Modular magnetic nanobead chromatography separation device

Abstract

The application relates to the technical field of magnetic separation, and discloses a modular magnetic nano-bead chromatographic separation device, which comprises a base and a top plate, the top plate is placed on the top of the base, and a plurality of magnetic rod bodies are installed on the top of the base. The modular magnetic nano-bead chromatographic separation device is characterized in that the top plate is of a magnetic attraction type, when the test tube needs to be moved, a person holds the handle and lifts it upwards, the top plate can be detached from the top of the base, and the test tube can be moved after the detachment; the magnetic attraction structure of the iron block and the magnet can shorten the detachment time; when the test tube is assisted, the test tube can be combined after being placed; the limiting ring is arranged, the bottom of the test tube can be limited when the test tube is moved, the back-and-forth shaking of the bottom of the test tube can be avoided, the radial buffering can be provided under the action of the upper and lower rubber rings, and the position of the test tube can be limited in the placement hole and the limiting ring.

Description

Technical Field

[0001] This application relates to the field of magnetic separation technology, specifically a modular magnetic nanobead chromatography separation device. Background Technology

[0002] The general process of magnetic separation involves adding a magnetic material capable of binding to the sample to a solution containing the sample. After the magnetic material has fully bonded to the sample, an external magnetic field is applied to the solution using a magnetic separation frame. Under the influence of the external magnetic field, the magnetic material bound to the sample is concentrated in the solution, thus achieving sample separation. Existing magnetic separation frames typically consist of a main frame and a magnetic plate. The main frame has openings for centrifuge tubes, and the magnetic plate contains embedded magnets. In use, centrifuge tubes containing the sample are placed into the openings. Under the influence of the magnetic field, the magnetic material in the sample concentrates on the centrifuge tube wall on one side of the magnetic plate. The separation of the magnetic material is then achieved by using a pipette to remove the liquid.

[0003] An existing patent (publication number: CN207330906U) discloses a porous magnetic frame that is easy to separate and use, including a magnetic frame for connecting test tubes and a base connected with several magnets. The magnetic frame includes a connecting plate with several through-hole groups and a fixing plate for connecting the base. Each through-hole group includes four through holes for connecting test tubes. Several connecting slots are connected to the fixing plate. The number of connecting slots, through-hole groups and magnets is the same. When connected, the magnets on the base pass through the connecting slots, and the four through holes in each through-hole group surround a magnet.

[0004] While the device described in the aforementioned comparative document solves the problems of cumbersome separation operations, inconvenience, and low efficiency of existing magnetic racks when magnets are not used, it requires a complete moving device to move the test tube, which is cumbersome. In addition, it lacks a limiting structure, which cannot stabilize the position of the test tube when it is moved. To solve the above problems, a modular magnetic nanobead chromatography separation device is proposed. Utility Model Content

[0005] To address the shortcomings of existing technologies, this application provides a modular magnetic nanobead chromatography separation device, which has advantages such as disassembly and stabilization functions. It solves the problems that when moving test tubes, a whole moving device is required, which is cumbersome to operate and cannot stabilize the position of the test tubes.

[0006] To achieve the above objectives, this application provides the following technical solution: a modular magnetic nanobead chromatography separation device, comprising a base and a top plate, wherein the top plate is placed on top of the base, and multiple magnetic rod bodies are installed and connected to the top of the base;

[0007] The base has support rods fixedly connected to its four top corners, and connecting blocks are fixedly connected to the top of the support rods. Magnets are fixedly connected to the top of the connecting blocks. A protruding plate is fixedly connected to the bottom of the top plate. The top plate is located on top of the four support rods, and the protruding plate is engaged in the middle of the four support rods. Iron blocks are fixedly connected to the four bottom corners of the top plate, and the bottom of the iron blocks is magnetically attracted to the top of the magnets. The top of the top plate has multiple placement holes, and the top of the base has multiple support slots. Connecting rods are fixedly connected to the opposite sides of the bottom of each placement hole. Limiting rings are fixedly connected to the bottom ends of the connecting rods. The number of placement holes and support slots is the same, and each placement hole corresponds to one support slot.

