TOPICAL CIPROFLOXACIN COMPOSITIONS

Abstract

Embodiments of the invention provide pharmaceutical compositions of ciprofloxacin that are formulated for topical application to a body surface and to have at least a local antibacterial effect. In some embodiments, the compositions are further formulated for localized anti-inflammatory activity, antifungal activity, antiviral activity, or combinations thereof. Such compositions comprise a therapeutically effective amount of non-betaine form of ciprofloxacin (e.g., ciprofloxacin hydrochloride monohydrate); one of a pH adjusting agent of about 5.5 to about 10. In some embodiments, such compositions may be free or devoid of an additional skin penetration enhancer and / or contain betaine form of ciprofloxacin.