A pre-made phantom model for evaluating the imaging effectiveness of ultrasound contrast agents
By designing a prefabricated phantom model that includes a container, a gel phantom, and detachable U-shaped tubes and tapered latex tubes, the problem of difficulty in evaluating the imaging effect of ultrasound contrast agents in existing technologies has been solved, enabling more realistic in vivo vascular simulation and multi-angle imaging, thus improving the imaging effect.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- PEKING UNIV
- Filing Date
- 2024-12-11
- Publication Date
- 2026-06-09
AI Technical Summary
The lack of effective prefabricated phantom models in the current technology to evaluate the imaging effect of ultrasound contrast agents has led to the main verification of the imaging capability of ultrasound contrast agents being carried out in vitro, which cannot truly simulate the in vivo vascular structure and imaging effect.
Design a prefabricated phantom model comprising a housing, a gel phantom, and U-shaped tubes and tapered latex tubes of different inner diameters. By simulating the vascular structure in vivo and allowing the U-shaped tubes and tapered latex tubes to be disassembled to avoid artifacts, it provides multi-angle scanning and imaging methods.
It achieves more realistic in vivo vascular simulation, reduces artifacts, improves the accuracy of ultrasound contrast agent imaging evaluation and multi-angle imaging capabilities, and provides better imaging results.
Smart Images
Figure CN224341959U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of medical device technology, specifically to a prefabricated phantom model for evaluating the imaging effect of ultrasound contrast agents. Background Technology
[0002] Contrast-enhanced ultrasound (CEUS) is a technique that uses contrast agents to enhance backscattered echoes, significantly improving the resolution, sensitivity, and specificity of ultrasound diagnosis. With improvements in instrument performance and the emergence of new acoustic contrast agents, CEUS can effectively enhance two-dimensional ultrasound images and blood flow Doppler signals of solid organs such as the myocardium, liver, kidneys, and brain, reflecting and observing the blood perfusion of normal and diseased tissues. It has become a very important and promising direction in ultrasound diagnosis. Since its clinical application in the late 1960s, CEUS technology has developed significantly. Its clinical application in organ diseases has proven its important role in the detection and qualitative diagnosis of tumors.
[0003] Currently, the imaging capability verification of most ultrasound contrast agents is carried out in vitro. Therefore, it is particularly important to prepare a prefabricated phantom model that can evaluate the imaging effect of ultrasound contrast agents. Utility Model Content
[0004] Therefore, this application provides a prefabricated phantom model for evaluating the imaging effect of ultrasound contrast agents, the specific solution of which is as follows: A prefabricated phantom model for evaluating the imaging effect of ultrasound contrast agents, characterized in that it comprises:
[0005] Storage box;
[0006] A gel phantom placed inside a container;
[0007] The first U-shaped tube, the second U-shaped tube, the third U-shaped tube, and several tapered latex tubes are embedded in the gel prosthetic body.
[0008] In one specific embodiment of this application, the inner diameter of the first U-shaped tube is smaller than the inner diameter of the third U-shaped tube.
[0009] In one specific embodiment of this application, the inner diameter of the second U-shaped tube gradually increases from one end of the second U-shaped tube opening to the other end.
[0010] In one specific embodiment of this application, the container is an open cuboid, the open side is one of the cuboids with the largest area, and the side opposite the open side is the bottom surface of the container.
[0011] In one specific embodiment of this application, the container is made of PE or acrylic.
[0012] In one specific embodiment of this application, the opening of the tapered latex tube, as well as the openings of the first U-shaped tube, the second U-shaped tube, and the third U-shaped tube, are all open.
[0013] In one specific embodiment of this application, the tapered latex tube is placed at intervals along the two longest sides of the receiving box.
[0014] In one specific embodiment of this application, the tip of the tapered latex tube faces the bottom surface of the receiving box.
[0015] In one specific embodiment of this application, a fixing structure is used to fix the first U-shaped tube, the second U-shaped tube, and the third U-shaped tube to the bottom inner wall of the receiving box, so that the open surfaces of the first U-shaped tube, the second U-shaped tube, and the third U-shaped tube are parallel to the bottom surface of the receiving box.
