Anti-settling suspension dynamic circulation device

Abstract

The application relates to a dynamic circulating device for a suspension liquid preventing sedimentation. The device comprises a liquid storage tank, a feeding pipe is penetrated through the front top of the liquid storage tank and fixedly connected, a sealing groove is formed in the top of the feeding pipe, uniformly distributed springs are fixedly connected in the sealing groove, a sealing ring is fixedly connected at the top of the springs, a sealing cover is arranged at the top of the feeding pipe, a sealing ring is fixedly connected at the bottom of the sealing cover, a motor is fixedly connected at the middle top of the liquid storage tank, a stirring rod is fixedly connected at the output end of the motor and penetrates through the liquid storage tank, uniformly distributed stirring blades are fixedly connected at the outer circle of the stirring rod, a peristaltic pump is fixedly connected below the outer side of the liquid storage tank, a circulating pipe is fixedly connected at the water outlet of the peristaltic pump, the circulating pipe is penetrated through the top of the liquid storage tank and fixedly connected, and a controller is fixedly connected above the front side of the liquid storage tank. The application can improve the sealing property, prevent pollution, avoid particle sedimentation and caking, and facilitate dismounting and maintenance.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical equipment technology, specifically to a dynamic circulation device for anti-settling suspension. Background Technology

[0002] In industries such as pharmaceuticals and diagnostic reagents, sterile suspension preparation systems are typically made of stainless steel to meet the demands of commercial production. However, traditional stainless steel systems have several limitations in the preparation process: First, it is difficult to achieve multi-product co-production, especially for contract development and manufacturing organizations (CDMOs), as system cleaning is challenging, the effectiveness of cleaning validation is difficult to guarantee, and the risk of residual active pharmaceutical ingredients (APIs) cannot be effectively controlled; second, the initial investment cost of using all stainless steel systems is too high for products in the clinical stage.

[0003] While CDMO companies have widely adopted single-use dispensing systems for the production of general liquid formulations, successful precedents for sterile suspensions remain limited. Suspensions, as drug dispersion systems, consist of solid or liquid drug particles dispersed in a liquid solvent, with particle sizes typically ranging from 0.1 to 100 μm. During storage, due to the density difference between the particles and the liquid, these heterogeneous systems experience particle settling under gravity.

[0004] In existing technologies, suspensions are typically stored in storage tanks, but this method has the following drawbacks: settled particles tend to clump at the bottom of the tank, requiring re-shaking before use, which can lead to uneven dosage; simultaneously, the inlet of the storage tank generally lacks an effective sealing structure, allowing airborne contaminants such as dust, microorganisms, and oil to enter the tank through gaps in the inlet pipe, causing material contamination. Furthermore, existing devices also present inconvenience in disassembling and maintaining the inlet sealing structure.

[0005] To address the aforementioned issues, existing technologies urgently need improvement. Utility Model Content

[0006] In view of the above-mentioned deficiencies of the prior art, this utility model provides a dynamic circulation device for anti-settling suspension, including a storage tank, wherein a feed pipe is connected through and fixedly connected to the top front end of the storage tank, a sealing groove is formed at the top of the feed pipe, a uniformly distributed spring is fixedly connected in the sealing groove, a sealing ring is fixedly connected to the top of the spring, a sealing cover is provided at the top of the feed pipe, connecting blocks are fixedly connected to both sides of the sealing cover, a locking groove is formed on both sides of the connecting blocks, and a disassembly assembly is connected to both sides of the feed pipe, the disassembly assembly being located on the outside of the connecting blocks. A sealing ring is fixedly connected to the bottom of the sealing cap. A motor is fixedly connected to the top center of the storage tank. A stirring rod is fixedly connected to the output end of the motor through the storage tank. Evenly distributed stirring blades are fixedly connected to both sides of the outer ring of the stirring rod. Two connecting rods are fixedly connected to the front and rear sides of the outer ring of the stirring rod. A scraper is fixedly connected between the two connecting rods. A peristaltic pump is fixedly connected to the lower outer side of the storage tank. A circulation pipe is fixedly connected to the outlet end of the peristaltic pump. The end of the circulation pipe passes through and is fixedly connected to the top of the storage tank. A controller is fixedly connected to the upper front side of the storage tank.

