Voice control medicine dispensing and storing cabinet

By using array-type unit boxes and voice-controlled anesthetic drug storage cabinets, the problems of drug misselection and mismatch have been solved, enabling accurate storage and safe management of drugs, and improving operational efficiency and safety.

CN224366459UActive Publication Date: 2026-06-16ANHUI PROVINCIAL HOSPITAL

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
ANHUI PROVINCIAL HOSPITAL
Filing Date
2025-06-11
Publication Date
2026-06-16

AI Technical Summary

Technical Problem

Existing anesthetic drug storage cabinets are prone to drug misselection and mismatch in emergency situations, lack real-time monitoring and operation guidance, posing safety hazards, especially for interns and visiting doctors who are at high risk of operational errors.

Method used

The unit boxes are arranged in an array, with each group of unit boxes containing different anesthetic drugs. Combined with voice control and input terminal commands, the system achieves precise drug storage and retrieval and real-time monitoring through the coordinated operation of safety doors and switch units. It is equipped with scanners and warning lights to improve operational safety.

🎯Benefits of technology

It effectively avoids mixing and mistaking of drugs, improves drug retrieval efficiency, reduces physical exertion, ensures drug safety and standardization, and is suitable for clinical anesthetic drug management.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN224366459U_ABST
    Figure CN224366459U_ABST
Patent Text Reader

Abstract

The utility model relates to provide a kind of voice control dispensing medicine storage cabinet, including unit box array type setting multiple groups, each group unit box places different narcotic drugs, safety door is located the box mouth position of unit box, and implement safety door opens or closes from the box mouth of unit box, unit box is set in the upper position of cabinet body, switch unit is set between safety door and the box mouth of unit box, input end is used to receive the instruction of medical staff, and instruction is sent to control unit, control unit is used to control the start-stop of switch unit, to control safety door to open from the opening of safety door, the switch unit between safety door and unit box box mouth, construct medicine access control mechanism.Safety door must be opened and closed by medical staff sending instruction through input end, control unit accurately controls switch unit according to instruction, realizes the opening and closure of safety door.Unauthorized medicine use is effectively prevented, the risk of medicine mistake, misuse is reduced, and the security of narcotic drug use is guaranteed.
Need to check novelty before this filing date? Find Prior Art

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, and in particular to a voice-controlled dispensing and storage cabinet. Background Technology

[0002] In modern healthcare systems, the safe storage and accurate dispensing of anesthetic drugs are crucial for surgical and treatment procedures. Intelligent anesthesia storage cabinets, as core equipment for the information-based and standardized management of anesthetic drugs, effectively improve drug management efficiency and safety. However, in actual clinical applications, this equipment still faces pressing technical challenges and safety hazards that need to be addressed.

[0003] From the perspective of operational timeliness, anesthesia surgeries are often sudden and urgent, requiring anesthesiologists to accurately select and prepare medications within a short period. While existing intelligent anesthesia storage cabinets can achieve basic medication storage and retrieval functions, under time constraints, doctors may make mistakes such as incorrect drug selection or preparation due to haste. This risk is further exacerbated by the high workload and limited operating time, especially during emergency surgeries or when multiple surgeries are performed simultaneously. From the perspective of personnel composition, anesthesiology departments have a group of interns and visiting doctors with relatively insufficient clinical experience. Furthermore, the packaging of some anesthetic drugs is very similar, and some interns and visiting doctors may easily pick up the wrong one in a rush, and there are instances where interns and visiting doctors mistakenly take the wrong one due to negligence. Therefore, there are indeed pain points that urgently need to be addressed.

[0004] Furthermore, existing anesthetic drug display cabinets lack effective real-time monitoring and operation guidance mechanisms, making it impossible to provide timely warnings and interventions for potential drug mismatch risks during operation. Even with basic identity verification and access recording functions, it is difficult to fundamentally eliminate safety hazards caused by human error. Therefore, there is an urgent need to develop an intelligent dispensing and storage cabinet with efficient operation guidance, intelligent risk warning, and precise voice control functions to meet the actual needs of clinical anesthetic drug safety management. Utility Model Content

[0005] The purpose of this invention is to provide a voice-controlled dispensing and storage cabinet, which aims to solve the above-mentioned technical problem of incorrect anesthetic drug preparation, avoid safety hazards to patients, and ensure the accurate preparation of anesthetic drugs.

