Push-through blister pack with plastic lid

Abstract

Plastic push-through blister packaging, comprehensive: a tearable plastic lid film or substrate; and a blister layer formed over the tearable plastic lid film or substrate, whereby a cavity remains between the tearable plastic lid layer and the layer forming the blister cavity, wherein the cavity is designed to contain a product, and wherein the tearable plastic lid film has micro cavities, micro-crystallinity or a combination of both.

Description

Cross-reference to related registration

[0001] This application claims priority over U.S. Provisional Application No. 63 / 386,156, filed on December 5, 2022, the entire contents of which are hereby incorporated by reference. background

[0002] Currently, push-through blister packs in the pharmaceutical industry consist of a plastic cavity containing a product, sealed with hard-tempered aluminum foil, generally between 18 and 25 microns thick. While aluminum-based lidding foils provide a nearly complete barrier, the tight seal over the cavity and the brittle nature of the hard-tempered aluminum foil mean that the foil is easily punctured, pushed through, or even the blister pack is torn during transport and handling, exposing the contents of the cavity to environmental factors such as moisture and dust. Such external influences lead to drug degradation, resulting in a loss of efficacy and even ineffectiveness in certain classes of moisture-sensitive medications.Furthermore, current blister packaging cannot be easily reused due to the combination of plastic and aluminum materials.

[0003] In light of this, a single-material push-through blister pack was investigated, in which both the cavity and the lid are made of the same material. However, due to the high strength and flexible nature of the plastic, the plastic lid component does not break easily enough and frequently results in physical damage to the tablet during the dispensing process.

[0004] To overcome this disadvantage, external weakening of the plastic lid films through mechanical weakening via micro-perforation was investigated. However, this mechanism can also create pores through which moisture penetrates the cavity and can even cause sealing problems, leading to the same moisture ingress into the product and thus to a shelf-life issue. Furthermore, weakening technologies such as lasers require additional steps and equipment in the blister manufacturing process, which significantly reduces line productivity.

[0005] Another proposed design was a "peel-off" opening instead of a push-through seal, achieved by applying a peel-off adhesive to the lid film. However, this requires the blister pack to be larger to accommodate the unsealed "flange" for each cavity. This design makes the blister packs unnecessarily bulkier and requires more packaging material not only for the primary packaging but also for the secondary and even tertiary packaging, thus increasing overall manufacturing costs. This also increases the environmental impact by generating unnecessary packaging waste. The peel-off opening is also unpopular with older people due to their limited finger dexterity, which makes it difficult to grasp and pull the delicate flange.Furthermore, the pulling motion by grasping and pulling is more difficult to achieve than a simple pushing motion, especially for elderly citizens or patients with reduced or limited motor function.

[0006] Accordingly, a single-material push-through blister pack is highly desirable and needed in the field of pharmaceutical drug packaging, which is easily recyclable without loss of the structural integrity of the blister pack, the packaging productivity and the suitability of the void contents for removal. Brief description

[0007] One purpose of this revelation is to address the current challenges for blister packaging for pharmaceuticals, with regard to sustainability requirements concerning plastics, particularly recycling standards, without sacrificing patient usability and ease of manufacture.

[0008] A cavitated polymer film, produced by mixing with additives such as inorganic additives and / or incompatible polymers, which create discontinuities in the polymer matrix during the film manufacturing process. This modification results in internal tearing of the polymer, which, at a certain degree of tensile force, leads to the entire film rupturing.

[0009] One or more embodiments of the present disclosure relate to push-through blister packs (or blister packaging), primarily for pharmaceutical packaging, which can be manufactured from plastic components of the same class for both the blister layer and the lidding films or substrates, without requiring any external action on the material to weaken the lidding film during post-processing. The lidding film of the blister pack can be manufactured with plastic films having micro-voids / micro-cavities in the film matrix, which tear the internal walls to propagate the internal tear required to rupture the film.

