A high-efficiency micro-channel continuous flow reaction device for drug synthesis
By introducing components such as a mixing Z-shaped reaction tube, an insert inner tube, and an electric heating rod into a microchannel reactor, combined with a pressure pump and magnetic stirring, the problems of mixing dead zones and insufficient temperature control in existing technologies have been solved, achieving a highly efficient drug synthesis process and improving reaction yield and temperature control accuracy.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- LIAONING BENYUAN PHARMACY CO LTD
- Filing Date
- 2025-05-22
- Publication Date
- 2026-06-09
Smart Images
Figure CN224332126U_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of drug synthesis technology, specifically to a high-efficiency microchannel continuous flow reaction device for drug synthesis. Background Technology
[0002] In the field of drug synthesis, microchannel continuous flow reactors are gradually replacing traditional batch reactors due to their advantages such as high mass and heat transfer efficiency and strong controllability of reaction conditions. However, existing technologies still face many bottlenecks in practical applications, hindering their further promotion in the synthesis of complex drugs: traditional microchannel reactors often employ straight tubes or simple curved structures, resulting in significant laminar flow effects, especially for high-viscosity fluids, which can easily lead to mixing dead zones, requiring external mechanical stirring devices. This not only increases equipment complexity but also poses a risk of contamination due to the difficulty in sealing the rotating shaft. For example, reactors using conventional helical tube designs have insufficient Dean vortex strength to achieve nanoscale homogeneous mixing, resulting in a reaction yield reduction of more than 15%; existing equipment often uses external jacketed temperature control, with long heat conduction paths and heating / cooling rates generally below 5℃ / s, making it difficult to meet the rapid cooling and heating requirements in multi-step synthesis processes. Studies have shown that when temperature fluctuations exceed ±2℃, the enantiomeric excess value of chiral drugs decreases by 20-30%. In addition, traditional PID temperature control algorithms are prone to overshoot in rapid temperature change scenarios, leading to the decomposition of thermosensitive intermediates. Existing technologies may already have solutions to the above problems, but this case aims to provide an alternative or replacement technical solution. Utility Model Content
[0003] To achieve the above objectives, this utility model is implemented through the following technical solution: a high-efficiency microchannel continuous flow reaction device for drug synthesis, comprising: a support platform, multiple raw material tanks, multiple mixing Z-shaped reaction tubes, a pressurizing pump, a feeding structure, and a temperature regulating structure. The multiple raw material tanks, the pressurizing pump, and the multiple mixing Z-shaped reaction tubes are uniformly installed on the support platform. The multiple mixing Z-shaped reaction tubes are connected by pipes. The feeding structure is connected to the multiple raw material tanks and the multiple mixing Z-shaped reaction tubes. The temperature regulating structure is uniformly inserted into the multiple mixing Z-shaped reaction tubes. The temperature regulating structure includes: multiple inserted inner tubes, multiple electric heating rods, multiple coolers, multiple radiators, multiple sleeve shaft tubes, a stirring gear set, a stirring drive, multiple stirring rings, multiple stirring arc magnets, multiple metal strips, and multiple stirring arc blades.
[0004] Multiple insertable inner tubes are respectively inserted into the inner side of multiple mixing Z-shaped reaction tubes. Multiple electric heating rods, multiple coolers, and multiple radiators are evenly installed on the inner side of the multiple insertable inner tubes. Multiple sleeve shaft tubes are respectively sleeved on the inner side of the multiple mixing Z-shaped reaction tubes through bearings. The stirring drive is installed on the support platform. The stirring gear set is sleeved on the multiple sleeve shaft tubes and the stirring drive. Multiple stirring rings are respectively movably sleeved on the multiple insertable inner tubes. Multiple stirring arc magnets are respectively installed on the multiple stirring rings and the multiple sleeve shaft tubes. Multiple metal strips are evenly inserted into the multiple mixing Z-shaped reaction tubes. Multiple stirring arc blades are respectively installed on the multiple stirring rings.
