A fluid component test control circuit
By incorporating sensor signal conditioning circuits, control signal generation circuits, and control signal conditioning circuits, the problems of complex and costly test control circuits for flow cytometer fluid systems are solved. Flexible linkage control of pumps, valves, and pressure sensors is achieved, simplifying the circuit structure and reducing costs.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- CYTEK (WUXI) BIOSCIENCES CO LTD
- Filing Date
- 2025-05-28
- Publication Date
- 2026-07-07
AI Technical Summary
Existing flow cytometers have complex, inflexible, and costly fluid system test control circuits, making it difficult to achieve flexible and coordinated control of pumps, valves, and pressure sensors.
By employing sensor signal conditioning circuits, control signal generation circuits, and control signal conditioning circuits, the amplification of sensor signals, the generation of basic control signals, and the generation of final control signals are achieved through hardware circuits. Flexible linkage control of pumps, valves, and pressure sensors is realized through simple hardware circuits.
It realizes flexible linkage control of fluid component testing control circuit, simplifies circuit structure, reduces cost, and improves system flexibility and control accuracy.
Smart Images
Figure CN224471969U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of electronic technology, specifically to a test control circuit for fluid components. Background Technology
[0002] Flow cytometry belongs to the field of in vitro diagnostic equipment and is used for biochemical analysis. The fluid system of a flow cytometer often needs to maintain a stable internal pressure to propel the sheath fluid and sample steadily through the flow chamber, which is usually achieved through the coordinated work of components such as pumps, valves, and pressure sensors.
[0003] Pumps, valves, and pressure sensors that can operate stably are key to the stable operation of flow cytometers. During component evaluation, the system's operating conditions are simulated to perform linkage control tests on these components, such as pressurization and depressurization, and pressure maintenance. This often involves adjusting the firmware program in conjunction with the system circuit, and may even require the cooperation of host computer software to achieve linkage test control of multiple components. This method of test setup is complex, lacks flexibility, and is costly. Utility Model Content
[0004] To address the aforementioned technical problems, this utility model provides a fluid component testing and control circuit that can achieve flexible linkage testing and control using simple hardware circuitry.
[0005] The present invention adopts the following technical solution: a fluid component testing and control circuit, characterized in that it comprises;
[0006] Sensor signal conditioning circuit, used to amplify sensor signals;
[0007] Control signal generation circuit, used to generate basic control signals;
[0008] The control signal conditioning circuit generates the final control signal based on the basic control signal.
[0009] A further feature is that the sensor signal conditioning circuit includes an instrumentation amplifier U1. The positive input terminal of the instrumentation amplifier U1 is connected to the positive output terminal Pressure+ of the sensor through a resistor R1. The inverting input terminal of the instrumentation amplifier U1 is connected to the inverting output terminal Pressure- of the sensor through a resistor R2. The positive input terminal of the instrumentation amplifier U1 is also connected to one end of capacitor C3 and one end of capacitor C4. The inverting input terminal of the instrumentation amplifier U1 is also connected to one end of capacitor C5 and the other end of capacitor C4. The other ends of capacitor C3 and capacitor C5 are both grounded. The output terminal of the instrumentation amplifier U1 is connected to one end of an adjustable potentiometer POT1 and outputs a sensor amplified signal Sensor_Sig. The feedback terminal of the instrumentation amplifier U1 is connected to the adjustment terminal of the adjustable potentiometer POT1. The REF terminal of the instrumentation amplifier U1 is connected to the other end of the adjustable potentiometer POT1 and grounded.
[0010] The control signal generation circuit includes a comparator U2. The positive input terminal of the comparator U2 receives the sensor amplified signal Sensor_Sig. The inverting input terminal of the comparator U2 is connected to the adjustment terminal of the adjustable potentiometer POT2. One end of the adjustable potentiometer POT2 is connected to one end of resistor R3, one end of capacitor C6, power supply Power1, and the positive power supply terminal of the comparator U2. The other end of the adjustable potentiometer POT2 is connected to the negative power supply terminal of the comparator U2 and grounded. The other end of capacitor C6 is grounded. The output terminal of the comparator U2 is connected to one end of resistor R6 and the other end of resistor R3. The other end of capacitor R6 is connected to one end of capacitor C9 and outputs the basic control signal Ctrl_Sig. The other end of capacitor C9 is grounded.
