Detergents and / or disinfectants for washing and / or disinfecting

Abstract

Washing and disinfecting agent (100) for washing and disinfecting skin surfaces (1), comprising - a base agent (2) which is designed and intended to be used to wash and disinfect skin surfaces (1), characterized in that at least one substance additive (3) is mixed into the base agent (2), which after contact with the surface (1) assumes a different color consistency than the base agent (2) for a predeterminable period of time, so that the substance additive (3) serves as a marking agent by which the user can read whether the desired areas of the surface (1) to be washed and disinfected have been cleaned with a sufficient amount and a contact time of the base agent (2) has been completed, wherein the additive contains cresol red and the base agent contains at least one of the following substances: Cationic substances, amphoteric substances, and metals and metal salts, The change in colour takes a certain amount of time, and this time is called the exposure time, and both the colour and the exposure time can be shortened or extended depending on the concentration of the dye in the disinfectant, whereby the more of the dye is contained, the faster the discolouration takes place.

Description

The present invention relates to a washing and / or disinfecting agent for washing and / or disinfecting surfaces and to a use of a washing and / or disinfecting agent as well as to a method for producing a washing and / or disinfecting agent according to the respective preamble of patent claims 1, 6 and 7.In particular in the corona pandemic times prevailing at the application time, it is necessary to sanitize areas which are subject to a high hygiene scale, for example in an old home, a hospital or else against weakened people, skin surfaces and / or also other surfaces.In this respect, the present invention relates to the object of specifying a washing and / or disinfectant for washing and / or disinfecting surfaces, in which it is possible in a particularly simple manner to determine whether an exposure and / or sufficient degree of surface wetting prevails.As a result, complex measurement methods or also a specific test method, which is based in particular on empirical values of the respective user, can be dispensed with.According to at least one embodiment, the washing and / or disinfecting agent for washing and / or disinfecting surfaces, in particular skin surfaces, comprises a base agent which is configured and provided for washing and / or disinfecting surfaces, in particular skin surfaces, wherein at least one substance additive is mixed with this base agent, which, after contact with the surface, assumes a different color of consistency than the base agent for a predeterminable period of time, so that the substance additive serves as a marking agent, by means of which it can be read by the user whether the desired points of the surface to be washed and / or disinfected have been wetted with the base agent in a sufficient amount or at all and / or an action time of the base agent is substantially concluded.In particular, for the purposes of the invention, these are surfaces in the sense of the inventionmedical area (stationary and ambulant,...)Food area (manufacturing, processing, selling,... )- Cosmetic areaIndustry (clean room, production, processing...)private area (home environment...)- social area (formation sites, children's garden... )public area (churches, meetings, offices, Gemeinden......)Workplaces (office and handwork... )Recreational equipment (sports, baths..., wherever hygiene rules apply...)rice, leaf and other surfaces, in particular use surfaces.Cresol Redfrom red to yellow0,2-1,8Thymol blue bluefrom red to yellow1,2-2,8Methyl Yellow Yellowfrom red to yellow2,4-4,0Methyl orangefrom red to yellow3,1-4,4Methyl Redfrom red to yellow4,4-6,2Litmusfrom red to blue5,0-8,0Bromothymol blue bluefrom yellow to blue6,2-7,6Cresol Redfrom yellow to violet-red7,0-8,8Thymol blue bluefrom yellow to blue8,0-9,8Phenolphthaleinfrom colorless to red8,0-9,8Alizarin Yellow Rfrom yellow to orange-brown10,1-12,0In a Friedel-Crafts acylation, two equivalents of phenol and one equivalent of phthalic anhydride are reacted in the presence of small amounts of concentrated sulfuric acid or zinc chloride: Phenolphthalein is a white crystalline powder and is substantially insoluble in water. It is usually used in 1% alcoholic solution. It is itself a weak acid.Phenolphthalein has a pK s- value of 9.7. when the turnover range is determined at an indicator acid / base ratio of 1:10 to 10:1, a turnover range of pH = pK s ± 1 (8.7 to 10.7) is obtained according to the Henderson-Hasselbalch equation. At a pH of less than 0, an aqueous phenolphthalein solution is red-orange, colorless at a pH of 0 to about 8.2, and at a higher pH, the solution colors pink-violet, turns pink-violet in the strongly alkaline range-at a pH close to 13-, and turns colorless again. It is therefore well suited as an indicator, for example, in the titration of basic