Reaction fermenter

Abstract

This utility model discloses a reaction fermenter, relating to the field of biopharmaceutical technology. It includes a tank body and a cooling device. The tank body comprises a heat exchange chamber and a fermentation chamber. The fermentation chamber is fixedly connected within the heat exchange chamber, with the heat exchange chamber circumferentially positioned outside the fermentation chamber. The heat exchange chamber and the fermentation chamber are not interconnected. The heat exchange chamber has an inlet and an outlet. The inlet is used to introduce a cooling medium into the heat exchange chamber, and the outlet is used to discharge the cooling medium from the heat exchange chamber. The cooling device includes a power drive device capable of driving the flow of the cooling medium within the heat exchange chamber. Fixing the fermentation chamber within the heat exchange chamber and circumferentially positioning it outside the fermentation chamber increases the contact area between the cooling medium and the fermentation chamber. The power drive device, capable of driving the flow of the cooling medium within the heat exchange chamber, results in a more uniform temperature distribution of the cooling medium, leading to more precise temperature control of the reaction fermenter.

Description

Technical Field

[0001] This utility model relates to the field of biopharmaceutical technology, and in particular to a reaction fermenter. Background Technology

[0002] In biopharmaceutical processes, product quality is a crucial indicator, and temperature control directly impacts it. This is especially true in blood product manufacturing, where each component reaction solution must be processed at a specified temperature to extract the desired active ingredients from the blood. Exceeding the specified temperature range can lead to decreased product yield or even product failure. Therefore, proper temperature control is essential for ensuring product quality in biopharmaceutical processes. Existing cooling equipment typically involves installing warm water pipes inside the fermentation tank. For example, patent CN205420378U discloses a biopharmaceutical fermentation tank with high-efficiency cooling. This tank has cooling coils connected to its inner wall, with the bottom of the coils connected to a cooling water outlet pipe and the top connected to a cooling water inlet pipe. However, uneven heat transfer between the cooling water in the coils and the tank can easily lead to excessive cooling, resulting in an excessively low temperature inside the tank and inaccurate temperature control. Utility Model Content

[0003] The purpose of this invention is to provide a reaction fermenter to solve the problems existing in the prior art and to make the temperature control of the reaction fermenter more precise.

[0004] To achieve the above objectives, this utility model provides the following solution:

[0005] This utility model provides a reaction fermenter, comprising: a tank body and a cooling device. The tank body includes a heat exchange chamber and a fermentation chamber. The fermentation chamber is fixedly connected to the heat exchange chamber and is arranged in a ring around the outside of the fermentation chamber. The heat exchange chamber and the fermentation chamber are not in communication with each other. The heat exchange chamber has a liquid inlet and a liquid outlet. The liquid inlet is used to introduce a cooling medium into the heat exchange chamber, and the liquid outlet is used to discharge the cooling medium from the heat exchange chamber. The cooling device includes a power drive device that can drive the cooling medium to flow in the heat exchange chamber.

[0006] In some embodiments, the cooling device further includes a circulation pipeline, one end of which is connected to the liquid inlet and the other end of which is connected to the liquid outlet. A first valve is connected to the circulation pipeline, and the power drive device is a circulation pump connected to the circulation pipeline.

[0007] In some embodiments, the cooling device further includes an inlet pipe and an outlet pipe, the inlet pipe being connected to the inlet port and equipped with a second valve, the outlet pipe being connected to the outlet port and equipped with a third valve.

[0008] In some embodiments, the second valve is a proportional control valve.

[0009] In some embodiments, the reaction fermenter also includes a stirring device for stirring the pharmaceuticals within the fermentation chamber.

[0010] In some embodiments, the stirring device includes a motor and a stirring rod, the stirring rod being fixedly connected to the rotating output end of the motor, and a stirring blade being fixedly connected to the end of the stirring rod away from the motor. The motor is capable of driving the stirring rod to rotate. The stirring rod is rotatably connected to the tank body, and the end of the stirring rod having the stirring blade extends into the fermentation chamber.

[0011] In some embodiments, the reaction fermenter further includes a temperature detection device, which includes a first temperature sensor fixedly connected to the inner wall of the fermentation chamber.

[0012] In some embodiments, the temperature detection device further includes a second temperature sensor, which is fixedly connected to the inner wall of the heat exchange chamber.

[0013] In some embodiments, the tank body is also fixedly connected to an inlet / outlet channel, which communicates with the fermentation chamber and is used to feed or discharge material into the fermentation chamber.

[0014] In some embodiments, there is a space for the flow of cooling medium between the bottom wall of the fermentation chamber and the inner wall of the heat exchange chamber.

