Blood dialysis line anti-coagulation shaker structure
By combining vertical vibration and horizontal reciprocating motion to simulate human blood circulation, the problem of blood clotting in hemodialysis tubing is solved, improving the stability and individual adaptability of the equipment, and reducing the risk of blood clotting and treatment costs.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- THE 980TH HOSPITAL OF THE CHINESE PEOPLES LIBERATION ARMY JOINT LOGISTICS SUPPORT FORCE
- Filing Date
- 2025-07-18
- Publication Date
- 2026-06-26
AI Technical Summary
Blood in extracorporeal circulation tubing lacks natural flow momentum and is prone to clotting due to stagnation or eddies. Existing oscillator devices have limitations, cannot effectively simulate the state of human blood circulation, and are costly, unstable, and difficult to adapt to individual needs.
Combining a vertical vibration unit and a horizontal reciprocating motion module, the system simulates the human blood circulation state through vertical vibration and horizontal reciprocating motion. It uses detachable retaining rings to fix the hemodialysis tube and integrates casters and a self-locking mechanism to improve its mobility and fixation capabilities.
It effectively reduces the risk of blood clotting, improves dialysis safety, extends filter life, reduces tubing damage and bleeding complications, lowers treatment costs, and adapts to the needs of different patients.
Smart Images

Figure CN224404952U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of hemodialysis, and in particular to the structure of an anticoagulation vibrator for hemodialysis tubing. Background Technology
[0002] Hemodialysis is a key clinical treatment for kidney diseases such as acute and chronic renal failure and uremia. It involves draining the patient's blood outside the body and exchanging substances with the help of a dialyzer to remove metabolic waste, excess water, and electrolytes from the blood, thereby maintaining the stability of the patient's internal environment and protecting the patient's life and health.
[0003] However, blood is prone to clotting in tubing due to prolonged stagnation. This is because blood lacks the natural flow dynamics of the body during extracorporeal circulation. In addition, factors such as tubing material, temperature, and flow rate can cause blood to stagnate or form eddies within the tubing, thus triggering the clotting mechanism. Without a vibrator, blood can only flow in the tubing by its own gravity and pump pressure. This flow is often insufficient and uneven, easily creating dead zones and eddies within the tubing, providing conditions for clotting. Utility Model Content
[0004] To overcome the problem that blood lacks natural flow momentum in extracorporeal circulation tubing, is prone to stagnation or eddies that trigger coagulation mechanisms, and that insufficient and uneven flow without a vibrator can easily create dead zones leading to coagulation.
[0005] The technical solution of this utility model is as follows: a hemodialysis tubing anticoagulation vibrator structure, including a base plate, a caster wheel with a built-in self-locking mechanism integrated at the lower end of the base plate, a vertical vibration unit fixedly connected to the upper end of the base plate, a support plate installed inside the vertical vibration unit, a vibration motor configured at the lower end of the support plate as a drive source to perform vertical vibration action; a horizontal reciprocating motion module is set at the upper end of the support plate, a receiving plate is set inside the horizontal reciprocating motion module; a vertical plate is also fixed on the support plate, and a linkage sliding mechanism is set on the surface of the vertical plate. The sliding mechanism works in conjunction with the horizontal reciprocating motion module to achieve the guiding displacement of the receiving plate; a support plate is installed at the upper end of the receiving plate, and a detachable retaining ring is configured on the side end of the support plate to accommodate and fix the hemodialysis tubing.
[0006] Preferably, the vertical vibration unit includes a column mounted on a base plate, a telescopic rod at the lower end of a support plate, the telescopic rod being slidably connected to the column, and a spring being provided between the end face of the column and the lower end of the support plate, the spring being sleeved on the outer wall of the telescopic rod.
[0007] Preferably, the horizontal reciprocating motion module includes a fixed plate on a support plate, a servo motor on the end face of the fixed plate, an eccentric wheel connected to the output shaft of the servo motor, a connecting rod on the eccentric wheel, a slider at the end of the connecting rod, a slide block on the side of the fixed plate that is adapted to the slider, the slider and the slide block being slidably connected, a groove on the surface of the fixed plate, and the side end of the slider extending into the groove and connecting to the side end of the receiving plate.
[0008] Preferably, the sliding mechanism includes a slide rail disposed on the surface of the vertical plate, a movable block slidably connected on the slide rail, and the end face of the movable block being connected to the side end of the receiving plate.
