A portable detection device for bidirectional lateral flow chromatographic test strips

Abstract

The utility model discloses a portable detection device for two -way lateral flow chromatography test paper strip, including box, box cover, color developing agent drop adding mechanism, controller, camera, carousel and test paper mechanism, color developing agent drop adding mechanism, controller and camera all set up in the box, and the controller is electrically connected with camera, be equipped with detection room in the box, and the detection room is equipped with the opening in the one side of box, and the carousel rotation sets up in the detection room, and the test paper mechanism sets up on the carousel, and the camera and color developing agent drop adding mechanism all are located carousel top. The technical effect for reaching is: adopt built -in camera, and the distance, focal length of shooting some setting parameters are fixed, effectively avoid the error caused because of the difference of shooting condition, make LFIA colorimetric analysis result more accurate, be equipped with color developing agent drop adding mechanism, can realize the automatic addition of color developing agent, be convenient for positioning quantitative addition color developing agent, avoid the error caused by manual addition.

Description

Technical Field

[0001] This utility model relates to the field of lateral flow chromatography technology, specifically to a portable detection device for bidirectional lateral flow chromatography test strips. Background Technology

[0002] Lateral flow assay (LFA) is an analytical technique based on economical and sustainable paper-based materials. It integrates sample separation and detection, enabling multi-throughput sample analysis; however, its binary ("yes / no") signal output limits its application to qualitative detection. In recent years, some researchers have developed smartphone-based image signal acquisition platforms to capture images of the signals on the LFA detection line. These images are then converted into absolute values ​​using image processing software (such as ImageJ) for quantitative analysis. However, various factors during the image capture process, such as lighting conditions, optical settings, and focal length, can interfere with the detection results. Given these challenges, there is an urgent need to develop a portable LFA detection device that is simple to operate, stable in performance, and can directly output detection images.

[0003] In addition, a large number of studies are currently focused on nanozyme-labeled LFIA (Lateral Flow Immunochromatography Assay). They usually enhance the signal by adding dyes. However, this requires additional procedural steps. The chromogenic dyes, including TMB, AEC, DAB, indoblue, thioacetamide, and luminol, need to be manually added to the detection area. During manual operation, it is not easy to fix the volume and position of the added dyes, and manual operation causes a large error. Utility Model Content

[0004] Therefore, this invention provides a portable detection device for bidirectional side-flow chromatography test strips to solve the above-mentioned problems in the prior art.

[0005] To achieve the above objectives, this utility model provides the following technical solution:

[0006] According to a first aspect of the present invention, a portable detection device for bidirectional side-flow chromatography test strips includes a housing, a housing cover, a color reagent dispensing mechanism, a controller, a camera, a turntable, and a test strip mechanism. The color reagent dispensing mechanism, the controller, and the camera are all disposed within the housing, and the controller is electrically connected to the camera.

[0007] The lid is located on the top of the box body, and the lid has a window. The controller has a control button, which is located inside the window.

[0008] The chamber contains a detection chamber with an opening on one side of the chamber. The turntable is rotatably mounted in the detection chamber. The test strip mechanism is mounted on the turntable. The camera and the color developer dispensing mechanism are both located above the turntable.

[0009] The colorimetric reagent dispensing mechanism includes a drive mechanism and a syringe. The syringe is detachably disposed inside the housing. The liquid outlet end of the syringe needle is correspondingly disposed to the test strip mechanism. The output end of the drive mechanism is connected to the piston rod of the syringe. The drive mechanism is electrically connected to the controller.

[0010] Furthermore, the drive mechanism includes a motor, a drive seat, a lead screw, and a base. The base is installed inside the housing, the motor is installed on the base, the lead screw is arranged along the length of the piston rod of the syringe, and one end of the lead screw is connected to the output shaft of the motor. The drive seat is slidably connected to the base, and the drive seat is provided with a lead screw nut, which is threadedly connected to the lead screw. The piston rod of the syringe is detachably connected to the drive seat.

[0011] Furthermore, the drive seat is provided with a slot, and the end of the syringe piston rod opposite to the piston is disposed in the slot.

