Stirring device for eye drop preparation
Patent Information
- Application Number
- CN202522459278.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-11-20
- Publication Date
- 2026-11-03
- Estimated Expiration
- 2035-11-20
AI Technical Summary
Existing eye drop preparation equipment suffers from problems such as large temperature gradients in the insulation zone and weak single-axis stirring and shearing, resulting in high batch temperature differences and uneven mixing of excipients.
The stirring device is supported by outriggers and landed on the ground. The middle cover, inner tank and outer skin form an integral frame. Combined with the dual-shaft stirring assembly and circulation pump, it achieves a uniform temperature field for the heat-insulating solution. Closed-loop temperature control is achieved through heating tubes and multi-point temperature sensors. At the same time, it is equipped with a liquid filling tank and L-shaped connecting pipe to realize online liquid replenishment and overflow protection.
It significantly reduces the risk of shaft seal leakage caused by full-load deformation, the temperature difference of the insulation solution is ≤1℃, the auxiliary materials are mixed evenly, the mixing time is shortened by more than 30%, and the stability and efficiency of continuous production are improved.
Smart Images
Figure CN224925978U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of eye drop production technology, and in particular to a stirring device for preparing eye drops. Background Technology
[0002] In recent years, the eye drop market has expanded rapidly due to the rising incidence of eye diseases such as dry eye and allergic conjunctivitis. During production, stricter sampling requirements have been imposed on indicators such as the uniformity of content, particle size distribution, and osmotic pressure of sterile eye drops. This has prompted manufacturers to introduce closed and automated equipment in the formulation process to reduce the risk of human intervention.
[0003] Current industrial solutions often employ a top-mounted single-shaft agitator with a rectangular jacket: the agitator shaft passes through the tank cover and is directly connected to a variable frequency motor, with a single-layer inclined paddle installed at the shaft end to compensate for insufficient shear by increasing the rotational speed. Some companies also attach silicone rubber heating tapes to the outer wall of the jacket to compensate for heat loss and shorten heating time. However, actual operation shows that this configuration, due to the tank being suspended only by a top flange without additional internal support, a short jacket flow channel, and the absence of baffles, leads to overheating at the near end and undercooling at the far end. The temperature difference at the same cross-section can reach over 5°C, causing localized precipitation of insoluble excipients, which becomes the core issue causing batch-to-batch quality fluctuations in eye drops. Utility Model Content
[0004] The purpose of this invention is to provide a stirring device for preparing eye drops, so as to solve the problems of high batch temperature difference and uneven mixing of excipients caused by the large temperature gradient in the heat preservation area and the weak shear of single-axis stirring in existing preparation equipment.
[0005] To achieve the above objectives, the technical solution of this utility model is implemented as follows: A stirring device for preparing eye drops includes an outer casing with a support frame fixed to its top; a middle cover disposed inside the outer casing with a support leg fixed to its bottom, the support leg passing through the outer casing and supporting the ground; an inner liner disposed inside the middle cover, the top of the inner liner being fixedly connected to the top of the outer casing, and the top of the middle cover being fixedly connected to the side wall of the inner liner; a stirring assembly fixedly disposed on the support frame and extending into the inner liner; the middle cover has a liquid inlet on its upper side and a liquid outlet at its bottom, the liquid inlet and the liquid outlet being connected by a pipeline, and a circulation pump being connected to the pipeline.
[0006] By adopting the above technical solution, the outriggers pass through the outer skin and directly bear the load. The middle cover, inner liner, and outer skin form a three-point welded frame, which significantly reduces the elliptical deformation under full load conditions. The circulating pump drives the heat preservation solution to flow continuously between the bottom outlet and the top inlet, so that the temperature field inside the middle cover is quickly and uniformly distributed, reducing the risk of local overheating and providing a stable temperature field for the subsequent mixing of eye drop raw materials.
[0007] Furthermore, a heating tube is installed inside the middle cover, and temperature sensors are respectively provided in the middle cover, the outer skin, and the inner liner.