[0010] The plastic push-through blister pack can be made exclusively from a single type of plastic. The tear-open lid film and / or the blister layer is made of a thermoplastic material. The thermoplastic material used for the lid film can be BOPET. Both the blister layer and the lid film can be made from a polymer selected from the group consisting of PET, PVC, PE, PP, PETG, and a combination thereof. An additive can be added to impart micro-crystallinity to the lid film. This additive can act as a cavitation agent. Internal brittleness can be created in the cavitated film, which forms the substrate, to facilitate tearing when removing the product, by adding crystalline particles of any shape. A base polymer used as the continuous phase of the cavitated film can be selected from PET, PVC, PE, PETG, PS (polystyrene), and a combination thereof.The cavitation agent can be an incompatible polymer selected from the group consisting of cellulose, starch, polyketones, polyesters, polycarbonates, polysulfones, polypropylene, cycloolefins, polyethylene and a combination thereof.

[0011] The additive can be an inorganic micro-additive selected from the group consisting of silica, talc, mica, titanium dioxide (TiO2), non-stoichiometric silicon dioxide (SiO2). x ) and a combination thereof. The additive may be an incompatible polymer selected from the group consisting of cellulose, cycloolefins, polypropylene, polyethylene, and combinations thereof. The concentration of the cavitation agent is between approximately 1 and approximately 30 wt% based on the total weight of the tearable lid film.

[0012] The barrier properties of micro-cavitated film can be increased by additional coating, metallization and barrier improvement processes in the unsealed area of ​​the cavitated film.

[0013] The blister layer and / or the lidding film may have more than one layer. Preferably, each is manufactured as a single layer, as this provides at least a more efficient manufacturing process.

[0014] In one or more embodiments, a manufacturing process for a plastic push-through blister pack is provided. The process may involve providing a tear-off lid film and a blister layer, thermoforming the blister layer, thereby creating a cavity between the tear-off lid film and the blister layers, and extruding the tear-off lid film to seal it to the blister layer. The tear-off lid film may have microcavities, microcrystalline structure, or a combination thereof.

[0015] The tear-off lid film and the blister layer can be made of the same thermoplastic or of the same class, making the blister packaging recyclable. The plastic push-through blister pack can be made of a single type of plastic. The tear-off lid film can be coated or laminated with a different polymer layer to act as a sealing layer for the blister layer. An additive can be added to impart micro-crystallinity or micro-cavities to the lid film. An additional polymeric, inorganic, or metallic layer can be layered onto the tear-off lid film to improve barrier properties.

[0016] The embodiments of the disclosure could be the ultimate sustainable packaging solution that consumers have been seeking; a robust, all-plastic, recyclable push-through blister pack that performs as well as or better, in terms of both packability and openability, compared to state-of-the-art plastic-aluminium multi-material blister packs, without any external weakening technology. Brief description of the drawings Fig. Figure 1 shows an example of a single-material blister pack made primarily of PET polymer on both sides according to one or more embodiments of the present disclosure. Fig. 2 shows an example of a torn blister pack of Fig. 1 for removing the cavity contents according to one or more embodiments of the present disclosure. Fig. Figure 3 shows a close-up view of the surface of the area in which Fig.1 blister pack shown uses micro-cavitated lid film in which the impression of the embedded crystalline particles and voids is visible, according to one or more embodiments of the present disclosure. Fig. Figure 4 shows a microscopic view of the surface of the [substance] in the [substance]. Fig. 1 blister pack shown lid film used at 200x magnification, in which micro voids and micro particles are visible, according to one or more embodiments of the present disclosure. Fig. Figure 5 shows a microscopic view of the surface of the [substance] in the [substance]. Fig. 1 blister pack shown using lid foil at 550x magnification, in which micro voids and micro particles are visible, according to one or more embodiments of the present disclosure. Fig. Figure 6 shows a cross-sectional view of the [structure / area] in the [structure / area]. Fig.1 blister pack shown using lid film by means of SEM (scanning electron microscope), wherein the voids and particles embedded in the film are visible, according to one or more embodiments of the present disclosure. Fig. Figure 7 shows a higher magnification SEM image of the cross-section of the same lid film as in Fig. 6, which shows voids and discontinuity in the film matrix created by incompatible polymer or embedded particles, according to one or more embodiments of the present disclosure. Description of the embodiments

[0017] As used herein, the term “approximately” refers to a range that is ±10% of the values ​​given in the particular context.

[0018] As used herein, the terms ‘substrate’ and ‘capping / capping film’ are used interchangeably.