[0012] Furthermore, the number of syringes is two, the drive seat is provided with two slots, the two syringes are arranged parallel to each other, and the piston rod of each syringe is respectively disposed in one of the slots at the end opposite to the piston.

[0013] Furthermore, the base is provided with multiple fixing seats, and the fixing seats are provided with mounting holes.

[0014] Furthermore, the turntable is circular, and a receiving groove is provided at the top of the turntable. The receiving groove is arranged radially along the turntable, and the test strip mechanism is disposed in the receiving groove. A rotating shaft is provided at the bottom of the turntable, and the rotating shaft is rotatably connected to the bottom of the detection chamber.

[0015] Furthermore, the bottom of the testing chamber is provided with a rotating groove, and the rotating shaft is rotatably disposed within the rotating groove.

[0016] Furthermore, the test strip mechanism includes a test strip and a housing, the test strip is disposed inside the housing, and the top of the housing is provided with a detection liquid droplet inlet and a colorimetric reagent droplet inlet.

[0017] Furthermore, the detection liquid inlet is located in the middle of the outer shell, and there are two color developer inlets, which are symmetrically arranged on both sides of the detection liquid inlet along the length of the test strip.

[0018] Furthermore, the outer casing includes an upper casing and a lower casing, the upper casing being fastened to the top of the lower casing, and both the detection liquid inlet and the color developer inlet being disposed on the upper casing.

[0019] This invention has the following advantages: It employs a built-in camera with fixed settings such as shooting distance and focal length, effectively avoiding errors caused by differences in shooting conditions and making LFIA colorimetric analysis results more accurate; it is equipped with a colorimetric reagent adding mechanism, enabling automatic addition of the colorimetric reagent, facilitating precise and quantitative addition and avoiding errors caused by manual addition; the entire device can automatically add the colorimetric reagent and automatically take pictures, making the detection process more convenient and effectively avoiding errors caused by manual operation. Attached Figure Description

[0020] To more clearly illustrate the embodiments of this utility model or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings in the following description are merely exemplary, and those skilled in the art can derive other embodiments based on the provided drawings without creative effort.

[0021] The structures, proportions, sizes, etc. illustrated in this specification are only for the purpose of assisting those skilled in the art in understanding and reading the content disclosed herein, and are not intended to limit the implementation conditions of this utility model. Therefore, they have no substantial technical significance. Any modifications to the structure, changes in the proportional relationships, or adjustments to the size, without affecting the effects and purposes that this utility model can produce, should still fall within the scope of the technical content disclosed in this utility model.

[0022] Figure 1 An exploded view of a portable detection device for bidirectional side-flow chromatography test strips provided in some embodiments of this utility model.

[0023] Figure 2 A perspective view of a portable detection device for bidirectional side-flow chromatography test strips provided for some embodiments of this utility model.

[0024] Figure 3 This is a schematic diagram of the drive mechanism of a portable detection device for bidirectional side-flow chromatography test strips, provided for some embodiments of the present invention.

[0025] Figure 4 This is a schematic diagram of the structure of a portable detection device for bidirectional side-flow chromatography test strips, provided for some embodiments of the present invention.

[0026] Figure 5This is a schematic diagram of the structure of a turntable for a portable detection device for bidirectional side-flow chromatography test strips, provided for some embodiments of this utility model.

[0027] In the diagram: 1. Box body, 2. Drive mechanism, 3. Controller, 4. Window, 5. Box cover, 6. Camera, 7. Syringe, 8. Test strip mechanism, 9. Detection chamber, 10. Turntable, 11. Motor, 12. Drive base, 13. Slot, 14. Lead screw, 15. Base, 16. Fixing base, 17. Lower shell, 18. Upper shell, 19. Color developer dropper, 20. Detection liquid dropper, 21. Receptacle. Detailed Implementation

[0028] The following specific embodiments illustrate the implementation of this utility model. Those skilled in the art can easily understand other advantages and effects of this utility model from the content disclosed in this specification. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0029] Example 1

[0030] like Figures 1 to 5 As shown, a portable detection device for bidirectional lateral flow chromatography test strips according to the first aspect embodiment of this utility model includes a box 1, a box cover 5, a color reagent adding mechanism, a controller 3, a camera 6, a turntable 10, and a test strip mechanism 8. The color reagent adding mechanism, the controller 3, and the camera 6 are all disposed inside the box 1. The controller 3 is electrically connected to the camera 6. The camera 6 is a 4K high-definition camera, which is more advantageous for quantitative analysis of the test strips by taking pictures.

