the second mixing blade to be bent directly when the mixing assembly needs to be removed, thereby changing the overall length of the mixing assembly. This makes it easier for workers to remove the mixing assembly from the top opening of the tank, avoiding the limitation of a small opening restricting the quick removal of the mixing assembly. After removal, it is convenient to clean the inside of the tank and the mixing assembly separately, preventing the mixing assembly from obstructing the inner bottom wall of the tank and making it inconvenient to thoroughly clean the inside of the tank.

[0015] Second, in this application, the pelletizing knife assembly, hexagonal insert rod, and locking screw are designed to facilitate the removal of the pelletizing knife assembly from the power shaft of the servo motor. This allows for easy removal from the material tank for individual cleaning and avoids obstruction of the pelletizing knife assembly inside the material tank when cleaning the inner wall of the material tank. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall three-dimensional structure of this utility model;

[0017] Figure 2 This is a side sectional view of the material tank of this utility model;

[0018] Figure 3 This is a schematic diagram of the connection structure between stirring blade one and stirring blade two of this utility model;

[0019] Figure 4 This is a three-dimensional structural diagram of the fixing sleeve after it has been unscrewed from the threaded rod.

[0020] Figure 5 This is a top view of the stirring assembly of this utility model;

[0021] Figure 6 This is a side cross-sectional view of the granulation blade assembly of this utility model.

[0022] The reference numerals and names in the figure are as follows:

[0023] 1. Granulator body; 2. Material tank; 3. Cover plate; 4. Fixing plate; 5. Discharge pipe; 6. Servo motor one; 601. Power shaft; 6011. Hexagonal insert rod; 7. Granulating knife assembly; 701. Drive rod; 702. Granulating blade; 8. Servo motor two; 9. Drive bevel gear; 10. Driven bevel gear; 11. Rotating shaft; 1101. Positioning rod; 1102. Threaded rod; 12. Fixing sleeve; 1201. Positioning hole; 13. Fastening cover; 14. Stirring blade one; 1401. Permanent magnet one; 15. Stirring blade two; 1501. Permanent magnet two; 16. Hinge; 17. Tightening block; 18. Locking screw. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0025] Please see Figure 1-6A wet granulation machine for oral solid dosage forms includes a granulator body 1 and a material tank 2 disposed on its top. A discharge pipe 5 is connected to the bottom of one side of the material tank 2. A cover plate 3 is disposed on the top of the material tank 2, and a feed inlet is provided on the cover plate 3. The discharge pipe 5 facilitates the discharge of the granulated medicine, and the feed inlet facilitates the addition of material to the material tank 2. A rotating shaft 11 driven by a servo motor 8 is rotatably connected to the inner bottom wall of the material tank 2. A positioning rod 1101 is welded to the top of the rotating shaft 11. A threaded rod 1102 is welded to the top of 01, and a stirring assembly is provided on the rod body of the positioning rod 1101. The stirring assembly includes a fixed sleeve 12, stirring blade 14 and stirring blade 15. Multiple stirring blades 14 are welded to the side of the fixed sleeve 12 in a ring at equal intervals. Stirring blade 15 is connected to one side of stirring blade 14 via a hinge 16. Permanent magnet 1401 and permanent magnet 1501 that attract each other are respectively provided on the side of stirring blade 14 and stirring blade 15 that are close to each other.

[0026] Please see Figure 2 , Figure 4 and Figure 5 In this embodiment, the positioning rod 1101 is a hexagonal rod body, and the inner cavity of the fixing sleeve 12 is provided with a positioning hole 1201 that is adapted to the positioning rod 1101 and is also hexagonal. The fixing sleeve 12 is inserted into the positioning rod 1101 through the positioning hole 1201 and fits against the top of the rotating shaft 11. A fastening cover 13 is threadedly connected to the threaded rod 1102, and the fastening cover 13 is tightly pressed against the top of the fixing sleeve 12.

[0027] Specifically, the hexagonal positioning rod 1101 can be engaged with the hexagonal positioning hole 1201 to facilitate positioning and ensure the stability of the fixing sleeve 12. The positioning rod 1101 has a threaded rod 1102. When the fastening cover 13 is screwed in, the pressure of the fastening cover 13 can be used to stabilize the fixing sleeve 12, ensuring the stability of the fixing sleeve 12 after installation. In order to increase the fastening force, a rubber ring can be fitted on the top of the rotating shaft 11 to improve the firmness after the fastening cover 13 is tightened.

[0028] Please see Figure 2 In this embodiment, a driven bevel gear 10 is provided at the bottom of the rotating shaft 11, a servo motor 8 is installed inside the pellet mill body 1, and a driving bevel gear 9 is provided on the power output shaft of the servo motor 8, which meshes with the driven bevel gear 10.