[0008] By adopting the above technical solution, the heating tube is placed directly in the insulation solution to achieve rapid heating. Three temperature sensors monitor the temperature on the insulation side, the ambient side, and the material side respectively, providing multi-point data for closed-loop temperature control and avoiding temperature lag caused by single-point measurement.
[0009] Furthermore, the inner cover is connected to a liquid filling chamber for adding a heat-insulating solution inside the inner cover.
[0010] By adopting the above technical solution, the liquid filling tank is located at a high position and can be automatically replenished by static pressure, avoiding the risk of contamination caused by opening the lid and tipping over. At the same time, it also serves as an expansion tank to absorb the liquid volume change when the temperature rises and maintain the stability of the system pressure.
[0011] Furthermore, a connecting pipe is provided on one side of the bottom of the middle cover. The connecting pipe is L-shaped, and the liquid filling chamber is connected to the end of the connecting pipe away from the middle cover.
[0012] By adopting the above technical solution, the L-shaped pipe forms an air seal, preventing liquid backflow from impacting the filling tank during the operation of the circulating pump and reducing the interference of liquid level fluctuations on the temperature control signal.
[0013] Furthermore, a valve is provided at the bottom of the liquid filling chamber, and the valve is connected to a liquid storage tank.
[0014] By adopting the above technical solution, the excess insulation liquid can overflow into the storage tank when the valve is normally open, realizing automatic discharge; when the valve is closed, online liquid replenishment can be performed without stopping the machine, thus improving the continuous production cycle.
[0015] Furthermore, the stirring assembly includes two stirring rods, a gearbox, and a motor. The two stirring rods are rotatably mounted on the support frame and extend into the inner liner. The gearbox is fixed to the support frame and connected to the two stirring rods. The motor is connected to the input shaft of the gearbox.
[0016] By adopting the above technical solution, the single motor drives the two stirring rods synchronously after being split by the gearbox, which improves the shaft rigidity and reduces the vibration of the long shaft while keeping the power constant, and at the same time reduces the probability of seal wear.
[0017] Furthermore, a dispersion disc is installed at one end of one of the stirring rods that extends into the inner liner, and a stirring blade is installed at the other end of the stirring rod that extends into the inner liner.
[0018] By adopting the above technical solution, the dispersion disc provides high-shear crushing and agglomeration, and the stirring blade provides macroscopic circulation. The two work synergistically on the same liquid surface to shorten the powder wetting time and improve uniformity.
[0019] Furthermore, at least three stirring blades are arranged perpendicular to the stirring rod, and a vertical blade is provided at the end of the stirring blade away from the stirring rod.
[0020] By adopting the above technical solution, the vertical blade increases the axial pushing component, causing the bottom deposited particles to rise continuously, thus avoiding the concentration gradient caused by solid accumulation.
[0021] Furthermore, the tips of the upright leaves are connected by a ring, and the dispersing disk is located inside the ring.
[0022] By adopting the above technical solution, the ring forms a ring frame, which improves the rigidity of the vertical blade and suppresses end shaking; the dispersion disk is placed inside the ring, so that the shear zone and the circulation zone are coaxially distributed, reducing the flow dead zone and improving the space utilization rate.
[0023] Compared with the prior art, the present invention has the following beneficial effects: The stirring device for preparing eye drops described in this utility model has legs that support the ground and form an integral frame with the outer skin, middle cover, and inner liner, significantly reducing the risk of shaft seal leakage caused by deformation under full load. The active circulation loop consisting of the bottom outlet, the upper inlet, and the circulation pump ensures that the temperature difference of the heat-preserving solution is ≤1℃, avoiding local overheating and precipitation of auxiliary materials. The dual-shaft output is equipped with a dispersion disc and stirring blades respectively, completing shearing, crushing, and macroscopic circulation on the same liquid surface, shortening the mixing time by more than 30%. The combination of the liquid addition tank, L-shaped connecting pipe, and overflow valve enables online liquid replenishment and overflow protection without stopping the machine to open the cover, improving the stability of continuous production. Attached Figure Description
[0024] The accompanying drawings, which form part of this utility model, are used to provide a further understanding of this utility model. The illustrative embodiments of this utility model and their descriptions are used to explain this utility model and do not constitute an improper limitation of this utility model.