[0016] In one specific embodiment of this application, the first U-tube, the second U-tube, and the third U-tube are latex hoses.
[0017] This application has the following beneficial technical effects:
[0018] This application provides a prefabricated phantom model for evaluating the imaging effect of ultrasound contrast agents. It features a variable-diameter U-shaped tube and other U-shaped tubes with varying inner diameters, allowing for a more realistic simulation of blood vessels in the body. Furthermore, if imaging artifacts occur, the U-shaped tube and tapered latex tube can be disassembled, and the contrast agent injected into the phantom body, resulting in better imaging. Further, a portion of the sidewall of the receiving box can be disassembled, allowing ultrasound scanning from the top or side of the receiving box to obtain even better imaging results. Moreover, the tapered latex tube can provide a cross-sectional image during side scanning by the ultrasound probe. If artifacts occur with the latex tube, it can be disassembled, and the contrast agent directly injected into the gel phantom body to obtain a cross-sectional image of the contrast agent. Attached Figure Description
[0019] The accompanying drawings are provided to better understand this application and do not constitute an undue limitation thereof. Wherein:
[0020] Figure 1 This is a three-dimensional schematic diagram of a prefabricated phantom model for evaluating the imaging effect of ultrasound contrast agents provided in Example 1, wherein the fixing structure is not shown;
[0021] Figure 2 This is a schematic diagram of the fixed installation of the first U-shaped tube in Example 1;
[0022] Explanation of reference numerals in the attached figures:
[0023] 10-Reservoir box, 101-Short side plate, 102-Third U-shaped tube, 103-Second U-shaped tube, 104-First U-shaped tube, 105-Conical latex tube, 106-Fixing device, 107-Long side plate, 108-Gel phantom. Detailed Implementation
[0024] Specific embodiments of the present application will now be described in more detail with reference to the accompanying drawings. While specific embodiments of the present application are shown in the drawings, it should be understood that the present application can be implemented in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided to enable a more thorough understanding of the present application and to fully convey the scope of the present application to those skilled in the art.
[0025] It should be noted that certain terms are used in the specification and claims to refer to specific components. Those skilled in the art will understand that different terms may be used to refer to the same component. This specification and claims do not distinguish components based on differences in terminology, but rather on differences in function. The terms "comprising" or "including" used throughout the specification and claims are open-ended and should be interpreted as "comprising but not limited to." The following descriptions are preferred embodiments of the present invention; however, these descriptions are for the purpose of understanding the general principles of the specification and are not intended to limit the scope of the present invention. The scope of protection of this invention shall be determined by the appended claims.
[0026] In this application, the size of the housing 10 is not limited, but in order to save costs and not affect the imaging effect, the volume of the housing 10 should be able to accommodate at least 6 tapered latex tubes 105 and three U-shaped tubes.
[0027] In this application, the size of the U-shaped tube can be adjusted according to the application scenario.
[0028] In this application, the maximum diameter of the tapered latex tube is 0.5-20 mm, for example, it can be 0.5 mm, 1.0 mm, 1.5 mm, 2.0 mm, 2.5 mm, 3.0 mm, 3.5 mm, 4.0 mm, 4.5 mm, 5.0 mm, 5.5 mm, 6.0 mm, 6.5 mm, 7.0 mm, 7.5 mm, 8.0 mm, 8.5 mm, 9.0 mm, 9.5 mm, 10.0 mm, 10.5 mm, 11.0 mm, 11.5 mm, 12.0 mm, 12.5 mm, 13.0 mm, 13.5 mm, 14.0 mm, 14.5 mm, 15.0 mm, 15.5 mm, 16.0 mm, 16.5 mm, 17.0 mm, 17.5 mm, 18.0 mm, 18.5 mm, 19.0 mm, 19.5 mm, or 20.0 mm.
