An ultrafiltration device

Abstract

The utility model relates to ultrafiltration system technical field discloses a kind of ultrafiltration devices, including support, the support inside fixedly connected with multiple connecting barrels, multiple the connecting barrel inside is all provided with multiple backflow pipelines, the support inside is provided with backflow mixing component, the backflow mixing component includes barrel, the barrel outer wall fixedly connected in the support side wall, the barrel inside is provided with magnetic flow agitator, one end of one the backflow pipeline is fixedly connected with static mixer, static mixer bottom end is fixedly connected in one end of another the backflow pipeline.The utility model in, by setting static mixer between backflow pipeline and barrel, while additionally setting magnetic flow agitator in barrel, and the interface of backflow pipeline and barrel is changed to bottom, to realize the effect that Buffer liquid and phospholipid bilayer sphere are fully mixed, solve the problem that both are not mixed sufficiently in prior art, improve phospholipid bilayer sphere outer phase water replacement efficiency.

Description

Technical Field

[0001] This utility model relates to the field of ultrafiltration system technology, and in particular to an ultrafiltration device. Background Technology

[0002] An ultrafiltration device is mainly used in ultrafiltration systems that require replacement of the external phase water of phospholipid spheres. It belongs to the field of ultrafiltration system technology, and particularly relates to the improvement of the feed liquid structure of ultrafiltration systems. In biopharmaceutical and other fields, phospholipid molecules form phospholipid sphere structures with hydrophilic heads and lipophilic tails after hydration treatment. The composition of the external phase water has a significant impact on the effect of subsequent processes, and it is often necessary to replace the external phase water with a specific liquid (such as buffer). The core function of this ultrafiltration device is to achieve efficient and precise replacement of the external phase water of phospholipid spheres by optimizing the feed liquid and filtration structure, so as to meet the requirements of material purity and processing efficiency in related fields.

[0003] In existing technologies, ultrafiltration devices used in similar liquid replacement scenarios typically include mechanical structures such as inlet pipes, ultrafiltration pipes, material cylinders, and filter components. Their technical principle is based on the separation characteristics of semi-permeable membranes. Small molecules are separated by the filter screen in the ultrafiltration pipe (which can retain substances with a specific molecular weight or higher, such as phospholipid spheres). At the same time, the target liquid (such as buffer) is continuously replenished through the inlet device, gradually achieving the replacement of the external phase water. The entire process relies on the liquid's own flow dynamics and a simple container storage structure, and the replacement operation is completed through the continuous cycle of inlet and filtration.

[0004] However, ultrafiltration devices suffer from significant deficiencies in the mixing process when replacing the external phase water with phospholipid spheres. In traditional structures, the buffer liquid and the material containing phospholipid spheres often only come into contact through simple pipeline transport or natural flow, lacking a dedicated premixing structure. This results in uneven initial mixing, requiring a longer time to achieve full integration. Furthermore, the layout design of the stirring device is inadequate, making it difficult for the material and buffer liquid to quickly contact the stirring components after entering the container, further prolonging the mixing cycle. This not only reduces the efficiency of external phase water replacement but also leads to variations in replacement effects due to insufficient local mixing, impacting the stability and consistency of the final product. This problem of untimely and insufficient mixing causes the entire ultrafiltration process to consume more buffer liquid and incur higher time costs, making it difficult to meet the requirements for efficient and precise treatment. Therefore, this paper proposes an ultrafiltration device to address these issues. Utility Model Content

[0005] To overcome the above shortcomings, this utility model provides an ultrafiltration device, which aims to improve the problem of insufficient mixing and low efficiency of the buffer liquid and phospholipid bilayer when replacing the water phase of phospholipid spheres in the prior art.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: an ultrafiltration device, comprising: a support frame, wherein multiple connecting barrels are fixedly connected inside the support frame, and multiple reflux pipes are provided inside the multiple connecting barrels; and a reflux mixing component is provided inside the support frame. The reflux mixing assembly includes a barrel, the outer wall of which is fixedly connected to the side wall of the support. A magnetic flux stirrer is installed inside the barrel. One end of one of the reflux pipes is fixedly connected to a static mixer, the bottom end of which is fixedly connected to one end of another reflux pipe. One end of the other reflux pipe is fixedly connected to the inside of the barrel. One side of one of the reflux pipes is fixedly connected to a feed inlet. A connecting pipe is fixedly connected inside the barrel, and a connecting assembly is installed on the outer wall of the connecting pipe.