[0008] With the above solution, by setting a magnetic top plate, when the test tube needs to be moved, people can simply grasp the handle and move it upwards to detach the top plate from the top of the base. After detachment, the test tube can be moved. The magnetic attraction structure between the iron block and the magnet can shorten the detachment time. When assisting in moving the test tube, it can also achieve "one-click closure". At the same time, the snap-fit ​​design between the convex plate and the support rod can prevent horizontal displacement. The corresponding design of the support groove and the placement hole ensures that the magnetic rod is vertically aligned with the experimental container, improves the uniformity of the magnetic field, and enhances the separation efficiency. By setting a limiting ring, the bottom of the test tube can be limited when moving it, which can prevent the bottom of the test tube from shaking back and forth.

[0009] Furthermore, a threaded hole is provided on the side of the support groove, and an installation bolt is fixedly connected to the bottom end of the magnetic rod body, with the bottom end of the installation bolt threaded into the threaded hole.

[0010] The above solution facilitates the installation of the magnetic rod by connecting the bottom of the mounting bolt to the threaded hole. At the same time, the threaded connection also allows for free configuration of the spacing and number of magnetic rods.

[0011] Furthermore, rubber rings are fixedly connected to both the inner side of the placement hole and the inner side of the limiting ring.

[0012] The above solution, by setting rubber rings, can provide radial buffering and stabilization under the action of the upper and lower rubber rings, and can limit the position of the test tube within the placement hole and the limiting ring.

[0013] Furthermore, a support pad is fixedly connected to the bottom of the support groove.

[0014] The above solution, by setting up a support pad made of silicone, can provide soft support for the bottom of the test tube when it is placed.

[0015] Furthermore, protective pads are provided on both the surface and the inner side of the support rod.

[0016] The above solution, by setting up a protective pad, can prevent the test tube from making hard contact with the support rod when it is moved, reducing the risk of breakage, and is especially suitable for high-frequency laboratory environments.

[0017] Furthermore, handles are fixedly connected to both opposite sides of the top plate.

[0018] The above solution, through the design of the handle, facilitates the overall transfer of the top panel, avoiding displacement caused by direct contact with the magnetic rod and improving operational safety.

[0019] Furthermore, adjustable support feet are fixedly connected to the four corners of the bottom of the base.

[0020] The above solution, by setting adjustable support feet, can adapt to uneven surfaces, ensure the overall level of the device, and avoid uneven distribution of magnetic beads due to tilting.

[0021] Furthermore, an anti-slip pad is fixedly connected to the bottom of the adjustable support foot.

[0022] The above solution, by setting up anti-slip mats made of rubber, can enhance the friction of the base.

[0023] Compared with the prior art, the technical solution of this application has the following beneficial effects:

[0024] This modular magnetic nanobead chromatography separation device features a magnetically attached top plate. To move the test tube, the user simply grips the handle and moves upwards to detach the top plate from the base. The magnetic structure of the iron block and magnet shortens the detachment time and allows for easy placement and closure of the test tube. The interlocking design of the convex plate and support rod prevents horizontal displacement. A limiting ring restricts the movement of the test tube at its bottom, preventing it from wobbling. Two layers of rubber rings provide radial cushioning and keep the test tube within the placement hole and limiting ring. Attached Figure Description

[0025] Figure 1 This is a frontal three-dimensional structural diagram of this application;

[0026] Figure 2 This is a side-view perspective three-dimensional structural diagram of this application;

[0027] Figure 3 This is a schematic diagram of the base structure in this application;

[0028] Figure 4 This is a schematic diagram of the structure of the placement rack in this application;

[0029] Figure 5 This is a schematic diagram of the structure of the magnetic rod body in this application.

[0030] In the picture:

[0031] 1. Base; 101. Support rod; 102. Connecting block; 103. Magnet; 104. Protective pad; 105. Support groove; 106. Support pad; 107. Adjustable support foot; 108. Anti-slip pad; 109. Threaded hole;

[0032] 2. Top plate; 201. Convex plate; 202. Placement hole; 203. Rubber ring; 204. Connecting rod; 205. Limiting ring; 206. Iron block; 207. Handle;

[0033] 3. Magnetic rod body; 301. Mounting bolts. Detailed Implementation

[0034] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0035] Please see Figure 1 , Figure 2 and Figure 3 A modular magnetic nanobead chromatography separation device in this embodiment includes a base 1 and a top plate 2. The top plate 2 is placed on top of the base 1, and multiple magnetic rod bodies 3 are installed and connected to the top of the base 1.