[0009] Preferably, the end face of the fixing plate and the upper end face of the support plate are provided with reinforcing ribs.
[0010] Preferably, the inner wall of the slide groove of the horizontal reciprocating motion module is provided with a wear-resistant coating, and the contact surface between the slider and the slide groove is an arc-shaped convex surface, forming a line contact sliding fit between the two.
[0011] Preferably, the top of the vertical vibration unit column is provided with a buffer pad, which contacts the lower end face of the support plate.
[0012] The beneficial effects of this utility model are:
[0013] Compared to dialysis tubing without an oscillator, the combination of vertical vibration generated by the vertical vibration unit and horizontal reciprocating motion provided by the horizontal reciprocating motion module more effectively simulates the state of human blood circulation, reducing the risk of blood clotting in the tubing. At the same time, the universal wheels with built-in self-locking mechanism integrated at the bottom of the base plate enable the oscillator to have flexible movement and stable fixation performance, making it convenient to adjust its position in different working scenarios. Attached Figure Description
[0014] Figure 1 This is a schematic diagram of one embodiment of the anticoagulation shaker structure for hemodialysis tubing of this utility model;
[0015] Figure 2 What is shown is Figure 1 Schematic diagram of the vertical vibration unit;
[0016] Figure 3 What is shown is Figure 1 A schematic diagram of the sliding mechanism;
[0017] Figure 4 What is shown is Figure 1 A schematic diagram of the first structure of the horizontal reciprocating motion module;
[0018] Figure 5 What is shown is Figure 1 A schematic diagram of the second structure of the horizontal reciprocating motion module.
[0019] Explanation of reference numerals in the attached diagram: 1. Base plate; 2. Caster wheel; 3. Support plate; 4. Vibration motor; 5. Support plate; 6. Vertical plate; 7. Support plate; 8. Snap ring; 9. Column; 10. Telescopic rod; 11. Spring; 12. Fixing plate; 13. Servo motor; 14. Eccentric wheel; 15. Connecting rod; 16. Slider; 17. Slide block; 18. Slide groove; 19. Slide rail; 20. Moving block; 21. Reinforcing rib. Detailed Implementation
[0020] The present invention will be further described below with reference to the accompanying drawings and embodiments.
[0021] Hemodialysis is a key treatment for end-stage renal disease patients to maintain their lives. Its core goal is to remove metabolic waste and excess water from the blood through the extracorporeal circulation system. However, during this process, the non-physiological retention of blood in the extracorporeal tubing can easily trigger a coagulation cascade reaction, leading to tubing blockage, filter failure, and even endangering the patient's life. To address this clinical challenge, the hemodialysis tubing anticoagulation vibrator has been developed. It simulates the hemodynamic environment in the body through physical means and has become an important auxiliary device to ensure the safety of dialysis.
[0022] The technological innovation of anticoagulant shakers is driven by clinical needs. The risk of blood clotting during extracorporeal circulation stems primarily from three factors: First, blood stagnates in dead space areas of the tubing, such as joints and bends, causing a sudden drop in blood flow velocity and activating the intrinsic coagulation pathway. Second, the interaction between blood and the hydrophobic tubing surface attracts plasma proteins, triggering platelet adhesion and aggregation. Finally, anticoagulant management is also a challenge; insufficient heparin dosage may lead to clotting, while excessive dosage may increase the risk of bleeding. Statistics show that approximately 15% of dialysis treatments worldwide are interrupted annually due to coagulation events, resulting in direct economic losses exceeding $1 billion.
[0023] Even more worrying is that the characteristics of the patient population are exacerbating this risk. The average age of dialysis patients in my country has reached 58 years old, and more than 40% of them have decreased vascular elasticity and abnormal coagulation function. At the same time, the increase in comorbidities further increases the risk of coagulation. Patients with diabetic nephropathy and hypertensive nephropathy often have hyperplatelet function, and their coagulation risk is 2-3 times higher than that of normal people. The dependence on long-term treatment means that patients undergo dialysis an average of 130 times a year. A single coagulation event may result in a loss of 0.5-1.0 ml / kg of blood, and long-term accumulation will lead to aggravated anemia.
