A high performance liquid chromatography tandem mass spectrometer based on clinical detection

Abstract

This application relates to the field of liquid chromatography-tandem mass spectrometry (LC-MS / MS) technology, and particularly to a high-performance liquid chromatography-tandem mass spectrometer (HPLC-MS / MS) for clinical testing. The instrument includes a detection chamber with a door at its front end. A control panel is located on the upper part of the front end of the door, and a transparent cover is fixedly connected to the middle of the front end of the door. This application achieves this by establishing an electrical connection between the control panel and the internal circuitry of the detection chamber, and by coordinating the base with a sliding groove, a slider with a pull-out plate, a left clamping plate with a right clamping plate, and a drive motor with a screw. This allows for flexible opening and closing of the door, stable control of the equipment functions via the control panel, convenient sliding of the pull-out plate, and precise movement of the right clamping plate via screw transmission to clamp test tubes. A limiting rod and a rubber layer further ensure test tube stability. This facilitates convenient operation for equipment maintenance and sample retrieval, and ensures stable and reliable test tube fixation, preventing sample loss and ensuring accurate test results.

Description

Technical Field

[0001] This application relates to the field of liquid chromatography-tandem mass spectrometry (LC-MS / MS) technology, and in particular to a high-performance liquid chromatography-tandem mass spectrometer (HPLC-MS / MS) for clinical testing. Background Technology

[0002] High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS) is a powerful analytical technique that combines the high separation capability of HPLC with the high sensitivity and selectivity of mass spectrometry. It plays an increasingly important role in the field of clinical testing. However, there are still some problems that need to be solved in the current technology. For example, in terms of sample placement and equipment maintenance, the traditional HPLC-MS / MS chassis structure design is not reasonable enough, and the door opening method is inconvenient. This makes the operation process cumbersome for operators when placing samples and performing maintenance and repair on the internal equipment, which affects work efficiency. At the same time, in terms of test tube fixation and sample management, the existing test tube fixing devices are not stable enough. During equipment movement or operation, test tubes are easy to shake or even fall, which may not only cause sample loss but also affect the accuracy of the test results.

[0003] According to the search, Chinese Patent Publication No. CN212586312U discloses a high performance liquid chromatography-tandem mass spectrometer, which includes an instrument body, a test bottle, and a box fixed to the upper side of the instrument body. The box has a storage cavity, the test bottle is embedded in the storage cavity, and the bottom of the storage cavity is provided with several suction cups, the openings of the suction cups are set to the side away from the instrument body.

[0004] While this technology improves the fixation of the test bottles to some extent, making them less prone to movement or tilting when impacted and reducing contamination of the instrument body by the solution inside the test bottles, it still fails to effectively solve the aforementioned problems of inconvenient chassis structure design and unstable test tube fixation. However, this patented technology does not provide a solution to this problem. Utility Model Content

[0005] To address the problems mentioned in the background section, this application provides a high-performance liquid chromatography-tandem mass spectrometer for clinical testing.

[0006] This application provides a high-performance liquid chromatography-tandem mass spectrometer for clinical testing, employing the following technical solution: It includes a detection chamber, a door at the front end of the chamber, a control panel at the upper front of the door, a transparent cover fixedly connected to the middle front of the door, a handle fixedly connected to the right front of the door, a power supply box on the rear right wall of the detection chamber, and a base fixedly connected to the middle of the lower wall of the detection chamber. The upper left and upper right sides of the base have sliding grooves, within which sliders are slidably connected.

[0007] Optionally, the upper ends of the two sliders are fixedly connected to a pull plate, the upper end of the pull plate is fixedly connected to five left clamping plates, the front part of the left frame wall and the front part of the right frame wall of the pull plate are fixedly connected to a limit rod, the front part of the lower frame wall of the pull plate is provided with a handle groove, and the rear part of the right end of the pull plate is fixedly connected to a drive motor.

[0008] Optionally, the output end of the drive motor passes through the pull-out plate and is fixedly connected to a screw. Multiple limiting collars are fixedly connected to the outer surface of the screw. Five right clamping plates are movably connected to the outer surface of the screw. Multiple clamping grooves are opened at the right end of the left clamping plate and the left end of the right clamping plate. A rubber layer is fixedly connected in each clamping groove.

