An automated detection device for disease markers

Abstract

The utility model belongs to the field of marker detection, especially a kind of disease marker automation detection device, the existing device cannot be realized to the quick clamping and release of needle tube, realize the fixed effect of absolute stability, lead to the problem of low detection efficiency and the stability of detection result is poor, present and propose the following scheme, it includes case, the side of case is inlaid with touch screen and is arranged, the inside of case is fixed with mounting bracket by screw;Clamping mechanism is provided on the mounting bracket, and the clamping mechanism is used to clamp and fix the needle tube loaded with blood sample.The utility model in the quick clamping and release of needle tube loaded with blood sample are realized by the setting of clamping mechanism, improve operating efficiency, also realize the stable clamping and fixing of needle tube, ensure that there is no movement or drop during detection process, so as to guarantee the efficiency and stability of detection.

Description

Technical Field

[0001] This utility model relates to the field of biomarker detection technology, and in particular to an automated detection device for disease biomarkers. Background Technology

[0002] Disease biomarker detection devices are important tools used to detect disease biomarkers to assist in disease diagnosis, assess disease condition, and monitor treatment efficacy. They identify abnormally concentrated biomolecules such as proteins, nucleic acids, and hormones in a patient's body fluids and use technologies such as chemiluminescence immunoassay, electrochemistry, and photoelectrochemistry to convert biomolecular signals into measurable electrical or optical signals, enabling rapid, accurate, and sensitive detection of disease biomarkers.

[0003] Currently, existing disease biomarker detection devices typically require manual clamping of the needle containing the blood sample during sample processing. While this provides some initial fixation of the needle for testing, it lacks the ability to quickly and automatically clamp and release the needle. The operation is manual, inefficient, and susceptible to human error. Furthermore, it is difficult to guarantee an absolutely stable fixation of the needle during testing, leading to needle movement or detachment, resulting in low testing efficiency and unstable test results. Utility Model Content

[0004] The purpose of this invention is to address the shortcomings of existing technologies, such as the inability to quickly clamp and release needles to achieve a secure fixation, resulting in low detection efficiency and poor stability of detection results. Therefore, this invention proposes an automated detection device for disease biomarkers.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] An automated detection device for disease biomarkers, comprising:

[0007] A chassis, wherein a touch screen is embedded on one side of the chassis, and a mounting bracket is fixed inside the chassis by screws;

[0008] The mounting bracket is equipped with a clamping mechanism for clamping and fixing the needle containing the blood sample.

[0009] In one possible design, the clamping mechanism includes a bracket fixedly mounted on one side of the mounting frame, a connecting plate fixedly mounted at the bottom of the bracket, fixing frames fixedly mounted on both sides of the connecting plate, clamping arms rotatably mounted on the inner sides of the two fixing frames, clamping frames fixedly mounted at the front ends of the two clamping arms, a double-headed cylinder fixedly mounted on the rear side of the connecting plate, the two output ends of the double-headed cylinder being hinged to the rear ends of the clamping arms respectively, and a switch being mounted at the bottom of the connecting plate.

[0010] In one possible design, a pressure block is slidably disposed on one side of the bracket, and a pressing cylinder is embedded in the top of the bracket, with the output end of the pressing cylinder being fixedly connected to the pressure block.

[0011] In one possible design, a liquid storage tank is fixedly installed on one side of the mounting bracket next to the support. A three-way pipe is fixedly connected to the bottom of the liquid storage tank. The other two ends of the three-way pipe are respectively plugged with caps. An inlet is fixedly connected to the top of the liquid storage tank, and a cap is provided on the inlet.

[0012] In one possible design, a detection head is provided on one side of the mounting bracket next to the liquid storage tank, and a detection platform is fixedly provided on the top of the mounting bracket, with the detection window of the detection platform located directly below the detection head.

[0013] In one possible design, the inlet of the testing station is fixedly connected to two liquid inlet pipes, the outlet of the testing station is fixedly connected to a suction pipe, a peristaltic pump is fixedly installed on the top of the mounting frame next to the testing station, the input end of the peristaltic pump is fixedly connected to the suction pipe, the output end of the peristaltic pump is fixedly connected to a delivery pipe, a waste liquid bottle is placed on the testing station next to the peristaltic pump, and the delivery pipe is fixedly connected to the top cover of the waste liquid bottle.

[0014] In one possible design, a cover is hinged to one side opening of the chassis, and hydraulic rods are hinged to both sides of the bottom of the cover. The piston ends of the two hydraulic rods are respectively hinged to the inner walls of the chassis, and a handle is provided on one side of the cover.