[0011] The control signal conditioning circuit includes a dual comparator U3. The first positive input and second negative input of the dual comparator U3 are respectively input to the basic control signal Ctrl_Sig. The first negative input of the dual comparator U3 is connected to one end of capacitor C7 and the adjustment terminal of adjustable potentiometer POT3. One end of the adjustable potentiometer POT3 is connected to power supply Power2, and the other end is connected to the other end of capacitor C7 and ground. The second positive input of the dual comparator U3 is connected to one end of capacitor C10 and the adjustment terminal of adjustable potentiometer POT4. One end of OT4 is connected to power supply Power2, and the other end is connected to the other end of capacitor C10 and ground. The positive power supply terminal of the dual comparator U3 is connected to one end of capacitor C8 and power supply Power2, and the negative power supply terminal of the dual comparator U3 is grounded. The first output terminal of the dual comparator U3 is connected to one end of resistor R4 and outputs the valve control signal Valve_Ctrl. The second output terminal of the dual comparator U3 is connected to one end of resistor R5 and outputs the valve control signal Pump_Ctrl. The other ends of resistors R4 and R5 are both connected to power supply Power2.
[0012] With this invention, the sensor signal conditioning circuit receives the sensor signal, amplifies it, and sends it to the control signal generation circuit to obtain the basic control signal. The signal is then compared to obtain the final control signal. Closed-loop linkage control is achieved using only hardware, and the control parameters can be flexibly adjusted. Attached Figure Description
[0013] Figure 1 This is the circuit schematic diagram of this utility model;
[0014] Figure 2 This is a circuit diagram of one embodiment of the circuit of this utility model.
[0015] Figure 3 This is a graph showing the time between pressurization and depressurization. Detailed Implementation
[0016] See Figure 1 As shown, a fluid component test control circuit includes:
[0017] Sensor signal conditioning circuit, used to amplify sensor signals;
[0018] Control signal generation circuit, used to generate basic control signals;
[0019] The control signal conditioning circuit generates the final control signal based on the basic control signal.
[0020] The sensor signal conditioning circuit includes an instrumentation amplifier U1. The positive input terminal IN+ of instrumentation amplifier U1 is connected to the positive output terminal Pressure+ of the sensor via resistor R1. The inverting input terminal IN- of instrumentation amplifier U1 is connected to the inverting output terminal Pressure- of the sensor via resistor R2. The positive input terminal IN+ of instrumentation amplifier U1 is also connected to one end of capacitor C3 and one end of capacitor C4. The inverting input terminal IN- of instrumentation amplifier U1 is also connected to one end of capacitor C5 and the other end of capacitor C4. The other end of capacitor C3 and the other end of capacitor C5... One end of each component is grounded. The output terminal VOUT of instrumentation amplifier U1 is connected to one end of adjustable potentiometer POT1 and outputs the amplified sensor signal Sensor_Sig. The feedback terminal FB of instrumentation amplifier U1 is connected to the adjustment terminal of adjustable potentiometer POT1. The REF terminal of instrumentation amplifier U1 is connected to the other end of adjustable potentiometer POT1 and grounded. The positive power supply terminal V+ of instrumentation amplifier U1 is connected to power supply Power1, one end of capacitor C1, and one end of capacitor C2. The other ends of capacitors C1 and C2 are both grounded. Among them, capacitors C3, C4, and C5, along with resistors R1 and R2, work together to attenuate sensor signal noise. Adjustable potentiometer POT1 is used to adjust the signal amplification factor. This embodiment is an example of... Figure 2 The instrumentation amplifier U1 uses the Analog Devices AD8420, which has a unity-gain bandwidth of 250kHz, a common-mode rejection ratio greater than 100dB, and a maximum input differential voltage of 1V. It can adapt to the output signals of most pressure sensors. Resistors R1 and R2 are 1KΩ, 1% precision resistors. Capacitors C3 and C5 are 0.1uF capacitors, working with resistors R1 and R2 to attenuate common-mode noise. Capacitor C4 is 1uF capacitor, working with resistors R1 and R2 to attenuate differential-mode noise. Capacitor C1 is 1uF capacitor, and capacitor C2 is 0.1uF capacitor. The adjustable potentiometer POT1 is a potentiometer with a total resistance of 10KΩ. The signal gain G = (1 + R 78 / R 67 ), where R 78 R67 is the resistor between VOUT and FB of instrumentation amplifier U1, R68 is the resistor between FBT and REF of instrumentation amplifier U1, and Power1 is 5V.