[0031] The lid 5 is located on the top of the box body 1. The lid 5 has a window 4, and the controller 3 has a control button located inside the window 4.

[0032] The chamber 1 is equipped with a detection chamber 9, which has an opening on one side of the chamber 1. A turntable 10 is rotatably installed inside the detection chamber 9. The test strip mechanism 8 is installed on the turntable 10. The camera 6 and the color developer dripping mechanism are both located above the turntable 10.

[0033] The color reagent addition mechanism includes a drive mechanism 2 and a syringe 7. The syringe 7 is detachably installed inside the housing 1. The liquid outlet end of the syringe 7 is correspondingly arranged with the test paper mechanism 8. The output end of the drive mechanism 2 is connected to the piston rod of the syringe 7. The drive mechanism 2 is electrically connected to the controller 3.

[0034] In this embodiment, it should be noted that the entire device is powered by an external power source or by a built-in rechargeable battery. The camera 6 has a memory card that can automatically store the captured photos, and the camera 6 has a USB interface that can transfer the captured photos to a mobile phone or computer.

[0035] Furthermore, the workflow of the entire device is as follows: First, add the detection liquid to the test strip mechanism 8, then place the test strip mechanism 8 on the turntable 10 and rotate and adjust the position of the turntable 10 so that the liquid outlet of the syringe 7 is directly above the color reagent addition port of the test strip mechanism 8; then press or touch the control button on the controller 3 to use the drive mechanism to push the piston rod of the syringe 7 to move, thereby quantitatively adding the color reagent; after the test strip mechanism 8 shows a color reaction, rotate and adjust the position of the turntable 10 so that the color development area of ​​the test strip mechanism 8 is directly below the camera, then use the corresponding control button on the controller 3 to control the camera 6 to take a picture; finally, export the picture taken by the camera 6, and use existing technology to import the picture into image processing software for quantitative analysis.

[0036] The technical effects achieved in this embodiment are as follows: The built-in camera has fixed settings such as shooting distance and focal length, effectively avoiding errors caused by differences in shooting conditions, thus making the LFIA colorimetric analysis results more accurate; a colorimetric reagent adding mechanism is provided, enabling automatic addition of the colorimetric reagent, facilitating precise and quantitative addition, and avoiding errors caused by manual addition; the entire device can automatically add the colorimetric reagent and automatically take pictures, making the detection process more convenient and effectively avoiding errors caused by manual operation.

[0037] Example 2

[0038] like Figures 1 to 5 As shown in the figure, another portable detection device for bidirectional side-flow chromatography test strips provided in this embodiment has the same structure as in Embodiment 1. Only the different parts are described below.

[0039] In this embodiment, the drive mechanism 2 includes a motor 11, a drive seat 12, a lead screw 14, and a base 15. The base 15 is installed inside the housing 1, the motor 11 is installed on the base 15, the lead screw 14 is arranged along the length direction of the piston rod of the syringe 7, one end of the lead screw 14 is connected to the output shaft of the motor 11, and the other end of the lead screw 14 is rotatably connected to the base 15; the drive seat 12 is slidably connected to the base 15, and a lead screw nut is provided on the drive seat 12, which is threadedly connected to the lead screw 14; the piston rod of the syringe 7 is detachably connected to the drive seat 12; the motor 11 is a servo motor, and during use, the controller 3 controls the operation of the motor 11, thereby using the lead screw mechanism to drive the drive seat 12 to move along the length direction of the piston rod of the syringe 7, thereby moving the piston rod of the syringe 7 to add the color developer. During operation, the number of rotations of the motor 11 shaft can be controlled to add the color developer quantitatively.

[0040] In this embodiment, it should be noted that the drive seat 12 is provided with a slot 13, and the piston rod of the syringe 7 is located in the slot 13 at the end away from the piston; the base 15 is provided with multiple fixing seats 16, and the fixing seats 16 are provided with mounting holes. The mounting holes are used in conjunction with screws to fix the base 15 in the housing 1.