[0024] Faced with this serious situation, the technology of anticoagulant shakers has been constantly evolving. In the early stages (1970s-1990s), the equipment used a single-frequency reciprocating oscillation with an amplitude of approximately ±15° and a frequency between 60-80 times / min. This mechanical force disrupted the formation of microthrombi. However, this method had significant limitations. Long-term oscillation could lead to cracks in the PVC tubing, increasing the risk of bacterial colonization. Furthermore, because it could not reproduce the characteristics of a pulsating flow field, the anticoagulant effect was highly dependent on high doses of heparin.
[0025] In the 21st century, breakthroughs have been achieved in multimodal physical intervention technology. Modern equipment integrates a variety of innovative technologies, such as gradient pressure pulse technology, three-dimensional oscillation systems, and intelligent monitoring modules. Gradient pressure pulse technology creates a pressure gradient of 0-300 mmHg in the tubing through the periodic inflation and deflation of an airbag, simulating the contraction and relaxation of the myocardium. The three-dimensional oscillation system adopts an XYZ three-axis linkage design to achieve a composite motion of swinging (±10°), rotation (360° / min), and compression, reducing the coefficient of variation (CV) of blood flow velocity in the tubing from 28% to 12%. The intelligent monitoring module integrates pressure sensors and coagulation index algorithms, automatically adjusting the oscillation parameters when thromboelastography (TEG) parameters are abnormal.
[0026] During the development of anticoagulant oscillators, several feasible methods have been discovered. In terms of structural optimization, elastic silicone clamps can be used to replace traditional metal clips, reducing stress concentration points in the tubing and lowering the risk of tubing damage. The design of the oscillation platform can also be improved by using magnetic levitation bearings instead of mechanical bearings to reduce vibration noise (<45dB) and improve positioning accuracy (±0.1mm), thereby improving the stability and service life of the device. In addition, detachable oscillation units can be developed to support rapid switching between single-needle and dual-needle dialysis modes to meet the needs of different patients.
[0027] Clinical validation results also demonstrate the significant advantages of the anticoagulant shaker. A multicenter RCT study showed that using the shaker can extend the filter life by 40% (from 6.2h to 8.7h), reducing the frequency and cost of filter replacement. At the same time, compared with the control group, the incidence of tubing membrane rupture decreased from 0.8% to 0.2%, and the number of bleeding complications in patients decreased by 33%, improving the safety of dialysis treatment. In addition, the cost of consumables per dialysis session decreased by 18%, and the annual treatment cost was reduced by about RMB 12,000 per patient, alleviating the economic burden on patients.
[0028] However, anticoagulant oscillators still face several technical bottlenecks and challenges. First, long-term stability is a pressing issue; the failure rate of the oscillation mechanism remains at 8% after 5000 hours of continuous operation, necessitating further improvements in equipment reliability and durability. Second, individualized adaptation is also a challenge; existing models struggle to accurately simulate the unique hemodynamic characteristics of obese patients (BMI > 35), requiring the development of more personalized oscillation parameters and models. Finally, cost-effectiveness is a significant factor limiting its widespread adoption. The equipment purchase cost is approximately 150,000 yuan per unit, a substantial expense for primary healthcare institutions.
[0029] Please see Figure 1 - Figure 5This utility model provides an embodiment of an anticoagulation vibrator structure for hemodialysis tubing, comprising a base plate 1, with a caster wheel 2 integrated at the lower end of the base plate 1 and a vertical vibration unit fixedly connected to the upper end of the base plate 1. A support plate 3 is installed inside the vertical vibration unit, and a vibration motor 4 is configured at the lower end of the support plate 3 as a drive source to perform vertical vibration. A horizontal reciprocating motion module is provided at the upper end of the support plate 3, and a receiving plate 5 is provided inside the horizontal reciprocating motion module. A vertical plate 6 is also fixed on the support plate 3, and a linkage sliding mechanism is provided on the surface of the vertical plate 6. The sliding mechanism works in conjunction with the horizontal reciprocating motion module to achieve the guiding displacement of the receiving plate 5. A support plate is installed at the upper end of the receiving plate 5. 