[0007] In the aforementioned anti-settling suspension dynamic circulation device, optionally, the disassembly assembly includes a mounting slot, which is fixedly connected to the outside of the feed pipe. A bidirectional threaded rod is rotatably connected through the mounting slot, and clamping arms are threaded to both sides of the outer ring of the bidirectional threaded rod.

[0008] In the aforementioned anti-settling suspension dynamic circulation device, optionally, the sealing ring is disposed in the sealing groove, and the outer side of the sealing ring is slidably connected to the inner wall of the sealing groove.

[0009] In the aforementioned anti-settling suspension dynamic circulation device, optionally, the sealing ring is disposed in the sealing groove, and the outer side of the sealing ring is slidably connected to the inner wall of the sealing groove.

[0010] In the aforementioned anti-settling suspension dynamic circulation device, optionally, a delivery pipe is connected through and fixedly connected to the middle of the bottom of the storage tank, and the end of the delivery pipe is fixedly connected to the water inlet of the peristaltic pump.

[0011] In the aforementioned anti-settling suspension dynamic circulation device, optionally, a discharge pipe is connected through and fixedly connected to the bottom front end of the storage tank.

[0012] In the aforementioned anti-settling suspension dynamic circulation device, optionally, brackets are fixedly connected to the four corners of the bottom of the storage tank.

[0013] In the aforementioned anti-settling suspension dynamic circulation device, optionally, a knob is fixedly connected to the front end of the bidirectional threaded rod, and the knob is located on the outside of the mounting slot.

[0014] In the aforementioned anti-settling suspension dynamic circulation device, optionally, the scraper is attached to the inner wall of the storage tank.

[0015] In the aforementioned anti-settling suspension dynamic circulation device, optionally, the clamping arms are disposed on both sides of the connecting block.

[0016] The present invention provides a dynamic circulation device for preventing sedimentation of suspension, which has the following beneficial effects:

[0017] (1) The anti-settling suspension dynamic circulation device provided in this application firstly uses a motor, stirring rod, stirring blade, connecting rod, scraper, conveying pipe, peristaltic pump and circulation pipe to work together. The stirring rod drives the stirring blade to rotate, which can make the suspension form a complex flow state, promote the continuous movement of particles in the suspension, prevent particles from settling due to gravity, and with the rotation of the scraper, the suspension adhering to the tank wall can be scraped off, avoiding the accumulation of suspension on the tank wall and affecting uniformity. With the peristaltic pump, the suspension is extracted through the conveying pipe and transported back to the storage tank through the circulation pipe. Under the action of the peristaltic pump and the circulation pipe, the suspension forms a circulating flow in the storage tank. This circulating flow forms convection in the storage tank. With the stirring action of the stirring rod and stirring blade, the anti-settling function is achieved.

[0018] (2) The feed pipe, sealing groove, spring, sealing ring, sealing cover, connecting block, slot, sealing ring, and disassembly assembly work together. The disassembly assembly drives the two clamping arms to move relative to each other or away from each other. By controlling the clamping arms to insert into or pull out of the slots on both sides of the connecting block, the sealing cover can be quickly installed and removed. The sealing ring is inserted into the sealing groove to cooperate with the sealing ring, which can ensure the sealing effect of the sealing cover. The elastic force of the spring can make the sealing ring fit tightly against the sealing ring, further enhancing the sealing effect and preventing external dust and impurities from entering the storage tank and contaminating the suspension, while avoiding suspension leakage.

[0019] In summary, the anti-settling suspension dynamic circulation device and its disassembly components provided in this application achieve multiple seals at the feed inlet through the cooperation of springs and sealing rings, prevent particle settling by combining stirring blades and scrapers, realize dynamic circulation by using a peristaltic pump, and quickly disassemble and install the sealing cover by a clamping arm driven by a bidirectional threaded rod. This effectively solves the problems of poor sealing, easy agglomeration, and inconvenient maintenance of traditional devices, and has the advantages of improving sealing performance to prevent pollution, avoiding particle settling and agglomeration, and facilitating disassembly and maintenance.

