A rotary evaporator device for the preparation of intermediates

Abstract

The utility model discloses a kind of rotary evaporator of intermediate preparation, it is related to medical instrument technical field, including base.The utility model in which, through the setting of two liquid level sensors, when the liquid level in first recess reaches the liquid level sensor height located below, the liquid level sensor located below sends signal to controller at this time, controller controls motor start, motor start makes rotating screw rod rotate, and then make screw rod cover and L-shaped rod move downwards, L-shaped rod moves and drives rectangular sealing plate to move downwards, rectangular sealing plate moves and extrudes water in second recess to make it enter first recess through water inlet hole, so that the liquid level in first recess reaches the liquid level sensor located above, the liquid level sensor located above sends signal to controller at this time, controller controls motor to close, to achieve the automatic water replenishment of first recess, and the water of supplement and the water temperature in first recess are same, and heating effect of evaporating flask is not affected.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, and in particular to a rotary evaporation apparatus for preparing intermediates. Background Technology

[0002] In the final stage of pharmaceutical intermediate preparation, the crude pharmaceutical intermediate needs to be purified to remove intermediate reagents and obtain a higher purity pharmaceutical intermediate end product. The purification of pharmaceutical intermediates requires the use of a rotary evaporator, a commonly used laboratory evaporation instrument, mainly used for continuous distillation of volatile solvents under reduced pressure. It consists of a motor, distillation flask, heating pot, condenser, etc. The core components of the rotary evaporator are the distillation flask and the heating pot. The working principle of the rotary evaporator is to use the heat exchange between the liquid film inside the high-speed rotating cylinder and the outside to evaporate the solution, solvent, etc. in the liquid.

[0003] In the prior art, CN216677022U discloses a rotary evaporator for purifying pharmaceutical intermediates. Although it can raise the liquid level in the heating pot, it requires manual observation and cannot be automatically adjusted. Furthermore, it is adjusted by an upward-moving liquid level pusher, which is inconvenient for heating the heating pot. This utility model discloses a rotary evaporation device for intermediate preparation to solve the above problems. Summary of the Invention

[0004] The purpose of this application is to provide a rotary evaporation apparatus for preparing intermediates, so as to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this application provides the following technical solution: a rotary evaporation apparatus for intermediate preparation, comprising a base, an evaporator body mounted on the top of the base, a heater fixedly mounted on the top of the base, a heating pot mounted on the top of the heater, partitions fixedly mounted on the inner walls of the heating pot on three sides, a water inlet hole opened at the bottom of the partition, and the partition dividing the heating pot into a first groove and a second groove, wherein the first groove corresponds to the position of the evaporator body; A rectangular sealing plate is slidably installed on the four inner walls of the second groove, and a moving mechanism is installed on the side of the base, the moving mechanism being connected to the rectangular sealing plate; A sealing mechanism is installed on the base, and the sealing mechanism corresponds to the position of the evaporator body and the first groove.

[0006] Preferably, the moving mechanism includes a mounting plate fixedly installed on the side of the base, a motor fixedly installed at the bottom of the mounting plate, the output shaft of the motor passing through the top of the mounting plate and fixedly installed with a rotating lead screw, a lead screw sleeve threaded onto the rotating lead screw, an L-shaped rod fixedly installed on the side of the lead screw sleeve, and the bottom end of the L-shaped rod fixedly installed on the top of the rectangular sealing plate.

[0007] Preferably, a guide rod is fixedly installed on the top of the base, and the horizontal side of the L-shaped rod is slidably sleeved on the guide rod.

[0008] Preferably, two liquid level sensors are fixedly installed on the side of the partition, and the two liquid level sensors are located in the first groove.

[0009] Preferably, a controller is fixedly installed on the side of the base, and the controller is connected to the two liquid level sensors and the motor.

[0010] Preferably, the bottom of the base is provided with a clearance groove, and two electric telescopic rods are fixedly installed on the inner wall of the top side of the clearance groove. U-shaped rods are fixedly installed on the movable ends of the two electric telescopic rods, and half-boxes are fixedly installed on the top ends of the two U-shaped rods. The two half-boxes correspond to the positions of the first groove, and semi-circular holes are provided on the inner walls of the two half-boxes.

[0011] In summary, the technical effects and advantages of this utility model are as follows: In this invention, by setting two liquid level sensors, when the liquid level in the first groove reaches the height of the lower liquid level sensor, the lower liquid level sensor sends a signal to the controller. The controller then starts the motor, which causes the rotating screw to rotate, thereby causing the screw sleeve and L-shaped rod to move downwards. The movement of the L-shaped rod causes the rectangular sealing plate to move downwards, and the rectangular sealing plate squeezes the water in the second groove, forcing it to enter the first groove through the water inlet. This causes the liquid level in the first groove to reach the upper liquid level sensor, at which point the upper liquid level sensor sends a signal to the controller, which then stops the motor. This achieves automatic water replenishment of the first groove, and the replenished water is at the same temperature as the water in the first groove, so it does not affect the heating effect of the evaporation flask.