7. The side end of the support plate 7 is equipped with a detachable retaining ring 8, which is used to accommodate and fix the hemodialysis tubing. The base plate 1 serves as the basic support structure for the entire hemodialysis tubing anticoagulation shaker, providing a stable working platform for each functional module. The casters 2 are integrated into the lower end of the base plate 1, giving the shaker flexible movement capabilities and facilitating position adjustment in different working scenarios. The built-in self-locking mechanism plays a fixing role. When the shaker moves to the designated position, the casters 2 can be locked by operating the self-locking mechanism to prevent accidental movement of the shaker during operation and ensure operational safety. The vertical vibration unit is fixedly connected to the upper end of the base plate 1, providing vertical vibration function for the hemodialysis tubing. The vibration effectively promotes blood flow within the tubing, preventing blood clotting caused by prolonged stillness. The vibration motor 4, acting as the drive source for the vertical vibration unit, generates centrifugal force through the high-speed rotation of its internal eccentric block when activated, causing periodic vibration of the motor itself. This enables the vertical vibration unit to operate. The horizontal reciprocating motion module works in conjunction with the vertical vibration unit, providing horizontal reciprocating motion for the hemodialysis tubing. The combination of vertical vibration and horizontal reciprocating motion more effectively simulates the state of human blood circulation, further reducing the risk of blood clotting within the tubing. The receiving plate 5 transmits the horizontal displacement generated by the horizontal reciprocating motion module to the support plate 7, thereby... The hemodialysis tubing achieves horizontal reciprocating motion. The sliding mechanism is set on the surface of the vertical plate 6 and works in conjunction with the horizontal reciprocating motion module to achieve the guiding displacement of the receiving plate 5. When the horizontal reciprocating motion module drives the receiving plate 5 to move, the slider 16 moves linearly along the guide rail to ensure that the hemodialysis tubing can perform horizontal reciprocating motion. The retaining ring 8 is used to accommodate and fix the hemodialysis tubing. The detachable design makes the installation and removal of the hemodialysis tubing more convenient and quick, and easier for medical staff to operate. During installation, the hemodialysis tubing is placed in the retaining ring 8, and the tubing is firmly fixed to the support plate 7 by the buckle built into the retaining ring 8. After treatment, the retaining ring 8 can be easily opened and the hemodialysis tubing can be removed.
[0030] Please see Figure 2 - Figure 5In this embodiment, the vertical vibration unit includes a column 9 mounted on a base plate 1, a telescopic rod 10 mounted on the lower end of a support plate 3, the telescopic rod 10 being slidably connected to the column 9, a spring 11 being mounted between the end face of the column 9 and the lower end of the support plate 3, the spring 11 being sleeved on the outer wall of the telescopic rod 10, and the horizontal reciprocating motion module including a fixed plate 12 mounted on the support plate 3, a servo motor 13 mounted on the end face of the fixed plate 12, an eccentric wheel 14 connected to the output shaft of the servo motor 13, a connecting rod 15 mounted on the eccentric wheel 14, a slider 16 mounted at the end of the connecting rod 15, and a slide block 17 adapted to the slider 16 mounted on the side end of the fixed plate 12, the slider 16 being slidably connected to the slide block 17. The surface of the fixed plate 12 is provided with a groove 18. The side end of the slider 16 extends into the groove 18 and is connected to the side end of the receiving plate 5. The sliding mechanism includes a slide rail 19 set on the surface of the vertical plate 6. A moving block 20 is slidably connected to the slide rail 19. The end face of the moving block 20 is connected to the side end of the receiving plate 5. The column 9 serves as the support structure for the vertical vibration unit. When the vibration motor 4 drives the support plate 3 to vibrate vertically, the telescopic rod 10 slides up and down in the column 9 with the movement of the support plate 3, effectively transmitting the power of the vibration motor 4 to the support plate 3. At the same time, it restricts the support plate 3 to move only in the vertical direction, avoiding horizontal deviation, thereby ensuring the effectiveness of the vertical vibration. Spring 11 acts as a buffer and energy storage unit in the vertical vibration unit. When the support plate 3 moves downward under the action of the vibration motor 4, spring 11 is compressed, storing elastic potential energy. When the support plate 3 moves upward, spring 11 releases elastic potential energy, pushing the support plate 3 upward, assisting the vibration motor 4 in completing the vertical vibration action. The presence of spring 11 can reduce the impact of the vibration motor 4 on other components of the device at the moment of start-up and stop, reduce the vibration noise of the device, and at the same time make the vibration of the support plate 3 more stable and gentle, improving the stability of the hemodialysis tubing during the vibration process. The fixed plate 12 provides an installation platform for the various components of the horizontal reciprocating motion module, and the servo motor 13 serves as... The power source for the horizontal reciprocating motion module is the eccentric wheel 14, which is connected to the output shaft of the servo motor 13. When the servo motor 13 starts, the output shaft drives the eccentric wheel 14 to rotate, thereby driving the connecting rod 15 to move. During the rotation of the eccentric wheel 14, the connecting rod 15 continuously changes its angle and length as the position of the eccentric wheel 14 changes, thereby pushing the slider 16 to make linear reciprocating motion in the slide block 17, and thus driving the receiving plate 5 to move. The slide rail 19 provides another direction of guide track for the horizontal reciprocating motion of the receiving plate 5. The moving block 20 is slidably connected to the slide rail 19, connecting the receiving plate 5 to the slide rail 19, so that the receiving plate 5 can make linear reciprocating motion along the slide rail 19.
