A subcutaneous administration aid for mice

By designing a subcutaneous drug delivery aid device for mice, and using a pressing and positioning component to fix the experimental mice, isolate and adjust the injection incision position, the problem of drug delivery caused by the mice struggling was solved, and the safety and efficiency of the operation were improved.

CN224441517UActive Publication Date: 2026-07-03TIANJIN FIFTH CENT HOSPITAL (PEKING UNIV BINHAI HOSPITAL)

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
TIANJIN FIFTH CENT HOSPITAL (PEKING UNIV BINHAI HOSPITAL)
Filing Date
2025-03-04
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

When conducting rodent drug experiments, the mice struggle due to stress, making drug administration difficult and posing a risk of scratching or biting staff, thus affecting experimental efficiency.

Method used

A subcutaneous drug delivery device for mice was designed, including a sealing head, a support cylinder, a drug delivery cylinder, and a pressing and positioning component. The experimental mouse is fixed by the pressing and positioning component, the experimental mouse is isolated by the sealing head and the support cylinder, and the injection incision position is adjusted by rotating the drug delivery cylinder to deliver the drug subcutaneously.

Benefits of technology

It effectively restrains laboratory mice, preventing them from struggling and injuring staff, reducing the difficulty of drug administration, and improving experimental efficiency and safety.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model provides a kind of subcutaneous administration auxiliary device for mouse, comprising: plugging head, bearing cylinder, administration barrel and press positioning assembly.Plugging head is detachably connected with one end of bearing cylinder, administration barrel is rotatably connected with the other end of bearing cylinder, installation hole is equipped on the lateral wall of bearing cylinder, injection incision is equipped on the lateral wall of administration barrel.Press positioning assembly includes connecting rod, and connecting rod is slidably arranged inside installation hole, press head is equipped on the top end of connecting rod, and press head is located outside bearing cylinder, arc locating plate is further equipped on the bottom end of connecting rod, arc locating plate is located inside bearing cylinder, and the center of arc of arc locating plate is towards the axis of bearing cylinder.A kind of subcutaneous administration auxiliary device for mouse, can be conveniently fixed to experimental mouse, and prevent experimental mouse from injuring staff.
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Description

Technical Field

[0001] This utility model belongs to the field of experimental auxiliary equipment, and in particular relates to a subcutaneous drug delivery auxiliary device for rats. Background Technology

[0002] In drug experiments, because mice and humans share good physiological structural similarities and high genetic similarity, experimental drugs are usually injected into mice to facilitate subsequent research and analysis. Common methods of drug injection into mice include subcutaneous administration, intradermal administration, intramuscular injection, and tail vein injection. Subcutaneous administration involves injecting the drug into the subcutaneous connective tissue of the mouse, where it is absorbed through capillaries and lymphatic vessels.

[0003] Because subcutaneous drug administration requires sites with thin skin, loose subcutaneous tissue, and few blood vessels, the back of the laboratory mouse is usually chosen as the injection site. However, in practice, the laboratory mouse may become stressed due to being gripped by the staff. At this time, the gripped mouse will begin to struggle, and may even scratch or bite the staff, making it difficult to carry out the drug injection smoothly and seriously affecting the efficiency of the experiment. Utility Model Content

[0004] In view of this, the present invention aims to provide a subcutaneous drug delivery aid device for rats to solve the above-mentioned technical problems.

[0005] To achieve the above objectives, the technical solution of this utility model is implemented as follows:

[0006] A subcutaneous drug delivery aid for rats includes: a sealing head, a support cylinder, a drug delivery cylinder, and a pressing and positioning assembly; the sealing head is detachably connected to one end of the support cylinder, and the drug delivery cylinder is rotatably connected to the other end of the support cylinder; an installation hole is provided on the side wall of the support cylinder, and an injection incision is provided on the side wall of the drug delivery cylinder; the pressing and positioning assembly includes a connecting rod, which is slidably disposed inside the installation hole; a pressing head is provided at the top of the connecting rod and is located outside the support cylinder; an arc-shaped positioning plate is also provided at the bottom of the connecting rod, which is located inside the support cylinder, and the center of the arc of the arc-shaped positioning plate faces the axis of the support cylinder.

[0007] Furthermore, the inner wall of the drug delivery cylinder is provided with a limiting ring, and the limiting ring is provided with a positioning protrusion; the outer wall of the support cylinder is provided with a limiting groove for accommodating the limiting ring, and inside the limiting groove are multiple positioning grooves for accommodating the positioning protrusion, and the multiple positioning grooves are arranged in a ring around the axis of the support cylinder.