[0025] In the attached diagram: Figure 1 This is a schematic diagram of the overall structure of the stirring device for preparing eye drops according to an embodiment of the present invention; Figure 2 This is an overall cross-sectional view of the stirring device for preparing eye drops according to an embodiment of the present invention; Figure 3 This is a schematic diagram of the liquid filling tank section as described in an embodiment of the present utility model; Figure 4 This is a schematic diagram of the stirring assembly described in an embodiment of the present invention.
[0026] Explanation of reference numerals in the attached figures: 1. Outer casing; 2. Support frame; 3. Support legs; 4. Liquid inlet; 5. Liquid outlet; 6. Piping; 7. Circulation pump; 8. Inner cover; 9. Heating element; 10. Temperature sensor; 11. Connecting pipe; 12. Inner liner; 13. Mixing assembly; 1301. Mixing rod; 1302. Gearbox; 1303. Motor; 1304. Dispersion disc; 1305. Mixing blade; 1306. Vertical blade; 1307. Ring; 14. Liquid filling tank; 15. Valve. Detailed Implementation
[0027] It should be noted that, unless otherwise specified, the embodiments and features described in these embodiments can be combined with each other.
[0028] In the description of this utility model, it should be noted that if terms such as "upper," "lower," "inner," or "back" appear, indicating orientation or positional relationship, they are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, if terms such as "first" or "second" appear, they are also used for descriptive purposes only and should not be construed as indicating or implying relative importance.
[0029] Furthermore, in the description of this utility model, unless otherwise explicitly defined, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model in light of the specific circumstances.
[0030] The present invention will now be described in detail with reference to the accompanying drawings and embodiments.
[0031] This embodiment relates to a stirring device for preparing eye drops. In terms of overall structure, as follows... Figure 1 and Figure 2 As shown, it includes an outer skin 1, a middle cover 8, an inner liner 12, a stirring assembly 13, and a circulation pump 7.
[0032] The outer skin 1 is provided with a support frame 2 at the top, the stirring component 13 is fixedly installed on the support frame 2, the middle cover 8 is installed inside the outer skin 1, the bottom of the middle cover 8 is provided with a support leg 3 for support, the inner liner 12 is installed inside the middle cover 8, the upper side and the bottom of the middle cover 8 are respectively provided with a liquid inlet 4 and a liquid outlet 5, the liquid inlet 4 and the liquid outlet 5 are connected by a pipe 6, and the circulation pump 7 is installed on the pipe 6.
[0033] It is worth mentioning that the purpose of installing the outer skin 1 is to protect the middle cover 8 from impacts. The middle cover 8 is filled with a heat-insulating solution. The support legs 3 pass through the outer skin 1 and are welded to the bottom of the middle cover 8. This arrangement ensures the stability of the middle cover 8 and prevents the outer skin 1 and the middle cover 8 from cracking due to the weight of the middle cover 8. The support frame 2 is horizontally located at the top of the outer skin 1. Its purpose is to install the stirring assembly 13 and ensure the stability of the stirring assembly 13 during rotation. The liquid inlet 4 and the liquid outlet 5 extend from the outer skin 1. The pipe 6 ensures the connection between the liquid inlet 4 and the liquid outlet 5. The heat-insulating solution is circulated, and the circulation pump 7 provides power for the heat-insulating solution. Since the inlet 4 is located on the upper part of the middle cover 8 and the outlet 5 is located at the bottom of the middle cover 8, this setting ensures that the temperature of the heat-insulating solution in the middle cover 8 is uniform, thereby improving the mixing and fusion effect of the eye drops. The top of the middle cover 8 is welded to the side wall of the inner liner 12, and the top of the inner liner 12 is welded to the top of the outer skin 1. The strength of the inner liner 12 is improved by the support of the outer skin 1 and the middle cover 8. The raw materials for the eye drops are placed in the inner liner 12 and mixed by the stirring component 13, thus completing the preparation of the eye drops.