[0031] Please see Figure 1In this embodiment, reinforcing ribs 21 are provided on the end face of the fixed plate 12 and the upper end face of the support plate 3. The inner wall of the slide groove 18 of the horizontal reciprocating motion module is provided with a wear-resistant coating. The contact surface between the slider 16 and the slide groove 18 is an arc-shaped convex surface, and the two form a line contact sliding fit. The top of the column 9 of the vertical vibration unit is provided with a buffer pad, which contacts the lower end face of the support plate 3. The function of the reinforcing ribs 21 is to enhance the connection strength between the fixed plate 12 and the support plate 3 and the rigidity of the overall structure. During the horizontal reciprocating motion, the fixed plate 12 will be subjected to forces and torques from components such as the servo motor 13, the eccentric wheel 14, and the connecting rod 15. The reinforcing ribs 21 can effectively disperse these stresses, prevent deformation or loosening between the fixed plate 12 and the support plate 3, and ensure the stable operation of the horizontal reciprocating motion module. Since the slider 16 is inside the slide groove 18 Frequent linear reciprocating motion causes significant friction and wear on the inner wall of the slide groove 18. The wear-resistant coating increases the hardness and wear resistance of the inner wall of the slide groove 18, reduces frictional loss between the slider 16 and the slide groove 18, and extends the service life of both the slide groove 18 and the slider 16. The contact surface between the slider 16 and the slide groove 18 is an arc-shaped convex surface, forming a line contact sliding fit. Compared with the traditional surface contact sliding fit, this design has the following advantages: First, it reduces the contact area and frictional resistance, making the movement of the slider 16 within the slide groove 18 smoother. Second, the arc-shaped convex surface can better accommodate the slight offset and deformation of the slider 16 during movement, improving the stability and reliability of the movement. The function of the buffer pad is to buffer the contact point between the support plate 3 and the column 9, preventing a rigid collision between the support plate 3 and the top of the column 9.
[0032] Working principle: First, the universal wheels 2 with the built-in self-locking mechanism at the lower end of the base plate 1 are moved to the designated working position, and the self-locking mechanism is operated to lock the universal wheels 2, ensuring that the vibrator will not move unexpectedly during operation and ensuring operational safety.
[0033] During treatment, the middle part of the hemodialysis tube is placed in the detachable retaining ring 8 on the side of the support plate 7, and the tube is firmly fixed to the support plate 7 by the buckle built into the retaining ring 8.
[0034] At the same time, the vibration motor 4 is started as the driving source of the vertical vibration unit, thereby driving the vertical vibration unit to work. The telescopic rod 10 slides up and down inside the column 9, effectively transmitting the power of the vibration motor 4 to the support plate 3, and restricting the support plate 3 to move only in the vertical direction, avoiding horizontal deviation, and ensuring the effectiveness of vertical vibration. The spring 11 plays a role in buffering and storing energy during vibration, making the vibration of the support plate 3 more stable and gentle, and improving the stability of the hemodialysis tubing during vibration.
[0035] Meanwhile, the horizontal reciprocating motion module and the vertical vibration unit work together. The servo motor 13 serves as the power source for the horizontal reciprocating motion module. After starting, the output shaft drives the eccentric wheel 14 to rotate, thereby driving the connecting rod 15 to move. During the rotation of the eccentric wheel 14, the connecting rod 15 continuously changes its angle and length as the position of the eccentric wheel 14 changes, pushing the slider 16 to perform linear reciprocating motion in the slide block 17, thereby driving the receiving plate 5 to move. The receiving plate 5 transmits the horizontal displacement generated by the horizontal reciprocating motion module to the support plate 7, thereby driving the hemodialysis tubing to achieve horizontal reciprocating motion.