[0015] The present invention achieves the following technical advantages over the prior art:

[0016] This invention provides a reaction fermenter. By circling the heat exchange chamber around the fermentation chamber, a cooling medium is introduced into the heat exchange chamber from the liquid inlet. The cooling medium can be distributed around the fermentation chamber, increasing the heat exchange area between the drug and the cooling medium. The power drive device can drive the flow of the cooling medium in the heat exchange chamber, thereby making the temperature distribution of the cooling medium in the heat exchange chamber more uniform and the heat transfer between the cooling medium and the fermentation chamber more uniform. This effectively avoids uneven temperature distribution of the cooling medium in the heat exchange chamber, where the local temperature is too high, and excessive cooling of the drug in the fermentation chamber due to excessive introduction of cooling medium, thus enabling more precise temperature control of the reaction fermenter. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 This is a schematic diagram of the structure of the reaction fermenter in some embodiments of this utility model;

[0019] In the diagram: 1-Fermentation chamber, 2-Heat exchange chamber, 3-Tank body, 4-Second temperature sensor, 5-First temperature sensor, 6-Stirring blade, 7-Stirring rod, 8-Second valve, 9-Inlet pipe, 10-First valve, 11-Circulation pump, 12-Fourth valve, 13-Circulation pipeline, 14-Third valve, 15-Outlet pipe, 16-Motor, 17-Inlet and outlet channels. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0021] The purpose of this invention is to provide a reaction fermenter to solve the problems existing in the prior art and to make the temperature control of the reaction fermenter more precise.

[0022] To make the above-mentioned objectives, features and advantages of this utility model more apparent and understandable, the utility model will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0023] This utility model provides a reaction fermenter, such as Figure 1As shown, it includes: a tank body 3 and a cooling device. The tank body 3 includes a heat exchange chamber 2 and a fermentation chamber 1. The fermentation chamber 1 is fixedly connected inside the heat exchange chamber 2, and the heat exchange chamber 2 is arranged in a ring outside the fermentation chamber 1. The heat exchange chamber 2 and the fermentation chamber 1 are not connected to each other. The heat exchange chamber 2 has a liquid inlet and a liquid outlet. The liquid inlet is used to introduce cooling medium into the heat exchange chamber 2, and the liquid outlet is used to discharge cooling medium from the heat exchange chamber 2. The cooling device includes a power drive device, which can drive the cooling medium to flow in the heat exchange chamber 2. Fermentation chamber 1 can be used to hold pharmaceuticals. By circling heat exchange chamber 2 around the outside of fermentation chamber 1, cooling medium is introduced into heat exchange chamber 2 through the inlet. The cooling medium can be distributed around fermentation chamber 1, increasing the heat exchange area between the pharmaceuticals and the cooling medium. A power drive device can drive the flow of cooling medium within heat exchange chamber 2, resulting in a more uniform temperature distribution and heat transfer between the cooling medium and fermentation chamber 1. This effectively prevents uneven temperature distribution and localized high temperatures within heat exchange chamber 2, which could lead to excessive cooling of the pharmaceuticals in fermentation chamber 1. This allows for more precise temperature control of the reaction fermenter. The reaction fermenter provided in this embodiment can be applied to biopharmaceuticals, and fermentation chamber 1 can be used to hold pharmaceuticals.

[0024] When the drug in fermentation chamber 1 cools down to near the preset temperature, the cooling medium is stopped from being supplied to heat exchange chamber 2, and the power drive device is turned on to allow the cooling medium in heat exchange chamber 2 to flow. The cooling medium with a higher temperature near fermentation chamber 1 and the cooling medium with a lower temperature far away from fermentation chamber 1 can exchange heat through circulation. The cooling medium with a smaller temperature difference from the cooling medium in fermentation chamber 1 after heat exchange in heat exchange chamber 2 continues to cool fermentation chamber 1 until fermentation chamber 1 reaches the preset temperature. This avoids excessive cooling of fermentation chamber 1 caused by continuing to supply a lower temperature cooling medium, and makes the temperature control of the reaction fermenter more precise.

[0025] In another embodiment of this invention, the cooling device further includes a circulation pipeline 13. One end of the circulation pipeline 13 is connected to the liquid inlet, and the other end is connected to the liquid outlet. A first valve 10 is connected to the circulation pipeline 13, and the power drive device is a circulation pump 11, which is connected to the circulation pipeline 13. By setting up the circulation pipeline 13 and connecting the circulation pump 11 to it, the cooling medium is driven by the circulation pump 11 to flow through the circulation pipeline 13 for circulation. The structure is simple and the use is more convenient.

[0026] It should be noted that the power drive device of the reaction fermenter provided by this utility model is not limited to the structure in the above embodiments. The power drive device can also be a water turbine or other structure capable of driving the flow of cooling medium.