[0020] The following will further explain the concept, specific structure and technical effects of this utility model in conjunction with the accompanying drawings, so as to fully understand the purpose, features and effects of this utility model. Attached Figure Description

[0021] Figure 1 This is a three-dimensional structural schematic diagram of an embodiment of the anti-settling suspension dynamic circulation device of the present invention;

[0022] Figure 2 for Figure 1 Exploded view of the feed pipe;

[0023] Figure 3 for Figure 1 Cross-sectional view of the intermediate storage tank;

[0024] Figure 4 for Figure 1 A top view of a dynamic circulation device for suspension;

[0025] Figure 5 for Figure 1 Side view of the dynamic circulation device for suspension;

[0026] Figure 6 for Figure 1 Rear view of the suspension dynamic circulation device.

[0027] Figure label:

[0028] 1-Storage tank; 10-Mounting base; 11-Double threaded rod; 12-Knob; 13-Clamping arm; 14-Motor; 15-Stirring rod; 16-Stirring blade; 17-Connecting rod; 18-Scraper; 19-Transfer pipe;

[0029] 2-Infeed pipe; 20-Peristaltic pump; 21-Circulation pipe; 22-Discharge pipe; 23-Support; 24-Controller;

[0030] 3-Sealing groove;

[0031] 4-Spring;

[0032] 5-Sealing ring;

[0033] 6-Sealing cap;

[0034] 7-Connecting block;

[0035] 8-Card slot;

[0036] 9-Sealing ring. Detailed Implementation

[0037] To make the technical means, inventive features, objectives, and effects of this utility model readily understandable, the present utility model is further described below in conjunction with specific illustrations. However, this utility model is not limited to the embodiments described below.

[0038] It should be noted that the structures, proportions, sizes, etc., shown in the accompanying drawings of this specification are only used to complement the content disclosed in the specification for those skilled in the art to understand and read, and are not intended to limit the conditions under which this utility model can be implemented. Therefore, they have no substantial technical significance. Any modifications to the structure, changes in the proportional relationships, or adjustments to the size, without affecting the effects and purposes that this utility model can produce, should still fall within the scope of the technical content disclosed in this utility model.

[0039] Furthermore, the terms "first" and "second" are used for descriptive purposes only to distinguish one entity or operation from another, and should not be construed as indicating or implying relative importance or implicitly indicating the number of indicated technical features or any such actual relationship or order between these entities or operations. For any single technical feature described or implied in the embodiments mentioned herein, or any single technical feature shown or implied in the various drawings, the present invention still allows for any further combination or deletion of these technical features (or their equivalents) without any technical obstacle; therefore, these further embodiments according to the present invention should also be considered within the scope of this description.

[0040] Terms such as “comprising” and “including” indicate that, in addition to the components that are directly and explicitly stated in the specification and claims, the technical solution of the present invention does not exclude the presence of other components that are not directly or explicitly stated.

[0041] It should also be noted that the terms "upper," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this disclosure and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this disclosure.

[0042] Furthermore, the term "and / or" in this article is merely a description of the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent: A existing alone, A and B existing simultaneously, or B existing alone. Additionally, the character " / " in this article generally indicates that the preceding and following related objects have an "or" relationship.

[0043] In existing technologies, sterile suspension preparation systems used in the pharmaceutical and diagnostic reagent industries mostly employ stainless steel systems. These systems suffer from challenges such as difficult cleaning and poor flexibility in multi-product co-production. The initial investment cost of stainless steel systems is too high for clinical-stage products, while disposable preparation systems have limited application cases in the suspension field. In traditional storage tanks, suspension particles tend to settle and clump due to density differences, requiring manual shaking and resulting in uneven dosage. Insufficient sealing at the inlet can introduce contaminants, affecting material stability.

