A bubble interception device for use with a chromatography column

Abstract

The utility model relates to the technical field of chromatography column, disclose a bubble intercepting device for chromatography column, including the bottom plate, the top left side of bottom plate is fixedly connected with fixed block, the inner wall left side of fixed block is equipped with first round groove, the inner wall screw thread connection of first round groove has screw rod, the left end of screw rod is fixedly connected with rocker, the inner wall middle part of fixed block is equipped with guide slot, the outer wall screw thread connection of screw rod has first fixed link, the right end screw thread connection of screw rod has fixed T link, the inner wall right side of fixed block is equipped with sliding slot, the inner wall sliding connection of sliding slot has a plurality of sliding blocks. In the utility model, when chromatography column is put to the predetermined position, shake the rocker, drive screw rod, make the fixed T link on screw rod begin to move back and forth, the fixed T link is clamped in T groove, makes the sliding block move left and right in the sliding slot of fixed block, reaches the effect that chromatography column can be clamped.

Description

Technical Field

[0001] This utility model relates to the field of chromatography column technology, and in particular to a bubble interception device applied to chromatography columns. Background Technology

[0002] A chromatography column is the core device in chromatography used to separate and purify mixtures. It is typically a tubular container with a certain length and inner diameter. Its structure and function are designed to provide a controllable space for the interactions between different components in the sample and the stationary and mobile phases. The closed tubular structure constrains the path of the mobile phase, ensuring uniform packing of the stationary phase. As the sample components migrate with the mobile phase, differences in the intensity of their interaction with the stationary phase lead to variations in migration speed, ultimately causing them to flow out of the column sequentially. This achieves the separation, analysis, and purification of the target components.

[0003] The bubble interception device of the chromatography column clamps the chromatography column to eliminate gaps, prevent leakage of mobile phase, and ensure the continuity of the experiment. At present, chromatography columns are mostly handled manually, and the mobile phase will leak in the gaps. This not only wastes a lot of mobile phase, but also causes the sample to be lost after separation. As a result, trace amounts of sample may be lost directly, leading to experimental failure and increasing experimental costs. Utility Model Content

[0004] To overcome the above shortcomings, this utility model provides a bubble interception device for chromatography columns, which aims to improve the problem of leakage of mobile phase in gaps in the prior art. This not only wastes a large amount of mobile phase, but also causes the sample to be lost after separation, which may result in the complete loss of trace samples, leading to experimental failure and increased experimental costs.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: a bubble interception device for a chromatography column, comprising a base plate, a fixing block fixedly connected to the top left side of the base plate, a first circular groove formed on the left side of the inner wall of the fixing block, a threaded rod threadedly connected to the inner wall of the first circular groove, a rocker arm fixedly connected to the left end of the threaded rod, a guide groove formed in the middle of the inner wall of the fixing block, a first fixing rod threadedly connected to the outer wall of the threaded rod, a fixing T-shaped rod threadedly connected to the right end of the threaded rod, a sliding groove formed on the right side of the inner wall of the fixing block, a plurality of sliding blocks slidably connected to the inner wall of the sliding groove, a T-shaped groove formed on the adjacent side of each of the plurality of sliding blocks, a clamping plate fixedly connected to the right side of the sliding block, and a centrifugal mechanism fixedly connected to the top right side of the base plate, the centrifugal mechanism being used for bubble isolation.

[0006] As a further description of the above technical solution:

[0007] The centrifugal mechanism includes a motor, the bottom of which is fixedly connected to the top of a base plate. A first bevel gear is fixedly connected to the output end of the motor. A second bevel gear is meshed with the outer wall of the first bevel gear. A round rod is fixedly connected to the top of the second bevel gear. A cylinder is fixedly connected to the top of the round rod. A second circular groove is formed on the inner wall of the cylinder. A filter cylinder is fixedly connected to the top of the cylinder. A hollow cylinder is rotatably connected to the middle of the outer wall of the round rod. Multiple second fixing rods are fixedly connected to the top of the inner wall of the hollow cylinder. A first conduit is fixedly connected to an adjacent side of the multiple second fixing rods. A second conduit is fixedly connected to the bottom of the hollow cylinder.

[0008] As a further description of the above technical solution:

[0009] The outer wall of the fixing block is fixedly connected to a first cover plate, and each of the multiple clamping plates is fixedly connected to a pad on one side.

[0010] As a further description of the above technical solution:

[0011] A second cover plate is fixedly connected to the top of the hollow cylinder, and a first protective sleeve is fixedly connected to the top of the motor.