[0027] In another embodiment of this invention, the cooling device further includes an inlet pipe 9 and an outlet pipe 15. The inlet pipe 9 is connected to an inlet port and is equipped with a second valve 8. The outlet pipe 15 is connected to an outlet port and is equipped with a third valve 14. The second valve 8 can control the connection or disconnection between the inlet pipe 9 and the heat exchange chamber 2, and the third valve 14 can control the connection or disconnection between the outlet pipe 15 and the heat exchange chamber 2, making the reaction fermenter more convenient to use.

[0028] In another embodiment of this invention, the second valve 8 is a proportional control valve. The proportional control valve can adjust the flow rate of the cooling medium in the inlet pipe 9, thereby controlling the rate at which the cooling medium enters the heat exchange chamber 2, making the temperature control of the reaction fermenter more precise.

[0029] In another embodiment of this invention, a fourth valve 12 is also connected to the circulation pipeline 13. The first valve 10 and the fourth valve 12 are respectively located on both sides of the circulation pump 11. The fourth valve 12 can control the connection or disconnection between the circulation pipeline 13 and the outlet pipe 15, making the reaction fermenter more convenient to use.

[0030] In another embodiment of this invention, the reaction fermenter further includes a stirring device for stirring the pharmaceuticals within the fermentation chamber 1. When cooling the pharmaceuticals within the fermentation chamber 1, the stirring device can be used to stir the pharmaceuticals, resulting in a more uniform temperature and better cooling effect.

[0031] In another embodiment of this invention, the stirring device includes a motor 16 and a stirring rod 7. The stirring rod 7 is fixedly connected to the rotation output end of the motor 16, and a stirring blade 6 is fixedly connected to the end of the stirring rod 7 away from the motor 16. The motor 16 can drive the stirring rod 7 to rotate. The stirring rod 7 is rotatably connected to the tank 3, and the end of the stirring rod 7 with the stirring blade 6 extends into the fermentation chamber 1. By driving the stirring rod 7 to rotate through the motor 16, the stirring rod 7 drives the stirring blade 6 to rotate, thereby realizing the stirring of the medicine in the fermentation chamber 1. This method is convenient to use and saves manpower.

[0032] In another embodiment of this invention, the reaction fermenter further includes a temperature detection device, which includes a first temperature sensor 5 fixedly connected to the inner wall of the fermentation chamber 1. The first temperature sensor 5 can measure the temperature of the fermentation chamber 1, thereby controlling whether to continue supplying cooling medium, making the temperature control of the reaction fermenter more precise.

[0033] In another embodiment of this invention, the temperature detection device further includes a second temperature sensor 4, which is fixedly connected to the inner wall of the heat exchange chamber 2. The second temperature sensor 4 can measure the temperature inside the heat exchange chamber 2, obtaining the temperature difference between the fermentation chamber 1 and the heat exchange chamber 2, thereby enabling control of the amount and duration of cooling medium flow, resulting in more precise temperature control of the reaction fermenter.

[0034] In another embodiment of this invention, the tank body 3 is also fixedly connected to an inlet / outlet channel 17, which communicates with the fermentation chamber 1. The inlet / outlet channel 17 is used to feed or discharge materials into the fermentation chamber 1. This allows for the convenient use of the reaction fermenter, enabling the addition or removal of pharmaceuticals from the fermentation chamber 1 via the inlet / outlet channel 17.

[0035] In another embodiment of this invention, a cooling medium flows between the bottom wall of the fermentation chamber 1 and the inner wall of the heat exchange chamber 2. This allows the cooling medium to cool the medicine at the bottom of the fermentation chamber 1, increasing the heat exchange area and improving cooling efficiency.

[0036] In another embodiment of this invention, the cooling device further includes a refrigeration device. The inlet of the refrigeration device is connected to the liquid outlet of the heat exchange chamber 2, and the outlet of the refrigeration device is connected to the liquid inlet of the heat exchange chamber 2. The refrigeration device can cool the cooling medium within it, allowing the cooling medium to be recycled.

[0037] In another embodiment of this invention, the reaction fermenter also includes a control device. The first temperature sensor 5, the second temperature sensor 4, the motor 16, the first valve 10, the second valve 8, the third valve 14, the fourth valve 12, and the circulating pump 11 are all connected to the control device. This makes the reaction fermenter easier to use and improves its working efficiency.

[0038] The specific usage method of the reaction fermenter in this embodiment is as follows:

[0039] Step 1: Before operation, ensure that the refrigeration device is in normal operation. In the control system of the control device, set the first temperature T1 to which the medicine in fermentation chamber 1 needs to be cooled down, and the second temperature T2 which is slightly higher than the first temperature.

[0040] Step 2: Start the first cooling process. Open the second valve 8 and the third valve 14, close the first valve 10 and the fourth valve 12, and introduce the cooling medium into the heat exchange chamber 2. Turn on the motor 16 to drive the stirring rod 7 to rotate and drive the stirring blade 6 to rotate. When the temperature reported by the first temperature sensor 5 reaches the second temperature T2, close the second valve 8 and the third valve 14.

