A skin fixation structure for a drug transdermal testing device

Abstract

This utility model relates to the technical field of transdermal drug testing instruments, and discloses a skin fixation structure for a transdermal drug testing instrument, including a base and two plug-in shells. Connecting shells are fixedly connected to the front and rear ends of the left side of the top wall of the base. Flip plates are rotatably connected to the left and right sides of each connecting shell. Locking grooves are provided on the left and right sides of each plug-in shell, and one side of each flip plate engages with a locking groove. A locking plate is fixedly connected to the bottom wall of each plug-in shell, and a locking groove is provided on the top wall of the connecting shell. The bottom of the locking plate engages with the locking groove. Bolts are threaded to the opposite sides of each of the multiple flip plates. In this utility model, the bolts are rotated to release the locking mechanism from the flip plates. Subsequently, the rotation of the flip plates separates them from the plug-in shells, achieving the purpose of disassembling the plug-in shells and fixing straps. This improves the flexibility of the structure and avoids the inability to quickly replace the fixing straps.

Description

Technical Field

[0001] This utility model relates to the field of drug transdermal testing instrument technology, and in particular to a skin fixation structure for a drug transdermal testing instrument. Background Technology

[0002] The transdermal drug transdermal testing instrument operates primarily based on the principle of diffusion. Its core function is to simulate the penetration process of drugs into human skin. It consists of a donor pool and a recipient pool, with a skin sample placed between them to create a system that simulates skin penetration. The donor pool contains the drug-containing formulation, while the recipient pool contains the receiving medium, which is a buffer solution similar to the human physiological environment. The instrument monitors the change in drug concentration in the recipient pool over time in real time and calculates key parameters such as the drug penetration rate, penetration coefficient, and cumulative penetration amount to evaluate the transdermal performance of the drug. In use, a skin fixation structure is required.

[0003] Existing skin fixation structures, due to improper material selection or unreasonable design, are prone to damaging skin tissue when fixing skin samples. Using rigid fixation materials can leave indentations on the skin surface and even damage the skin's barrier function, preventing drug penetration from accurately reflecting normal physiological conditions and affecting the accuracy and scientific validity of test results. Current solutions use soft and biocompatible materials for the parts of the fixation structure that come into direct contact with the skin, such as silicone or polyurethane elastic materials, to create the fixation frame. This provides sufficient fixation force while reducing friction and pressure on the skin. However, the installation and adjustment process is still cumbersome, requiring operators to use multiple tools for adjustment, consuming a lot of time and energy, and does not allow for quick replacement or removal of the fixation straps. Utility Model Content

[0004] To overcome the above shortcomings, this utility model provides a skin fixation structure for a transdermal drug testing instrument, aiming to improve the problems of the existing technology where the installation and adjustment process is cumbersome, requiring operators to use multiple tools for adjustment, consuming a lot of time and energy, and not being able to quickly replace or remove the fixation strap.

[0005] To achieve the above objectives, this utility model adopts the following technical solution: a skin fixation structure for a transdermal drug testing instrument, comprising a base and two plug-in shells. Connecting shells are fixedly connected to the front and rear ends of the left side of the top wall of the base. Flipping plates are rotatably connected to the left and right sides of the connecting shells. Locking grooves are provided on the left and right sides of the plug-in shells. One side of the flipping plate engages with the locking groove. A locking plate is fixedly connected to the bottom wall of the plug-in shell. A locking groove is provided on the top wall of the connecting shell. The bottom of the locking plate engages with the locking groove. Bolts are threaded to the opposite sides of multiple flipping plates. The ends of multiple bolts are threaded to the left and right sides of the plug-in shells, respectively. A fixing strap is fixedly connected to the top wall of the plug-in shell. Limiting shells are fixedly connected to the front and rear ends of the right side of the top wall of the base. Two support frames are fixedly connected to the middle of the top wall of the base. A latex pad is fixedly connected to the middle of the support frames. Reinforcing mechanisms are provided on the inner walls of the two fixing straps to improve their service life.

[0006] As a further description of the above technical solution:

[0007] The reinforcing mechanism includes two breathable layers. The bottom walls of the two breathable layers are respectively fixedly connected to the inner bottom wall of the corresponding fixing belt. The top walls of the two breathable layers are provided with multiple honeycomb holes. A reinforcing layer is fixedly connected to the top wall of the breathable layer. Multiple reinforcing ribs are fixedly connected to the right side of the inner wall of the reinforcing layer. Multiple high-strength fibers are fixedly connected to the front side of the inner wall of the reinforcing layer. A silicone layer is fixedly connected to the top wall of the reinforcing layer. Multiple protective layers are fixedly connected to the top wall of the silicone layer.

