Artemisinin chromatographic separation device

Abstract

The utility model discloses an artemisinin chromatographic separation device relates to chromatography field, including fixed frame and chromatographic column body, the fixed frame is fixedly connected with material tank, the vertical fixedly connected with sleeve in material tank, the open lower extreme of sleeve and penetrate material tank bottom, a plurality of through -holes are seted up on the sleeve, the surface of chromatographic column body is equipped with the seal cover, and the seal cover and sleeve inner wall gap cooperation. Advantageous effect lies in: the utility model creatively combines the sedimentation method with chromatographic column separation. Set up sleeve and through -hole in material tank, cooperate the use of the precipitate, first through the sedimentation method and make the impurity precipitate to material tank bottom, control chromatographic column body's elevation again, only let the solution above the precipitate layer enter chromatographic column body and carry out chromatographic separation. This kind of double method cooperation operation, both reduce the interference of impurity to chromatographic process, and make up the defect of single sedimentation method purity deficiency, improve separation efficiency and artemisinin purity greatly.

Description

Technical Field

[0001] This utility model relates to the field of chromatography technology, specifically to an artemisinin chromatography separation device. Background Technology

[0002] Artemisinin, a highly effective antiviral drug extracted from Artemisia annua, has always been a focus of research in the pharmaceutical field due to its separation and purification technology. Currently, existing technologies for artemisinin separation mostly employ chromatography column separation or precipitation methods alone. If a stepwise approach is used, i.e., first treating the solution using precipitation and then transferring it to a chromatography column for separation, there are significant drawbacks due to the cumbersome conversion process. In stepwise operations, the precipitated solution must be carefully transferred to the chromatography column. This process not only involves multiple steps but is also prone to introducing new impurities or causing artemisinin loss due to spillage or excessive contact with air. Furthermore, the lack of effective connection between the precipitation equipment and the chromatography column necessitates readjusting equipment parameters and cleaning pipelines after each transfer, which is time-consuming and labor-intensive, significantly reducing overall work efficiency.

[0003] When using a chromatography column alone, the crude artemisinin extract is prone to clogging due to its complex impurities, resulting in low separation efficiency and high cost. On the other hand, using precipitation alone is insufficient to remove impurities with properties similar to artemisinin, thus failing to meet the requirements for high-purity separation. Utility Model Content

[0004] The purpose of this invention is to provide an artemisinin chromatography separation device to solve the above problems, as detailed below.

[0005] To achieve the above objectives, the present invention provides the following technical solution:

[0006] This utility model provides an artemisinin chromatography separation device, including a fixed frame and a chromatography column body. A material tank is fixedly connected to the fixed frame. A sleeve is vertically fixedly connected inside the material tank. The lower end of the sleeve is open and penetrates the bottom of the material tank. Several through holes are opened on the sleeve. A sealing sleeve is fitted on the surface of the chromatography column body. The sealing sleeve is clearance-fitted with the inner wall of the sleeve to seal the through holes.

[0007] An infrared sensor is fixedly connected to the liquid outlet at the bottom of the chromatography column body to identify the type of liquid effluent;

[0008] The fixed frame is fixedly connected to the bottom of the fixed frame, and at least two collection cups are placed on the movable frame. The collection cups move with the movable frame and can correspond to the lower end of the chromatography column body.

[0009] Using the aforementioned artemisinin chromatography separation device, the artemisinin solution mixed with impurities is poured into a material tank, and then a precipitant is injected into the material tank to allow the impurities to settle to the bottom. After the impurities have settled, the interface between the precipitate and other solutions is observed visually. Then, the chromatography column is moved downwards so that the upper part of the chromatography column is not lower than the precipitate layer. At that time, the solution above the precipitate layer will enter the chromatography column through the through-hole. The chromatography column can further separate this part of the solution. The composition of the solution output from the lower end of the chromatography column can be determined by an infrared sensor. The solution containing impurities flows out first, and the artemisinin solution flows out later. The collection cups are moved by a movable frame so that different collection cups correspond to the lower end of the chromatography column, and different solutions are collected through different collection cups.