solutions.Depending on the pH of the solution, the phenolphthalein changes its structure and thus its color.The Structures of PhenolphthaleinStructurepH<00 up to 8,28,2 from 12 to,0> 12,0Colorred red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red red redcolorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorlesspink-purplecolorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorless colorlessIn the pH range up to about 7.5, it is present in its colorless, uncharged basic form (H 2 In 1). In a more basic solution, the protons on the two hydroxyl groups are cleaved off. In a resulting mesomeric boundary structure, a quinoides system is present as chromophore (In 2-2). This is the colored structure of the indicator. In a very strongly basic environment, an OH group attaches to the central carbon atom, making it impossible to reach the chromophore structure (In(OH) 3-3). Phenolphthalein is recolored in strongly acidic solution. The lactone ring is cleaved by the H +. A positive charge is formed at the central carbon atom, which is hybridized with sp 2- and is thus stabilized again by the mesomeric boundary form (4).If, for example, at least one of the abovementioned dyes is applied to the skin, for example, the pH of the skin changes, so that the sites wetted with the disinfectant dyes from colorless to red or pink-violet, depending on the skin condition. The change in color takes a certain time, and exactly this time is referred to as "exposure time" in the sense of the application. Both the color and the exposure time can be shortened or prolonged depending on the concentration of the dye in the disinfectant. The more dye is present, the faster the discoloration occurs. Considering the reaction equation of reaction (A) according to (B), it is clear from the law of mass action why the color change takes place as quickly as possible:(K s is constant, the quasi-constant concentration of the water being included in K s):The concentration of the H 3 O +- ions is of a different order of magnitude. For acidic solutions, it is high, the equilibrium is on the side of (A). However, as soon as the concentration of H 3 O + becomes very low or the concentration of OH - becomes high, the concentration of (B) must increase sharply because of the constancy of the term. Since (B) is formed from (A), the concentration of (A) becomes extremely small--the color change is very fast.Disinfectants alter the proteinaceous structure of microorganisms and thereby have a denaturing effect. Depending on the type of disinfectant, they can also damage the lipid membranes and nucleic acids of the germs.The totality of disinfectants can be referred to as substance which has microbicidal effect due to their chemical properties. This means that they inactivate or kill microorganisms which cause diseases and / or infections.In contrast to sterilization, not all microbiological organisms are eliminated, but a certain variant of germs is reduced. The sense behind this is a number of bacterial strains which are essential for life or non-pathogenic (i.e. non-pathogenic) for humans. The risk of infection of microorganisms is linked to a specific population density. Only when a lower limit of pathogens is reached does it become dangerous for humans.Disinfectant should meet the following requirements:• They are intended to reduce the number of seeds quickly and extensively.• Disinfectant must achieve sufficient penetration depth.• The resistance to organic material has to be given.• Disinfectant should have only a low systemic toxic effect (not on the whole organism),• The compatibility with skin, mucosa and open wounds must be ensured.• The disinfectant must be long-lasting and at the same time biodegradable.• Finally, the odour load in the medical field should be kept low.Disinfectants specifically kill those microorganisms against which they are used. In this case, they must not contain any active ingredients which damage or alter the surrounding organic material. If a disinfectant is placed in the wound during surgery, it must not interfere with the intact or open skin or underlying tissue.Disinfectants have a denaturing effect, i.e. they alter the proteinaceous structures of the microorganisms and thus destroy them. Some disinfectants additionally damage the lipid membranes (for example the envelope of the viruses) or the nucleic acids of the germs. In addition to the specific active substance, disinfectants have so-called auxiliary substances which ensure that the active substance can reach the site of action. The modes of action allow disinfectant to be classified into the following categories:• Protein denaturation• Oxidation• Reduction of surface tension• Enzyme inhibition• Modification of nucleic acidsEach action of the disinfectants is triggered by specific ingredients, several combinations being used under certain circumstances. Protein denaturation is accomplished, for example, by disinfectants containing aldehydes or alcohols, whether a basic or acidic medium is involved. If microorganisms are to be oxidized, hydrogen