[0012] As a further description of the above technical solution:

[0013] The top of the first protective cover has a heat dissipation hole, and a controller is fixedly connected to the front side of the first protective cover.

[0014] As a further description of the above technical solution:

[0015] A pressure gauge is fixedly connected to the front end of the cylinder, and a switch valve is connected inside the second conduit.

[0016] As a further description of the above technical solution:

[0017] A nameplate is fixedly connected to the front end of the cylinder, and multiple screws are threaded to the four corners of the inner wall of the nameplate.

[0018] As a further description of the above technical solution:

[0019] A second protective sleeve is fixedly connected to the top of the outer wall of the hollow cylinder, and a third fixing rod is fixedly connected to the bottom of the hollow cylinder.

[0020] This utility model has the following beneficial effects:

[0021] 1. In this utility model, when the chromatography column is placed in the predetermined position, the rocker arm is shaken, which drives the threaded rod, causing the fixed T-shaped rod on the threaded rod to move back and forth. The fixed T-shaped rod is locked in the T-shaped groove, causing the sliding block to move left and right in the sliding groove of the fixed block, thereby driving the clamping plate to move left and right, thus achieving the function of clamping the equipment.

[0022] 2. In this utility model, when the liquid enters the first conduit, the motor drives the first bevel gear, which in turn drives the round rod at the top of the second bevel gear to rotate, thereby driving the cylinder to rotate, so that the liquid begins to rotate, causing the internal air bubbles to separate from the liquid, and the liquid begins to fall into the hollow cylinder, and then flows out through the second conduit, thereby achieving the effect of air bubble isolation. Attached Figure Description

[0023] Figure 1 This is a front perspective view of a bubble interception device applied to a chromatography column according to the present invention;

[0024] Figure 2 This is a top view of a bubble interception device applied to a chromatography column according to the present invention;

[0025] Figure 3 This is a partial structural diagram of the fixing block of a bubble interception device applied to a chromatography column according to the present invention;

[0026] Figure 4 This is a partial structural diagram of a threaded rod of a bubble interception device for chromatography columns proposed in this utility model;

[0027] Figure 5 This is a partial structural diagram of the fixing block of a bubble interception device applied to a chromatography column according to the present invention;

[0028] Figure 6 This is a partial structural diagram of a hollow cylinder for a bubble interception device applied to a chromatography column, as proposed in this utility model.

[0029] Figure 7 This is a partial structural diagram of a circular rod for a bubble interception device applied to a chromatography column, as proposed in this utility model.

[0030] Legend:

[0031] 1. Base plate; 2. Centrifugal mechanism; 201. Motor; 202. First bevel gear; 203. Second bevel gear; 204. Round rod; 205. Cylinder; 206. Second circular groove; 207. Filter cartridge; 208. First guide tube; 209. Hollow cylinder; 210. Second fixing rod; 211. Second guide tube; 3. Fixing block; 4. Rocker arm; 5. Threaded rod; 6. First fixing rod; 7. Fixing T-shaped rod; 8. Sliding block; 9. T-shaped groove; 10. Clamping plate; 11. First circular groove; 12. Guide groove; 13. Sliding groove; 14. Pad; 15. First protective sleeve; 16. Heat dissipation hole; 17. Controller; 18. Pressure gauge; 19. Nameplate; 20. Screw; 21. Second protective sleeve; 22. First cover plate; 23. Switch valve; 24. Second cover plate; 25. Third fixing rod. Detailed Implementation

[0032] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0033] Please see the appendix Figure 3 Appendix Figure 4 and attached Figure 5 An embodiment of this utility model provides a bubble interception device for a chromatography column, comprising a base plate 1, a fixing block 3 fixedly connected to the top left side of the base plate 1, a first circular groove 11 opened on the left side of the inner wall of the fixing block 3, a threaded rod 5 threadedly connected to the inner wall of the first circular groove 11, a rocker arm 4 fixedly connected to the left end of the threaded rod 5, a guide groove 12 opened in the middle of the inner wall of the fixing block 3, a first fixing rod 6 threadedly connected to the outer wall of the threaded rod 5, a fixing T-shaped rod 7 threadedly connected to the right end of the threaded rod 5, a sliding groove 13 opened on the right side of the inner wall of the fixing block 3, a plurality of sliding blocks 8 slidably connected to the inner wall of the sliding groove 13, a T-shaped groove 9 opened on the adjacent side of the plurality of sliding blocks 8, a clamping plate 10 fixedly connected to the right side of the sliding block 8, and a centrifugal mechanism 2 fixedly connected to the top right side of the base plate 1, the centrifugal mechanism 2 being used for bubble isolation;