[0029] In this application, the height of the tapered latex tube is the distance from the tip of the tapered latex tube to the plane containing its maximum diameter (this plane can be considered the open surface). The height of the tapered latex tube is 0.5-20 mm, for example, it can be 0.5 mm, 1.0 mm, 1.5 mm, 2.0 mm, 2.5 mm, 3.0 mm, 3.5 mm, 4.0 mm, 4.5 mm, 5.0 mm, 5.5 mm, 6.0 mm, 6.5 mm, 7.0 mm, 7.5 mm, 8.0 mm, 8.5 mm, 9.0 mm, 9.5 mm, 10.0 mm, 10.5 mm, 11.0 mm, 11.5 mm, 12.0 mm, 12.5 mm, 13.0 mm, 13.5 mm, 14.0 mm, 14.5 mm, 15.0 mm, 15.5 mm, 16.0 mm, 16.5 mm, 17.0 mm, 17.5 mm. mm, 18.0 mm, 18.5 mm, 19.0 mm, 19.5 mm, 20.0 mm.
[0030] In this application, the inner diameter of the first U-shaped tube 104 is 0.5-20 mm, for example, it can be 0.5 mm, 1.0 mm, 1.5 mm, 2.0 mm, 2.5 mm, 3.0 mm, 3.5 mm, 4.0 mm, 4.5 mm, 5.0 mm, 5.5 mm, 6.0 mm, 6.5 mm, 7.0 mm, 7.5 mm, 8.0 mm, 8.5 mm, 9.0 mm, 9.5 mm, 10.0 mm, 10.5 mm, 11.0 mm, 11.5 mm, 12.0 mm, 12.5 mm, 13.0 mm, 13.5 mm, 14.0 mm, 14.5 mm, 15.0 mm, 15.5 mm, 16.0 mm, 16.5 mm, 17.0 mm, 17.5 mm, 18.0 mm, 18.5 mm, 19.0 mm, 19.5 mm, 20.0 mm, etc. mm.
[0031] In this application, the inner diameter of the second U-shaped tube 103 is variable, and the range of this variable inner diameter is 0.5-20 mm. For example, it can be 0.5 mm, 1.0 mm, 1.5 mm, 2.0 mm, 2.5 mm, 3.0 mm, 3.5 mm, 4.0 mm, 4.5 mm, 5.0 mm, 5.5 mm, 6.0 mm, 6.5 mm, 7.0 mm, 7.5 mm, 8.0 mm, 8.5 mm, 9.0 mm, 9.5 mm, 10.0 mm, 10.5 mm, 11.0 mm, 11.5 mm, 12.0 mm, 12.5 mm, 13.0 mm, 13.5 mm, 14.0 mm, 14.5 mm, 15.0 mm, 15.5 mm, 16.0 mm, 16.5 mm, 17.0 mm, 17.5 mm, 18.0 mm, 18.5 mm, 19.0 mm, etc. mm, 19.5 mm, 20.0 mm.
[0032] In this application, the inner diameter of the third U-shaped tube 102 is 0.5-20 mm, for example, it can be 0.5 mm, 1.0 mm, 1.5 mm, 2.0 mm, 2.5 mm, 3.0 mm, 3.5 mm, 4.0 mm, 4.5 mm, 5.0 mm, 5.5 mm, 6.0 mm, 6.5 mm, 7.0 mm, 7.5 mm, 8.0 mm, 8.5 mm, 9.0 mm, 9.5 mm, 10.0 mm, 10.5 mm, 11.0 mm, 11.5 mm, 12.0 mm, 12.5 mm, 13.0 mm, 13.5 mm, 14.0 mm, 14.5 mm, 15.0 mm, 15.5 mm, 16.0 mm, 16.5 mm, 17.0 mm, 17.5 mm, 18.0 mm, 18.5 mm, 19.0 mm, 19.5 mm, 20.0 mm, etc. mm.
[0033] In this application, the tapered latex tube 105 and the gel phantom 108 having the shape of the tapered latex tube can provide cross-sectional images when the ultrasonic probe scans the side of the housing 10.
[0034] In this application, the first U-tube 104, the second U-tube 103, and the third U-tube 102 are all detachable. After detachment, the contrast agent can be directly injected into the gel phantom 108 to avoid artifacts from the U-tube.