[0044] This application proposes a dynamic circulation device for preventing sedimentation of suspensions. For example... Figure 1-6 As shown, the device includes a storage tank 1 for storing a suspension. A feed pipe 2 is connected and fixedly connected to the top front end of the storage tank 1, and the feed pipe 2 is used to inject the suspension into the storage tank 1. A sealing groove 3 is formed at the top of the feed pipe 2, and evenly distributed springs 4 are fixedly connected within the sealing groove 3. A sealing ring 5 is fixedly connected to the top of each spring 4, allowing the sealing ring 5 to expand and contract within the sealing groove 3 due to the elastic force of the springs 4. A sealing cover 6 is provided at the top of the feed pipe 2 to prevent dust and impurities from entering the storage tank 1 and causing contamination. Connecting blocks 7 are fixedly connected to both sides of the sealing cover 6, and slots 8 are formed on both sides of each connecting block 7, serving as a limiting mechanism. Disassembly components are connected to both sides of the feed pipe 2, and these components are located outside the connecting blocks 7. A sealing ring 9 is fixedly connected to the bottom of the sealing cover 6, and the sealing ring 9, when inserted into the sealing groove 3, improves the sealing effect of the sealing cover 6. A motor 14 is fixedly connected to the top center of the storage tank 1. The output end of the motor 14 passes through the storage tank 1 and is fixedly connected to a stirring rod 15, which can drive the stirring rod 15 to rotate. Evenly distributed stirring blades 16 are fixedly connected to both the left and right sides of the outer ring of the stirring rod 15. The stirring blades 16 prevent the suspension from settling when they rotate. Two connecting rods 17 are fixedly connected to the front and rear sides of the outer ring of the stirring rod 15. A scraper 18 is fixedly connected between the two connecting rods 17, and the scraper 18 fits against the inner wall of the storage tank 1. A peristaltic pump 20 is fixedly connected to the lower outer side of the storage tank 1. The peristaltic pump 20 can extract the suspension through a delivery pipe 19. A circulation pipe 21 is fixedly connected to the outlet end of the peristaltic pump 20, and the end of the circulation pipe 21 passes through and is fixedly connected to the top of the storage tank 1. A controller 24 is fixedly connected to the upper front side of the storage tank 1.

[0045] Reference Figure 2The disassembly assembly may include a mounting slot 10, which is fixedly connected to the outside of the feed pipe 2. A bidirectional threaded rod 11 is rotatably connected through the mounting slot 10. Clamping arms 13, L-shaped, are threadedly connected to both sides of the outer ring of the bidirectional threaded rod 11. The clamping arms 13 are located on both sides of the connecting block 7. A knob 12 is fixedly connected to the front end of the bidirectional threaded rod 11, and the knob 12 is located on the outside of the mounting slot 10. The disassembly assembly can drive the two clamping arms 13 to move relative to or away from each other. By controlling the clamping arms 13 to insert into or pull out of the slots 8 on both sides of the connecting block 7, the sealing cover 6 can be quickly installed and removed.

[0046] A sealing ring 5 is disposed within the sealing groove 3, and its outer surface is slidably connected to the inner wall of the sealing groove 3, allowing the sealing ring 5 to extend and retract within the sealing groove 3. A sealing ring 9 is disposed within the sealing groove 3, and its outer surface is slidably connected to the inner wall of the sealing groove 3, allowing the sealing ring 9 to be inserted into the sealing groove 3. A conveying pipe 19 is connected through and fixedly to the middle of the bottom of the storage tank 1, and its end is fixedly connected to the inlet of the peristaltic pump 20, enabling the conveying of the suspension. A discharge pipe 22 is connected through and fixedly to the front end of the bottom of the storage tank 1, and a solenoid valve (not shown in the figure) is installed on the outside of the discharge pipe 22 for easy control of material discharge. Supports 23 are fixedly connected to the four corners of the bottom of the storage tank 1, providing support for the storage tank 1.