[0034] Specifically, the base plate 1 is used to support the device, the fixing block 3 is used to equip the device, the first circular groove 11 is used to protect the device, the threaded rod 5 is used to drive the device, the rocker arm 4 is used to start the device, the guide groove 12 is used to equip the device, the first fixing rod 6 is used to fix the threaded rod 5, the sliding groove 13 is used to limit the position of the sliding block 8 to achieve the predetermined sliding, the sliding block 8 is used to drive the clamping plate 10 to slide, the clamping plate (10) is used to clamp the device, and the T-shaped groove 9 and the fixed T-shaped rod 7 are used for limiting.

[0035] Please see the appendix Figure 2 Appendix Figure 6 and attached Figure 7 The centrifugal mechanism 2 includes a motor 201, the bottom of which is fixedly connected to the top of the base plate 1. A first bevel gear 202 is fixedly connected to the output end of the motor 201. A second bevel gear 203 is meshed with the outer wall of the first bevel gear 202. A round rod 204 is fixedly connected to the top of the second bevel gear 203. A cylinder 205 is fixedly connected to the top of the round rod 204. A second round groove 206 is opened on the inner wall of the cylinder 205. A filter cylinder 207 is fixedly connected to the top of the cylinder 205. A hollow cylinder 209 is rotatably connected to the middle of the outer wall of the round rod 204. Multiple second fixing rods 210 are fixedly connected to the top of the inner wall of the hollow cylinder 209. A first conduit 208 is fixedly connected to the adjacent side of the multiple second fixing rods 210. A second conduit 211 is fixedly connected to the bottom of the hollow cylinder 209.

[0036] Specifically, motor 201 is used to drive the device, first bevel gear 202 and second bevel gear 203 are used to drive the device, round rod 204 is used to rotate cylinder 205, cylinder 205 is used to support the device, filter cylinder 207 is used to filter the device, hollow cylinder 209 is used to equip the device, second fixed rod 210 is used to support first conduit 208, first conduit 208 is used to pour into the device, and second conduit 211 is used to flow out of the device.

[0037] Please see the appendix Figure 1 Appendix Figure 2 and attached Figure 4 The top of the hollow cylinder 209 is fixedly connected to a second cover plate 24, the top of the motor 201 is fixedly connected to a first protective sleeve 15, the outer wall of the fixing block 3 is fixedly connected to a first cover plate 22, and multiple clamping plates 10 are fixedly connected to pads 14 on adjacent sides. The top of the first protective sleeve 15 is provided with a heat dissipation hole 16, and the front side of the first protective sleeve 15 is fixedly connected to a controller 17.

[0038] Specifically, the second cover plate 24 is used to protect the device and prevent experimental errors, the first protective sleeve 15 is used to protect the motor 201, the fixing block 3 is used to protect the device, the pad plate 14 is used to buffer the chromatography column to prevent the equipment from being squeezed, the heat dissipation hole 16 is used for heat dissipation, and the controller 17 is used to control the motor 201 switch.

[0039] Please see the appendix Figure 1 Appendix Figure 2 and attached Figure 3A pressure gauge 18 is fixedly connected to the front end of the cylinder 205. A switch valve 23 is connected inside the second conduit 211. A second protective sleeve 21 is fixedly connected to the top of the outer wall of the hollow cylinder 209. A third fixing rod 25 is fixedly connected to the bottom of the hollow cylinder 209. A nameplate 19 is fixedly connected to the front end of the cylinder 205. Multiple screws 20 are threadedly connected to the four corners of the inner wall of the nameplate 19.

[0040] Specifically, pressure gauge 18 is used to check the internal condition of the device cylinder 205, switch valve 23 is used to control the opening and closing of the second conduit 211, second protective sleeve 21 is used to protect the device, nameplate 19 is used to write the name, third fixing rod 25 is used to support the device and prevent it from falling, and screw 20 is used to fix the second protective sleeve 21.