[0010] The chromatography column body is moved by a lifting assembly, making it more stable and labor-saving.

[0011] Preferably, the upper end of the sealing sleeve is flush with the upper end of the chromatography column body.

[0012] Preferably, the movable frame includes a housing, which is placed on the upper side of the bottom of the fixed frame. Two parallel guide grooves are formed on the housing, and a guide plate is slidably connected in the guide groove. The guide plate is fixedly connected to the fixed frame. A limiting groove adapted to the collection cup is formed on the top of the housing.

[0013] Preferably, a lifting assembly is fixedly connected to the fixing frame for vertically moving the chromatography column body.

[0014] Preferably, the lifting assembly includes a fixed plate fixedly connected to a fixed frame, a screw vertically rotatably connected to the fixed plate, the upper end of the screw being rotatably connected to the fixed frame, a knob fixedly connected to the lower end of the screw, a connecting plate threadedly connected to the screw, and the connecting plate being fixedly connected to the chromatography column body.

[0015] Preferably, both the material tank and the chromatography column body are made of transparent material.

[0016] Preferably, the sealing sleeve is elastic and corrosion-resistant.

[0017] Preferably, the sealing sleeve is made of fluororubber or polypropylene.

[0018] Preferably, the upper end of the sleeve is open.

[0019] The beneficial effects are:

[0020] 1. This invention creatively combines precipitation with column chromatography. A sleeve and through-hole are installed inside the material tank for use with the precipitate. First, impurities are precipitated to the bottom of the tank. Then, the rise and fall of the column is controlled to allow only the solution above the precipitate to enter the column for chromatographic separation. This dual-method synergy reduces interference from impurities in the chromatography process and compensates for the insufficient purity of precipitation alone, significantly improving separation efficiency and artemisinin purity.

[0021] 2. An infrared sensor installed at the liquid outlet at the bottom of the chromatography column can identify the type of liquid in real time and accurately determine whether the outflowing solution is impurities or artemisinin. Combined with the design of a movable rack and multiple collection cups, the collection containers can be switched to achieve precise collection of different solutions and avoid mixing and contamination.

[0022] 3. Both the material tank and the chromatography column body are made of transparent materials, allowing operators to visually observe the internal solution state and separation process, and adjust operations promptly. The sealing sleeve is made of elastic and corrosion-resistant fluororubber or polypropylene, ensuring a good seal between the sleeve and the chromatography column body to prevent solution leakage, while also adapting to different chemical environments, extending the service life of the device, and reducing maintenance costs.

[0023] 4. The chromatography column can be moved stably, accurately, and effortlessly through the lifting assembly. Attached Figure Description

[0024] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0025] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0026] Figure 2 This is a front view structural diagram of the present invention;

[0027] Figure 3 This is a schematic diagram of the three-dimensional structure of the movable frame of this utility model;

[0028] Figure 4 This is a three-dimensional structural diagram of the material tank of this utility model;

[0029] Figure 5 This is a schematic diagram of the three-dimensional structure of the chromatography column body of this utility model.

[0030] The annotations in the attached figures are explained as follows:

[0031] 1. Fixed frame; 2. Movable frame; 3. Collection cup; 4. Material tank; 5. Chromatography column body; 6. Infrared sensor; 7. Lifting assembly; 8. Screw; 9. Connecting plate; 10. Fixed plate; 11. Knob; 12. Sleeve; 13. Through hole; 14. Sealing sleeve; 15. Shell; 16. Guide groove; 17. Guide plate. Detailed Implementation

[0032] To make the objectives, technical solutions, and advantages of this utility model clearer, the technical solutions of this utility model will be described in detail below. Obviously, the described embodiments are only a part of the embodiments of this utility model, and not all of them. Based on the embodiments of this utility model, all other implementation methods obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.

[0033] See Figures 1-5 As shown, this utility model provides an artemisinin chromatography separation device, including a fixed frame 1 and a chromatography column body 5. A material tank 4 is fixedly connected to the fixed frame 1. A sleeve 12 is vertically fixedly connected inside the material tank 4. The lower end of the sleeve 12 is open and penetrates the bottom of the material tank 4. A plurality of through holes 13 are provided on the sleeve 12. A sealing sleeve 14 is fitted on the surface of the chromatography column body 5. The sealing sleeve 14 is clearance-fitted with the inner wall of the sleeve 12 to seal the through holes 13.