[0008] Furthermore, the pressing and positioning assembly also includes a return spring, which is sleeved on the connecting rod, with one end of the return spring connected to the pressing head and the other end connected to the outer wall of the bearing cylinder.

[0009] Furthermore, the pressing and positioning component also includes a silicone protective sleeve, which is fitted over the outside of the arc-shaped positioning plate.

[0010] Furthermore, a finger receiving groove is provided on the top surface of the pressing head.

[0011] Furthermore, the outer wall of the bearing cylinder is provided with two finger receiving rings, and the two finger receiving rings are arranged in a mirror image on both sides of the mounting hole.

[0012] Furthermore, the end of the sealing head furthest from the bearing cylinder is provided with a top spherical surface.

[0013] Furthermore, the sidewall of the sealing head is provided with multiple vent holes, and the multiple vent holes are arranged in a ring around the axis of the bearing cylinder.

[0014] Compared with the prior art, the subcutaneous drug delivery device for rats described in this utility model has the following advantages:

[0015] (1) The subcutaneous drug delivery device for mice described in this utility model has a pressing and positioning component on the support cylinder. When it is necessary to administer subcutaneous drugs to laboratory mice, the operator can place the laboratory mouse inside the device and press down on the pressing and positioning component to hold and fix the laboratory mouse against the arc-shaped positioning plate and the inner wall of the support cylinder, thereby preventing the laboratory mouse from moving due to struggling. Secondly, the device has a sealing head at one end of the support cylinder, so when the laboratory mouse enters the device, the sealing head and the support cylinder can isolate the laboratory mouse, thereby preventing the laboratory mouse from scratching or biting the operator. In addition, the drug delivery cylinder in the device is rotatably connected to the support cylinder and has an injection incision on the drug delivery cylinder. After the laboratory mouse is fixed by pressing and positioning component, the operator can rotate the drug delivery cylinder to move the injection incision to the back area of ​​the laboratory mouse and insert the needle into the laboratory mouse body along the injection incision, thereby reducing the difficulty of subcutaneous drug delivery.

[0016] (2) The subcutaneous drug delivery device for rats described in this utility model has a spherical abutment on the sealing head and a finger receiving ring on the carrying cylinder. When grasping and operating this device, the operator can hold the spherical abutment against the palm and insert the index and middle fingers into the two finger receiving rings, thereby improving the grip reliability of this device and facilitating the pressing and positioning operation of the thumb.

[0017] (3) The subcutaneous drug delivery device for rats described in this utility model has a positioning protrusion on the limiting ring and multiple positioning grooves inside the limiting groove. When the drug delivery cylinder is rotated, the positioning protrusion will move between the multiple positioning grooves. When the injection incision moves to the appropriate position, the positioning protrusion enters the corresponding positioning groove to limit the rotation of the drug delivery cylinder and prevent abnormal rotation of the drug delivery cylinder during drug injection. Attached Figure Description

[0018] The accompanying drawings, which form part of this utility model, are used to provide a further understanding of the utility model. The illustrative embodiments of the utility model and their descriptions are used to explain the utility model and do not constitute an undue limitation of the utility model. In the drawings:

[0019] Figure 1 This is a schematic diagram of the subcutaneous drug delivery aid device for rats according to an embodiment of the present invention;

[0020] Figure 2 This is an explosion diagram of the subcutaneous drug delivery aid device for rats described in an embodiment of the present invention;

[0021] Figure 3 This is a cross-sectional view of the subcutaneous drug delivery aid device for rats according to an embodiment of the present invention (with the pressing and positioning component at its maximum rising position);

[0022] Figure 4 This is a cross-sectional view of the subcutaneous drug delivery aid device for mice according to an embodiment of the present invention (the pressing and positioning component is in the lowering limit position);

[0023] Figure 5 This is a schematic diagram of the structure of the carrier cylinder and the drug delivery cylinder according to an embodiment of the present invention.

[0024] Explanation of reference numerals in the attached figures:

[0025] 1-Sealing head; 11-Spherical abutment surface; 12-Ventilation hole; 2-Bearing cylinder; 21-Mounting hole; 22-Limiting groove; 23-Positioning groove; 24-Finger receiving ring; 3-Administration cylinder; 31-Injection incision; 32-Limiting ring; 33-Positioning protrusion; 4-Connecting rod; 41-Pressing head; 411-Finger receiving groove; 42-Arc-shaped positioning plate; 5-Reset spring; 6-Silicone protective sleeve. Detailed Implementation

[0026] It should be noted that, unless otherwise specified, the embodiments and features described in these embodiments can be combined with each other.