[0007] The above technical solutions have achieved the effect of improving material mixing efficiency.

[0008] Preferably, the connecting assembly includes a first connecting ring and a second connecting ring, both of which are slidably connected to the outer wall of the connecting pipe.

[0009] The above technical solution achieves the effect of facilitating the connection between the pipe and the return pipe.

[0010] Preferably, a sealing ring is fixedly connected to the inner wall of the second connecting ring, and the sealing ring is in contact with the connection between the connecting pipe and one of the return pipes.

[0011] The above technical solution achieves a sealing effect.

[0012] Preferably, the outer wall of the connecting ring is fixedly connected with symmetrical limiting blocks, and each of the limiting blocks has a limiting groove inside.

[0013] The above technical solution achieves the effect of facilitating the initial connection of the limit switch by the user.

[0014] Preferably, the outer wall of the connecting ring is fixedly connected with symmetrical support blocks, and each of the support blocks is fixedly connected with a support rod.

[0015] The above technical solution achieves the effect of ensuring a stable connection.

[0016] Preferably, each of the multiple support rods is fixedly connected to a connecting plate inside, and each of the multiple connecting plates is provided with symmetrical springs on its sidewalls.

[0017] The above technical solution achieves the effect of providing elastic support for the connecting components.

[0018] Preferably, one end of each of the multiple springs is fixedly connected to the side wall of the connecting plate, the other end of each of the multiple springs is fixedly connected to a rubber block, one side of each of the multiple rubber blocks is fixedly connected to a fixing block, and the multiple rubber blocks are slidably connected inside the support rod.

[0019] The above technical solution achieves the reset effect of the connecting components.

[0020] Preferably, each of the multiple fixed blocks has a limiting rod fixedly connected to its upper surface, and each of the multiple limiting rods has a limiting post fixedly connected inside its interior. The multiple limiting posts and the limiting rods are engaged with the limiting grooves.

[0021] The above technical solution achieves a stable locking effect.

[0022] This utility model has the following beneficial effects: 1. In this utility model, a static mixer is set between the return pipe and the material cylinder to achieve pre-mixing of the buffer liquid and the material. At the same time, a magnetic flow stirrer is added inside the material cylinder, and the interface between the return pipe and the material cylinder is moved to the bottom, so that the material and the buffer liquid come into contact with the stirring components earlier. This achieves the effect of thorough mixing of the buffer liquid and the phospholipid bimolecular spheres, solves the problem of insufficient mixing in the prior art, and improves the external phase water replacement efficiency of the phospholipid bimolecular spheres.

[0023] 2. In this utility model, the rubber block is pressed to drive the fixed block to move, and then the limiting post is inserted into the limiting block. The pressing force on the rubber block is released, and the elastic restoring force of the spring pushes the limiting post into the limiting groove to achieve locking. The sealing ring can ensure the connection is sealed, thereby achieving the effect of quick pipe connection. This solves the problems of time-consuming, labor-intensive and cumbersome operation of traditional pipe connection, and improves the efficiency of pipe installation and disassembly. Attached Figure Description