peroxide, among other things, cleaves the electrons of the microorganisms.Susceptibility of pathogens is achieved by reducing the surface tension, for which purpose phenols, for example, are added to the disinfectant. At the time of syphilis, disinfectants with heavy metal compounds have been increasingly used to inhibit the enzymes of the pathogens. The last large group of disinfectants contains peracids (peroxyacids) and thus alters the build-up of nucleic acids, in principle acting as an oxidizing agent.The exact definition of the individual active substances and auxiliaries is a biochemical science on its own. This overview is intended merely to provide the fundamentals for being able to understand the differentiation of the disinfectants. The following substances are to be understood as base agents in the sense of the application. Each of the base agents can be mixed with at least one of the base substances presented above. "mixing" means, in the sense of the present application, the mixing of two or more substances to achieve the most uniform possible distribution of the individual components over the entire mixture. Mixing is used in the preparation of compositions and mixtures, suspensions, emulsions and solutionsPhenolsPhenols act against bacteria, fungi and against myoorganisms only in a strongly dosed concentration. Phenols are predominantly used for disinfection of the surface area.AlcoholsAlcohols can be used in multitoxic fashion. They denature proteins of bacteria, viruses and fungi. However, this quickly effective disinfectant must be diluted with water or the disinfectant must be kept wet during the entire exposure time. Usually 3 to 5 ml of alcoholic solution will suffice for sufficient disinfection.AldehydesAldehydes such as, for example. Formaldehyde would be an ideal disinfectant because it also acts in the gaseous state. Thus, large areas can be vapor-deposited as well as fine-grained devices. The cleavage of the carbon and hydrogen atoms (change in the nucleic acids), however, is strongly dependent on external influences. Furthermore, the long exposure time of six hours and the stinging odor of the gas are disadvantageous.SurfactantsSurfactants reduce surface tension. In detergents they ensure that water and oils bind together; in the disinfectant they are classic auxiliaries in order to transport the active ingredients in the pathogens to be controlled.Cationic substancesCation active substances have a growth inhibiting effect at a low concentration. In a higher mixing ratio or with a longer exposure time, they kill the microorganisms. Cationic substances are characterized by a positive, water-soluble group, which enables them to split off electrons from the microorganisms-entry heading oxidation.Amphoteric substancesAmphoteric substances have both electron-positive and electron-negatively charged particles. The effect of the amphoteric substances is thus equally effective at all pH values. Due to their good skin compatibility, they are used in particular in hygiene disinfection of the hands.HalogensHalogens such as chlorine, iodine or fluorine occupy the next-to-last shell on the periodic table and are therefore extremely striving to blim the last shell for configuration of the inert gas by electron uptake. The disinfectants are not only toxic to bacteria in high concentration and should therefore be used with caution.• Chlorine and chlorine compounds oxidize in particular SH groups of the proteins. Chlorine is used, for example, in drinking water sterilisation, so-called hypochlorites being formed. These also have a microtoxic effect and are used for coarse disinfection.• Id is poorly water-soluble and is therefore used in conjunction with potassium iodide as potassium tincture. Since iodine as disinfectant causes allergic reactions in some cases, it has been used predominantly for the treatment of medical devices and instruments.Metals and Metal SaltsMetals and metal salts such as cadmium, silver, copper and mercury have a microbiocidal effect known as oligodynamia. The released metal ions block the proteins of the microorganisms and thereby kill them. A typical example of application is covering open wounds with a silver foil. Oxidants or also called oxidizing agents transfer oxygen to other substances or bacteria, viruses & Co, which are thereby modified. The mode of action as disinfectant is comparable with the halogens:• Ozone is effective in aqueous solution and at high humidity against all bacteria, viruses, fungi and even spores. In dry air, on the other hand, it has no influence at all on the reduction of germs.• Peroxides are used as a 30 percent solution in medicine. Since it breaks down by peroxidases (which are numerous in the skin) without previous action, it is substantially replaced by alcohol-containing disinfectants.• Peracids have a strong corrosive action and are therefore not suitable for disinfection close to the patient. They are used predominantly in disinfection of the space and area.