[0041] Furthermore, there are two syringes 7. The drive seat 12 is provided with two slots 13. The two syringes 7 are arranged in parallel with each other. The piston rod of each syringe 7 is located in a slot 13 at the end away from the piston. The slot 13 is T-shaped.

[0042] The technical effects achieved in this embodiment are as follows: the drive mechanism 2 adopts a lead screw structure, which can realize the quantitative addition of color developer; and it is equipped with two syringes 7, which can add two different color developers at the same time.

[0043] Example 3

[0044] like Figures 1 to 5 As shown in the figure, another portable detection device for bidirectional side-flow chromatography test strips provided in this embodiment has the same structure as in Embodiment 1. Only the different parts are described below.

[0045] In this embodiment, the turntable 10 is circular, and a receiving groove 21 is provided on the top of the turntable 10. The receiving groove 21 is arranged radially along the turntable 10, and the test paper mechanism 8 is arranged in the receiving groove 21. Specifically, the receiving groove 21 is a rectangular groove, and grooves are provided at both ends of the receiving groove 21. The width of the grooves is smaller than the width of the receiving groove 21. The grooves facilitate the removal of the test paper mechanism 8 from the receiving groove 21. A rotating shaft is provided at the bottom of the turntable 10. The rotating shaft is arranged along the axis of the turntable 10. The rotating shaft and the turntable 10 are an integral structure. The rotating shaft is rotatably connected to the bottom of the detection chamber 9.

[0046] In this embodiment, it should be noted that the bottom of the detection chamber 9 is provided with a rotating groove, and the rotating shaft is rotatably arranged in the rotating groove.

[0047] The technical effects achieved in this embodiment are as follows: the turntable 10 has a simple structure. By setting the receiving groove 21, it is easy to pick up and put down the test strip mechanism. At the same time, by adopting the rotation setting, it can rotate 360°, which makes it easy to adjust the position of the test strip mechanism 8, thereby facilitating the positioning of the color developer and taking pictures.

[0048] Example 4

[0049] like Figures 1 to 5 As shown in the figure, another portable detection device for bidirectional side-flow chromatography test strips provided in this embodiment has the same structure as in Embodiment 1. Only the different parts are described below.

[0050] In this embodiment, the test strip mechanism 8 includes a test strip and a housing. The test strip is disposed inside the housing. The top of the housing is provided with a detection liquid droplet 20 and a colorimetric reagent droplet 19. Both the detection liquid droplet 20 and the colorimetric reagent droplet 19 are rectangular. The detection liquid droplet 20 is disposed along the length direction of the test strip, and the colorimetric reagent droplet 19 is disposed along the width direction of the test strip.

[0051] In this embodiment, it should be noted that the detection liquid droplet inlet 20 is located in the middle of the outer shell, and there are two color developer droplet inlets 19. The two color developer droplet inlets 19 are symmetrically arranged on both sides of the detection liquid droplet inlet 20 along the length of the test strip.

[0052] Furthermore, the outer casing includes an upper casing 18 and a lower casing 17. The upper casing 18 is fastened to the top of the lower casing 17, and the detection liquid droplet inlet 20 and the color developer droplet inlet 19 are both disposed on the upper casing 18.

[0053] The technical effect achieved by this embodiment is that by setting two color reagent addition ports 19, and the two color reagent addition ports 19 are located on both sides of the detection liquid addition port 20, bidirectional detection can be performed using the test strip.

[0054] Although the present invention has been described in detail above with general descriptions and specific embodiments, some modifications or improvements can be made to it, which will be obvious to those skilled in the art. Therefore, all such modifications or improvements made without departing from the spirit of the present invention fall within the scope of protection claimed by the present invention.

[0055] The terms such as "upper," "lower," "left," "right," and "middle" used in this specification are merely for clarity of description and are not intended to limit the scope of implementation of this utility model. Any changes or adjustments to their relative relationships, without substantially altering the technical content, shall also be considered within the scope of implementation of this utility model.