[0024] Figure 1 This is a three-dimensional schematic diagram of an ultrafiltration device proposed in this utility model; Figure 2 This is a schematic diagram of the structure of a support for an ultrafiltration device proposed in this utility model; Figure 3 This is a schematic diagram of the internal structure of the support frame of the ultrafiltration device proposed in this utility model; Figure 4 This is a schematic diagram of the connecting ring of an ultrafiltration device proposed in this utility model; Figure 5 This is a schematic diagram of the material cylinder of an ultrafiltration device proposed in this utility model; Figure 6 for Figure 5 Enlarged view of point A in the middle; Explanation of reference numerals in the attached drawings: 1. Support; 2. Connecting barrel; 3. Return pipe; 4. Material cylinder; 5. Magnetorheological stirrer; 6. Static mixer; 7. Feed inlet; 8. Connecting pipe; 9. Connecting ring one; 10. Connecting ring two; 11. Sealing ring; 12. Limiting block; 13. Limiting groove; 14. Support block; 15. Support rod; 16. Connecting plate; 17. Spring; 18. Rubber block; 19. Fixing block; 20. Limiting rod; 21. Limiting post. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0026] Reference Figure 1 - Figure 4 The present invention provides an embodiment of an ultrafiltration device, including a support 1. The support 1 has an overall frame structure, which provides stable support for the various components of the device. Multiple connecting tanks 2 are fixedly connected inside the support 1. Multiple reflux pipes 3 are provided inside the multiple connecting tanks 2. These reflux pipes 3 are reasonably distributed inside the connecting tanks 2. The pipes achieve smooth flow and diversion of liquid through a specific layout. A reflux mixing component is provided inside the support 1. The reflux mixing assembly includes a cylinder 4, which is a hollow cylindrical structure. Its outer wall is fixedly connected to the side wall of the support 1 via bolts or other connectors to ensure that the cylinder 4 does not shake during operation. A magnetic flux stirrer 5 is installed inside the cylinder 4. The stirring blades of the magnetic flux stirrer 5 can rotate 360 ​​degrees inside the cylinder 4 to thoroughly mix the material entering the cylinder 4. A static mixer 6 is fixedly connected to one end of a reflux pipe 3 for static mixing. The interior of the mixer 6 is equipped with multiple sets of staggered guide vanes, which can effectively mix the incoming liquid. The bottom of the static mixer 6 is fixedly connected to one end of another return pipe 3, and one end of the other return pipe 3 is fixedly connected to the inside of the material cylinder 4. One side of one of the return pipes 3 is fixedly connected to the feed inlet 7, which is funnel-shaped to facilitate the introduction of the material to be processed. The inside of the material cylinder 4 is fixedly connected to the connecting pipe 8, and the outer wall of the connecting pipe 8 is provided with a connecting component to achieve a stable connection between the connecting pipe 8 and other pipes. Reference Figure 5 and Figure 6The connecting assembly includes a first connecting ring 9 and a second connecting ring 10. Both the first connecting ring 9 and the second connecting ring 10 are annular structures. They are sleeved on the outer wall of the connecting pipe 8 and can slide along the axial direction of the connecting pipe 8. The first connecting ring 9 and the second connecting ring 10 are slidably connected to the outer wall of the connecting pipe 8. A sealing ring 11 is fixedly connected to the inner wall of the second connecting ring 10. The sealing ring 11 is annular. When the connecting pipe 8 is connected to one of the return pipes 3, the sealing ring 11 can fit tightly against the connection between the connecting pipe 8 and the return pipe 3, thereby effectively preventing liquid leakage. The sealing ring 11 fits against the connection between the connecting pipe 8 and one of the return pipes 3. The outer wall of the connecting ring 19 is fixedly connected with symmetrical limiting blocks 12. The limiting blocks 12 are block-shaped and extend outward from the connecting ring 19. Each limiting block 12 has a limiting groove 13 inside. The shape of the limiting groove 13 is adapted to the subsequent locking component to achieve quick locking and unlocking. The outer wall of the connecting ring 20 is fixedly connected with symmetrical support blocks 14. Each support block 14 has a support rod 15 fixedly connected inside. Each support rod 15 has a connecting plate 16 fixedly connected inside. Each connecting plate 16 has a symmetrical spring 17 on its side wall. One end of each spring 17 is fixedly connected to the side wall of the connecting plate 16, and the other end of each spring 17 is fixedly connected to a rubber block 18. The rubber block 18 has a certain elasticity and can deform under force, thereby providing comfortable operating conditions for the user. Each of the multiple rubber blocks 18 has a fixed block 19 fixedly connected to one side. The multiple rubber blocks 18 are slidably connected inside the support rod 15. Each of the multiple fixed blocks 19 has a limit rod 20 fixedly connected to its upper surface. Each of the multiple limit rods 20 has a limit post 21 fixedly connected inside its interior. The limit post 21 is set perpendicular to the limit rod 20 and extends to one side of the limit rod 20. The multiple limit posts 21 and the limit rods 20 can engage with the limit groove 13, thereby firmly connecting the connecting ring 1 9 and the connecting ring 2 10 together, thus realizing a reliable connection between the connecting pipe 8 and the return pipe 3. The multiple limit posts 21 and the limit rods 20 are all engaged with the limit groove 13.