[0034] This design achieves an integrated connection between precipitation and chromatography. After the mixed liquid is poured into the material tank 4 and the precipitant is added, the impurities precipitate. By controlling the rise and fall of the chromatography column body 5, the solution on the precipitate layer flows into the chromatography column body 5 through the through hole 13, avoiding the cumbersome operation and potential loss of solution transfer. It can also prevent shaking when transferring the precipitated solution, which would cause the precipitate and solution to re-merge.

[0035] An infrared sensor 6 is fixedly connected to the liquid outlet at the bottom of the chromatography column body 5 to identify the type of liquid effluent.

[0036] Infrared sensor 6 utilizes the difference in infrared light absorption characteristics between impurities and artemisinin to identify the type of liquid in real time, accurately determine the composition of the outflowing solution, and provide signal support for subsequent collection.

[0037] The bottom of the fixed frame 1 is fixedly connected to the movable frame 2, and at least two collection cups 3 are placed on the movable frame 2. The collection cups 3 move with the movable frame 2 and can correspond to the lower end of the chromatography column body 5.

[0038] As an optional implementation, the upper end of the sealing sleeve 14 is flush with the upper end of the chromatography column body 5.

[0039] The movable frame 2 includes a housing 15, which is placed on the upper side of the bottom of the fixed frame 1. Two parallel guide grooves 16 are provided on the housing 15. A guide plate 17 is slidably connected in the guide grooves 16 and is fixedly connected to the fixed frame 1. A limiting groove adapted to the collection cup 3 is provided on the top of the housing 15.

[0040] The movable frame 2 is placed at the bottom of the fixed frame 1. Its housing 15 is provided with a guide groove 16, which is slidably connected to the guide plate 17 on the fixed frame 1 to ensure smooth movement. The limiting groove at the top of the housing 15 is adapted to the collection cup 3. The collection cup 3 can move with the movable frame 2 and correspond to the lower end of the chromatography column body 5. According to the signal switching of the infrared sensor 6, the impurities and artemisinin solution are accurately separated and collected.

[0041] A lifting assembly 7 is fixedly connected to the fixed frame 1 for vertically moving the chromatography column body 5.

[0042] The lifting assembly 7 includes a fixed plate 10 fixedly connected to the fixed frame 1. A screw 8 is vertically rotatably connected to the fixed plate 10. The upper end of the screw 8 is rotatably connected to the fixed frame 1. A knob 11 is fixedly connected to the lower end of the screw 8. A connecting plate 9 is threadedly connected to the screw 8. The connecting plate 9 is fixedly connected to the chromatography column body 5.

[0043] With the cooperation of the fixed plate 10, screw 8, knob 11 and connecting plate 9, the operator rotates the knob 11 to drive the screw 8 to rotate, causing the connecting plate 9 to move axially, thereby precisely controlling the lifting and lowering of the chromatography column body 5, adjusting its relative position with the material tank 4, and realizing the orderly inflow of solution and control of the separation process.

[0044] Both the material tank 4 and the chromatography column body 5 are made of transparent material.

[0045] The sealing sleeve 14 is elastic and corrosion resistant.

[0046] The sealing sleeve 14 is made of fluororubber or polypropylene.

[0047] The sealing sleeve 14 is fitted onto the surface of the chromatography column body 5, and fits with the inner wall of the sleeve 12 with a clearance, thus sealing the through hole 13. The upper end of the sealing sleeve 14 is flush with the upper end of the chromatography column body 5, and is made of elastic, corrosion-resistant fluororubber or polypropylene material, which can ensure a seal to prevent solution leakage and adapt to different chemical environments. In addition, when a pressurization device is required, moving the sealing sleeve 14 to block all through holes 13 can achieve pressure regulation of the solution inside the column, accelerating solution flow and separation.