[0009] Optionally, the door is rotatably connected to the front end of the testing chamber via a hinge, the control panel is located at the upper center of the front end of the door, and the control panel is connected to the internal circuit of the testing chamber via a wire, and the transparent cover is rectangular.

[0010] Optionally, the screw is rotatably connected to the pull plate via a bearing, the output shaft of the drive motor is fixedly connected to the screw via a coupling, and multiple limiting collars are fixed at equal intervals along the screw axial direction.

[0011] Optionally, the five right clamps are threadedly connected to the screw through internal threaded holes, and the right clamps can move between the limiting collars.

[0012] Optionally, the clamping grooves are symmetrically distributed at the right end of the left clamping plate and the left end of the right clamping plate, and the rubber layer is fixed to the inner wall of the clamping grooves by adhesive.

[0013] In summary, this application includes the following beneficial technical effects:

[0014] This invention, by incorporating components such as a door, hinges, and a control panel, and through the coordinated relationship between the door and hinges, and between the control panel and the internal circuitry of the testing chamber, allows the door to be flexibly opened and closed via the hinges, and the control panel to stably control the internal functions of the testing chamber. This enables the device to perform maintenance, repairs, sample placement and removal within the testing chamber through convenient door opening and closing and intuitive operation control, thereby improving the ease of use and work efficiency of the equipment.

[0015] This invention utilizes components such as a base, a sliding groove, a slider, a pull-out plate, a left clamping plate, a right clamping plate, a drive motor, a screw, and a limiting rod. Through the coordinated relationships between the base and the sliding groove, the slider and the pull-out plate, the left clamping plate and the right clamping plate, and the drive motor and the screw, the pull-out plate can be flexibly pulled out and pushed in by the slider sliding within the sliding groove. The right clamping plate can be precisely moved by the drive motor driving the screw to rotate. Thus, this device achieves the effect of stably fixing test tubes placed on the pull-out plate through stable pull-out plate operation and precise test tube clamping mechanism, avoiding sample loss and affecting test results. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the first-view structure in an embodiment of this application;

[0017] Figure 2 This is a schematic diagram of the second-view structure in an embodiment of this application;

[0018] Figure 3 These are partial structural schematic diagrams of embodiments of this application;

[0019] Figure 4 This is a magnified structural diagram of section A in the embodiments of this application.

[0020] Reference numerals in the attached diagram: 1. Testing chassis; 2. Chassis door; 3. Base platform; 4. Slide groove; 5. Handle; 6. Control panel; 7. Transparent cover; 8. Power supply box; 9. Pull-out plate; 10. Slider; 11. Hand lever groove; 12. Limiting rod; 13. Left clamping plate; 14. Pipe clamping groove; 15. Rubber layer; 16. Drive motor; 17. Screw; 18. Limiting collar; 19. Right clamping plate. Detailed Implementation

[0021] The following is in conjunction with the appendix Figure 1-4 This application will be described in further detail.

[0022] This application discloses a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS) instrument for clinical testing. For example... Figure 1 and Figure 2As shown, the device includes a testing housing 1, with a door 2 at the front end. The door 2 is hinged to the front end of the testing housing 1, allowing for flexible opening and closing. This facilitates maintenance, repair, sample placement, and removal for operators, improving the ease of use of the equipment. A control panel 6 is located at the upper front end of the door 2, centered on the front. The control panel 6 is connected to the internal circuitry of the testing housing 1 via wires. Positioning the control panel 6 at the upper front end of the door 2 conforms to ergonomic design. For easy and intuitive operation and observation by operators, the control panel 6 is connected by wires to ensure stable control of various functions inside the testing chamber 1, guaranteeing normal operation of the equipment. A transparent cover 7 is fixedly connected to the front center of the door 2. The transparent cover 7 is cuboid in shape. The transparent cover 7 allows operators to directly observe the testing process and sample condition inside the testing chamber 1 without opening the door 2, avoiding the impact of frequent opening of the chamber on the testing environment and ensuring the accuracy of the test results. The cuboid design also provides a large field of view. A handle 5 is fixedly connected to the front right side of the door 2.