[0019] As used herein, the term “microcavity” or “micro-cavity” in relation to a polymer film is defined as an internal discontinuity in the polymer network structure, caused, for example, by incompatible polymer or other inorganic particles in the structure.

[0020] As used herein, the terms “micro-cavity” or “microcavity” and “micro-vacancy” or “micro-empty” are used interchangeably.

[0021] As used herein, the term “microcrystalline” or “micro-crystallinity” refers to a solid form which contains the substance in a predominantly crystalline state in which specific crystals constitute the main part of the crystalline composition, the longest dimension of which is typically in the range of 1 to 100 microns.

[0022] As used herein, the term “push-through force,” when used in reference to a blister packaging system, refers to the force required to allow the products or contents to break through the substrate or lid film. The quantified “push-through force” is measured using a method described in the United States Pharmacopeia, Chapter 382 (at 50 mm / min as the test speed), and a Shimadzu EZ-LX or Zwick as the push-through force tester.

[0023] As used herein, the term single component or single material, when used in reference to a blister packaging system, means a system that consists substantially of the same polymer family throughout the entire system, for both cavity-forming blister and substrate / lid materials. As used herein, the term "polymer" is a natural or synthetic compound consisting of repeating strands of large, chemically bonded molecules, or monomers.

[0024] As used herein, the term "same class," when used in reference to a plastic, means a plastic that comprises the same majority of monomeric units and / or that can enter the same recycling stream (meets the same composition requirements for that recycling stream). As used herein, the term "plastic" means petroleum-derived synthetic polymer material. In some embodiments, the term "majority" means approximately 99%, approximately 98%, approximately 97%, approximately 96%, approximately 95%, approximately 94%, approximately 93%, approximately 92%, approximately 91%, approximately 90%, approximately 85%, approximately 80%, approximately 75%, approximately 70%, approximately 65%, approximately 60%, approximately 55%, approximately 50%.

[0025] As used herein, the expression “consists substantially of”, when used in reference to a blister pack, means that the blister pack may contain minor amounts of other ingredients which do not substantially affect the functionality of the present disclosure and / or objectives, in a content of less than 10% of the total weight of the blister pack.

[0026] As used herein, the term ‘tearable’, when used in reference to part of a blister pack, means that the part contains at least partially microcavities and / or microcrystals which reduce the puncture force of the part.

[0027] As used herein, the term "visibly clear" means that the transmission of the composition for visible light is greater than 60%, preferably greater than 80%. "Translucent" means that the transmission of the composition for visible light may be less than 60%, and "opaque" means that the transmission of the composition for visible light may be less than 10%. The light transmission of the composition is measured by UV-Vis spectrophotometry, which determines the absorption or transmission of light by a sample.

[0028] The illustrative examples described in the detailed description and the claims are not intended to be limiting. Other examples may be used, and other modifications may be made, without departing from the concept or scope of the subject matter presented herein. It will be readily understood that the aspects of the present disclosure, as generally described herein, may be arranged, substituted, combined, separated, and designed in a multitude of different configurations, all of which are implicitly included herein.

[0029] In some embodiments, the lid film made of biaxially oriented polyethylene terephthalate (BOPET) has a thickness in the range of about 10 to about 100 microns, preferably between about 18 and about 30 microns. In some embodiments, the thickness is about 10 to about 20 microns. In some embodiments, the thickness is about 10 to about 20 microns. In some embodiments, the thickness is about 10 to about 20 microns. In some embodiments, the thickness is about 20 to about 30 microns. In some embodiments, the thickness is about 30 to about 40 microns. In some embodiments, the thickness is about 40 to about 50 microns. In some embodiments, the thickness is about 50 to about 60 microns. In some embodiments, the thickness is about 60 to about 70 microns. In some embodiments, the thickness ranges from approximately 70 microns to approximately 80 microns.In some embodiments, the thickness ranges from approximately 80 microns to approximately 90 microns. In other embodiments, the thickness ranges from approximately 90 microns to approximately 100 microns. The lidding film can be produced by co-extrusion of films with different layers, including a sealing layer that allows the lidding film to tightly seal the thicker polymer film.