[0036] Support rods 101 are fixedly connected to the four corners of the top of the base 1. Connecting blocks 102 are fixedly connected to the top of the support rods 101. Magnets 103 are fixedly connected to the top of the connecting blocks 102. A protruding plate 201 is fixedly connected to the bottom of the top plate 2. The top plate 2 is located on top of the four support rods 101. The protruding plate 201 is snapped into the middle of the four support rods 101. Iron blocks 206 are fixedly connected to the four corners of the bottom of the top plate 2. The bottom of the iron blocks 206 is magnetically attracted to the top of the magnets 103. Multiple placement holes 202 are opened on the top of the top plate 2. Multiple support grooves 105 are opened on the top of the base 1. Connecting rods 204 are fixedly connected to the opposite sides of the bottom of the placement holes 202. Limiting rings 205 are fixedly connected to the bottom of the connecting rods 204. The number of placement holes 202 and support grooves 105 is the same, and each placement hole 202 corresponds to one support. The support groove 105, with its magnetically attached top plate 2, allows the test tube to be moved by simply gripping the handle 207 upwards to detach the top plate 2 from the top of the base 1. The magnetic attraction between the iron block 206 and the magnet 103 shortens the disassembly time and enables "instant engagement" when assisting in the movement of the test tube. The interlocking design between the protruding plate 201 and the support rod 101 prevents horizontal displacement. The corresponding design of the support groove 105 and the placement hole 202 ensures the vertical alignment of the magnetic rod with the experimental container, improving the uniformity of the magnetic field and enhancing separation efficiency. The limiting ring 205 limits the movement of the test tube at its bottom, preventing it from wobbling back and forth.

[0037] Please see Figure 3 , Figure 4 and Figure 5 The support groove 105 has a threaded hole 109 on its side. The bottom end of the magnetic rod body 3 is fixedly connected to the mounting bolt 301. The bottom end of the mounting bolt 301 is threaded into the threaded hole 109. By connecting the bottom end of the mounting bolt 301 into the threaded hole 109, it is convenient for people to install the magnetic rod body 3. At the same time, the threaded connection also makes it easy for people to freely configure the spacing and number of magnetic rod bodies 3. The inner side of the placement hole 202 and the inner side of the limiting ring 205 are both fixedly connected to the rubber ring 203. By setting the rubber ring 203, the upper and lower rubber rings 203 can provide radial buffering and stabilization, and can limit the position of the test tube within the placement hole 202 and the limiting ring 205.

[0038] Please see Figure 3 and Figure 4A support pad 106 is fixedly connected to the bottom of the support groove 105. The support pad 106 is made of silicone and provides soft support for the bottom of the test tube when it is placed. Protective pads 104 are provided on the surface and inner side of the support rod 101. The protective pads 104 prevent the test tube from making hard contact with the support rod 101 when it moves, reducing the risk of breakage. This is especially suitable for high-frequency laboratory environments. Handles 207 are fixedly connected to opposite sides of the top plate 2. The design of 07 facilitates the overall transfer of the top plate 2, avoiding direct contact with the magnetic rods and thus improving operational safety. Adjustable support feet 107 are fixedly connected to the four corners of the bottom of the base 1. By setting the adjustable support feet 107, it can adapt to uneven surfaces, ensure the overall level of the device, and prevent uneven distribution of magnetic beads due to tilting. Anti-slip pads 108 are fixedly connected to the bottom of the adjustable support feet 107. The anti-slip pads 108 are made of rubber, which enhances the friction of the base 1.