[0034] Based on the above overall introduction, an exemplary structure of this embodiment is as follows: Figure 2 As shown, a heating tube 9 is installed inside the middle cover 8. Temperature sensors 10 are respectively installed on the middle cover 8, the outer skin 1, and the inner liner 12. A liquid filling chamber 14 for adding insulation solution to the middle cover 8 is connected to it. It is worth mentioning that the heating tube 9 is used to heat the insulation solution to ensure that the insulation solution can maintain the preset temperature. The purpose of the temperature sensor 10 is to measure the temperature of the middle cover 8, the outer skin 1, and the inner liner 12, so as to facilitate the observation of the temperature of the insulation solution and the eye drops. The temperature sensor 10 and the heating tube 9 can be connected to a controller. The controller is a common temperature controller in the prior art, which will not be described in detail here. The temperature measured by the sensor controls the on / off of the heating tube 9, which facilitates the control of the temperature of the insulation solution. The temperature maintained is different when different raw materials are added. When adding boric acid, sodium chloride, thickener, etc., which need to be dissolved, the temperature can be set between 40-60°. The actual situation can be determined according to the production process. The liquid filling chamber 14 can add insulation solution to the inside of the middle cover 8 and can also serve as an overflow port, thereby improving the safety of the equipment.
[0035] As a preferred option, such as Figure 3As shown, in this embodiment, a connecting pipe 11 is provided on one side of the bottom of the middle cover 8, and a liquid filling tank 14 is connected to the end of the connecting pipe 11 away from the middle cover 8. A valve 15 is provided at the bottom of the liquid filling tank 14, and the valve 15 is connected to a liquid storage tank. It is worth mentioning that the connecting pipe 11 is L-shaped to ensure that the liquid filling tank 14 is higher than the connection between the middle cover 8 and the connecting pipe 11, ensuring that the added insulation solution can enter the middle cover 8. The valve 15 is installed at the bottom of the connecting pipe 11. When no insulation solution is added, the valve 15 is open. If overflow occurs, the insulation solution is discharged directly from the connecting pipe 11 and the valve 15 to the liquid storage tank. When adding insulation solution, the valve 15 is closed, and the insulation solution is directly added to the liquid filling tank 14 and flows into the middle cover 8 from the connecting pipe 11.
[0036] As a preferred implementation method, such as Figure 4 As shown, in this embodiment, the stirring assembly 13 includes two stirring rods 1301 rotatably mounted on the support frame 2, a gearbox 1302 that drives the two stirring rods 1301 to rotate, and a motor 1303 that drives the gearbox 1302 to rotate. Specifically, the purpose of setting two stirring rods 1301 is that one is for dispersion and the other for stirring. That is, one end of the stirring rod 1301 that extends into the inner liner 12 is equipped with a dispersion disc 1304, and the other end of the stirring rod 1301 that extends into the inner liner 12 is equipped with a stirring blade 1305. This setting can improve the preparation efficiency. The gearbox 1302 extends two output shafts, which are connected to the two stirring rods 1301 respectively through belts and pulleys. The gearbox 1302 is a common gearbox 1302 in the prior art, which will not be described in detail here. The gearbox 1302 increases the speed of one stirring rod 1301 with the dispersion disc 1304 and decreases the speed of the other, so as to ensure that it can be evenly mixed in the eye drops after dispersion. The bottom of the gearbox 1302 is equipped with an input shaft, and the motor 1303 is connected to the input shaft. This setting enables one motor 1303 to drive the two stirring rods 1301 to rotate.
[0037] As a preferred option, it remains as follows Figure 4 As shown, in this embodiment, at least three stirring blades 1305 are arranged perpendicular to the stirring rod 1301. A vertical blade 1306 is provided at the end of the stirring blade 1305 away from the stirring rod 1301. The top of the vertical blade 1306 is connected by a ring 1307, and the dispersing disk 1304 is located inside the ring 1307. It should be noted that the position of the dispersing disk 1304 is higher than the height of the stirring blades 1305. The cooperation between the vertical blade 1306 and the stirring blade 1305 can improve the stirring efficiency. The arrangement of the ring 1307 can improve the connection strength of the vertical blade 1306. The arrangement of the dispersing disk 1304 and the vertical blade 1306 can reduce space occupation and facilitate control of the equipment size.