[0047] Specifically, during operation, the suspension is injected into the storage tank 1 through the feed pipe 2. When the sealing cap 6 is closed, the sealing ring 9 at the bottom of the sealing cap 6 inserts into the sealing groove 3, initially sealing the space inside the sealing groove 3. At the same time, the sealing cap 6 drives the sealing ring 9 to press down on the sealing ring 5, compressing the spring 4. The spring 4 generates an upward elastic force to push the sealing ring 5 tightly against the sealing ring 9 at the bottom of the sealing cap 6, further enhancing the sealing effect and preventing external dust and impurities from entering the storage tank 1 and contaminating the suspension, while also preventing suspension leakage. After the sealing cap 6 is placed on top of the feed pipe 2, the knob 12 is turned to rotate the bidirectional threaded rod 11. As the bidirectional threaded rod 11 drives the two clamping arms 13 to move relative to each other along the groove at the top of the mounting base 10, they are engaged in the slots 8 on both sides of the connecting block 7, thus firmly clamping the sealing cap 6 onto the feed pipe 2. To disassemble, the knob 12 is turned in the opposite direction, and the clamping arms 13 move outward to disengage from the slots 8, allowing the sealing cap 6 to be easily removed. After the motor 14 starts, its output end drives the stirring rod 15 to rotate, and the stirring blades 16 on the stirring rod 15 rotate accordingly, stirring the suspension in the storage tank 1, making the suspension flow, promoting the continuous movement of particles in the suspension, and preventing particles from settling due to gravity. At the same time, the connecting rod 17 and scraper 18 on the outer ring of the stirring rod 15 rotate with the stirring rod 15. The scraper 18 is in close contact with the inner wall of the storage tank 1, scraping off the suspension adhering to the tank wall, avoiding the accumulation of suspension on the tank wall and affecting uniformity, further enhancing the stirring effect, and ensuring the dispersion stability of the suspension. The delivery pipe 19 at the bottom of the storage tank 1 is used to transport the suspension in the tank to the inlet of the peristaltic pump 20. After the peristaltic pump 20 starts, it applies pressure to the suspension, causing it to enter the circulation pipe 21 from the outlet of the peristaltic pump 20, and finally be transported back to the storage tank 1 through the circulation pipe 21. Under the action of the peristaltic pump 20 and the circulation pipe 21, the suspension forms a circulating flow within the storage tank 1. This circulating flow creates convection within the storage tank 1, which, combined with the stirring action of the stirring rod 15 and the stirring blade 16, continuously breaks the sedimentation tendency of the particles, effectively preventing stratification and sedimentation of the suspension. When the suspension is needed, it can be discharged through the discharge pipe 22 at the bottom front of the storage tank 1.

[0048] The sealing groove 3 refers to the annular groove structure set at the top of the feed pipe 2, which can be formed by machining. It is used to accommodate the spring 4 and the sealing ring 5, and the compression stroke of the sealing element is controlled by the groove depth. The spring 4 refers to the elastic support element, which can be a stainless steel helical spring 4, evenly distributed in the sealing groove 3. It maintains the contact pressure between the sealing ring 5 and the sealing cover 6 through pre-tightening force. The disassembly component refers to the clamping and fixing mechanism, which can be a bidirectional threaded drive clamp arm 13 structure. The clamp arm 13 is quickly locked by rotating the threaded rod to embed into the slot 8. The scraper 18 is a cleaning component that contacts the inner wall of the tank. It can be made of polytetrafluoroethylene sheet. It is synchronously rotated with the stirring rod 15 through the connecting rod 17 to remove the sediment attached to the tank wall. The peristaltic pump 20 is a fluid conveying device, which can be a pump body structure with rollers squeezing the hose. It re-injects the bottom suspension into the top of the storage tank 1 through the circulation pipe 21 to form a circulating flow.

[0049] When the motor 14 drives the stirring rod 15 to rotate, the stirring blades 16 generate radial shear force on the suspension, disrupting the tendency of particles to agglomerate. The scraper 18 rotates synchronously with the stirring rod 15, continuously scraping away the deposits on the tank wall to prevent clumping. The peristaltic pump 20 draws the suspension from the bottom of the tank and returns it to the top through the circulation pipe 21, forming a vertical convection motion to counteract the effect of gravity settling. When the sealing cover 6 is closed, the spring 4 is compressed, generating a reverse force that tightly fits the sealing ring 5 and the sealing ring 9 to form a double sealing interface. The clamping arm 13 in the disassembly assembly adjusts the clamping force through the thread to ensure that the connecting block 7 remains fixed under vibration. The controller 24 adjusts the speed of the motor 14 and the pumping frequency according to the material characteristics to maintain a dynamic balance.