[0029] Specifically, after the servo motor 8 is started, it can drive the active bevel gear 9 to rotate through its power output shaft, thereby driving the driven bevel gear 10 to rotate, which in turn drives the rotating shaft 11 to rotate. When the rotating shaft 11 rotates, it can drive the stirring component installed on it to rotate.

[0030] Please see Figure 2 and Figure 3 In this embodiment, the hinge 16 is bolted to the top between the first stirring blade 14 and the second stirring blade 15, and the first permanent magnet 1401 and the second permanent magnet 1501 are the same size.

[0031] Specifically, when the second stirring blade 15 rotates via the hinge 16, it can rotate to the top of the first stirring blade 14, thereby shortening the original length of the first stirring blade 14 and the second stirring blade 15, making it easier to remove from the top of the material tank 2. The first permanent magnet 1401 and the second permanent magnet 1501 are attracted together by the principle of opposite poles attracting each other, thereby ensuring the stability of the first stirring blade 14 and the second stirring blade 15 after they are in a straight line.

[0032] Please see Figure 1 , Figure 2 and Figure 6 In this embodiment, a fixing plate 4 is also provided on one side of the top of the pellet mill body 1. A servo motor 6 is installed on the fixing plate 4. A power shaft 601 is provided on one side of the servo motor 6. The end of the power shaft 601 away from the servo motor 6 moves through the inside of the material tank 2 and is fixed with a hexagonal insert rod 6011. A pelletizing knife assembly 7 is provided on the hexagonal insert rod 6011. The pelletizing knife assembly 7 includes a drive rod 701 and a pelletizing blade 702 fixed on the drive rod 701. The inner cavity of the drive rod 701 is provided with a hexagonal insertion hole adapted to the hexagonal insert rod 6011. The drive rod 701 is inserted into the hexagonal insert rod 6011 through the hexagonal insertion hole. A screwing block 17 is also provided on one side of the drive rod 701. A locking screw 18 is fixed on one side of the screwing block 17. The locking screw 18 is threaded through the drive rod 701 and threadedly connected to the inside of the hexagonal insert rod 6011.

[0033] Specifically, the servo motor 6 can drive the power shaft 601 to rotate, thereby driving the connected pelletizing knife assembly 7 to rotate. When it is necessary to remove the pelletizing knife assembly 7 for cleaning, it can be done by loosening the locking screw 18. One end of the power shaft 601 has a hexagonal insert 6011, and the inside of the drive rod 701 has a hexagonal insertion hole. Therefore, when the drive rod 701 is inserted into the hexagonal insert 6011, the positioning effect during insertion can be improved, and the stability after locking can also be guaranteed. A rubber ring can also be fitted on one side of the power shaft 601 to improve the firmness of the drive rod 701 after tightening.

[0034] When using:

[0035] After the material tank 2 has been used for a period of time, a certain amount of material will often adhere to the inner side wall, inner bottom wall, stirring assembly and granulation knife assembly 7 of the material tank 2. In order not to affect the subsequent use, the operator can first open the cover plate 3, then loosen the fastening cover 13 so that the fastening cover 13 is detached from the threaded rod 1102. Then the stirring blade 15 can be bent upward. After the stirring blade 15 is subjected to force, the permanent magnet 1501 on the stirring blade 15 separates from the permanent magnet 1401 on the stirring blade 14 and is bent through the hinge 16, so that the stirring blade 15 bends to the top of the stirring blade 14. After multiple stirring blades 15 have been bent, the operator can directly take the fixing sleeve 12, thereby driving the entire stirring assembly to be lifted and taken out from the opening at the top of the material tank 2.

[0036] The locking screw 18 can also be driven out of the hexagonal insert 6011 by rotating the screw block 17, so that the drive rod 701 can be easily removed from the hexagonal insert 6011, and the entire pelletizing knife assembly 7 can be easily removed from the material tank 2.

[0037] After the mixing component and the pelletizing blade assembly 7 are removed from the inside of the tank 2, the inside of the tank 2 is no longer blocked or obstructed by the mixing component and the pelletizing blade assembly 7. Therefore, the staff can easily clean the inner side wall and the inner bottom wall of the tank 2. The removed mixing component and pelletizing blade assembly 7 can also be cleaned separately. After cleaning, the mixing component and the pelletizing blade assembly 7 can be reinstalled inside the tank 2.