[0027] In the description of this utility model, it should be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating orientation or positional relationships based on the orientation or positional relationships shown in the accompanying drawings, are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, features defined with "first," "second," etc., may explicitly or implicitly include one or more of that feature. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0028] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0029] The present invention will now be described in detail with reference to the accompanying drawings and embodiments.

[0030] A subcutaneous drug delivery aid device for mice, the structure of which can be made of Figures 1-5 The following is an illustration. In this embodiment, the subcutaneous drug delivery device for mice includes: a sealing head 1, a support cylinder 2, a drug delivery cylinder 3, and a pressing and positioning component. The support cylinder 2 has a mounting hole 21 on its side wall for accommodating the pressing and positioning component, and the drug delivery cylinder 3 has an injection incision 31 on its side wall. During assembly, the sealing head 1 is detachably connected to one end of the support cylinder 2, while the drug delivery cylinder 3 is rotatably connected to the other end of the support cylinder 2. In use, the operator first places the laboratory mouse inside the device, then presses down on the pressing and positioning component to hold and fix the mouse, preventing movement within the device. Next, the drug delivery cylinder 3 can be rotated to move the injection incision 31 to the back area of ​​the laboratory mouse, and the drug injection needle is inserted into the mouse's body along the injection incision 31 to complete the drug injection.

[0031] Specifically, such as Figure 2As shown, the pressing and positioning assembly includes a connecting rod 4, a pressing head 41 at the top of the connecting rod 4, and an arc-shaped positioning plate 42 at the bottom of the connecting rod 4. During assembly, the connecting rod 4 should be slidably positioned inside the mounting hole 21, so that the pressing head 41 is located outside the bearing cylinder 2, the arc-shaped positioning plate 42 is located inside the bearing cylinder 2, and the center of the arc of the arc-shaped positioning plate 42 should face the axis of the bearing cylinder 2. Figure 3 and Figure 4 As shown, during use, the operator can apply downward pressure to the pressing head 41, causing the arc-shaped positioning plate 42 to descend inside the support cylinder 2. This, combined with the arc-shaped positioning plate 42 and the inner wall of the support cylinder 2, secures the experimental mouse, preventing it from moving due to stress and reducing the difficulty of subsequent drug injection. Furthermore, because this device isolates the experimental mouse, it also protects the operator during subcutaneous drug administration, preventing them from being scratched or bitten by the mouse.

[0032] Optionally, to improve the ease of operation of the pressing and positioning component, the pressing and positioning component in this embodiment may include a return spring 5, which should be sleeved on the connecting rod 4. One end of the return spring 5 is connected to the pressing head 41, and the other end is connected to the outer wall of the bearing cylinder 2. When the operator applies downward pressure to the pressing head 41, the return spring 5 will enter a compressed state. When the downward pressure on the pressing head 41 is removed, the elastic force generated by the compression of the return spring 5 can drive the connecting rod 4 to rise and return to its original position, so as to remove the experimental mouse inside the device from the outside.

[0033] In addition, to prevent the experimental mice from being injured inside the device, the pressing positioning component may also include a silicone protective sleeve 6, and the silicone protective sleeve 6 should be fitted over the outside of the arc-shaped positioning plate 42, thereby preventing the arc-shaped positioning plate 42 from causing excessive pressure on the experimental mice.

[0034] Figure 5The diagram shows the structure of the support cylinder 2 and the drug delivery cylinder 3 in this embodiment. To prevent the drug delivery cylinder 3 from separating from the support cylinder 2 during rotation, a limiting ring 32 is provided on the inner wall of the drug delivery cylinder 3, and a limiting groove 22 for accommodating the limiting ring 32 is provided on the outer wall of the support cylinder 2. This allows the drug delivery cylinder 3 to be axially limited by the cooperation of the limiting ring 32 and the limiting groove 22. Furthermore, to prevent abnormal rotation of the injection incision 31 on the drug delivery cylinder 3 during use, a positioning protrusion 33 is provided on the limiting ring 32, and multiple positioning grooves 23 for accommodating the positioning protrusion 33 are provided inside the limiting groove 22. These multiple positioning grooves 23 should be arranged in a ring around the axis of the support cylinder 2. When the drug delivery cylinder 3 rotates, the positioning protrusion 33 can move between the multiple positioning grooves 22. When the injection incision 31 moves to a suitable position, the positioning protrusion 33 enters the corresponding positioning groove 22, thus limiting the rotation of the drug delivery cylinder 3 and preventing abnormal rotation.