[0023] Please see Figure 1 , Figure 2 and Figure 4 A base platform 3 is fixedly connected to the middle of the lower wall of the testing machine housing 1. The upper left and upper right sides of the base platform 3 each have a sliding groove 4. A slider 10 is slidably connected within the sliding groove 4. A pull-out plate 9 is fixedly connected to the upper ends of both sliders 10. The coordinated arrangement of the base platform 3, sliding groove 4, sliders 10, and pull-out plate 9 allows the pull-out plate 9 to be flexibly pulled out and pushed in from below the testing machine housing 1, facilitating the storage and retrieval of items placed on the pull-out plate 9. This increases the storage function of the equipment and improves space utilization. Five left clamps 13 are fixedly connected to the upper end of the pull plate 9. The left clamps 13 are used to initially fix the relevant test tubes. The limiting rod 12 can prevent the test tubes from shaking or falling during the movement of the pull plate 9, ensuring the stability of the test tubes. The limiting rod 12 is fixedly connected between the front part of the left frame wall and the front part of the right frame wall of the pull plate 9. The front part of the lower frame wall of the pull plate 9 has a handle groove 11. The handle groove 11 makes it convenient for the operator to manually pull out or push in the pull plate 9. The drive motor 16 is fixedly connected to the rear right end of the pull plate 9.

[0024] Please see Figure 3 and Figure 4A power supply box 8 is installed on the rear right wall of the testing machine housing 1. This power supply box 8 allows for the reasonable storage and management of the equipment's power lines, resulting in a more organized overall layout and reducing safety hazards caused by tangled wiring. The output end of the drive motor 16 passes through the pull-out plate 9 and is fixedly connected to a screw 17. The screw 17 is rotatably connected to the pull-out plate 9 via bearings. The output shaft of the drive motor 16 is fixedly connected to the screw 17 via a coupling. This connection method allows the drive motor 16 to stably transmit power to the screw 17, enabling the movement of related components through the rotation of the screw 17, ensuring the stability and reliability of power transmission. Multiple limiting collars 18 are fixedly connected to the outer surface of the screw 17. These limiting collars 18 are evenly spaced along the axial direction of the screw 17, restricting the movement range of the right clamping plate 19, ensuring that the right clamping plate 19 moves within a specified range, guaranteeing its accuracy and stability. The outer surface of the screw 17 is flexible... The device has five right clamping plates 19, which are threadedly connected to the screw 17 through internal threaded holes. The right clamping plates 19 can move between the limiting collars 18. The threaded connection between the right clamping plates 19 and the screw 17 allows the right clamping plates 19 to move precisely as the screw 17 rotates, enabling precise clamping and loosening of the test tube. Multiple tube-clamping grooves 14 are provided at the right end of the left clamping plate 13 and the left end of the right clamping plate 19. The symmetrical distribution of the clamping grooves 14 ensures uniform clamping of the test tubes, guaranteeing a good clamping effect. Each clamping groove 14 is fixedly connected with a rubber layer 15. The rubber layer 15 increases the friction between the clamping groove 14 and the test tube, preventing the test tube from sliding during clamping. At the same time, the rubber layer 15 has a certain elasticity, which can buffer and protect the test tube, avoiding damage to the test tube due to excessive clamping force. The rubber layer 15 is fixed to the inner wall of the clamping groove 14 by adhesive.