[0008] As a further description of the above technical solution:

[0009] The reinforcing mechanism also includes two wear-resistant layers, the top walls of which are respectively fixedly connected to the inner top wall of the corresponding fixing belt.

[0010] As a further description of the above technical solution:

[0011] The high-strength fibers and the reinforcing ribs are fixedly connected on adjacent sides and form a rectangular grid structure.

[0012] As a further description of the above technical solution:

[0013] A handle is fixedly connected to the front side of the base, and a rubber shell is fixedly connected to the middle of the handle.

[0014] As a further description of the above technical solution:

[0015] The base has two rubber plates fixedly connected to its bottom wall, and both rubber plates are designed symmetrically.

[0016] As a further description of the above technical solution:

[0017] Multiple rubber blocks are fixedly connected to the front and rear sides of the two plug-in shells, and the multiple rubber blocks are arranged at equal intervals.

[0018] As a further description of the above technical solution:

[0019] Each of the bolts has a rubber ring fixedly connected to its center, and the rubber rings are all designed symmetrically.

[0020] This utility model has the following beneficial effects:

[0021] 1. In this utility model, the bolt is rotated to unlock it from the flip plate. Then, the flip plate is rotated to separate it from the plug-in shell. At the same time, the plug-in shell is pulled to separate the locking plate at the bottom from the locking groove, thereby achieving the purpose of disassembling the plug-in shell and the fixing strap. This improves the flexibility of the structure, avoids the situation where the fixing strap cannot be quickly replaced, and achieves the effect of selecting the appropriate fixing strap according to different usage specifications.

[0022] 2. In this utility model, the connection of the breathable layer avoids the situation where the drug penetration rate is affected when the skin tissue is fixed. Subsequently, the connection of the reinforcing layer can improve the internal strength of the fixation band, thereby increasing its toughness. At the same time, the connection of the silicone layer improves the protection of the skin tissue, thus extending the service life of the fixation band. Attached Figure Description

[0023] Figure 1 This is a three-dimensional view of a skin fixation structure for a transdermal drug testing instrument proposed in this utility model;

[0024] Figure 2 This is a front view of a skin fixation structure for a transdermal drug testing instrument proposed in this utility model;

[0025] Figure 3 This is a cross-sectional view of the fixing strap of a skin fixation structure for a drug transdermal testing instrument proposed in this utility model;

[0026] Figure 4 This is an exploded view of the snap plate of a skin fixation structure for a transdermal drug testing instrument proposed in this utility model;

[0027] Figure 5 This is a schematic diagram of the reinforcing mechanism of the skin fixation structure for a transdermal drug testing instrument proposed in this utility model.

[0028] Legend:

[0029] 1. Base; 2. Reinforcing mechanism; 201. Breathable layer; 202. Honeycomb holes; 203. Reinforcing layer; 204. High-strength fiber; 205. Reinforcing rib; 206. Silicone layer; 207. Protective layer; 208. Wear-resistant layer; 3. Connecting shell; 4. Flip plate; 5. Insert shell; 6. Locking groove; 7. Snap-fit ​​plate; 8. Snap-fit ​​groove; 9. Bolt; 10. Fixing strap; 11. Rubber block; 12. Handle; 13. Rubber shell; 14. Rubber plate; 15. Support frame; 16. Latex pad; 17. Rubber ring; 18. Limiting shell. Detailed Implementation

[0030] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0031] Reference Figure 1 , Figure 2 and Figure 4 This utility model provides an embodiment of a skin fixation structure for a transdermal drug testing instrument, comprising a base 1 and two insertion shells 5. Connecting shells 3 are fixedly connected to the front and rear ends of the left side of the top wall of the base 1. Flip plates 4 are rotatably connected to the left and right sides of the connecting shells 3, allowing the insertion shells 5 to be locked in place when the flip plates 4 are flipped. Locking grooves 6 are provided on the left and right sides of the insertion shells 5, with one side of the flip plate 4 engaging with the locking groove 6. Engaging plates 7 are fixedly connected to the bottom wall of the insertion shells 5, and engaging grooves 8 are provided on the top wall of the connecting shells 3. A preliminary engagement connection is achieved through the engagement of the engaging plates 7 and engaging grooves 8. The bottom of the engaging plates 7 engages with the engaging grooves 8. Multiple... Bolts 9 are threadedly connected to the opposite side of the flip plate 4. The ends of the multiple bolts 9 are threadedly connected to the left and right sides of the plug shell 5, respectively. The rotation of the bolts 9 improves the locking effect between the flip plate 4 and the plug shell 5. A fixing strap 10 is fixedly connected to the top wall of the plug shell 5. Limiting shells 18 are fixedly connected to the front and rear ends of the right side of the top wall of the base 1. Two support frames 15 are fixedly connected to the middle of the top wall of the base 1. The skin test model can be supported by the support frames 15 and the latex pad 16. The latex pad 16 is fixedly connected to the middle of the support frame 15. A reinforcing mechanism 2 is provided on the inner wall of the two fixing straps 10. The reinforcing mechanism 2 is used to improve the service life of the fixing straps 10.