[0005] It should be noted that, as described above, the raw liquid is drawn into the inner side of the mixing Z-shaped reaction tube by a pressure pump on the support platform. Multiple mixing Z-shaped reaction tubes are connected end to end, and the liquid is drawn in an S-shape. Different raw materials from multiple raw material tanks are drawn into the inner side of multiple mixing Z-shaped reaction tubes one by one by a feeding structure. The temperature of the insert inner tube is controlled by an electric heating rod, a cooler, and a radiator. The temperature of the mixing Z-shaped reaction tube is controlled by the insert inner tube. The stirring drive motor runs, driving the stirring gear set to rotate. The stirring gear set drives the sleeve shaft tube to rotate stably. The sleeve shaft tube drives the stirring arc magnet on it. Multiple metal strips on the mixing Z-shaped reaction tube transmit the magnetism to the stirring arc magnet on the stirring ring for magnetic drive. The rotating stirring ring drives the stirring arc blades on it to rotate. Multiple rotating stirring arc blades drive the liquid inside the mixing Z-shaped reaction tube in one direction. Thus, the raw materials are stirred and mixed at the same time, and the reaction is accelerated by internal temperature control.
[0006] Preferably, the feeding structure includes: multiple feeding pneumatic pipes, multiple three-way pneumatic valves, multiple feeding hydraulic push rods, and multiple feeding push discs;
[0007] Multiple three-phase pneumatic valves are respectively connected to multiple mixing Z-type reaction tubes, multiple feeding pneumatic tubes are respectively connected to multiple three-phase pneumatic valves, multiple feeding hydraulic push rods are respectively installed on the inner side of multiple feeding pneumatic tubes, and multiple feeding push discs are respectively installed on the pushing end of multiple feeding hydraulic push rods;
[0008] It should be noted that, as described above, the feeding hydraulic push rod inside the feeding pneumatic pipe operates, driving the feeding push disc on the push end. The feeding push disc stably extends and retracts along the inner side of the feeding pneumatic pipe, thereby guiding the gas inside the feeding pneumatic pipe to the three-phase pneumatic valve. The three-phase pneumatic valve then guides the gas to the inner side of the raw material box. Through high pressure, the raw material inside the raw material box is guided to the inner side of the mixing Z-shaped reaction tube, thereby achieving rapid mixing and stirring.
[0009] Preferably, flow sensors are installed on the three pressure valves and the mixing Z-shaped reaction tube.
[0010] Preferably, the mixing Z-type reaction tube is equipped with a Tesla valve tube.
[0011] Preferably, the mixing Z-shaped reaction tube is equipped with a scanning camera.
[0012] Preferably, a temperature sensor is provided on the inner side of the mixing Z-shaped reaction tube. Beneficial effects
[0013] This invention provides a highly efficient microchannel continuous flow reaction device for drug synthesis. Compared with existing technologies, this highly efficient microchannel continuous flow reaction device for drug synthesis achieves the following advantages: Multiple S-shaped turbulent flow paths are formed under the drive of a pressurized pump, and three-dimensional dynamic mixing is achieved with magnetic stirring: The stirring drive motor drives the rotating shaft tube through a gear set, and the magnetic force of the metal strip drives the arc-shaped blades on the stirring ring to perform directional shearing, so that the high-viscosity pig blood raw material achieves microscopic homogenization under the synergistic effect of centrifugal force and magnetic coupling force. The integrated temperature control adopts a nested inner tube design, and through the combination of electric heating rod, semiconductor cooling chip and heat sink, it can achieve precise temperature control over a wide range from -20℃ to 150℃ within 3 seconds. Combined with the multi-segment independent temperature control module of the Z-shaped tube, it effectively avoids the denaturation and inactivation of heat-sensitive components. The high-pressure feeding innovatively adopts gas-liquid dual-phase push technology. Three pneumatic valves, combined with a hydraulic push rod driven push disc, can achieve millisecond-level precise metering and feeding of multiple raw materials at a pressure of 0.5MPa. Real-time control by a flow sensor ensures that the mixing ratio error is <0.3%. The device is equipped with an intelligent monitoring system consisting of scanning cameras and temperature sensors, which can dynamically capture phase changes during the reaction process and achieve adaptive optimization of process parameters with the help of edge computing algorithms. The whole machine adopts a compact vertical layout, with the support platform integrating 8 reaction units. It occupies only 0.8m² but has 3 times the processing capacity of traditional equipment, making it particularly suitable for the needs of multiple batch parallel experiments in the laboratory. Attached Figure Description
[0014] Figure 1 This is a top cross-sectional view of the efficient microchannel continuous flow reaction apparatus for drug synthesis described in this utility model.
[0015] Figure 2 This is a front cross-sectional view of the efficient microchannel continuous flow reaction apparatus for drug synthesis described in this utility model.
[0016] Figure 3 for Figure 2 A magnified view of the letter "A" in the image.