[0035] In practical use, since the operator needs one hand to grasp and operate the device while controlling the drug injector with the other, the reliability of the grip and the comfort of operation directly affect the efficiency of subcutaneous drug administration in laboratory mice. To improve the reliability of the grip, two finger-receiving rings 24 can be provided on the outer wall of the support cylinder 2, and the two finger-receiving rings 24 should be arranged in a mirror image on both sides of the mounting hole 21. When gripping the device, the operator can insert their index and middle fingers into the two finger-receiving rings 24 respectively, and operate the pressing and positioning component with their thumb. At this time, the sealing head 1 will be pressed against the operator's palm, and the index and middle fingers can provide a good fixing effect on the device, thereby ensuring that the device is reliably gripped in the operator's hand.

[0036] Secondly, in this embodiment, a top spherical surface 11 can be provided at the end of the sealing head 1 away from the bearing cylinder 2, thereby improving the comfort of the operator's palm by means of the top spherical surface 11, making it easier for the operator to use the device for a long time.

[0037] In addition, to improve the comfort of operators operating the pressing and positioning components, a finger receiving groove 411 can be provided on the top surface of the pressing head 41, so as to avoid discomfort to the operator's thumb during the pressing and positioning process.

[0038] As an optional implementation of this embodiment, to prevent the laboratory mice from suffocating inside the device, multiple vent holes 12 can be provided on the side wall of the sealing head 1, and the multiple vent holes 12 should be arranged in a ring around the axis of the supporting cylinder 2. By providing vent holes 12, it is possible for air from the external environment to enter the device, ensuring that the laboratory mice receive a sufficient oxygen supply.

[0039] The effects of the above solution are explained below:

[0040] This embodiment provides a subcutaneous drug delivery aid device for mice. It uses a support cylinder and a pressing and positioning component to hold and fix the laboratory mouse in place, preventing it from moving due to struggling. Secondly, the device isolates the laboratory mouse through the sealing head, support cylinder, and drug delivery cylinder, preventing injury to personnel. The position of the injection incision can be adjusted by rotating the drug delivery cylinder, facilitating subcutaneous drug delivery. Furthermore, the device improves grip reliability and operational comfort through a finger-receiving ring and abutment spherical surface, enhancing its ease of use.

[0041] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A subcutaneous administration aid for mice, characterized in that, include: The sealing head (1), the support cylinder (2), the administration cylinder (3), and the pressing and positioning assembly are provided. The sealing head (1) is detachably connected to one end of the support cylinder (2), and the administration cylinder (3) is rotatably connected to the other end of the support cylinder (2). An installation hole (21) is provided on the side wall of the support cylinder (2), and an injection incision (31) is provided on the side wall of the administration cylinder (3). The pressing and positioning assembly includes a connecting rod (4), which is slidably disposed inside the installation hole (21). A pressing head (41) is provided at the top of the connecting rod (4), and the pressing head (41) is located outside the support cylinder (2). An arc-shaped positioning plate (42) is also provided at the bottom of the connecting rod (4), which is located inside the support cylinder (2), and the center of the arc of the arc-shaped positioning plate (42) faces the axis of the support cylinder (2).

2. A subcutaneous administration aid for mice according to claim 1, characterized in that: The inner wall of the drug delivery cylinder (3) is provided with a limiting ring (32) and a positioning protrusion (33) is provided on the limiting ring (32); the outer wall of the support cylinder (2) is provided with a limiting groove (22) for accommodating the limiting ring (32), and a plurality of positioning grooves (23) for accommodating the positioning protrusion (33) are provided inside the limiting groove (22), and the plurality of positioning grooves (23) are arranged in a ring around the axis of the support cylinder (2).

3. The subcutaneous injection device for mice according to claim 1, wherein: The pressing and positioning assembly also includes a reset spring (5), which is sleeved on the connecting rod (4), and one end of the reset spring (5) is connected to the pressing head (41), and the other end is connected to the outer wall of the bearing cylinder (2).

4. The subcutaneous injection device for mice according to claim 1, wherein: The pressing and positioning component also includes a silicone protective sleeve (6), which is fitted over the outside of the arc-shaped positioning plate (42).

5. The subcutaneous injection device for mice according to claim 1, wherein: The top surface of the pressing head (41) is provided with a finger receiving groove (411).

6. The subcutaneous drug delivery aid for mice according to claim 1, wherein: The outer wall of the bearing cylinder (2) is also provided with two finger receiving rings (24), and the two finger receiving rings (24) are arranged in a mirror image on both sides of the mounting hole (21).

7. The subcutaneous drug delivery aid for mice according to claim 1, wherein: The end of the sealing head (1) away from the bearing cylinder (2) is provided with a top spherical surface (11).

8. The subcutaneous drug delivery aid device for rats according to claim 1, characterized in that: The sealing head (1) has multiple vent holes (12) on its side wall, and the multiple vent holes (12) are arranged in a ring around the axis of the bearing cylinder (2).