[0032] Specifically, when starting disassembly and replacement work, rotating bolt 9 separates the end of bolt 9 from the plug-in housing 5. By flipping the flip plate 4, the locking state between the flip plate 4 and the plug-in housing 5 can be released. Then, by flipping the flip plate 4 downward, the top of the plate 4 separates from the plug-in housing 5, allowing the plug-in housing 5 to be removed. Pulling the plug-in housing 5 upward separates the locking plate 7 at the bottom of the plug-in housing 5 from the locking groove 8 at the top of the connecting housing 3, thereby achieving the purpose of disassembling the plug-in housing 5 and the fixing strap 10. Conversely, installation is completed, thereby improving the flexibility of the structure and avoiding the situation where the fixing strap 10 cannot be quickly disassembled and assembled. This allows for the selection of a suitable fixing strap 10 according to different usage requirements, thereby achieving the best usage effect.

[0033] Reference Figure 1 , Figure 3 and Figure 5 The reinforcing mechanism 2 includes two breathable layers 201. The bottom walls of the two breathable layers 201 are fixedly connected to the inner bottom walls of the corresponding fixing belts 10. The top walls of the two breathable layers 201 are provided with multiple honeycomb holes 202. The connection between the breathable layers 201 and the multiple honeycomb holes 202 improves the breathability of the fixing belts 10 and avoids affecting the penetration rate when the skin test model is used. The top wall of the breathable layer 201 is fixedly connected to a reinforcing layer 203. The right side of the inner wall of the reinforcing layer 203 is fixedly connected to multiple reinforcing ribs 205. The connection between the multiple reinforcing ribs 205 and the high-strength fibers 204 improves the toughness inside the fixing belts 10. The front side of the inner wall of the reinforcing layer 203 is fixedly connected to multiple high-strength fibers 204. The top wall of the reinforcing layer 203 is fixedly connected to a silicone layer 206. The top wall of the silicone layer 206 is fixedly connected to multiple protective layers 207.

[0034] Specifically, the breathable layer 201 and multiple honeycomb holes 202 are designed to avoid the negative impact of the material's non-breathability on the drug penetration rate when fixing the skin tissue model. Subsequently, the connection of multiple high-strength fibers 204 and reinforcing ribs 205 further enhances the internal structural strength of the fixation band 10. This not only strengthens the overall toughness of the fixation band 10, making it more durable, but also, with the assistance of the silicone layer 206, utilizes its soft and elastic properties to improve the protective effect on the skin tissue, extending the service life of the fixation band 10 and maintaining good performance and comfort during long-term use.

[0035] Reference Figure 2 , Figure 3 and Figure 5The reinforcing mechanism 2 also includes two wear-resistant layers 208, the top walls of which are fixedly connected to the inner top walls of the corresponding fixing belts 10; multiple high-strength fibers 204 and multiple reinforcing ribs 205 are fixedly connected on adjacent sides and form a rectangular grid structure; a handle 12 is fixedly connected to the front side of the base 1, and a rubber shell 13 is fixedly connected to the middle of the handle 12.

[0036] Specifically, the wear-resistant layer 208 enhances the protection of the inside of the fixing strap 10, and the high-strength fiber 204 and the reinforcing rib 205 form a rectangular grid structure, which improves the toughness of the reinforcing layer 203. The handle 12 and the rubber shell 13 make it easy to carry the structure.

[0037] Reference Figure 1 , Figure 2 and Figure 3 The bottom wall of the base 1 is fixedly connected to two rubber plates 14, both of which are symmetrically designed; the front and rear sides of the two plug-in shells 5 are fixedly connected to multiple rubber blocks 11, which are equidistantly arranged; the middle of multiple bolts 9 is fixedly connected to a rubber ring 17, which is symmetrically designed.

[0038] Specifically, the rubber plate 14 can improve the anti-slip effect of the bottom of the base plate 1, the multiple rubber blocks 11 can reduce the wear of the front and rear sides of the plug shell 5 by the outside world, and the connection of multiple rubber rings 17 can reduce the rotational damage of the bolt 9 to the flip plate 4.