[0048] The upper end of the sleeve 12 is open, which allows it to be connected to the pressurizing device. When using the pressurizing device, the sealing sleeve 14 needs to be moved to a position that blocks all through holes 13.

[0049] Using the above structure, the artemisinin solution mixed with impurities is poured into the material tank 4, and then the precipitate is injected into the material tank 4 to allow the impurities to settle to the bottom of the material tank 4. After the impurities have settled, the interface between the precipitate and other solutions is observed by the naked eye. Then, the chromatography column body 5 is moved downward so that the upper end of the chromatography column body 5 is not lower than the precipitate layer. At that time, the solution above the precipitate layer will enter the chromatography column body 5 through the through hole 13. The chromatography column body 5 can further separate this part of the solution. The infrared sensor 6 can determine the composition of the solution output from the lower end of the chromatography column body 5. The solution containing impurities flows out first, and the artemisinin solution flows out later. The collection cup 3 is moved by the movable frame 2 so that different collection cups 3 correspond to the lower end of the chromatography column body 5. Different solutions are collected through different collection cups 3.

[0050] The chromatography column body 5 is moved by the lifting component 7, making it more stable and labor-saving.

[0051] The above description is merely a specific embodiment of this utility model, but the protection scope of this utility model is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in this utility model should be included within the protection scope of this utility model. Therefore, the protection scope of this utility model should be determined by the protection scope of the claims.

Claims

1. An artemisinin chromatography separation device, characterized in that: The system includes a fixed frame (1) and a chromatography column body (5). A material tank (4) is fixedly connected to the fixed frame (1). A sleeve (12) is vertically fixedly connected inside the material tank (4). The lower end of the sleeve (12) is open and penetrates the bottom of the material tank (4). Several through holes (13) are provided on the sleeve (12). A sealing sleeve (14) is fitted on the surface of the chromatography column body (5). The sealing sleeve (14) is clearance-fitted with the inner wall of the sleeve (12) to seal the through holes (13). An infrared sensor (6) is fixedly connected to the bottom outlet of the chromatography column body (5) to identify the type of effluent. The fixed frame (1) is fixedly connected to the bottom of the movable frame (2), and at least two collection cups (3) are placed on the movable frame (2). The collection cups (3) move with the movable frame (2) and can correspond to the lower end of the chromatography column body (5).

2. The artemisinin chromatography separation apparatus according to claim 1, characterized in that: The upper end of the sealing sleeve (14) is flush with the upper end of the chromatography column body (5).

3. The artemisinin chromatography separation apparatus according to claim 1, characterized in that: The movable frame (2) includes a housing (15), which is placed on the upper side of the bottom of the fixed frame (1). Two parallel guide grooves (16) are provided on the housing (15). A guide plate (17) is slidably connected in the guide groove (16). The guide plate (17) is fixedly connected to the fixed frame (1). A limiting groove adapted to the collection cup (3) is provided on the top of the housing (15).

4. The artemisinin chromatography separation apparatus according to claim 1, characterized in that: A lifting assembly (7) is fixedly connected to the fixed frame (1) for vertically moving the chromatography column body (5).

5. The artemisinin chromatography separation apparatus according to claim 4, characterized in that: The lifting assembly (7) includes a fixed plate (10) fixedly connected to the fixed frame (1), a screw (8) is vertically rotatably connected to the fixed plate (10), the upper end of the screw (8) is rotatably connected to the fixed frame (1), a knob (11) is fixedly connected to the lower end of the screw (8), a connecting plate (9) is threadedly connected to the screw (8), and the connecting plate (9) is fixedly connected to the chromatography column body (5).

6. The artemisinin chromatography separation apparatus according to claim 1, characterized in that: Both the material tank (4) and the chromatography column body (5) are made of transparent material.

7. The artemisinin chromatography separation apparatus according to claim 1, characterized in that: The sealing sleeve (14) is elastic and corrosion resistant.

8. The artemisinin chromatography separation apparatus according to claim 7, characterized in that: The sealing sleeve (14) is made of fluororubber or polypropylene.

9. The artemisinin chromatography separation apparatus according to claim 1, characterized in that: The upper end of the sleeve (12) is open.

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