• Acids and alkalis destroy microorganisms, but generally also damage the disinfectant. Strong hydrochloric acids or sodium hydroxide solutions are therefore not used as disinfectant. However, by means of special preparations, organic acids such as lactic acid can be used for disinfection of dialysis machines and mouth showers or for supplementing other disinfectants.In addition to the ingredients and modes of action, various methods have become established for combining disinfectants. On the one hand, the field of use of the disinfectant can be used as a grouping feature, and on the other hand, the microorganism against which it is to be used.Classification of Disinfectants According to Field of UseThe list of uses for disinfectant is long. In clinical practice, a distinction is made mainly between four different regions:Skin DisinfectantDuring disinfection of the skin, both constantly present germs and also attack germs are to be treated. The so-called resident and transient germs do not present any problem in the case of intact skin. If, during invasive measures, they reach the patient's body, they can, on the other hand, spread almost unimpeded without prior treatment with disinfectants for skin and wounds. The time of action of the disinfectant depends both on the active ingredient used and on the condition of the skin. Disinfectants intended for direct skin contact usually contain alcohols such as ethanol or propanol.Surface DisinfectantSurface disinfection is a solid component in the disinfection plan and is carried out both routinely and in particular events. The floors in patient rooms are, for example, routinely disinfected after the patient has been released. If the same soil comes into contact with organic material (fecal, blood, peas, etc.), an extra-plan area disinfection is carried out. Especially suitable for this purpose are disinfectants which contain aldehydes, chloramines, cation-active substances or percompounds, such as our product desonova.Instrument DisinfectantIn the case of instrument disinfection, it is important that the disinfectant also reaches very small depressions and bores. It should consequently be readily water-soluble and dry rapidly or have a short exposure time. As a rule, disinfectants with cation-active substances are also used for this purpose or various halogens are used.Drinking water disinfectantDrinking water disinfection is clearly an important factor in clinics and nursing homes. After sterilisation, no pathogenic germs may remain in the drinking water or any residues caused by the disinfectant. In Germany, oxidative active ingredients such as calcium hypo- and sodium chloride, chlorine dioxide, chlorine and ozone are permitted.The name of the disinfectant when classified according to target organisms simultaneously provides information about which microorganisms they are to act against. The different disinfectants are divided into the following rubrices in the hygiene sector:• A very common bactericide is the antibiotic. Bacteria are damaged by the use of a bactericide in such a way that cell death is triggered.• The virucidal agent is a disinfectant against viruses. For the most part, the nucleic acids of the viruses are irreversibly damaged, as a result of which the microorganism is deactivated or completely killed.• Fungicide means "antifungal". In the treatment with medicaments, they are also referred to as antifungal agents (mycosis is fungal attack). Fungicidal disinfectants partially only act against existing fungal cultures (for example alcohols), but are free of the deposited spores.• This deficiency is cancelled by a sporicide. Chlorine dioxide is, for example, a fast acting sporicide and is used in the treatment of surfaces, instruments and drinking water. To free the skin or mucosa from spores, the more compatible hydrogen peroxide is relied upon.• Leuvurocidal agent is a fungicide which can also be successfully used against yeast fungi.• Virostat and fungistat disinfectants: inhibit the multiplication of viruses or bacteria, but do not kill them.Most disinfectants are multitoxic. That is, they can be used against several kinds of pathogens. Peracetic acid, sodium hypochlorite, formaldehyde or ethylene oxideine, for example, achieve efficient results as bactericide, sporicide, fungicide and viruicide. Which disinfectant is selected with the same effectiveness decides the field of application in which the active substance is to be introduced.According to at least one embodiment, the substance additive is mixed with at least 3 vol % and / or at least 3 mol % of the base agent and in particular with a predefined weight and / or volume amount of the base agent. It has been recognized that this concentration range is particularly well suited to being able to produce as complete a disinfection as possible and that the time range of the discoloration is also selected in such a way that the user does not have to wait too long for the result and thus for a sufficient discoloration.According to at least one embodiment, the substance additive comprises at least one dye which reflects and / or generates light