[0006] The technical problem solved by this utility model is addressed by the following technical solution: a voice-controlled dispensing and storage cabinet, comprising:

[0007] The unit boxes are arranged in an array of multiple groups, with each group of unit boxes containing different anesthetic drugs;

[0008] A safety door is located at the opening of the unit box, and the safety door is opened or closed from the opening of the unit box;

[0009] The cabinet, wherein the unit box is located at the top of the cabinet;

[0010] A switch unit is provided between the safety door and the opening of the unit box;

[0011] The input terminal is used to receive instructions from medical personnel and send the instructions to the control unit. The control unit is used to control the start and stop of the switch unit to control the safety door to open from the opening of the safety door.

[0012] This utility model also has the following technical features:

[0013] In one embodiment of the present invention, the switching unit includes a first electromagnetic suction strip disposed on the safety door, and a second electromagnetic suction strip disposed inside the opening of the unit box, wherein the first electromagnetic suction strip and the second electromagnetic suction strip are attracted together.

[0014] In one embodiment of this utility model, a confirmation button is provided on the safety door. When the confirmation button is pressed, the switch unit controls the first electromagnetic suction strip and the second electromagnetic suction strip to be de-energized, so that the safety door can be opened from the opening of the unit box.

[0015] In one embodiment of the present invention, a drug dispensing unit is provided inside the unit box, the drug dispensing unit being used to dispense anesthetic drugs from the opening of the unit box.

[0016] In one embodiment of this utility model, the unit box is generally rectangular, and the opening of the unit box is vertically arranged. The drug dispensing unit includes a dispensing base plate disposed on the lower side wall of the unit box. The dispensing base plate can slide along the length direction of the bottom of the unit box. One end of the dispensing base plate extending out of the unit box is slidably disposed on a slide rod. A spring is sleeved on the slide rod, and the two ends of the spring abut against the outer wall of the unit box and the extended end of the dispensing base plate, respectively.

[0017] In one embodiment of this utility model, the end face of the ejector base plate abuts against or separates from the inner side of the safety door.

[0018] In one embodiment of this utility model, the lower end face of the safety door is connected to the lower wall of the unit box via a hinge shaft. The hinge shaft of the safety door is horizontal, and a torsion spring is provided on the hinge shaft of the safety door. The two ends of the torsion spring abut against the safety door and the hinge shaft, respectively.

[0019] In one embodiment of this utility model, a backing plate is provided on the unit box, and the outer side of the safety door abuts against or separates from the backing plate.

[0020] In one embodiment of this utility model, a scanner is provided on the cabinet, and the scanner is used to scan barcodes.

[0021] In one embodiment of this utility model, a warning light is provided on the outside of the safety door, and when the safety door is opened, the warning light changes from being constantly lit to flashing.

[0022] In one embodiment of this utility model, the cabinet is also provided with a barcode printer outlet. When the medical staff takes out the anesthetic drugs from the unit box, the outlet outputs the barcode of the anesthetic drugs.

[0023] Compared with existing technologies, the beneficial effects of this invention are reflected in the array-style arrangement of multiple unit boxes, each holding different anesthetic drugs, forming an orderly drug storage system. This categorized storage method effectively avoids retrieval errors caused by mixed storage of anesthetic drugs, while also facilitating medical staff to quickly locate the required drugs, greatly improving drug retrieval efficiency. Especially in time-sensitive scenarios such as emergency surgeries, it can significantly reduce the time wasted searching for drugs, ensuring the smooth conduct of the surgery.

[0024] A switch unit located between the safety door and the unit box opening, working in conjunction with the control unit and input terminal, establishes a strict drug storage and retrieval control mechanism. Medical personnel must send commands through the input terminal, and the control unit precisely controls the switch unit according to the commands, thereby opening and closing the safety door. This process effectively prevents unauthorized drug access, reduces the risk of drug misuse or incorrect handling, and ensures the safety and standardization of anesthetic drug use.