[0041] Step 3: Begin the second cooling process by opening the first valve 10 and the fourth valve 12, and starting the circulation pump 11 to drive the cooling medium to flow through the circulation pipeline 13 for circulation.

[0042] Step 4: If, after a preset time, the temperature reported by the first temperature sensor 5 reaches the first temperature T1, close the first valve 10 and the fourth valve 12, the circulating pump 11 and the motor 16, open the third valve 14, and discharge the cooling medium in the heat exchange chamber 2, thus completing the cooling of the medicine in the fermentation chamber 1; if, after a preset time, the temperature reported by the first temperature sensor 5 is still higher than the first temperature T1, proceed to Step 5 until the temperature reported by the first temperature sensor 5 reaches the first temperature T1, close the first valve 10 and the fourth valve 12, the circulating pump 11 and the motor 16, open the third valve 14, and discharge the cooling medium in the heat exchange chamber 2, thus completing the cooling of the medicine in the fermentation chamber 1.

[0043] Step 5: Open the second valve 8 and the third valve 14. At this time, the opening degree of the second valve 8 is less than that in Step 1, so that a small amount of cooling medium slowly flows into the heat exchange chamber 2. Then close the second valve 8 and the third valve 14, open the first valve 10 and the fourth valve 12, start the circulation pump 11, and start the circulation pump 11 to drive the cooling medium to flow through the circulation pipeline 13 for circulation.

[0044] This utility model uses specific examples to illustrate its principles and implementation methods. The above description of the embodiments is only for the purpose of helping to understand the method and core idea of ​​this utility model. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the idea of ​​this utility model. In summary, the content of this specification should not be construed as a limitation of this utility model.

Claims

1. A reaction fermenter, characterized in that: include: The tank (3) and the cooling device are provided. The tank (3) includes a heat exchange chamber (2) and a fermentation chamber (1). The fermentation chamber (1) is fixedly connected to the heat exchange chamber (2) and the heat exchange chamber (2) is arranged around the outside of the fermentation chamber (1). The heat exchange chamber (2) and the fermentation chamber (1) are not connected to each other. The heat exchange chamber (2) has a liquid inlet and a liquid outlet. The liquid inlet is used to introduce cooling medium into the heat exchange chamber (2), and the liquid outlet is used to discharge cooling medium from the heat exchange chamber (2). The cooling device includes a power drive device that can drive the cooling medium in the heat exchange chamber (2) to flow.

2. The reaction fermenter according to claim 1, characterized in that: The cooling device also includes a circulation pipeline (13), one end of which is connected to the liquid inlet and the other end of which is connected to the liquid outlet. A first valve (10) is connected to the circulation pipeline (13), and the power drive device is a circulation pump (11), which is connected to the circulation pipeline (13).

3. The reaction fermenter according to claim 1, characterized in that: The cooling device further includes an inlet pipe (9) and an outlet pipe (15). The inlet pipe (9) is connected to the inlet port and a second valve (8) is provided on the inlet pipe (9). The outlet pipe (15) is connected to the outlet port and a third valve (14) is provided on the outlet pipe (15).

4. The reaction fermenter according to claim 3, characterized in that: The second valve (8) is a proportional regulating valve.

5. The reaction fermenter according to claim 1, characterized in that: It also includes a stirring device for stirring the medicine in the fermentation chamber (1).

6. The reaction fermenter according to claim 5, characterized in that: The stirring device includes a motor (16), a stirring rod (7), and a stirring blade (6). The stirring rod (7) is fixedly connected to the rotation output end of the motor (16). The stirring blade (6) is fixedly connected to the end of the stirring rod (7) away from the motor (16). The motor (16) can drive the stirring rod (7) to rotate. The stirring rod (7) is rotatably connected to the tank (3). The end of the stirring rod (7) with the stirring blade (6) extends into the fermentation chamber (1).

7. The reaction fermenter according to claim 1, characterized in that: It also includes a temperature detection device, which includes a first temperature sensor (5) that is fixedly connected to the inner wall of the fermentation chamber (1).

8. The reaction fermenter according to claim 7, characterized in that: The temperature detection device also includes a second temperature sensor (4), which is fixedly connected to the inner wall of the heat exchange chamber (2).

9. The reaction fermenter according to claim 1, characterized in that: The tank (3) is also fixedly connected to an inlet / outlet channel (17), which is connected to the fermentation chamber (1) and is used to feed or discharge material into the fermentation chamber (1).

10. The reaction fermenter according to claim 1, characterized in that: There is a space for the flow of cooling medium between the bottom wall of the fermentation chamber (1) and the inner wall of the heat exchange chamber (2).

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