[0041] Working principle: When the rocker arm 4 is rocked, the threaded rod 5 is rotated. Since the threaded rod 5 is fixed by the first fixed rod 6 on the inner wall of the fixed block 3, the fixed T-shaped rod 7 is moved back and forth. When the fixed T-shaped rod 7 moves back and forth, the left and right sides of the fixed T-shaped rod 7 are stuck by the T-shaped groove 9 on the inner wall of the sliding block 8, causing the sliding block 8 to move left and right in the sliding groove 13 on the inner wall of the fixed block 3. When the sliding block 8 moves left and right, the top clamping plate 10 of the sliding block 8 moves left and right, thereby tightening the chromatography column and achieving the function of clamping the equipment.

[0042] When the bubbly liquid is poured into the first conduit 208, the motor 201 is started, driving the first bevel gear 202, which in turn drives the second bevel gear 203. The second bevel gear 203 then causes the cylinder 205 to start centrifugal rotation via the round rod 204, thus causing the bubbly liquid to rotate. The rotation begins to separate the liquid and the bubbles. The liquid falls through the filter cylinder 207 into the inner wall of the hollow cylinder 209, while the bubbles rise through the first conduit 208. The liquid then falls through the second conduit 211 inside the hollow cylinder 209, thus achieving the effect of bubble interception.

[0043] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A bubble interception device for use in a chromatography column comprising a base plate (1), characterised in that: A fixing block (3) is fixedly connected to the top left side of the base plate (1). A first circular groove (11) is opened on the left side of the inner wall of the fixing block (3). A threaded rod (5) is threadedly connected to the inner wall of the first circular groove (11). A rocker arm (4) is fixedly connected to the left end of the threaded rod (5). A guide groove (12) is opened in the middle of the inner wall of the fixing block (3). A first fixing rod (6) is threadedly connected to the outer wall of the threaded rod (5). A fixed T-shaped rod (7) is threadedly connected to the right end of the threaded rod (5). A sliding groove (13) is opened on the right side of the inner wall of the fixing block (3). Multiple sliding blocks (8) are slidably connected to the inner wall of the sliding groove (13). A T-shaped groove (9) is opened on the adjacent side of the multiple sliding blocks (8). A clamping plate (10) is fixedly connected to the right side of the sliding block (8). A centrifugal mechanism (2) is fixedly connected to the top right side of the base plate (1). The centrifugal mechanism (2) is used for bubble isolation.

2. The bubble trap for use in a chromatography column according to claim 1, characterized in that: The centrifugal mechanism (2) includes a motor (201), the bottom of which is fixedly connected to the top of the base plate (1). A first bevel gear (202) is fixedly connected to the output end of the motor (201). A second bevel gear (203) is meshed with the outer wall of the first bevel gear (202). A round rod (204) is fixedly connected to the top of the second bevel gear (203). A cylinder (205) is fixedly connected to the top of the round rod (204). 5) The inner wall is provided with a second circular groove (206), the top of the cylinder (205) is fixedly connected to a filter cylinder (207), the outer wall of the circular rod (204) is rotatably connected to a hollow cylinder (209), the top of the inner wall of the hollow cylinder (209) is fixedly connected to multiple second fixing rods (210), the adjacent side of the multiple second fixing rods (210) is fixedly connected to a first conduit (208), and the bottom of the hollow cylinder (209) is fixedly connected to a second conduit (211).

3. The bubble trap for use in a chromatography column according to claim 1, wherein: The outer wall of the fixing block (3) is fixedly connected to a first cover plate (22), and a pad plate (14) is fixedly connected to each of the multiple clamping plates (10) on adjacent sides.

4. The bubble trap for use in a chromatography column according to claim 2, wherein: The top of the hollow cylinder (209) is fixedly connected to a second cover plate (24), and the top of the motor (201) is fixedly connected to a first protective sleeve (15).

5. A bubble trap for use in a chromatography column according to claim 4, characterized in that: The top of the first protective cover (15) is provided with a heat dissipation hole (16), and a controller (17) is fixedly connected to the front side of the first protective cover (15).

6. The bubble trap for use in a chromatography column according to claim 2, wherein: A pressure gauge (18) is fixedly connected to the front end of the cylinder (205), and a switch valve (23) is connected inside the second conduit (211).

7. The bubble trap for use in a chromatography column according to claim 2, wherein: The front end of the cylinder (205) is fixedly connected to a nameplate (19), and multiple screws (20) are threadedly connected to the four corners of the inner wall of the nameplate (19).

8. The bubble trap for use in a chromatography column according to claim 2, wherein: The top of the outer wall of the hollow cylinder (209) is fixedly connected to a second protective sleeve (21), and the bottom of the hollow cylinder (209) is fixedly connected to a third fixing rod (25).

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