in the visible wavelength spectrum.According to at least one embodiment, the additive is added to the base agent in gel and / or viscous and / or liquid form. Gels can be described as viscoelastic fluids. The fluid properties of a gel are thus between that of an ideal liquid and that of an ideal solid body. Frequently, for classifying the gel-like nature of a viscoelastic fluid in rheology, the storage modulus and the loss modulus are used as parameters. As a rule, a fluid is then attributed gel character if the storage modulus is greater in magnitude than the loss modulus.Gels are semi-solid, more or less transparent products. They consist of a three-dimensional network of so-called builder substances (e.g. gelatin, cellulose derivatives and polyacrylates), in the interstices of which large amounts of moisture and care substances can be incorporated. A distinction is made between three different gel types: anhydrous oleogels, oil-free hydrogels and oil / water gels.Gels are distinguished by an intensive moisture action and a rapid pull-in capacity. They can be spread particularly quickly on the skin and are drawn in immediately without sticking. Frequently, a cooling, refreshing effect is added by special additives, e.g. menthol. These application properties have led to an increasing popularity of gels, especially in humans with sensitive skin.If an emulsion is additionally integrated into the network of a gel, a gel cream is formed which combines the moisturizing properties of a gel with the care effects of an emulsion.According to at least one embodiment, the additive comprises at least one time marker which, after application to the surface, in particular to the skin surface, illuminates on the surface on the basis of the colorant for a predetermined period of time, and, after this period of time has elapsed, stops the illumination at least partially, which indicates to the user that an action time of the base agent has elapsed.According to at least one embodiment, the present invention relates to the use of a washing and / or disinfectant.According to at least one embodiment, the method for producing a washing and / or disinfecting agent for washing and / or disinfecting surfaces comprises a base agent which is configured and provided for the purpose of washing and / or disinfecting surfaces, in particular skin surfaces, and also the provision of a substance additive which, after contact with the surface, assumes a different colour consistency than the base agent for a predeterminable period of time, so that the substance additive serves as a marking agent, by means of which it is possible to read by the user whether the desired points of the surface to be washed and / or disinfected have been wetted with the base agent in a sufficient amount or at all and / or an action time of the base agent is substantially concluded, wherein this additive is mixed with the base agent.The substance additive can be a luminescent and / or fluorescent agent or at least comprise such an agent. This may be a light spectrum visible to the human eye. In this context, "gel-like" means that the base agent has a consistency with essential boundary conditions of a gel. For example, the additive may actually be a gel.The same applies to the terms viscous and liquid.In this case, a viscous substance can be one which has a viscosity which indicates that the higher the viscosity, the more viscous (less flowable) a fluid is and the lower the viscosity, the more viscous (flowable) it is.For example, the additive is a viscous or gel-like substance.It is conceivable that the base forms a suspension together with the additive.It is also conceivable for the additive to form an emulsion together with the base material or else for the additive to be dissolved in the base material, such that a solution develops.The time marker described here can be a chemical element either in the additive and / or in the base material, which changes in such a way after contact with surrounding oxygen and / or after contact with a skin surface and therefore initiates a corresponding chemical and / or physical process within the time marker, which takes place over a predefined period of time. It is conceivable that after distributing the washing and / or disinfecting agent on the skin surface, the user experiences a lighting or another color coding for a period of 30 seconds or 40 seconds or another period that can be arbitrarily set on the basis of the substance mixture and the time marker. This color coding disappears after a predetermined period of time, which is preferably dimensioned such that this indicates that a sufficient disinfection action time has been exceeded. In other words, it applies that, if only in principle the illumination has disappeared, sufficient disinfection has been achieved with a view to reducing bacteria and / or viruses or a corresponding complete killing.The invention described here is illustrated in more detail below with reference to a figure and the associated description.In FIG. 1, it can be seen in a top view of