[0021] The control signal generation circuit includes a comparator U2. The positive input terminal IN+ of the comparator U2 inputs the sensor amplified signal Sensor_Sig. The negative input terminal IN- of the comparator U2 is connected to the adjustment terminal of the adjustable potentiometer POT2. One end of the adjustable potentiometer POT2 is connected to one end of the resistor R3, one end of the capacitor C6, the power supply Power1, and the positive power supply terminal V+ of the comparator U2. The other end of the adjustable potentiometer POT2 is connected to the negative power supply terminal V- of the comparator U2 and grounded. The other end of the capacitor C6 is grounded. The output terminal OUT of the comparator U2 is connected to one end of the resistor R6 and the other end of the resistor R3. The other end of the resistor R6 is connected to one end of the capacitor C9 and outputs the basic control signal Ctrl_Sig. The other end of the capacitor C9 is grounded; the adjustable potentiometer POT2 generates a voltage labeled Vset by voltage division and supplies it to the negative input terminal IN- of the comparator U2. When the processed sensor signal Sensor_Sig > Vset, the output terminal OUT of the comparator U2 is in a high impedance state with respect to the ground GND. The power supply Power1 charges the capacitor C9 through the resistor R3 and the resistor R6, and the voltage of Ctrl_Sig gradually rises. When Sensor_Sig < Vset, the output terminal OUT of the comparator U2 is conductive with a low resistance with respect to the ground GND, and the capacitor C9 discharges through the resistor R6, and the voltage of Ctrl_Sig gradually drops to near GND. The larger the Vset is set, the greater the pressure maintained by the system when the Ctrl_Sig signal rises. In this embodiment, for example Figure 2 , the comparator U2 is selected as the TLV1701 of TI, its single-ended supply voltage is up to 36V, and it has an open collector output. The adjustable potentiometer POT2 is selected as a potentiometer with a total resistance of 10K. The resistors R3 and R6 are selected as 100K resistors. The capacitor C9 is selected as a 1uF capacitor. The capacitor C6 is selected as a 0.1uF capacitor. A voltage is generated by voltage division of the adjustable potentiometer POT2 and supplied to the IN+ of the comparator U2.
[0022] The control signal conditioning circuit includes a dual comparator U3. The first non-inverting input terminal IN1+ and the second inverting input terminal IN2- of the dual comparator U3 are respectively input with the basic control signal Ctrl_Sig. The first inverting input terminal IN1- of the dual comparator U3 is connected to one end of a capacitor C7 and the adjustment terminal of a variable potentiometer POT3. One end of the variable potentiometer POT3 is connected to the power supply Power2, and the other end is connected to the other end of the capacitor C7 and the ground. The second non-inverting input terminal IN2+ of the dual comparator U3 is connected to one end of a capacitor C10 and the adjustment terminal of a variable potentiometer POT4. One end of the variable potentiometer POT4 is connected to the power supply Power2, and the other end is connected to the other end of the capacitor C10 and the ground. The positive power supply terminal V+ of the dual comparator U3 is connected to one end of a capacitor C8 and the power supply Power2. The negative power supply terminal V- of the dual comparator U3 is grounded. The first output terminal OUT1 of the dual comparator U3 is connected to one end of a resistor R4 and outputs a valve control signal Valve_Ctrl. The second output terminal OUT2 of the dual comparator U3 is connected to one end of a resistor R5 and outputs a valve control signal Pump_Ctrl. The other ends of the resistor R4 and the resistor R5 are both connected to the power supply Power2. A voltage is generated by dividing the voltage of the variable potentiometer POT3, marked as Vref1. When Vref1 > Ctrl_sig, the OUT1 terminal of the dual comparator U3 conducts to the ground with a low resistance, and Valve_Ctrl is a low level close to GND. When Vref1 < Ctrl_sig, the OUT1 terminal of U3 has a high impedance to the ground, and Valve_Ctrl is pulled up to Power2, and the voltage is close to Power2, and the control valve opens for pressure relief. Since the Ctrl_Sig signal is pulled up and pulled down during the capacitor charging and discharging process, the voltage change is a relatively smooth curve. By adjusting the magnitude of Vref1, the opening time of Valve_Ctrl can be adjusted. The larger the Vref1 is set, the longer the opening time of Valve_Ctrl. The conditioning principle of the Pump_Ctrl signal is similar. The larger the Vref2 is set, the longer the opening time of Pump_Ctrl, and the pump is controlled to open for pressurization. By adjusting the opening times of Valve_Ctrl and Pump_Ctrl, the pressurization and pressure relief platform times can be adjusted, such as Figure 3 . The voltage of Power2 can be selected according to the requirements of the pump valve drive module. In this embodiment, for example Figure 2 , the dual comparator U3 selects the TLV1702 of TI, which is a dual-channel open-collector output comparator with characteristics similar to those of the TLV1701. The variable potentiometers POT3 and POT4 select potentiometers with a total resistance of 10K. The capacitors C7 and C10 select 0.1uF capacitors. The resistors R4 and R5 select 1K resistors. The capacitor C8 selects a 0.1uF capacitor. The power supply Power2 is 5V.