[0017] In the diagram: 1. Support platform; 2. Raw material box; 3. Mixing Z-shaped reaction tube; 4. Pressure pump; 5. Inserted inner tube; 6. Electric heating rod; 7. Cooler; 8. Radiator; 9. Set shaft tube; 10. Stirring gear set; 11. Stirring drive motor; 12. Stirring ring; 13. Stirring arc magnet; 14. Metal strip; 15. Stirring arc blade; 16. Feeding air pressure pipe; 17. Three-way air pressure valve; 18. Feeding hydraulic push rod; 19. Feeding push disc. Detailed Implementation
[0018] Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.
[0019] Those skilled in the art should connect all electrical components and their compatible power supplies in this case via wires. Appropriate controllers and encoders should be selected according to the actual situation to meet control requirements. The specific connection and control sequence should refer to the working principle described below, where the electrical components are connected in sequence. The detailed connection methods are well-known in the art. The following mainly introduces the working principle and process, and will not describe the electrical control further. Example
[0020] The present invention will now be described in detail with reference to the accompanying drawings, such as... Figure 1-3As shown, multiple raw material tanks 2, pressure pumps 4, and multiple mixing Z-shaped reaction tubes 3 are evenly installed on the support platform 1. The multiple mixing Z-shaped reaction tubes 3 are connected by pipes. The feeding structure is connected to the multiple raw material tanks 2 and the multiple mixing Z-shaped reaction tubes 3. The temperature regulating structure is evenly inserted into the multiple mixing Z-shaped reaction tubes 3. The temperature regulating structure includes: multiple inserted inner tubes 5, multiple electric heating rods 6, multiple coolers 7, multiple radiators 8, multiple sleeve shaft tubes 9, stirring gear set 10, stirring drive motor 11, and multiple stirring circles. The system comprises a ring 12, multiple arc-shaped stirring magnets 13, multiple metal strips 14, and multiple arc-shaped stirring blades 15; multiple insertable inner tubes 5 are respectively inserted into the inner sides of multiple mixing Z-shaped reaction tubes 3; multiple electric heating rods 6, multiple coolers 7, and multiple radiators 8 are evenly installed on the inner sides of the multiple insertable inner tubes 5; multiple sleeved shaft tubes 9 are respectively sleeved on the inner sides of the multiple mixing Z-shaped reaction tubes 3 via bearings; a stirring drive motor 11 is mounted on the support platform 1; and a stirring gear set 10 is sleeved on the multiple sleeved shaft tubes 9 and the stirring drive motor 11. Above, multiple stirring rings 12 are movably mounted on multiple insert inner tubes 5, multiple stirring arc magnets 13 are respectively mounted on multiple stirring rings 12 and multiple sleeve shaft tubes 9, multiple metal strips 14 are evenly inserted on multiple mixing Z-shaped reaction tubes 3, and multiple stirring arc plates 15 are respectively mounted on multiple stirring rings 12; the feeding structure includes: multiple feeding air pressure pipes 16, multiple three-way air pressure valves 17, multiple feeding hydraulic push rods 18, and multiple feeding push discs 19; the multiple three-way air pressure valves 17 are respectively connected to multiple On the mixing Z-shaped reaction tube 3, multiple feeding pneumatic pipes 16 are respectively connected to multiple three-phase pneumatic valves 17, multiple feeding hydraulic push rods 18 are respectively installed on the inner side of multiple feeding pneumatic pipes 16, and multiple feeding push discs 19 are respectively installed on the pushing end of multiple feeding hydraulic push rods 18; flow sensors are provided on the three-phase pneumatic valves 17 and the mixing Z-shaped reaction tube 3; Tesla valve tube is provided on the mixing Z-shaped reaction tube 3; scanning camera is provided on the mixing Z-shaped reaction tube 3; temperature sensor is provided on the inner side of the mixing Z-shaped reaction tube 3.