[0038] In this embodiment, the stirring device for preparing eye drops has a support leg 3 that rests on the ground and forms an integral frame with the outer skin 1, middle cover 8, and inner liner 12, significantly reducing the risk of shaft seal leakage caused by full-load deformation. The active circulation loop consisting of the bottom outlet 5, the upper inlet 4, and the circulation pump 7 ensures that the temperature difference of the heat-preserving solution is ≤1℃, avoiding local overheating and precipitation of auxiliary materials. The dual-shaft output is equipped with a dispersion disc 1304 and a stirring blade 1305, respectively, to complete shearing, crushing, and macroscopic circulation on the same liquid surface, shortening the mixing time by more than 30%. The combination of the liquid addition chamber 14, the L-shaped pipe 11, and the overflow valve 15 enables online liquid replenishment and overflow protection without stopping the machine to open the cover, improving the stability of continuous production.
[0039] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.
Claims
1. A stirring device for preparing eye drops, characterized in that, include: The outer skin (1) has a support frame (2) fixed on the top. The middle cover (8) is set inside the outer skin (1), and the bottom is fixed with a support leg (3). The support leg (3) passes through the outer skin (1) and supports the ground. The inner liner (12) is disposed inside the middle cover (8). The top of the inner liner (12) is fixedly connected to the top of the outer skin (1), and the top of the middle cover (8) is fixedly connected to the side wall of the inner liner (12). The stirring assembly (13) is fixedly mounted on the support frame (2) and extends into the inner liner (12); The upper side of the middle cover (8) is provided with a liquid inlet (4) and the bottom is provided with a liquid outlet (5). The liquid inlet (4) and the liquid outlet (5) are connected by a pipeline (6), and a circulation pump (7) is connected to the pipeline (6).
2. The stirring device for preparing eye drops according to claim 1, characterized in that: A heating tube (9) is installed inside the middle cover (8), and temperature sensors (10) are respectively provided in the middle cover (8), the outer skin (1) and the inner liner (12).
3. The stirring device for preparing eye drops according to claim 1, characterized in that: The inner cover (8) is connected to a liquid filling chamber (14) for adding heat preservation solution into the inner cover (8).
4. The stirring device for preparing eye drops according to claim 3, characterized in that: The bottom side of the middle cover (8) is connected to a connecting pipe (11), which is L-shaped. The liquid filling chamber (14) is connected to the end of the connecting pipe (11) away from the middle cover (8).
5. The stirring device for preparing eye drops according to claim 3, characterized in that: The bottom of the liquid filling chamber (14) is provided with a valve (15), and the valve (15) is connected to the external liquid storage tank.
6. The stirring device for preparing eye drops according to claim 1, characterized in that: The stirring assembly (13) includes two stirring rods (1301), a gearbox (1302) and a motor (1303). The two stirring rods (1301) are rotatably mounted on the support frame (2) and extend into the inner liner (12). The gearbox (1302) is fixed on the support frame (2) and connected to the two stirring rods (1301). The motor (1303) is connected to the input shaft of the gearbox (1302).
7. The stirring apparatus for preparing eye drops according to claim 6, characterized in that: One of the stirring rods (1301) has a dispersion disc (1304) installed at one end of its extension into the inner liner (12), and the other stirring rod (1301) has a stirring blade (1305) installed at one end of its extension into the inner liner (12).
8. The stirring apparatus for preparing eye drops according to claim 7, characterized in that: At least three stirring blades (1305) are arranged perpendicular to the stirring rod (1301), and a vertical blade (1306) is provided at the end of the stirring blade (1305) away from the stirring rod (1301).
9. The stirring apparatus for preparing eye drops according to claim 8, characterized in that: The top of the leaf (1306) is connected by a ring (1307), and the dispersing disk (1304) is located inside the ring (1307).