a surface 1, in particular a skin surface 1, that the washing and / or disinfectant 100 there serves for washing and / or disinfecting surfaces 1, in particular skin surfaces 1.A base agent is recognizable which is configured and provided for the purpose of washing and / or disinfecting surfaces 1, in particular skin surfaces 1, wherein at least one additional substance 3 is mixed with this base agent, which after contact with the surface 1 assumes a different color consistency than the base agent 2 for a predeterminable period of time, so that the additional substance 3 serves as a marking agent, by means of which it is possible to read by the user whether the desired sites of the surface 1 to be washed and / or disinfected have been wetted with the base agent with a sufficient amount or at all and / or an exposure time of the base agent is substantially concluded.The substance additive 3 is mixed with at least 3 vol % and / or at least 3 mol % of the base agent and in particular with a predefined weight and / or volume amount of the base agent and comprises at least one dye which reflects and / or generates light in the visible wavelength spectrum.It can be seen that the substance additive 3 is added to the base agent in gel and / or liquid form.This additive 3 comprises at least one time marker which, after application to the surface 1, in particular to the skin surface 1, illuminates on the surface 1 on the basis of the dye for a predetermined period of time, and after this period of time has elapsed, the illumination stops at least partially, which indicates to the user that an action time of the base agent has elapsed.FIG. 1 thus shows a washing and / or a disinfectant for washing and / or disinfecting surfaces 1 and a use of a washing and / or disinfectant 200 as well as a method for producing a washing and / or disinfectant 300 for washing and / or disinfecting surfaces 1, which comprises a blowing agent which is configured and provided for the purpose of washing and / or disinfecting surfaces 1, in particular skin surfaces 1.In addition, the method 300 comprises the provision of a substance additive 3 which is mixed with the base agent and which, after contact with the surface 1, assumes a different colour consistency than the base agent 2 for a predeterminable period of time, such that the substance additive 3 serves as a marking agent, by means of which it is possible to read off by the user whether the desired points of the surface 1 to be washed and / or disinfected have been wetted with the base agent in a sufficient amount or at all and / or an action time of the base agent is substantially concluded.List of reference characters1 Surface, skin surface 2 Base agent 3 Addition of substance 100 Washing and / or disinfectant 200 Use of a washing and / or disinfectant 300 Method of a washing and / or disinfectant

Claims

Washing and disinfecting agent (100) for washing and disinfecting skin surfaces (1), comprising - a base agent (2) which is configured and provided for the purpose of washing and disinfecting skin surfaces (1), characterized in that at least one substance additive (3) is mixed with the base agent (2), which after contact with the surface (1) assumes a different colour consistency than the base agent (2) for a predeterminable period of time, so that the substance additive (3) serves as a marking agent, by means of which it can be read by the user whether the desired sites of the surface (1) to be washed and disinfected have become with a sufficient amount and an exposure time of the base agent (2) has been concluded, wherein the additive contains cresol red and the base agent contains at least one of the following substances: cation-active substances, amphoteric substances, Metals and metal salts, wherein the change of colour takes a certain time, and exactly this time is called the exposure time, and both the colour and the exposure time can be shortened or prolonged, depending on the concentration of the dye in the disinfectant, the more the dye is contained, the more rapid the discoloration occurs.Washing and disinfecting agent (100) according to claim 1, characterised in that the substance additive (3) comprises at least one dye im which reflects and / or generates light in the visible wavelength spectrum.Washing and disinfecting agent (100) according to claim 1, characterised in that the substance additive (3) is added to the base agent (2) in gel and / or viscous and / or liquid form.Washing and disinfecting agent (100) according to claim 1, characterised in that the additive (3) comprises at least one time marker which, after application to the surface (1), in particular to the skin surface (1), lights up on the surface (1) on the basis of the dye for a predetermined period of time, and after this period of time has elapsed, the lighting stops at least partially, which indicates to the user that an action time of the base agent (2) has elapsed.Use of a washing and disinfecting agent (200) according to claim 1 for washing and disinfecting skin surfaces (1).

Images