[0039] Working principle: When disassembling and replacing, the bolt 9 is rotated to separate its end from the plug-in shell 5, thereby unlocking the flip plate 4 from the plug-in shell 5. Then, as the flip plate 4 flips downward, its top separates from the plug-in shell 5, allowing the plug-in shell 5 to be removed. At the same time, the plug-in shell 5 is pulled upward to separate the locking plate 7 at its bottom from the locking groove 8 at the top of the connecting shell 3, thus achieving the purpose of disassembling the plug-in shell 5 and the fixing strap 10. Conversely, installation is completed, thereby improving the flexibility of the structure and avoiding the situation where the fixing strap 10 cannot be quickly disassembled and assembled, achieving the effect of selecting the appropriate fixing strap 10 according to different usage requirements.

[0040] Furthermore, the breathable layer 201 and multiple honeycomb holes 202 prevent the skin tissue model from being fixed due to poor air permeability, which could affect the drug penetration rate. Subsequently, the reinforcement layer 203, along with multiple high-strength fibers 204 and reinforcing ribs 205, enhances the internal strength of the fixation band 10, thereby increasing its toughness. At the same time, the silicone layer 206, with its soft properties, improves the protection of the skin tissue, thus extending the service life of the fixation band 10.

[0041] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A skin fixation structure for a transdermal drug testing device, comprising a base (1) and two insertion shells (5), characterized in that: The top left side of the base (1) is fixedly connected to the front and rear ends of the connecting shell (3). The left and right sides of the connecting shell (3) are rotatably connected to the flip plate (4). The left and right sides of the plug-in shell (5) are provided with locking grooves (6). One side of the flip plate (4) is engaged with the locking groove (6). The bottom wall of the plug-in shell (5) is fixedly connected to the engaging plate (7). The top wall of the connecting shell (3) is provided with the engaging groove (8). The bottom of the engaging plate (7) is engaged with the engaging groove (8). The opposite sides of the multiple flip plates (4) are threaded with bolts (9). The ends of the multiple bolts (9) are threaded to the left and right sides of the plug shell (5). The top wall of the plug shell (5) is fixedly connected to a fixing strap (10). The front and rear ends of the right side of the top wall of the base (1) are fixedly connected to a limiting shell (18). The middle of the top wall of the base (1) is fixedly connected to two support frames (15). The middle of the support frame (15) is fixedly connected to a latex pad (16). The inner walls of the two fixing straps (10) are provided with a reinforcing mechanism (2). The reinforcing mechanism (2) is used to improve the service life of the fixing strap (10).

2. The skin fixation structure for a drug transdermal testing instrument according to claim 1, characterized in that: The reinforcing mechanism (2) includes two breathable layers (201). The bottom walls of the two breathable layers (201) are respectively fixedly connected to the inner bottom wall of the corresponding fixing band (10). The top walls of the two breathable layers (201) are provided with multiple honeycomb holes (202). The top wall of the breathable layer (201) is fixedly connected to a reinforcing layer (203). The right side of the inner wall of the reinforcing layer (203) is fixedly connected to multiple reinforcing ribs (205). The front side of the inner wall of the reinforcing layer (203) is fixedly connected to multiple high-strength fibers (204). The top wall of the reinforcing layer (203) is fixedly connected to a silicone layer (206). The top wall of the silicone layer (206) is fixedly connected to multiple protective layers (207).

3. The skin fixation structure for a drug transdermal testing instrument according to claim 2, characterized in that: The reinforcing mechanism (2) also includes two wear-resistant layers (208), the top walls of which are respectively fixedly connected to the inner top wall of the corresponding fixing belt (10).

4. The skin fixation structure for a drug transdermal testing instrument according to claim 2, characterized in that: The high-strength fibers (204) and the reinforcing ribs (205) are fixedly connected on their adjacent sides and form a rectangular grid structure.

5. The skin fixation structure for a drug transdermal testing instrument according to claim 1, characterized in that: A handle (12) is fixedly connected to the front side of the base (1), and a rubber shell (13) is fixedly connected to the middle of the handle (12).

6. The skin fixation structure for a drug transdermal testing instrument according to claim 1, wherein: The bottom wall of the base (1) is fixedly connected to two rubber plates (14), and both rubber plates (14) are symmetrically designed.

7. The skin fixation structure for a drug transdermal testing instrument according to claim 1, characterized in that: Multiple rubber blocks (11) are fixedly connected to the front and rear sides of the two plug-in shells (5), and the multiple rubber blocks (11) are arranged at equal intervals.

8. The skin fixation structure for a drug transdermal testing instrument according to claim 1, characterized in that: A rubber ring (17) is fixedly connected to the middle of each of the bolts (9), and the rubber rings (17) are all symmetrically designed.

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