[0015] In this application, when starting to use the device, first place it stably on the experimental table, ensuring that there are no obstructions around the device to facilitate operation and heat dissipation. Then connect all the electric and pneumatic components on the device to the power and air supply to ensure that the device can work normally. Then, lift the lid upwards using the handle on one side of the lid. The hydraulic rod will automatically extend to support the lid and keep it in the open state for easy subsequent operation.

[0016] Next, remove the syringe containing the blood sample and check that it is intact and leak-free. Connect the two inlet tubes on the testing platform to the outlet of the syringe and the bottom of the three-way valve on the reservoir, respectively, ensuring a tight connection without leakage. Then, place the syringe containing the blood sample between the two clamps and press the switch at the bottom of the connecting plate to start the double-headed cylinder. The output ends on both sides of the double-headed cylinder extend synchronously, pushing the rear ends of the two clamping arms to move away from each other around the connection point of the fixing frame. When the rear ends of the two clamping arms move away from each other, the front ends of the two clamping arms and the clamping frames on them move towards each other, clamping and fixing the syringe to ensure that it will not move or fall off during the testing process. Then, add an appropriate amount of sheath fluid into the reservoir through the inlet at the top of the reservoir. After adding, close the cap on the inlet to prevent sheath fluid leakage. The preparation work is now complete.

[0017] Then, gently lower the lid. The hydraulic rod retracts automatically, smoothly closing the lid. The touchscreen controls the downward-pressing cylinder, extending its output end to push the pressure block down. During this downward movement, the pressure block presses against the connecting rod on the syringe, causing it to move downwards. As the connecting rod moves downwards, it moves the piston inside the syringe downwards, delivering the blood sample through the inlet tube to the testing station. Meanwhile, the sheath fluid also flows into the testing station by gravity. Both the blood sample and the sheath fluid enter the testing station through the inlet tube and flow at their respective speeds into the microfluidic core at the testing window. Inside the device, the sheath fluid flow carries cells or particles from the blood sample into the laser irradiation area (detection window or detection zone). When the liquid is irradiated by blue excitation light, it produces green fluorescence. This fluorescence is collected by a photodiode after passing through a slit and filter inside the detection head, and is converted into a current signal. The current signal is converted into a voltage signal by an I / V circuit. This voltage signal is filtered and amplified before being collected by an A / D converter. Finally, it is sent to the ARM board for signal judgment and then displayed on a touch screen. The testing personnel can view the test results through the touch screen, including the concentration of disease markers and whether there are any abnormalities.

[0018] After the test is completed, open the lid and press the switch below the connecting plate to retract the output ends on both sides of the double-headed cylinder. This will move the clamping arm and clamping frame to the opposite side to release the syringe. Then, remove one of the inlet tubes from the syringe. Next, remove the other plug on the three-way pipe and install the inlet tube removed from the syringe onto it. Then, add cleaning fluid into the storage tank through the inlet. Then, start the peristaltic pump. The input end of the peristaltic pump will draw fluid into the test platform through the suction pipe. During the suction process, the pump will generate suction on the two inlet tubes at the inlet of the test platform, causing the two inlet tubes to draw out the cleaning fluid from the storage tank. The drawn-out cleaning fluid will clean the flow path of the liquid until it is drawn into the suction pipe. Then, the peristaltic pump will transport the cleaned cleaning fluid to the waste bottle for collection through the delivery pipe.

[0019] This utility model has the following beneficial effects:

[0020] The present invention utilizes a clamping mechanism to achieve rapid clamping and release of the needle containing the blood sample, improving operational efficiency. It also ensures stable clamping and fixation of the needle, preventing it from moving or falling off during the testing process, thereby guaranteeing the efficiency and stability of the testing. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the overall structure of an automated detection device for disease biomarkers proposed in this utility model;

[0022] Figure 2 This is a schematic diagram of the opening structure of the lid of an automated detection device for disease biomarkers proposed in this utility model;

[0023] Figure 3 This is a schematic diagram of the mounting frame structure of an automated detection device for disease biomarkers proposed in this utility model.

[0024] Figure 4 This is an enlarged structural diagram of part A of an automated detection device for disease biomarkers proposed in this utility model.

[0025] In the diagram: 1. Chassis; 2. Touchscreen; 3. Mounting bracket; 4. Support; 5. Pressure block; 6. Downward pressure cylinder; 7. Connecting plate; 8. Fixing bracket; 9. Clamping arm; 10. Clamping frame; 11. Double-headed cylinder; 12. Liquid storage tank; 13. T-connector; 14. Plug; 15. Liquid inlet; 16. Detection head; 17. Detection platform; 18. Liquid inlet pipe; 19. Suction pipe; 20. Peristaltic pump; 21. Delivery pipe; 22. Waste liquid bottle; 23. Tank cover; 24. Hydraulic rod. Detailed Implementation

[0026] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0027] In one embodiment

[0028] Reference Figure 1-4 A detection device, comprising:

[0029] The device consists of a chassis 1, a touch screen 2, a mounting bracket 3, and multiple components mounted on the mounting bracket 3. The chassis 1 serves as the main frame of the entire device, with the touch screen 2 embedded on one side for operators to set parameters, control the testing process, and view the test results. The mounting bracket 3 is securely fixed inside the chassis 1 with screws, providing a mounting base for other components.

