HUMAN ANTIBODIES THAT BINDING LYMPHOCYTE ACTIVATION GENE-3 (LEG-3), AND USES THEREOF

Abstract

The present disclosure provides isolated human monoclonal antibodies and antigen-binding fragments thereof that bind to human LAG-3, particularly antibodies and antigen-binding antibody fragments that can inhibit the binding of LAG-3 to MHC Class II molecules and that can stimulate antigen-specific T cell responses. Nucleic acid molecules encoding the antibodies and antigen-binding fragments of the invention as well as compositions and immunoconjugates of the antibodies and antigen-binding antibody fragments of the invention are also provided. This disclosure also provides for the use of the antibodies and antigen-binding antibody fragments of the invention in therapy.