Graphical User Interface for Protein Sequence Design for Electronic Devices

Abstract

1. Name of the Design Product: Graphical User Interface for Protein Sequence Design for Electronic Devices. 2. Use of the Design Product: For interaction with electronic devices. 3. Design Key Points of the Design Product: Lies in the interface content of the graphical user interface. 4. Picture or Photograph that Best Illustrates the Design Key Points: Front View. 5. Use of the Graphical User Interface: This graphical user interface of the appearance is used for protein sequence design. 6. Description of the Changing States of the Graphical User Interface: The front view is the initial interface for protein sequence design. In the upper part on the left side of the interface, it is used to input PDB codes and upload protein structure files (pdb files). In the lower part on the left side of the interface, there are option buttons for highlighting protein chains. Above the right side of the interface, the three-dimensional structure of the protein is displayed. In the middle of the interface, the sequence information of the protein is displayed, including: the current design number of the protein, the sequence length of the protein, and the folding panels of each chain of the protein. In the front view, select the folding panel of one of the chains, switch to the interface changing state diagram 1, expand the folding panel of the corresponding chain, and display the amino acid sequence of the corresponding chain. Among them, the abbreviations of each amino acid are displayed in order, and there is a corresponding serial number below each amino acid abbreviation; in the interface changing state diagram 1, click on the abbreviation of the amino acid to be modified, and switch to the interface changing state diagram 2. Above the folding panel, the serial number and abbreviation of the selected amino acid are displayed. In the interface changing state diagram 2, click on the design button on the right side of the sequence length, and switch to the interface changing state diagram 3; in the interface changing state diagram 3, the design results of the amino acids are displayed on the right side of the interface. Specifically, in the upper part on the right side of the interface, there is a "Temperature" adjustment button for adjusting the distribution smoothness of the probability histogram. The blue font below the "Temperature" adjustment button is the abbreviations of each amino acid displayed in order; below the selected amino acid, the replacement result is displayed. By default, the best replacement result of the selected amino acid is displayed. In the middle part on the right side of the interface, 20 candidate buttons are displayed, corresponding to 20 amino acids respectively; below the candidate buttons for the 20 amino acids, there is a corresponding probability histogram showing the predicted probabilities of the corresponding 20 amino acids. Among them, the amino acid with the highest proportion is used as the best replacement result, and by default, the best replacement result is highlighted. If the user wants to select other amino acids as replacement results, click on the corresponding candidate button, and the proportion of the candidate button corresponding to the probability histogram is highlighted. Below the selected amino acid, the replacement result selected by the user will be displayed. The three-dimensional structure of the designed protein is displayed at the lower part on the right side of the interface. A download button is displayed at the bottom on the right side for downloading the designed protein structure file.

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