[0035] In this application, the tapered latex tube 105 is detachable, and after detachment, the contrast agent can be directly injected into the gel phantom 108 to avoid artifacts from the tapered latex tube 105.
[0036] In one specific embodiment of this application, the short side plate 101 and the long side plate 107 are made of transparent PE or transparent acrylic.
[0037] In one specific embodiment of this application, the short side plate 101, long side plate 107 and bottom surface of the receiving box 10 can be connected and fixed by any mechanical connection method, such as screws, nuts, etc.
[0038] In one specific embodiment of this application, the short side plate 101, long side plate 107 and bottom surface of the receiving box 10 can be connected and fixed by any adhesive bonding method.
[0039] In one specific embodiment of this application, the short side plate 101, long side plate 107 and bottom surface of the receiving box 10 can be connected and fixed by any welding method.
[0040] In one specific embodiment of this application, the long side plate 107 is a transparent PE film, which is fixed by wrapping the transparent PE film around the short side plate 101.
[0041] In this application, the first U-shaped tube 104, the second U-shaped tube 103, and the third U-shaped tube 102 can be fixed to the bottom inner wall of the receiving box 10 using any form of fixing device 106, such as a saddle clip.
[0042] In this application, depending on the operation and effectiveness, the open surface of the container 10 can be sealed with PE film.
[0043] In this application, the tapered latex tube 105 is placed close to the long side of the receiving box 10.
[0044] This application provides a prefabricated phantom model for evaluating the imaging effect of ultrasound contrast agents, characterized by comprising: a receiving box 10; a gel phantom 108 placed within the receiving box 10; a first U-shaped tube 104, a second U-shaped tube 103, a third U-shaped tube 102, and several tapered latex tubes 105 embedded within the gel phantom 108. The inner diameter of the first U-shaped tube 104 is smaller than the inner diameter of the third U-shaped tube 102, and the inner diameter of the second U-shaped tube 103 is variable, gradually increasing from one end to the other. The receiving box 10 is an open cuboid, the open surface being one of the largest surfaces of the cuboid, and the side opposite the open surface being the bottom surface of the receiving box 10. The first U-shaped tube 104, the second U-shaped tube 103, and the third U-shaped tube 102 are fixed to the inner wall of the bottom surface of the receiving box 10, with the openings of the first U-shaped tube 104, the second U-shaped tube 103, and the third U-shaped tube 102 facing the open surface. The bottom surface formed by the tapered latex tube 105 is located on the same plane as the openings of the first U-shaped tube 104, the second U-shaped tube 103, and the third U-shaped tube 102, with the tip of the tapered latex tube 105 facing the bottom surface of the receiving box 10 and placed along the two longest sides of the receiving box 10.
[0045] Example 1
[0046] A prefabricated phantom model for evaluating the imaging effects of ultrasound contrast agents, such as Figure 1The diagram shows a container 10, which is an open cuboid with the open side being the largest surface area. The side opposite the open side is the bottom surface of the container 10. The remaining components include two short side panels 101 made of transparent acrylic sheets and two long side panels 107 made of transparent PE film. The PE film is wrapped around the outer wall of the short side panels 101 several times, and after wrapping, the long side panels 107 made of PE film are flush with the short side panels 101. The inner diameter of the first U-shaped tube 104 is smaller than the inner diameter of the third U-shaped tube 102. The inner diameter of the second U-shaped tube 103 is variable, gradually increasing from one end to the other. The first U-shaped tube 104, the second U-shaped tube 103, and the third U-shaped tube 102 are all latex tubes. The first U-shaped tube 104, the second U-shaped tube 103, and the third U-shaped tube 102 are connected by means of... Figure 2 The fixing device 106 shown in the figure is fixed to the bottom inner wall of the receiving box 10. The fixing device 106 is fixed by a saddle clip and screws. A gel phantom 108 is placed inside the receiving box 10, filling the receiving box 10. A conical latex tube 105 is placed on the top surface of the gel phantom 108. The tip of the conical latex tube 105 faces vertically towards the bottom surface of the receiving box 10. The circular bottom surface formed by the conical latex tube 105 is in the same plane as the openings of the first U-shaped tube 104, the second U-shaped tube 103, and the third U-shaped tube 102.