[0050] Through the above technical solutions, this application can effectively prevent agglomeration caused by the sedimentation of suspension particles, ensuring that the material uniformity meets the formulation requirements. The double-sealed structure blocks the intrusion path of external contaminants, ensuring the cleanliness of the material inside the tank. The dynamic circulation system reduces the frequency of manual intervention, and the scraper mechanism extends the tank cleaning cycle, thereby improving overall production efficiency and equipment reliability.

[0051] The preferred embodiments of this utility model have been described in detail above. It should be understood that those skilled in the art can make numerous modifications and variations based on the concept of this utility model without creative effort. Therefore, all technical solutions that can be obtained by those skilled in the art based on the concept of this utility model through logical analysis, reasoning, or limited experimentation on the basis of existing technology should be within the scope of protection defined by the claims.

Claims

1. A dynamic circulation device for preventing sedimentation of a suspension, comprising a storage tank (1), characterized in that, The top front end of the storage tank (1) is connected to a feed pipe (2), and a sealing groove (3) is opened at the top of the feed pipe (2). A uniformly distributed spring (4) is fixedly connected in the sealing groove (3). A sealing ring (5) is fixedly connected at the top of the spring (4). A sealing cover (6) is provided at the top of the feed pipe (2). A connecting block (7) is fixedly connected to both sides of the sealing cover (6). A slot (8) is opened on both sides of the connecting block (7). A disassembly assembly is connected to both sides of the feed pipe (2). The disassembly assembly is located on the outside of the connecting block (7). A sealing ring (9) is fixedly connected to the bottom of the sealing cover (6). A sealing ring (9) is fixedly connected to the middle of the top of the storage tank (1). A motor (14) is fixedly connected to a stirring rod (15) through the liquid storage tank (1) at its output end. Stirring blades (16) are fixedly connected to both the left and right sides of the outer ring of the stirring rod (15). Two connecting rods (17) are fixedly connected to the front and rear sides of the outer ring of the stirring rod (15). A scraper (18) is fixedly connected between the two connecting rods (17). A peristaltic pump (20) is fixedly connected to the lower outer side of the liquid storage tank (1). A circulation pipe (21) is fixedly connected to the water outlet of the peristaltic pump (20). The end of the circulation pipe (21) passes through and is fixedly connected to the top of the liquid storage tank (1). A controller (24) is fixedly connected to the upper front side of the liquid storage tank (1).

2. The anti-settling suspension dynamic circulation device according to claim 1, characterized in that, The disassembly assembly includes a mounting slot (10), which is fixedly connected to the outside of the feed pipe (2). A bidirectional threaded rod (11) is rotatably connected through the mounting slot (10), and clamping arms (13) are threaded on both sides of the outer ring of the bidirectional threaded rod (11).

3. The anti-settling suspension dynamic circulation device according to claim 1, characterized in that, The sealing ring (5) is disposed in the sealing groove (3), and the outside of the sealing ring (5) is slidably connected to the inner wall of the sealing groove (3).

4. The anti-settling suspension dynamic circulation device according to claim 1, characterized in that, The sealing ring (9) is disposed in the sealing groove (3), and the outside of the sealing ring (9) is slidably connected to the inner wall of the sealing groove (3).

5. The anti-settling suspension dynamic circulation device according to claim 1, characterized in that, The storage tank (1) has a delivery pipe (19) that runs through and is fixedly connected to the middle of its bottom, and the end of the delivery pipe (19) is fixedly connected to the water inlet of the peristaltic pump (20).

6. The anti-settling suspension dynamic circulation device according to claim 1, characterized in that, The bottom front end of the storage tank (1) is connected to a discharge pipe (22).

7. The anti-settling suspension dynamic circulation device according to claim 1, characterized in that, The storage tank (1) is fixedly connected to four corners of its bottom with brackets (23).

8. The anti-settling suspension dynamic circulation device according to claim 2, characterized in that, The front end of the bidirectional threaded rod (11) is fixedly connected to a knob (12), and the knob (12) is located on the outside of the mounting slot (10).

9. The anti-settling suspension dynamic circulation device according to claim 1, characterized in that, The scraper (18) is attached to the inner wall of the storage tank (1).

10. The anti-settling suspension dynamic circulation device according to claim 2, characterized in that, The clamping arms (13) are located on both sides of the connecting block (7).

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