[0025] The cabinet's unit boxes are positioned at the top, conforming to ergonomic design. This allows medical staff to quickly observe and retrieve medications during operation, reducing physical exertion caused by frequent bending and raising of arms, and improving operational comfort and convenience. At the same time, this layout also helps maintain a clean and orderly operating area, improving overall work efficiency.

[0026] Furthermore, this voice-controlled dispensing and storage cabinet achieves intelligent management of drug storage and retrieval through precise command reception and control logic. Compared to traditional storage cabinets, it can more effectively address the operational issues of inexperienced personnel such as interns and visiting doctors. Through standardized operating procedures and strict access control, it reduces human error and provides a more reliable guarantee for patient safety, demonstrating significant application value and promotional significance in the field of clinical anesthetic drug management. Attached Figure Description

[0027] Figure 1 This is a schematic diagram of the structure of a voice-controlled dispensing and storage cabinet according to one embodiment of the present invention;

[0028] Figure 2 This is a front view of a voice-controlled dispensing and storage cabinet according to one embodiment of the present invention;

[0029] Figure 3 This is a logic block diagram of a voice-controlled dispensing and storage cabinet according to one embodiment of the present invention;

[0030] Figure 4 and Figure 5 These are schematic diagrams of the voice-controlled dispensing and storage cabinet after it has been moved out of the cabinet in one embodiment of the present invention;

[0031] Figure 6 and Figure 7 These are schematic diagrams of two different perspectives showing the combination of a single unit box and a safety door in one embodiment of this utility model.

[0032] Figure 8 This is a cross-sectional structural diagram of a single unit box and a safety door in one embodiment of the present invention;

[0033] Figure 9 This is a cross-sectional plan view of a single unit box and a safety door in one embodiment of the present invention. Detailed Implementation

[0034] The following specific examples illustrate the implementation of this utility model. Those skilled in the art can easily understand other advantages and effects of this utility model from the content disclosed in this specification. This utility model can also be implemented or applied through other different specific embodiments, and various details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of this utility model.

[0035] It should be noted that the illustrations provided in this embodiment are only schematic representations of the basic concept of this utility model. Therefore, the drawings only show the components related to this utility model and are not drawn according to the actual number, shape and size of the components. In actual implementation, the form, quantity and proportion of each component can be arbitrarily changed, and the layout of the components may also be more complex.

[0036] It should be noted that while existing intelligent anesthesia storage cabinets can perform basic drug storage and retrieval functions, under time constraints, doctors may make mistakes such as incorrect drug selection or mixing due to rushed operation. This risk is further exacerbated by the high workload and limited operating time during emergency surgeries or multiple surgeries performed simultaneously. From the perspective of operator composition, anesthesiology departments include groups with relatively insufficient clinical experience, such as interns and visiting doctors. Due to their incomplete understanding of the pharmacological properties, applicable diseases, and contraindications of anesthetic drugs, they are highly susceptible to drug mixing errors when independently operating intelligent anesthesia storage cabinets due to biased drug knowledge or improper operation. For example, some interns may confuse anesthetic drugs with similar effects or incorrectly combine drugs with incompatible combinations. Such operational errors can directly threaten patient safety and lead to serious medical accidents. Furthermore, existing intelligent anesthesia storage cabinets lack effective real-time monitoring and operation guidance mechanisms, failing to provide timely warnings and interventions for potential drug mixing risks during operation. Even with basic authentication and access recording functions, it is difficult to fundamentally eliminate the security risks caused by human error. To address this, this utility model proposes a voice-controlled dispensing and storage cabinet, comprising: unit boxes 10, arranged in an array of multiple groups, each group of unit boxes 10 containing different anesthetic drugs; a safety door 20 located at the opening of each unit box 10, enabling the safety door 20 to open or close from the opening of the unit box 10; a cabinet body 30, with the unit boxes 10 positioned above the cabinet body 30; a switch unit is provided between the safety door 20 and the opening of each unit box 10; and an input terminal 40 for receiving instructions from medical personnel and sending these instructions to a control unit 50, which controls the start and stop of the switch unit to control the opening of the safety door 20 from its opening.