[0023] Power1 and Power2 are supplied by the power module Power. Practical application shows that the circuit of this invention is simple to manufacture, low in cost, and can flexibly achieve the coordinated control of pumps, valves, and pressure sensors.
Claims
1. A fluid component testing and control circuit, characterized in that, It includes; Sensor signal conditioning circuit, used to amplify sensor signals; Control signal generation circuit, used to generate basic control signals; The control signal conditioning circuit generates the final control signal based on the basic control signal.
2. The fluid component testing and control circuit according to claim 1, characterized in that, The sensor signal conditioning circuit includes an instrumentation amplifier U1. The positive input terminal of the instrumentation amplifier U1 is connected to the positive output terminal Pressure+ of the sensor through a resistor R1. The inverting input terminal of the instrumentation amplifier U1 is connected to the inverting output terminal Pressure- of the sensor through a resistor R2. The positive input terminal of the instrumentation amplifier U1 is also connected to one end of capacitor C3 and one end of capacitor C4. The inverting input terminal of the instrumentation amplifier U1 is also connected to one end of capacitor C5 and the other end of capacitor C4. The other ends of capacitors C3 and C5 are both grounded. The output terminal of the instrumentation amplifier U1 is connected to one end of an adjustable potentiometer POT1 and outputs the sensor amplified signal Sensor_Sig. The feedback terminal of the instrumentation amplifier U1 is connected to the adjustment terminal of the adjustable potentiometer POT1. The REF terminal of the instrumentation amplifier U1 is connected to the other end of the adjustable potentiometer POT1 and grounded.
3. The fluid component testing and control circuit according to claim 2, characterized in that, The control signal generation circuit includes a comparator U2. The positive input terminal of the comparator U2 receives the sensor amplified signal Sensor_Sig. The inverting input terminal of the comparator U2 is connected to the adjustment terminal of the adjustable potentiometer POT2. One end of the adjustable potentiometer POT2 is connected to one end of resistor R3, one end of capacitor C6, power supply Power1, and the positive power supply terminal of the comparator U2. The other end of the adjustable potentiometer POT2 is connected to the negative power supply terminal of the comparator U2 and grounded. The other end of capacitor C6 is grounded. The output terminal of the comparator U2 is connected to one end of resistor R6 and the other end of resistor R3. The other end of capacitor R6 is connected to one end of capacitor C9 and outputs the basic control signal Ctrl_Sig. The other end of capacitor C9 is grounded.
4. The fluid component testing and control circuit according to claim 3, characterized in that, The control signal conditioning circuit includes a dual comparator U3. The first positive input and second negative input of the dual comparator U3 are respectively input to the basic control signal Ctrl_Sig. The first negative input of the dual comparator U3 is connected to one end of capacitor C7 and the adjustment terminal of adjustable potentiometer POT3. One end of the adjustable potentiometer POT3 is connected to power supply Power2, and the other end is connected to the other end of capacitor C7 and ground. The second positive input of the dual comparator U3 is connected to one end of capacitor C10 and the adjustment terminal of adjustable potentiometer POT4. One end of OT4 is connected to power supply Power2, and the other end is connected to the other end of capacitor C10 and ground. The positive power supply terminal of the dual comparator U3 is connected to one end of capacitor C8 and power supply Power2, and the negative power supply terminal of the dual comparator U3 is grounded. The first output terminal of the dual comparator U3 is connected to one end of resistor R4 and outputs the valve control signal Valve_Ctrl. The second output terminal of the dual comparator U3 is connected to one end of resistor R5 and outputs the valve control signal Pump_Ctrl. The other ends of resistors R4 and R5 are both connected to power supply Power2.