[0025] The implementation principle of a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS) instrument for clinical testing in this application embodiment is as follows: When using the HPLC-MS / MS instrument for clinical testing to detect samples, the operator can open the door 2 through the handle 5 on the door 2 and place the sample inside the detection chamber 1. The door 2 is rotatably connected to the front end of the detection chamber 1 via a hinge, allowing for flexible opening and closing and easy operation. After placing the sample, the various functions inside the detection chamber 1 can be controlled through the control panel 6 located in the center of the upper part of the front end of the door 2. The control panel 6 is connected to the internal circuit of the detection chamber 1 via wires to ensure stable control. When it is necessary to operate on the test tube placed on the pull-out plate 9, the base 3, which is fixedly connected to the middle of the lower wall of the detection chamber 1, has sliding grooves 4 on the left and right sides of its upper end that are slidably connected to the slider 10, allowing the pull-out plate 9 to be flexibly pulled out and pushed in. The operator can achieve this through the handle groove 11 on the front of the lower wall of the pull-out plate 9. After the pull-out plate 9 is pulled out, if it is necessary to clamp the test tube, the drive motor 16 at the rear right end of the pull-out plate 9 is started, and its output end passes through... The pull-out plate 9 is fixedly connected to the screw 17 via a coupling, stably transmitting power to the screw 17. When the screw 17 rotates, the right clamping plate 19, threadedly connected to the screw 17 and located between the limiting collars 18, moves precisely with the rotation of the screw 17. It cooperates with the left clamping plate 13 at the upper end of the pull-out plate 9. The test tube is clamped by the clamping grooves 14 symmetrically distributed at the right end of the left clamping plate 13 and the left end of the right clamping plate 19. The rubber layer 15 inside the clamping grooves 14 increases friction, prevents the test tube from sliding, and also provides cushioning protection. Meanwhile, the limiting rod 12 at the front of the left clamping plate 13 and the pull plate 9 prevents the test tube from shaking or falling during the movement of the pull plate 9, ensuring the stability of the test tube. During the entire testing process, the operator can directly observe the testing process and sample condition inside the testing machine 1 through the transparent cover 7 at the front center of the door 2 without opening the door 2, avoiding frequent opening of the box and affecting the testing environment, and ensuring the accuracy of the test results. The power box 8 on the rear wall of the right side of the testing machine 1 is used to reasonably store and manage the power lines, making the equipment layout neat.

[0026] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS) instrument for clinical testing, comprising a detection enclosure (1), characterized in that: The front end of the testing machine housing (1) is provided with a door (2), and the upper part of the front end of the door (2) is provided with a control panel (6). A transparent cover (7) is fixedly connected to the middle of the front end of the door (2). A handle (5) is fixedly connected to the right side of the front end of the door (2). A power supply box (8) is provided on the rear wall of the right side of the testing machine housing (1). A base (3) is fixedly connected to the middle of the lower side of the testing machine housing (1). A sliding groove (4) is opened on the upper left and upper right sides of the base (3). A slider (10) is slidably connected in the sliding groove (4).

2. The high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS) instrument for clinical testing according to claim 1, characterized in that: The upper ends of the two sliders (10) are fixedly connected to a pull plate (9), and the upper end of the pull plate (9) is fixedly connected to five left clamps (13). The front part of the left frame wall and the front part of the right frame wall of the pull plate (9) are fixedly connected to a limit rod (12). The front part of the lower frame wall of the pull plate (9) has a handle groove (11). The rear right end of the pull plate (9) is fixedly connected to a drive motor (16).

3. The high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS) instrument for clinical testing according to claim 2, characterized in that: The output end of the drive motor (16) passes through the pull plate (9) and is fixedly connected to a screw (17). Multiple limiting collars (18) are fixedly connected to the outer surface of the screw (17). Five right clamping plates (19) are movably connected to the outer surface of the screw (17). Multiple clamping grooves (14) are opened at the right end of the left clamping plate (13) and the left end of the right clamping plate (19). A rubber layer (15) is fixedly connected in each clamping groove (14).

4. The high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS) instrument for clinical testing according to claim 1, characterized in that: The door (2) is rotatably connected to the front end of the testing machine box (1) via a hinge. The control panel (6) is located in the center of the upper part of the front end of the door (2), and the control panel (6) is connected to the internal circuit of the testing machine box (1) via a wire. The transparent cover (7) is rectangular.

5. A high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS) instrument for clinical testing according to claim 3, characterized in that: The screw (17) is rotatably connected to the pull plate (9) via a bearing, and the output shaft of the drive motor (16) is fixedly connected to the screw (17) via a coupling. Multiple limiting collars (18) are fixed at equal intervals along the axial direction of the screw (17).

6. The high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS) instrument for clinical testing according to claim 3, characterized in that: The five right clamps (19) are threaded to the screw (17) through internal threaded holes, and the right clamps (19) can move between the limiting collars (18).

7. A high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS) instrument for clinical testing according to claim 3, characterized in that: The clamping groove (14) is symmetrically distributed at the right end of the left clamping plate (13) and the left end of the right clamping plate (19), and the rubber layer (15) is fixed to the inner wall of the clamping groove (14) by adhesive.

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