[0037] In one embodiment, see Figure 1 The input terminal 40 includes at least one or more of the following: an input screen 41, a voice input device, and input buttons. Taking the input screen 41 as an example, it is installed on the cabinet 30. By typing the name of the required anesthetic drug on the input screen 41, the safety door 20 on the corresponding unit box 10 containing the anesthetic drug opens, while other safety doors 20 remain closed, thus preventing accidental retrieval. The input screen 41 and the control unit 50 control the opening of the safety doors 20, which is a mature existing method. (See reference...) Figure 3 The logic control block diagram can be used to realize the linkage between the input screen 41, the control unit 50, and the safety door 20 through corresponding software.

[0038] Taking a voice input device as an example, existing recognition software can be used to recognize voice commands and confirm the required anesthetic drugs on the input screen 41. Then, the safety door 20 on the unit box 10 where the anesthetic drugs are located can be opened. Therefore, the double-safety opening method of voice and input screen 41 can further avoid accidental operation.

[0039] Similarly, the safety door 20 on the unit box 10 containing the required anesthetic drugs can be opened directly by inputting the button, or it can be confirmed by inputting the screen 41, thus achieving a double insurance method.

[0040] In the above embodiments, the method of recognizing voice through a voice input device is actually a self-check by medical staff. If a check error occurs, the safety door 20 cannot be opened, which can ensure the absolute safety of medication retrieval.

[0041] In one embodiment, the number of unit boxes 10 is arranged according to the actual situation, and should be as many as possible, so as to realize that different anesthetic control drugs are set up with a separate unit box 10.

[0042] In one embodiment, all the safety doors 20 on the unit boxes 10 can be opened by setting a password on the input screen 41. When all the safety doors 20 on the unit boxes 10 are open, it is convenient for medical staff to place the controlled anesthetic drugs in a unified manner. When the anesthetic drugs in some unit boxes 10 are used up, prompts can be made by voice or by setting a prompt on the input screen 41 to remind medical staff to replenish the unit boxes 10 in a timely manner.

[0043] In one embodiment, see Figure 9 The switching unit includes a first electromagnetic suction strip 21 disposed on the safety door 20, and a second electromagnetic suction strip 11 disposed inside the opening of the unit box 10. The first electromagnetic suction strip 21 and the second electromagnetic suction strip 11 are attracted together.

[0044] A second electromagnetic suction strip 11 is provided above the inside of the opening of each unit box 10. The second electromagnetic suction strip 11 is arranged parallel to the opening surface of the unit box 10. When the safety door 20 is closed with the opening of the unit box 10, both the first electromagnetic suction strip 21 and the second electromagnetic suction strip 11 are energized, thereby enabling the safety door 20 to seal the opening of the unit box 10.

[0045] In one embodiment, to facilitate medical personnel in taking out and putting in the anesthetic drug, a drug ejection unit is provided in the unit box 10, which is used to eject the anesthetic drug in the unit box 10 from the box opening.

[0046] In one embodiment, when medical personnel use voice or input commands via the built-in voice recognition software or input screen 41 to de-energize the first electromagnetic suction bar 21 and the second electromagnetic suction bar 11, the safety door 20 opens from the opening of the unit box 10, and the drug ejection unit ejects the medicine for easy removal by medical personnel.

[0047] In one embodiment, see Figure 6 and Figure 7 The unit box 10 is generally rectangular, and the opening of the unit box 10 is vertically arranged. The drug dispensing unit includes a dispensing base plate 12 disposed on the lower side wall of the unit box 10. The dispensing base plate 12 can slide along the length of the bottom of the unit box 10. One end of the dispensing base plate 12 extending out of the unit box 10 is slidably disposed on a slide rod 13. A spring 131 is sleeved on the slide rod 13. The two ends of the spring 131 abut against the outer wall of the unit box 10 and the extended end of the dispensing base plate 12, respectively.