[0012] In this invention, the two electric telescopic rods allow the two U-shaped rods to move closer together, thereby bringing the two half-boxes closer together and covering the top of the first groove, which facilitates heating of the evaporation flask. Attached Figure Description

[0013] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0014] Figure 1 This is a first-view perspective three-dimensional structural diagram of an embodiment of this application; Figure 2 This is a second-view perspective three-dimensional structural diagram of an embodiment of this application; Figure 3 for Figure 1 Enlarged view of point A in the middle; Figure 4 This is a third-view stereoscopic structural diagram of an embodiment of this application.

[0015] In the diagram: 1. Base; 2. Evaporator body; 3. Controller; 4. Heater; 5. Heating pot; 6. Evaporation flask; 7. Mounting plate; 8. Rotating lead screw; 9. Lead screw sleeve; 10. L-shaped rod; 11. Guide rod; 12. U-shaped rod; 13. Electric telescopic rod; 14. Motor; 15. Partition plate; 16. Water inlet; 17. Liquid level sensor; 18. Rectangular sealing plate; 19. Half-box; 20. Semi-circular hole; 21. Connecting pipe. Detailed Implementation

[0016] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0017] Example: Reference Figures 1-4 The rotary evaporator for intermediate preparation shown includes a base 1, an evaporator body 2 mounted on the top of the base 1, and a heater 4 fixedly mounted on the top of the base 1. The heater 4 is a prior art device used to heat a heating pot 5, and is the same as the heating module in prior art announcement number CN222657792U. The heating pot 5 is mounted on the top of the heater 4, and partitions 15 are fixedly mounted on the inner walls of the three sides of the heating pot 5. A water inlet hole 16 is opened at the bottom of the partition 15. The partition 15 divides the heating pot 5 into a first groove and a second groove. The water inlet hole 16 is used to connect the first groove and the second groove. The first groove corresponds to the position of the evaporator body 2. A rectangular sealing plate 18 is slidably installed on the inner walls of the four sides of the second groove. The rectangular sealing plate 18 is composed of a rectangular plate and a frame-shaped sealing gasket, which can seal the top of the second groove. When heating, the second groove is sealed by the rectangular sealing plate 18, so that the water level in the second groove does not change. A moving mechanism is installed on the side of the base 1, and the moving mechanism is connected to the rectangular sealing plate 18. A sealing mechanism is installed on the base 1, and the sealing mechanism corresponds to the position of the evaporator body 2 and the first groove; The evaporator body 2 includes an evaporator flask position adjustment structure, an evaporator flask rotation control structure, a buffer flask, a heat exchange tube, a condenser tube, a collection flask, a connecting tube 21, and an evaporator flask 6. This is existing technology. For specific connection methods, please refer to the connection method of the heating pot, evaporator flask position adjustment structure, evaporator flask rotation control structure, evaporator flask, buffer flask, heat exchange tube, condenser tube, and collection flask in a rotary evaporator for the purification of pharmaceutical intermediates disclosed in prior art announcement number CN216677022U. The connecting tube 21 corresponds to the position of the two semi-circular holes 20, and the evaporator flask 6 is located in the first groove.

[0018] The moving mechanism includes a mounting plate 7 fixedly installed on the side of the base 1. A motor 14 is fixedly installed on the bottom of the mounting plate 7. The output shaft of the motor 14 passes through the top of the mounting plate 7 and is fixedly installed on a rotating lead screw 8. A lead screw sleeve 9 is threaded onto the rotating lead screw 8. An L-shaped rod 10 is fixedly installed on the side of the lead screw sleeve 9. The bottom end of the L-shaped rod 10 is fixedly installed on the top of the rectangular sealing plate 18.

[0019] Two liquid level sensors 17 are fixedly installed on the side of the partition 15, and the two liquid level sensors 17 are located in the first groove; a controller 3 is fixedly installed on the side of the base 1, and the controller 3 is connected to the two liquid level sensors 17 and the motor 14.

[0020] With the above structure, by setting two liquid level sensors 17, when the liquid level in the first groove reaches the height of the lower liquid level sensor 17, the lower liquid level sensor 17 sends a signal to the controller 3. The controller 3 controls the motor 14 to start. The motor 14 causes the rotating screw 8 to rotate, which in turn causes the screw sleeve 9 and the L-shaped rod 10 to move downward. The movement of the L-shaped rod 10 drives the rectangular sealing plate 18 to move downward. The movement of the rectangular sealing plate 18 squeezes the water in the second groove, causing it to enter the first groove through the water inlet 16. This causes the liquid level in the first groove to reach the upper liquid level sensor 17. At this time, the upper liquid level sensor 17 sends a signal to the controller 3. The controller 3 controls the motor 14 to turn off, thus realizing the automatic water replenishment of the first groove. Moreover, the replenished water has the same temperature as the water in the first groove and will not affect the heating effect of the evaporation bottle 6.

[0021] like Figure 2As shown, a guide rod 11 is fixedly installed on the top of the base 1, and the horizontal side of the L-shaped rod 10 is slidably sleeved on the guide rod 11. The guide rod 11 guides the L-shaped rod 10, allowing it to move only up and down.