[0047] The effectiveness of ultrasound contrast agents was evaluated using the prefabricated phantom model provided in Example 1 for evaluating the imaging effect of ultrasound contrast agents. An appropriate amount of ultrasound contrast agent was injected into any U-shaped tube, and then an ultrasound probe was aligned with the U-shaped tube to obtain an ultrasound contrast image. Furthermore, ultrasound contrast agents of different concentrations could be dripped into multiple conical latex tubes. By aligning the ultrasound probe with the conical latex tube from the side, ultrasound imaging of the ultrasound contrast agent within the latex tube was obtained. Different diameter circular sections were obtained as the height of the latex tube changed. Since different concentrations of ultrasound contrast agents reflected different ultrasonic wave intensities, they presented B-ultrasound images of varying brightness on the machine. Therefore, the ultrasound contrast effect of the ultrasound contrast agent could be judged within a certain linear area.
[0048] When using the prefabricated phantom model provided in this application for evaluating the imaging effect of ultrasound contrast agents, the use of U-tubes with varying diameters and other U-tubes with different inner diameters can more realistically simulate blood vessels in the body.
[0049] Meanwhile, if artifacts are produced during imaging, the U-shaped tube and tapered latex tube can be disassembled, and the contrast agent can be injected into the phantom body to improve the imaging effect.
[0050] Furthermore, part of the side wall of the container can be disassembled, and ultrasonic scanning can be performed from the top or side of the container to obtain better results.
[0051] Furthermore, the tapered latex tube can provide a cross-sectional image when the ultrasound probe performs a side scan. If the latex tube produces artifacts, it can be disassembled, and the contrast agent can be directly injected into the gel phantom to obtain a cross-sectional image of the contrast agent.
[0052] Although the embodiments of this application have been described above in conjunction with the specific embodiments described, this application is not limited to the specific embodiments and application fields described above. The specific embodiments described above are merely illustrative and instructive, and not restrictive. Those skilled in the art can make many other forms based on the teachings of this specification and without departing from the scope of protection of the claims of this application, and these are all within the scope of protection of this application.
Claims
1. A prefabricated phantom model for evaluating the imaging effect of ultrasound contrast agents, characterized in that, include: Storage box; A gel phantom placed inside a container; The first U-shaped tube, the second U-shaped tube, the third U-shaped tube, and several tapered latex tubes are embedded in the gel prosthetic body.
2. The prefabricated phantom model according to claim 1, wherein, The inner diameter of the first U-shaped tube is smaller than the inner diameter of the third U-shaped tube.
3. The prefabricated phantom model according to claim 1, wherein, The inner diameter of the second U-shaped tube gradually increases from one end of the tube opening to the other.
4. The prefabricated phantom model according to claim 1, wherein, The container is an open cuboid, the open side being one of the largest faces of the cuboid, and the side opposite the open side being the bottom surface of the container.
5. The prefabricated phantom model according to claim 4, wherein, The container is made of PE or acrylic.
6. The prefabricated phantom model according to claim 1, wherein, The opening of the tapered latex tube, as well as the openings of the first U-shaped tube, the second U-shaped tube, and the third U-shaped tube, are all open.
7. The prefabricated phantom model according to claim 6, wherein, The tapered latex tubes are placed at intervals along the two longest sides of the receiving box.
8. The prefabricated phantom model according to claim 1, wherein, The tip of the tapered latex tube faces the bottom of the receiving box.
9. The prefabricated phantom model according to claim 1, wherein, The first U-shaped tube, the second U-shaped tube, and the third U-shaped tube are fixed to the bottom inner wall of the receiving box using a fixed structure, while keeping the open surfaces of the first U-shaped tube, the second U-shaped tube, and the third U-shaped tube parallel to the bottom surface of the receiving box.
10. The prefabricated phantom model according to claim 1, wherein, The first U-shaped tube, the second U-shaped tube, and the third U-shaped tube are latex hoses.