[0039] In this embodiment, by setting a magnetic top plate 2, when the test tube needs to be moved, people can grasp the handle 207 and move it upwards to remove the top plate 2 from the top of the base 1. After removal, the test tube can be moved. The magnetic attraction structure between the iron block 206 and the magnet 103 can shorten the removal time and achieve "one-click placement and immediate engagement" when assisting in moving the test tube. At the same time, the snap-fit ​​design between the convex plate 201 and the support rod 101 can prevent horizontal displacement. The corresponding design of the support groove 105 and the placement hole 202 ensures the vertical alignment of the magnetic rod and the experimental container, improving the uniformity of the magnetic field. Uniformity and improved separation efficiency are achieved by setting a limiting ring 205, which can limit the bottom of the test tube when it is moved, thus preventing the bottom of the test tube from shaking back and forth. By connecting the bottom end of the mounting bolt 301 into the threaded hole 109, it is easy to install the magnetic rod body 3. At the same time, the threaded connection also allows for free configuration of the spacing and number of magnetic rod bodies 3. By setting a rubber ring 203, the upper and lower rubber rings 203 can provide radial buffering and stabilization, and limit the position of the test tube within the placement hole 202 and the limiting ring 205.

[0040] The working principle of the above embodiment is as follows: When in use, people install the magnetic rod body 3 on the top of the base 1 by installing the bolt 301 and the threaded hole 109. After installation, people place the top on the top of the four support rods 101 and make the convex plate 201 in the middle of the four support rods 101. Then, people can put the test tubes into the placement slots in turn. After the tubes are placed, the device can be used for magnetic separation.

[0041] When the test tube needs to be moved, people can grasp the handle 207 and move it upwards to remove the top plate 2 from the top of the base 1. After removal, the test tube can be moved. During the movement, the rubber ring 203 provides a stabilizing effect and can limit the position of the test tube within the placement hole 202 and the limiting ring 205. The limiting ring 205 can prevent the bottom of the test tube from shaking back and forth, making it more convenient to move.

[0042] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0043] Although embodiments of this application have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of this application, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A modular magnetic nanobead chromatography separation device, comprising a base (1) and a top plate (2), characterized in that: The top plate (2) is placed on top of the base (1), and multiple magnetic rod bodies (3) are installed and connected to the top of the base (1). The base (1) has four support rods (101) fixedly connected to its top corners. A connecting block (102) is fixedly connected to the top of each support rod (101). A magnet (103) is fixedly connected to the top of each connecting block (102). A protruding plate (201) is fixedly connected to the bottom of the top plate (2). The top plate (2) is located on top of the four support rods (101). The protruding plate (201) is engaged in the middle of the four support rods (101). Iron blocks (206) are fixedly connected to the four bottom corners of the top plate (2). The bottom of the block (206) is magnetically attached to the top of the magnet (103). The top plate (2) has multiple placement holes (202) on its top. The base (1) has multiple support grooves (105) on its top. The bottom of each placement hole (202) is fixedly connected to a connecting rod (204) on both sides. The bottom end of the connecting rod (204) is fixedly connected to a limit ring (205). The number of placement holes (202) and support grooves (105) is the same, and each placement hole (202) corresponds to one support groove (105).

2. The modular magnetic nanobead chromatography separation device according to claim 1, characterized in that: The support groove (105) has a threaded hole (109) on its side. The bottom end of the magnetic rod body (3) is fixedly connected to an installation bolt (301), and the bottom end of the installation bolt (301) is threaded into the threaded hole (109).

3. The modular magnetic nanobead chromatography separation device according to claim 1, characterized in that: Rubber rings (203) are fixedly connected to the inner side of the placement hole (202) and the inner side of the limiting ring (205).

4. The modular magnetic nanobead chromatography separation device according to claim 1, characterized in that: A support pad (106) is fixedly connected to the bottom of the support groove (105).

5. The modular magnetic nanobead chromatography separation device according to claim 1, characterized in that: The support rod (101) is provided with protective pads (104) on both its surface and inner side.

6. The modular magnetic nanobead chromatography separation device according to claim 1, characterized in that: The top plate (2) is fixedly connected to handles (207) on both sides.

7. The modular magnetic nanobead chromatography separation device according to claim 1, characterized in that: The base (1) has adjustable support feet (107) fixedly connected to the four corners of its bottom.

8. The modular magnetic nanobead chromatography separation device according to claim 7, characterized in that: The bottom of the four adjustable support feet (107) is fixedly connected with anti-slip pads (108).

Images