[0022] like Figure 2 and Figure 4 As shown, a clearance groove is provided at the bottom of the base 1. Two electric telescopic rods 13 are fixedly installed on the inner wall of the top side of the clearance groove. U-shaped rods 12 are fixedly installed at the movable ends of the two electric telescopic rods 13. Half-boxes 19 are fixedly installed at the top of each of the two U-shaped rods 12. The two half-boxes 19 correspond to the position of the first groove. After the two half-boxes 19 are brought close together, they form a whole box. The box is transparent for easy observation by the user. Semi-circular holes 20 are provided on the inner walls of the two half-boxes 19. The two electric telescopic rods 13 allow the two U-shaped rods 12 to move closer together, thereby bringing the two half-boxes 19 closer together and covering the top of the first groove, which facilitates the heating of the evaporation flask 6.

[0023] The working principle of this practical application is as follows: In use, the drug intermediate is located in the evaporation flask 6. Water is placed in the heating pot 5 and heated by the heater 4, thereby heating the drug intermediate in the evaporation flask 6 in a water bath. The two electric telescopic rods 13 can bring the two U-shaped rods 12 closer together, thereby bringing the two half-boxes 19 closer together, thus covering the top of the first groove, which facilitates the heating of the evaporation flask 6. By setting two liquid level sensors 17, when the liquid level in the first groove reaches the height of the lower liquid level sensor 17, the lower liquid level sensor 17 sends a signal to the controller 3. The controller 3 controls the motor 14 to start, and the motor 14 causes the rotating screw 8 to rotate, which in turn causes the screw sleeve 9 and the L-shaped rod 10 to move downward. The movement of the L-shaped rod 10 causes the rectangular sealing plate 18 to move downward. The movement of the rectangular sealing plate 18 squeezes the water in the second groove, causing it to enter the first groove through the water inlet 16. This causes the liquid level in the first groove to reach the upper liquid level sensor 17. At this time, the upper liquid level sensor 17 sends a signal to the controller 3, and the controller 3 controls the motor 14 to turn off, thus realizing the automatic water replenishment of the first groove. Moreover, the replenished water has the same temperature as the water in the first groove and will not affect the heating effect of the evaporation bottle 6.

[0024] Finally, it should be noted that the above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A rotary evaporator for intermediate preparation, comprising a base (1), wherein an evaporator body (2) is mounted on the top of the base (1), characterized in that: A heater (4) is fixedly installed on the top of the base (1), and a heating pot (5) is installed on the top of the heater (4). A partition (15) is fixedly installed on the inner walls of the three sides of the heating pot (5). A water inlet hole (16) is opened at the bottom of the partition (15). The partition (15) divides the heating pot (5) into a first groove and a second groove. The first groove corresponds to the position of the evaporator body (2). A rectangular sealing plate (18) is slidably installed on the inner walls of the four sides of the second groove. A moving mechanism is installed on the side of the base (1), and the moving mechanism is connected to the rectangular sealing plate (18). A sealing mechanism is installed on the base (1), and the sealing mechanism corresponds to the position of the evaporator body (2) and the first groove.

2. The rotary evaporation apparatus for preparing intermediates according to claim 1, characterized in that: The moving mechanism includes a mounting plate (7) fixedly installed on the side of the base (1). A motor (14) is fixedly installed on the bottom of the mounting plate (7). The output shaft of the motor (14) passes through the top of the mounting plate (7) and is fixedly installed with a rotating lead screw (8). A lead screw sleeve (9) is threaded onto the rotating lead screw (8). An L-shaped rod (10) is fixedly installed on the side of the lead screw sleeve (9). The bottom end of the L-shaped rod (10) is fixedly installed on the top of the rectangular sealing plate (18).

3. The rotary evaporation apparatus for intermediate preparation according to claim 2, characterized in that: A guide rod (11) is fixedly installed on the top of the base (1), and the horizontal side of the L-shaped rod (10) is slidably sleeved on the guide rod (11).

4. The rotary evaporation apparatus for preparing intermediates according to claim 2, characterized in that: Two liquid level sensors (17) are fixedly installed on the side of the partition (15), and the two liquid level sensors (17) are located in the first groove.

5. The rotary evaporation apparatus for preparing an intermediate according to claim 4, characterized in that: A controller (3) is fixedly installed on the side of the base (1), and the controller (3) is connected to the two liquid level sensors (17) and the motor (14).

6. The rotary evaporation apparatus for preparing intermediates according to claim 1, characterized in that: The bottom of the base (1) is provided with a clearance groove. Two electric telescopic rods (13) are fixedly installed on the inner wall of the top side of the clearance groove. U-shaped rods (12) are fixedly installed on the movable ends of the two electric telescopic rods (13). Half-boxes (19) are fixedly installed on the top of the two U-shaped rods (12). The two half-boxes (19) correspond to the position of the first groove. Semi-circular holes (20) are provided on the inner walls of the two half-boxes (19).

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