[0038] In summary, by effectively removing and cleaning the stirring components and granulation blade assembly 7 inside the material tank 2, the cleanliness of the material tank 2, the stirring components, and the granulation blade assembly 7 can be guaranteed, thereby ensuring the quality of the oral solid dosage form produced by the granulator body 1 and reducing the possibility of quality degradation of the oral solid dosage form due to incomplete cleaning.

[0039] It should be noted that the pellet mill body 1 in this application is common knowledge in the field, and its working principle is already known technology, so it will not be described in detail in the specification.

[0040] It should also be noted that, through a search of existing patent technologies such as CN211188312U and the known shapes of wet granulation tanks, we can find that the tanks of wet granulation machines are wide at the bottom and narrow at the top. Since the overall length of the agitator needs to be adapted to the diameter of the bottom wall of the tank, the length of the agitator is longer than the diameter of the tank opening, which makes it difficult to remove. If the tank is cleaned without removing the agitator, the agitator will undoubtedly become an obstruction because it is close to the bottom wall of the tank, making it inconvenient to clean and also inconvenient to thoroughly clean the agitator. Therefore, this application has designed this technical solution to effectively solve this technical defect and make the cleaning of the material tank 2 more comprehensive.

[0041] It will be apparent to those skilled in the art that this invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of this invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. A wet granulation machine for oral solid dosage forms, comprising a granulator body (1) and a feed tank (2) disposed on top thereon, characterized in that, The inner bottom wall of the material tank (2) is rotatably connected to a rotating shaft (11) driven by a servo motor (8). A positioning rod (1101) is welded to the top of the rotating shaft (11), and a threaded rod (1102) is welded to the top of the positioning rod (1101). A stirring assembly is provided on the rod body of the positioning rod (1101). The stirring assembly includes a fixed sleeve (12), a stirring blade one (14) and a stirring blade two (15). Multiple stirring blades one (14) are welded to the side of the fixed sleeve (12) in a ring at equal intervals. The stirring blade one (14) is connected to the stirring blade two (15) on one side by a hinge (16). The stirring blade one (14) and the stirring blade two (15) are respectively provided with a permanent magnet one (1401) and a permanent magnet two (1501) that attract each other on the side of the stirring blade one (14) and the stirring blade two (1501) that are close to each other.

2. The wet granulation machine for oral solid dosage forms according to claim 1, characterized in that, The positioning rod (1101) is a hexagonal rod body. The inner cavity of the fixing sleeve (12) is provided with a positioning hole (1201) that is adapted to the positioning rod (1101) and is hexagonal. The fixing sleeve (12) is inserted into the positioning rod (1101) through the positioning hole (1201) and fits against the top of the rotating shaft (11). The threaded rod (1102) is threaded with a fastening cap (13), and the fastening cap (13) is tightly pressed against the top of the fixing sleeve (12).

3. The wet granulation machine for oral solid dosage forms according to claim 1, characterized in that, The bottom of the rotating shaft (11) is provided with a driven bevel gear (10), the second servo motor (8) is installed inside the pellet mill body (1), and the power output shaft of the second servo motor (8) is provided with a driving bevel gear (9), which meshes with the driven bevel gear (10).

4. The wet granulation machine for oral solid dosage forms according to claim 1, characterized in that, The hinge (16) is bolted to the top between the first stirring blade (14) and the second stirring blade (15), and the first permanent magnet (1401) and the second permanent magnet (1501) are the same size.

5. The wet granulation machine for oral solid dosage forms according to claim 1, characterized in that, A fixing plate (4) is also provided on one side of the top of the pellet mill body (1). A servo motor (6) is installed on the fixing plate (4). A power shaft (601) is provided on one side of the servo motor (6). The end of the power shaft (601) away from the servo motor (6) moves through the inside of the material tank (2) and is fixed with a hexagonal insert rod (6011).

6. The wet granulation machine for oral solid dosage forms according to claim 5, characterized in that, A granulation knife assembly (7) is provided on the hexagonal insert (6011). The granulation knife assembly (7) includes a drive rod (701) and a granulation blade (702) fixed on the drive rod (701). The inner cavity of the drive rod (701) is provided with a hexagonal insertion hole adapted to the hexagonal insert (6011). The drive rod (701) is inserted into the hexagonal insert (6011) through the hexagonal insertion hole. A screwing block (17) is also provided on one side of the drive rod (701). A locking screw (18) is fixed on one side of the screwing block (17). The locking screw (18) is threaded through the drive rod (701) and threadedly connected to the inside of the hexagonal insert (6011).

7. The wet granulation machine for oral solid dosage forms according to claim 1, characterized in that, The bottom of one side of the material tank (2) is connected to a discharge pipe (5), and the top of the material tank (2) is provided with a cover plate (3), and the cover plate (3) is provided with a feed inlet.

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