[0030] The mounting frame 3 is equipped with a clamping mechanism for clamping and fixing the needle containing the blood sample. The clamping mechanism includes a bracket 4 fixedly mounted on one side of the mounting frame 3, a connecting plate 7 fixedly mounted at the bottom of the bracket 4, and fixing frames 8 fixedly mounted on both sides of the connecting plate 7. Clamping arms 9 are rotatably mounted on the inner sides of both fixing frames 8, and clamping frames 10 (the shape of the clamping frames 10 is adapted to the needle, as shown in Figure 4) are fixedly mounted on the front end of both clamping arms 9. A double-headed cylinder 11 is fixedly mounted on the rear side of the connecting plate 7, and the two output ends of the double-headed cylinder 11 are hinged to the rear ends of the clamping arms 9 respectively. A switch is provided at the bottom of the connecting plate 7. When the switch is pressed, the output ends on both sides of the double-headed cylinder 11 extend synchronously, pushing the rear ends of the two clamping arms 9 to move away from each other around the connection point of the fixing frame 8. This causes the front ends of the two clamping arms 9 and the clamping frame 10 on them to move towards each other, thereby clamping and fixing the needle tube. When the switch is pressed again, the output ends on both sides of the double-headed cylinder 11 retract, driving the clamping arms 9 and the clamping frame 10 to move away from each other, releasing the needle tube. The opening and closing of the clamping arms 9 and the clamping frame 10 can clamp needle tubes of different sizes, increasing its flexibility and adaptability.

[0031] A pressure block 5 is slidably mounted on one side of the support 4, and a pressure cylinder 6 is embedded in the top of the support 4. The output end of the pressure cylinder 6 is fixedly connected to the pressure block 5. After the needle is clamped and fixed, the pressure cylinder 6 is controlled to work by the touch screen 2. The output end of the pressure cylinder 6 extends and pushes the pressure block 5 down. During the process of the pressure block 5 pressing down, it presses against the connecting rod on the needle and pushes it to move downward. When the connecting rod moves down, it drives the piston inside the needle to move downward, squeezing out the blood sample inside the needle.

[0032] A liquid storage tank 12 is fixedly installed on one side of the mounting bracket 3 next to the support 4. It is used to store sheath fluid or cleaning fluid. A three-way pipe 13 is fixedly connected to the bottom of the liquid storage tank 12. The other two ends of the three-way pipe 13 are respectively plugged with caps 14. The corresponding caps 14 can be opened or closed as needed to realize the flow or blockage of liquid. A liquid inlet 15 is fixedly connected to the top of the liquid storage tank 12. A cap is provided on the liquid inlet 15. Liquid can be added into the liquid storage tank 12 by opening the cap.

[0033] A detection head 16 is installed on one side of the mounting bracket 3 next to the liquid storage tank 12. The detection head 16 contains modules such as a slit, a filter, and a photodiode. The slit limits the range of light transmission, allowing the light to concentrate on the detection area. The filter filters out unwanted wavelengths, allowing only specific wavelengths of green fluorescence to pass through. The photodiode collects the green fluorescence after it passes through the filter and converts it into an electrical signal. A detection platform 17 is fixedly installed on the top of the mounting bracket 3, and the detection window of the detection platform 17 is located directly below the detection head 16. To ensure that the light emitted from the detection window can accurately illuminate the detection area, the detection stage 17 is equipped with a microfluidic chip. The microfluidic chip has microchannels and microstructures inside, which can accurately control and process blood samples and sheath fluid flow. Two liquid inlet tubes 18 are fixedly connected at the inlet of the detection stage 17, which are used to connect the needle containing the blood sample and the three-way tube 13 on the liquid storage tank 12, respectively, so as to introduce the blood sample and sheath fluid flow into the microfluidic chip. A suction tube 19 is fixedly connected at the outlet of the detection stage 17, which is used to extract the liquid after detection.