[0021] According to the appendix Figure 1-3It is found that the original liquid is drawn into the inner side of the mixing Z-shaped reaction tube 3 by the pressure pump 4 on the support platform. The liquid is drawn into an S-shape by connecting the ends of multiple mixing Z-shaped reaction tubes 3. Different raw materials from the inside of multiple raw material tanks 2 are drawn into the inner side of multiple mixing Z-shaped reaction tubes 3 one by one by the feeding structure. The temperature of the insert inner tube 5 is controlled by the electric heating rod 6, the cooler 7 and the radiator 8. The temperature of the mixing Z-shaped reaction tube 3 is controlled by the insert inner tube 5. The stirring drive motor 11 runs and drives the stirring gear set 10 to rotate. The stirring gear set 10 drives the sleeve shaft tube 9 to rotate stably. The sleeve shaft tube 9 drives the stirring arc magnet 13 on it. The magnetism is transferred to the stirring arc magnet 13 on the stirring ring 12 by multiple metal strips 14 on the mixing Z-shaped reaction tube 3. Magnetic drive is used, with the rotating stirring ring 12 driving the stirring arc blades 15 on it to rotate. Multiple rotating stirring arc blades 15 drive the liquid inside the mixing Z-shaped reaction tube 3 in one direction, thus mixing the raw materials while accelerating the reaction through internal temperature control. The feeding hydraulic push rod 18 inside the feeding air pressure pipe 16 drives the feeding push disk 19 on the push end. The feeding push disk 19 stably extends and retracts along the inside of the feeding air pressure pipe 16, thereby guiding the gas inside the feeding air pressure pipe 16 to the three-way air pressure valve 17. The three-way air pressure valve 17 guides the gas to the inside of the raw material tank 2. Through high pressure, the raw materials inside the raw material tank 2 are guided to the inside of the mixing Z-shaped reaction tube 3, thereby achieving rapid mixing.
[0022] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.
Claims
1. A highly efficient microchannel continuous flow reaction apparatus for drug synthesis, comprising: The system comprises a support platform, multiple raw material tanks, multiple mixing Z-shaped reaction tubes, a pressurizing pump, a feeding structure, and a temperature regulating structure. The raw material tanks, pressurizing pump, and mixing Z-shaped reaction tubes are evenly mounted on the support platform. The mixing Z-shaped reaction tubes are connected by pipes. The feeding structure is connected to the raw material tanks and mixing Z-shaped reaction tubes. The temperature regulating structure is evenly inserted into the mixing Z-shaped reaction tubes. The temperature regulating structure includes: multiple insertable inner tubes, multiple electric heating rods, multiple coolers, multiple radiators, multiple sleeve shaft tubes, a stirring gear set, a stirring drive motor, multiple stirring rings, multiple stirring arc magnets, multiple metal strips, and multiple stirring arc blades. Multiple insertable inner tubes are respectively inserted into the inner side of multiple mixing Z-shaped reaction tubes. Multiple electric heating rods, multiple coolers, and multiple heat sinks are evenly installed on the inner side of the multiple insertable inner tubes. Multiple sleeve shafts are respectively sleeved on the inner side of the multiple mixing Z-shaped reaction tubes via bearings. The stirring drive is installed on the support platform. The stirring gear set is sleeved on the multiple sleeve shafts and the stirring drive. Multiple stirring rings are movably sleeved on the multiple insertable inner tubes. Multiple stirring arc magnets are respectively installed on the multiple stirring rings and the multiple sleeve shafts. Multiple metal strips are evenly inserted into the multiple mixing Z-shaped reaction tubes. Multiple stirring arc blades are respectively installed on the multiple stirring rings.
2. The high-efficiency microchannel continuous flow reaction apparatus for drug synthesis according to claim 1, characterized in that, The feeding structure includes: multiple feeding pneumatic pipes, multiple three-way pneumatic valves, multiple feeding hydraulic push rods, and multiple feeding push discs; Multiple three-phase pneumatic valves are respectively connected to multiple mixing Z-shaped reaction tubes, multiple feeding pneumatic pipes are respectively connected to multiple three-phase pneumatic valves, multiple feeding hydraulic push rods are respectively installed on the inner side of multiple feeding pneumatic pipes, and multiple feeding push discs are respectively installed on the pushing end of multiple feeding hydraulic push rods.
3. The high-efficiency microchannel continuous flow reaction apparatus for drug synthesis according to claim 2, characterized in that, The three pressure valves and the mixing Z-shaped reaction tube are equipped with flow sensors.
4. The high-efficiency microchannel continuous flow reaction apparatus for drug synthesis according to claim 3, characterized in that, The mixing Z-type reaction tube is equipped with a Tesla valve tube.
5. The high-efficiency microchannel continuous flow reaction apparatus for drug synthesis according to claim 4, characterized in that, A scanning camera is installed on the mixing Z-shaped reaction tube.
6. The high-efficiency microchannel continuous flow reaction apparatus for drug synthesis according to claim 5, characterized in that, A temperature sensor is installed on the inside of the mixing Z-shaped reaction tube.