Claims

1. A portable detection device for bidirectional side-flow chromatography test strips, characterized in that, It includes a box body (1), a box cover (5), a color developer dripping mechanism, a controller (3), a camera (6), a turntable (10), and a test paper mechanism (8). The color developer dripping mechanism, the controller (3), and the camera (6) are all located inside the box body (1). The controller (3) is electrically connected to the camera (6). The lid (5) is located on the top of the box body (1), and the lid (5) has a window (4). The controller (3) has a control button located inside the window (4). The box (1) is provided with a detection chamber (9), the detection chamber (9) has an opening on one side of the box (1), the turntable (10) is rotatably arranged in the detection chamber (9), the test strip mechanism (8) is arranged on the turntable (10), and the camera (6) and the color developer dripping mechanism are both located above the turntable (10). The color reagent dripping mechanism includes a drive mechanism (2) and a syringe (7). The syringe (7) is detachably disposed in the housing (1). The liquid outlet end of the syringe (7) is correspondingly disposed to the test paper mechanism (8). The output end of the drive mechanism (2) is connected to the piston rod of the syringe (7). The drive mechanism (2) is electrically connected to the controller (3).

2. The portable detection device for a bidirectional side-flow chromatography test strip according to claim 1, characterized in that, The drive mechanism (2) includes a motor (11), a drive seat (12), a lead screw (14), and a base (15). The base (15) is installed inside the housing (1). The motor (11) is installed on the base (15). The lead screw (14) is arranged along the length of the piston rod of the syringe (7). One end of the lead screw (14) is connected to the output shaft of the motor (11). The drive seat (12) is slidably connected to the base (15). The drive seat (12) is provided with a lead screw nut. The lead screw nut is threadedly connected to the lead screw (14). The piston rod of the syringe (7) is detachably connected to the drive seat (12).

3. A portable detection device for a bidirectional side-flow chromatography test strip according to claim 2, characterized in that, The drive seat (12) is provided with a slot (13), and the piston rod of the syringe (7) is located in the slot (13) at the end opposite to the piston.

4. A portable detection device for a bidirectional side-flow chromatography test strip according to claim 3, characterized in that, The number of syringes (7) is two, and the drive seat (12) is provided with two slots (13). The two syringes (7) are arranged in parallel to each other, and the piston rod of each syringe (7) is respectively located in one of the slots (13) at the end away from the piston.

5. A portable detection device for a bidirectional side-flow chromatography test strip according to claim 2, characterized in that, The base (15) is provided with a plurality of fixing seats (16), and the fixing seats (16) are provided with mounting holes.

6. A portable detection device for a bidirectional side-flow chromatography test strip according to claim 1, characterized in that, The turntable (10) is circular, and a receiving groove (21) is provided on the top of the turntable (10). The receiving groove (21) is arranged radially along the turntable (10), and the test paper mechanism (8) is arranged in the receiving groove (21). A rotating shaft is provided at the bottom of the turntable (10), and the rotating shaft is rotatably connected to the bottom of the detection chamber (9).

7. A portable detection device for a bidirectional side-flow chromatography test strip according to claim 6, characterized in that, The bottom of the testing chamber (9) is provided with a rotating groove, and the rotating shaft is rotatably disposed in the rotating groove.

8. A portable detection device for a bidirectional side-flow chromatography test strip according to claim 1, characterized in that, The test strip mechanism (8) includes a test strip and a housing. The test strip is disposed inside the housing. The top of the housing is provided with a detection liquid droplet inlet (20) and a colorimetric reagent droplet inlet (19).

9. A portable detection device for a bidirectional side-flow chromatography test strip according to claim 8, characterized in that, The detection liquid dispensing port (20) is located in the middle of the outer shell. There are two color reagent dispensing ports (19). The two color reagent dispensing ports (19) are respectively arranged symmetrically on both sides of the detection liquid dispensing port (20) along the length direction of the test strip.

10. A portable detection device for a bidirectional side-flow chromatography test strip according to claim 9, characterized in that, The outer shell includes an upper shell (18) and a lower shell (17). The upper shell (18) is fastened to the top of the lower shell (17). The detection liquid droplet inlet (20) and the color developer droplet inlet (19) are both located on the upper shell (18).

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