[0048] In one embodiment, when medical personnel use voice or input commands via the built-in voice recognition software or input screen 41 to de-energize the first electromagnetic suction bar 21 and the second electromagnetic suction bar 11, the safety door 20 opens from the opening of the unit box 10. Under the elastic force of the spring 131, the slide bar 13 slides horizontally, thereby causing the push-out base plate 12 to slide horizontally and extend out of the opening of the unit box 10, making it convenient for medical personnel to remove.

[0049] In one embodiment, the safety door 20 is provided with a confirmation button 23. When the confirmation button 23 is pressed, the switch unit controls the first electromagnetic suction strip 21 and the second electromagnetic suction strip 11 to be de-energized, so that the safety door 20 can be opened from the opening of the unit box 10.

[0050] In the above embodiments, when medical personnel wake up the system by voice, the system recognizes the anesthetic drugs required by the medical personnel and issues a control command through the control unit 50. The medical personnel press the confirmation button 23 set on the safety door 20, thereby de-energizing the first electromagnetic suction strip 21 and the second electromagnetic suction strip 11, and thus opening the safety door 20 from the opening of the unit box 10, ensuring absolute safety in taking the medicine.

[0051] In one embodiment, when medical personnel place medications, they can enter a password on the input screen 41 to open all the safety doors 20 of the unit boxes 10, allowing the push-out base plate 12 to extend out of the opening of the unit box 10, making it convenient for medical personnel to place controlled anesthetic drugs on the push-out base plate 12. When the safety doors 20 are closed, the push-out base plate 12 extends into the unit box 10 to control the anesthetic drugs.

[0052] In one embodiment, to allow the ejector base plate 12 to extend into the unit box 10, the end face of the ejector base plate 12 abuts against or separates from the inner side of the safety door 20. When the safety door 20 is closed, the inner side of the safety door 20 abuts against the end face of the ejector base plate 12, thereby compressing the spring 131 until the first electromagnetic suction bar 21 and the second electromagnetic suction bar 11 are energized and attracted, thus closing the unit box 10.

[0053] In one embodiment, the lower end face of the safety door 20 is connected to the lower wall of the unit box 10 via a hinge shaft. The hinge shaft of the safety door 20 is horizontal, and a torsion spring 22 is provided on the hinge shaft of the safety door 20. The two ends of the torsion spring 22 abut against the safety door 20 and the hinge shaft, respectively.

[0054] In one embodiment, the torsion spring 22 keeps the safety door 20 in an open state when the first electromagnetic suction bar 21 and the second electromagnetic suction bar 11 are de-energized, making it convenient for medical personnel to retrieve designated anesthetic drugs.

[0055] In one embodiment, if the safety door 20 is not closed after the anesthetic drugs are removed, an alarm is triggered by setting a closing time to notify medical personnel to close the safety door 20 in a timely manner.

[0056] In one embodiment, the unit box 10 is provided with abutment plate 14, and the outer side of the safety door 20 abuts against or separates from the abutment plate 14.

[0057] When the safety door 20 is opened, the safety door 20 is subjected to the restoring force of the torsion spring 22, causing the outer side of the safety door 20 to abut against the abutment plate 14, thereby limiting the safety door 20. When closed, the safety door 20 is manually operated to make the first electromagnetic suction bar 21 on the safety door 20 attract the second electromagnetic suction bar 11 on the unit box 10, thus completing the closing of the safety door 20.

[0058] In one embodiment, see Figure 1 The cabinet 30 is equipped with a scanner 60, which is used to scan barcodes.

[0059] In one embodiment, the scanner 60 is a common scanning device in the prior art. It can identify drug barcodes. When medical personnel place new anesthetic drugs on the safety door 20, the barcode on the anesthetic drugs is scanned to open the safety door 20, thereby placing the drugs in the unit box 10 and completing the placement of the new drugs.

[0060] When medical staff need to use it, they can scan the patient's barcode with the scanner 60, which will open the corresponding safety door 20, allowing the anesthetic drug to be taken out from the unit box 10, thus completing the use of the anesthetic drug.

[0061] In one embodiment, a warning light is provided on the outside of the safety door 20, and when the safety door 20 is opened, the warning light changes from being constantly lit to flashing.

[0062] In the above embodiments, see Figure 4 and Figure 5 When the safety door 20 and the unit box 10 are closed, the warning light is a solid blue light. When the safety door 20 is opened, the warning light on the safety door 20 flashes to alert medical personnel.