[0036] In addition, the sliding mechanism works in conjunction with the horizontal reciprocating motion module to achieve the guiding displacement of the receiving plate 5. When the horizontal reciprocating motion module drives the receiving plate 5 to move, the slider 16 moves in a straight line along the slide rail 19 to ensure that the hemodialysis tubing can perform stable horizontal reciprocating motion.
[0037] After treatment, the clasp 8 can be easily opened to remove the hemodialysis tubing.
[0038] Through the above steps, the combination of vertical vibration and horizontal reciprocating motion more effectively simulates human blood circulation and reduces the risk of blood clotting. At the same time, the bottom of the base plate 1 integrates self-locking casters 2, which makes the vibrator flexible in movement and stable in fixation, making it convenient to use in different scenarios. It solves the problem that blood lacks natural flow power in the extracorporeal circulation pipeline, which is prone to triggering the clotting mechanism due to stagnation or eddies. Without the vibrator, the flow is not sufficient and uniform, which can easily form dead zones and cause clotting.
Claims
1. A hemodialysis tubing anticoagulation shaker structure, comprising a base plate (1), the lower end of which is integrated with a caster wheel (2) having a built-in self-locking mechanism; characterized in that: A vertical vibration unit is fixedly connected to the upper end of the base plate (1). A support plate (3) is installed inside the vertical vibration unit. A vibration motor (4) is configured at the lower end of the support plate (3) as a drive source to perform vertical vibration. A horizontal reciprocating motion module is set at the upper end of the support plate (3). A receiving plate (5) is set inside the horizontal reciprocating motion module. A vertical plate (6) is also fixed on the support plate (3). A linkage sliding mechanism is set on the surface of the vertical plate (6). The sliding mechanism works in conjunction with the horizontal reciprocating motion module to achieve the guiding displacement of the receiving plate (5). A support plate (7) is installed at the upper end of the receiving plate (5). A detachable retaining ring (8) is configured on the side end of the support plate (7). The retaining ring (8) is used to accommodate and fix the hemodialysis tube.
2. The anticoagulation shaker structure for hemodialysis tubing according to claim 1, characterized in that: The vertical vibration unit includes a column (9) set on the base plate (1), a telescopic rod (10) set at the lower end of the support plate (3), the telescopic rod (10) is slidably connected to the column (9), and a spring (11) is set between the end face of the column (9) and the lower end of the support plate (3), and the spring (11) is sleeved on the outer wall of the telescopic rod (10).
3. The anticoagulation shaker structure for hemodialysis tubing according to claim 2, characterized in that: The horizontal reciprocating motion module includes a fixed plate (12) on a support plate (3), a servo motor (13) on the end face of the fixed plate (12), an eccentric wheel (14) connected to the output shaft of the servo motor (13), a connecting rod (15) on the eccentric wheel (14), a slider (16) at the end of the connecting rod (15), a slide seat (17) adapted to the slider (16) on the side end of the fixed plate (12), the slider (16) and the slide seat (17) are slidably connected, a groove (18) is opened on the surface of the fixed plate (12), and the side end of the slider (16) extends into the groove (18) and is connected to the side end of the receiving plate (5).
4. The anticoagulation shaker structure for hemodialysis tubing according to claim 3, characterized in that: The sliding mechanism includes a slide rail (19) set on the surface of the vertical plate (6), a movable block (20) is slidably connected on the slide rail (19), and the end face of the movable block (20) is connected to the side end of the receiving plate (5).
5. The anticoagulation shaker structure for hemodialysis tubing according to claim 4, characterized in that: The end face of the fixing plate (12) and the upper end face of the support plate (3) are provided with reinforcing ribs (21).
6. The anticoagulation shaker structure for hemodialysis tubing according to claim 5, characterized in that: The inner wall of the groove (18) of the horizontal reciprocating motion module is provided with a wear-resistant coating. The contact surface between the slider (16) and the groove (18) is an arc-shaped convex surface, and the two form a line contact sliding fit.
7. The anticoagulation shaker structure for hemodialysis tubing according to claim 6, characterized in that: The top of the column (9) of the vertical vibration unit is equipped with a buffer pad, which is in contact with the lower end face of the support plate (3).