[0027] Working Principle: When using this ultrafiltration device, the material containing phospholipid molecular spheres to be treated first enters through the inlet 7 and is conveyed to the static mixer 6 through the return pipe 3. Initial mixing occurs in the static mixer 6. After mixing, the material is further guided into the material cylinder 4 through the return pipe 3. Once inside the material cylinder 4, the magnetic flux stirrer 5 is activated to thoroughly stir the mixture, further fusing the phospholipid molecular spheres with the buffer liquid, achieving efficient replacement of the external phase water. The mixed and replaced material can be discharged through a preset path, thus completing the efficient replacement of the external phase water with the phospholipid molecular spheres. When the user needs to quickly connect the pipes, the sealing ring 11 is first passed through the outer wall of the connecting pipe 8. Then, align the connecting pipe 8 with the return pipe 3. After alignment, press the rubber block 18 to make it slide inside the support rod 15, thereby squeezing the spring 17 and causing the spring 17 to deform elastically. While the rubber block 18 is moving, it will also drive the fixing block 19 to move synchronously. After the fixing block 19 moves, the user will press the connecting ring 19 and the connecting ring 20 together, thereby driving the fixing block 19 to insert into the limiting groove 13. Then, release the pressing force of the rubber block 18, and the elastic restoring force of the spring 17 will push the limiting rod 20 into the limiting groove 13. The groove of the limiting rod 20 and the limiting post 21 will cooperate to achieve quick locking, which will facilitate the user to connect the pipe. The sealing ring 11 can ensure the sealing of the pipe connection.

Claims

1. An ultrafiltration device, comprising a support (1), characterized in that: The bracket (1) is fixedly connected to multiple connecting barrels (2), and multiple reflux pipes (3) are provided inside each of the multiple connecting barrels (2). The bracket (1) is provided with a reflux mixing component. The reflux mixing assembly includes a barrel (4), the outer wall of which is fixedly connected to the side wall of the support (1). A magnetic flow stirrer (5) is provided inside the barrel (4). One end of one of the reflux pipes (3) is fixedly connected to a static mixer (6). The bottom end of the static mixer (6) is fixedly connected to one end of another reflux pipe (3). One end of the other reflux pipe (3) is fixedly connected to the inside of the barrel (4). One side of one of the reflux pipes (3) is fixedly connected to a feed inlet (7). A connecting pipe (8) is fixedly connected inside the barrel (4). A connecting assembly is provided on the outer wall of the connecting pipe (8).

2. The ultrafiltration device according to claim 1, characterized in that: The connecting assembly includes a first connecting ring (9) and a second connecting ring (10), both of which are slidably connected to the outer wall of the connecting tube (8).

3. The ultrafiltration device according to claim 2, characterized in that: A sealing ring (11) is fixedly connected to the inner wall of the second connecting ring (10), and the sealing ring (11) is in contact with the connection between the connecting pipe (8) and one of the return pipes (3).

4. The ultrafiltration device according to claim 3, characterized in that: The outer wall of the connecting ring (9) is fixedly connected with left and right symmetrical limiting blocks (12), and each of the limiting blocks (12) has a limiting groove (13) inside.

5. The ultrafiltration device according to claim 4, characterized in that: The outer wall of the connecting ring 2 (10) is fixedly connected with symmetrical support blocks (14), and each of the support blocks (14) is fixedly connected with a support rod (15).

6. The ultrafiltration device according to claim 5, characterized in that: Each of the multiple support rods (15) is fixedly connected to a connecting plate (16), and each of the multiple connecting plates (16) is provided with a symmetrical spring (17) on its side wall.

7. An ultrafiltration device according to claim 6, characterized in that: One end of each of the multiple springs (17) is fixedly connected to the side wall of the connecting plate (16), and the other end of each of the multiple springs (17) is fixedly connected to a rubber block (18). One side of each of the multiple rubber blocks (18) is fixedly connected to a fixing block (19), and the multiple rubber blocks (18) are slidably connected inside the support rod (15).

8. An ultrafiltration device according to claim 7, characterized in that: Each of the fixed blocks (19) has a limiting rod (20) fixedly connected to its upper surface, and each of the limiting rods (20) has a limiting post (21) fixedly connected inside its interior. Each of the limiting posts (21) and the limiting rods (20) engages with the limiting groove (13).

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