[0063] In one embodiment, the cabinet 30 is also provided with a barcode printer outlet 31, which outputs the barcode of the anesthetic drug when the medical personnel take out the anesthetic drug from the unit box 10.

[0064] When medical staff take out the corresponding anesthetic drugs from unit box 10, the barcode printer starts and outputs the anesthetic drug label from outlet 31. The label can be affixed to the anesthetic syringe to promptly remind medical staff.

[0065] It will be apparent to those skilled in the art that this invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of this invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0066] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A voice-controlled dispensing and storage cabinet, characterized in that, include: Unit boxes (10) are arranged in multiple groups in an array, and each group of unit boxes (10) contains different anesthetic drugs; Safety door (20) is located at the opening of the unit box (10), and safety door (20) is opened or closed from the opening of the unit box (10); Cabinet (30), the unit box (10) is located above the cabinet (30); A switch unit is provided between the safety door (20) and the opening of the unit box (10); The input terminal (40) is used to receive instructions from medical personnel and send the instructions to the control unit (50). The control unit (50) is used to control the start and stop of the switch unit so as to control the safety door (20) to open from the opening of the safety door (20).

2. The voice-controlled dispensing and storage cabinet according to claim 1, characterized in that, The switching unit includes a first electromagnetic suction strip (21) disposed on the safety door (20), and a second electromagnetic suction strip (11) disposed inside the opening of the unit box (10). The first electromagnetic suction strip (21) and the second electromagnetic suction strip (11) are attracted together.

3. The voice-controlled dispensing and storage cabinet according to claim 2, characterized in that, The safety door (20) is provided with a confirmation button (23). When the confirmation button (23) is pressed, the switch unit controls the first electromagnetic suction bar (21) and the second electromagnetic suction bar (11) to be de-energized, so that the safety door (20) can be opened from the opening of the unit box (10).

4. The voice-controlled dispensing and storage cabinet according to claim 1, characterized in that, The unit box (10) is provided with a drug ejection unit, which is used to eject the anesthetic drug in the unit box (10) from the box opening.

5. The voice-controlled dispensing and storage cabinet according to claim 4, characterized in that, The unit box (10) is rectangular in shape, and the opening of the unit box (10) is vertically arranged. The drug ejection unit includes an ejection base plate (12) disposed on the lower side wall of the unit box (10). The ejection base plate (12) can slide along the length of the bottom of the unit box (10). One end of the ejection base plate (12) extending out of the unit box (10) is slidably disposed on a slide rod (13). A spring (131) is sleeved on the slide rod (13). The two ends of the spring (131) abut against the outer wall of the unit box (10) and the protruding end of the ejection base plate (12), respectively. The end face of the ejection base plate (12) abuts against or separates from the inner side of the safety door (20).

6. The voice-controlled dispensing and storage cabinet according to claim 1, characterized in that, The lower end face of the safety door (20) is connected to the lower wall of the unit box (10) by a hinge shaft. The hinge shaft of the safety door (20) is horizontal. A torsion spring (22) is provided on the hinge shaft of the safety door (20). The two ends of the torsion spring (22) abut against the safety door (20) and the hinge shaft, respectively.

7. The voice-controlled dispensing and storage cabinet according to claim 6, characterized in that, The unit box (10) is provided with a backing plate (14), and the outer side of the safety door (20) abuts against or separates from the backing plate (14).

8. The voice-controlled dispensing and storage cabinet according to claim 1, characterized in that, The cabinet (30) is equipped with a scanner (60) for scanning barcodes.

9. The voice-controlled dispensing and storage cabinet according to claim 1, characterized in that, A warning light is provided on the outside of the safety door (20). When the safety door (20) is opened, the warning light changes from being constantly lit to flashing.

10. The voice-controlled dispensing and storage cabinet according to claim 1, characterized in that, The cabinet (30) is also equipped with a barcode printer outlet (31). When the medical staff takes out the anesthetic drugs from the unit box (10), the outlet (31) outputs the barcode of the anesthetic drugs.