[0034] A peristaltic pump 20 is fixedly installed on the top of the mounting frame 3 next to the testing platform 17. The input end of the peristaltic pump 20 is fixedly connected to the suction pipe 19, and the output end is fixedly connected to the delivery pipe 21. The peristaltic pump 20 generates negative pressure by squeezing the hose, which draws out the liquid in the testing platform 17 and delivers it to the waste liquid bottle 22 through the delivery pipe 21. The waste liquid bottle 22 is placed next to the peristaltic pump 20 on the testing platform 17. The delivery pipe 21 is fixedly connected to the top cover of the waste liquid bottle 22 for collecting the waste liquid after testing.

[0035] This application can be used in the field of automated detection technology of disease biomarkers, or in other fields applicable to this application.

[0036] In another embodiment

[0037] Reference Figure 1-2 An automated detection device for disease biomarkers is described, which is applied to the field of automated detection technology for disease biomarkers. A cover 23 is hinged to one side of the opening of the housing 1. Hydraulic rods 24 are hinged to both sides of the bottom of the cover 23. The piston ends of the two hydraulic rods 24 are respectively hinged to the inner walls of the housing 1. A handle is provided on one side of the cover 23, which can be easily opened or closed. The hydraulic rods 24 play a supporting and buffering role, making the opening and closing of the cover 23 more stable.

[0038] However, as is well known to those skilled in the art, the working principles and wiring methods of the touch screen 2, the pressing cylinder 6, the double-headed cylinder 11, the detection head 16, the detection platform 17 and the peristaltic pump 20 are commonplace and belong to conventional methods or common knowledge. They will not be described in detail here. Those skilled in the art can make any selections according to their needs or convenience.

[0039] The accompanying drawings in this application are for illustrative purposes only. The dimensions and shapes of the components shown are not actual limitations but are merely schematic representations. In actual implementation, the components can be reasonably configured and adjusted according to specific needs and actual conditions.

[0040] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. An automated detection device for disease biomarkers, characterized in that, include: A chassis (1) is provided with a touch screen (2) embedded on one side of the chassis (1), and a mounting bracket (3) is fixed inside the chassis (1) by screws. The mounting bracket (3) is provided with a clamping mechanism, which is used to clamp and fix the needle containing the blood sample; The clamping mechanism includes a bracket (4) fixedly mounted on one side of the mounting frame (3). A connecting plate (7) is fixedly mounted on the bottom of the bracket (4). Fixing frames (8) are fixedly mounted on both sides of the connecting plate (7). Clamping arms (9) are rotatably mounted on the inner side of the two fixing frames (8). Clamping frames (10) are fixedly mounted on the front end of the two clamping arms (9). A double-headed cylinder (11) is fixedly mounted on the rear side of the connecting plate (7). The output ends on both sides of the double-headed cylinder (11) are respectively hinged to the rear end of the clamping arms (9). A switch is provided at the bottom of the connecting plate (7).

2. The automated detection device for disease biomarkers according to claim 1, characterized in that, A pressure block (5) is slidably provided on one side of the bracket (4), and a pressing cylinder (6) is embedded in the top of the bracket (4). The output end of the pressing cylinder (6) is fixedly connected to the pressure block (5).

3. The automated detection device for disease biomarkers according to claim 1, characterized in that, A liquid storage tank (12) is fixedly installed on one side of the mounting bracket (3) next to the support (4). A three-way pipe (13) is fixedly connected to the bottom of the liquid storage tank (12). The other two ends of the three-way pipe (13) are respectively plugged with caps (14). An inlet (15) is fixedly connected to the top of the liquid storage tank (12). A cap is provided on the inlet (15).

4. The automated detection device for disease biomarkers according to claim 1, characterized in that, A detection head (16) is provided on one side of the mounting bracket (3) next to the liquid storage tank (12), and a detection platform (17) is fixedly provided on the top of the mounting bracket (3). The detection window of the detection platform (17) is located directly below the detection head (16).

5. The automated detection device for disease biomarkers according to claim 4, characterized in that, The inlet of the testing platform (17) is fixedly connected to two liquid inlet pipes (18), and the outlet of the testing platform (17) is fixedly connected to a suction pipe (19). The top of the mounting bracket (3) is fixedly installed next to the testing platform (17) with a peristaltic pump (20). The input end of the peristaltic pump (20) is fixedly connected to the suction pipe (19), and the output end of the peristaltic pump (20) is fixedly connected to a delivery pipe (21). A waste liquid bottle (22) is placed next to the peristaltic pump (20) on the testing platform (17), and the delivery pipe (21) is fixedly connected to the top cover of the waste liquid bottle (22).

6. The automated detection device for disease biomarkers according to claim 1, characterized in that, A cover (23) is hinged to one side opening of the chassis (1). Hydraulic rods (24) are hinged to both sides of the bottom of the cover (23). The piston ends of the two hydraulic rods (24) are respectively hinged to the inner walls of the chassis (1). A handle is provided on one side of the cover (23).

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