[0030] In some embodiments, the lidding film can be a film with embedded microcrystalline polymer, microcrystalline particles, incompatible polymers, or a combination thereof. The film's properties can vary depending on the shape, type, and size of the particles used. For example, microcrystalline particles can not only create voids but also facilitate the tearing process.

[0031] When the main polymer resins are mixed with small amounts of inorganic or organic additives, or with a polymer incompatible with the main polymer resins, during a film formation process, cavitation can occur during its alignment process if adhesion fails between a dispersed phase (small amounts of external additive, incompatible polymer) and the continuous phase (the main polymer resins). This failure of adhesion can cause the main polymer matrix to stretch, while the dispersed phase retains essentially the same dimensions because no force can be transmitted to it across the interface.

[0032] Due to the presence of these microcavities, which scatter light, these films can generally be cloudy or translucent. In some embodiments, the size of the microcavities can vary from about 10 microns to about 50 microns. By reducing the size of the cavities and the number of microcavities, the cloudiness can be reduced, but full transparency is often not achieved. Methods for creating microcavities in the film can be found, for example, in U.S. Patent No. 8,986,591, which is hereby incorporated in its entirety by reference.

[0033] In some embodiments, the size of the particles used as the cavitation agent can range from about 0.1 to about 10 microns, preferably from about 0.75 microns to about 2 microns. In some embodiments, the micro-vacancies formed in the polymer matrix of the film can range from about 10 to about 50 microns, depending on the degree of film stretching, which is part of the process of producing a cavitated film.

[0034] There is a wide range of particles that can be used for cavitation, including inorganic and organic materials. The number and size of these vacancies and the resulting changes in film properties can depend on the type (e.g., inorganic, polymeric), size, physical form (e.g., crystalline, amorphous), and shape (e.g., spherical, irregular) of the particles.

[0035] In general, the effectiveness of cavitation can be determined by the particle size / shape, and the modulus and compatibility of the dispersed phase with respect to the continuous phase.

[0036] Fig. Figure 3 shows a close-up view of the surface of the area in which Fig. The blister pack shown in section 1 uses a micro-cavitated lid film. The impression of the embedded crystalline particles and voids is visible, according to one or more embodiments of the present disclosure.

[0037] Fig. Figures 4-5 show a microscopic view of the surface of the in which Fig. The lid foil used in the blister pack shown is magnified 200x and 500x. Micro-voids and micro-particles are visible in the images.

[0038] Fig. Figure 6 shows a cross-sectional view of the [structure / area] in the [structure / area]. Fig.1 blister pack shown using lid film by means of SEM (scanning electron microscope), wherein the voids and particles embedded in the film are clearly visible, according to one or more embodiments of the present disclosure. Fig. Figure 7 shows a higher magnification SEM image of the cross-section of the same lid film as in Fig. Figure 6 shows voids and discontinuities in the film matrix created by incompatible polymer or embedded particles.

[0039] The composition of the polymer mixture for producing the cavitated film could be approximately 70-85 wt% main polymer resin, approximately 10-20 wt% other polymers (e.g. incompatible polymers or cavity formation facilitators), approximately 1-5 wt% inorganic additives and other film formation facilitation additives.

[0040] The thicker polymer film can be thermoformed into a cavity under pressure or vacuum, with or without a plug assist. In some embodiments, the thicker polymer film can be a class of amorphous polyethylene terephthalate (PET), preferably an amorphous polyethylene terephthalate (APET) polymer, with a thickness in the range of 100 to 500 microns, preferably about 250 microns, depending on the cavity sizes. The cavity can be filled with contents such as medication tablets, and then the lid film is heat-sealed onto the thermoformed film to produce the push-through blister pack. The cavities can be custom-made in various shapes and dimensions to fit the products.In some embodiments, the thicker film used to create the cavity may be any plastic film used for thermoforming applications, such as, but not limited to, polyethylene terephthalate (PET), polyvinyl chloride (PVC), polyethylene (PE), polypropylene (PP) and polyethylene terephthalate glycol (PETG).

[0041] Fig. 1 and Fig. 2 show an embodiment of a sealed ( Fig. 1) or torn ( Fig. 2) Single-material push-through blister packs made of PET. This embodiment of the single-material push-through blister pack can require significantly less force to tear open the blister pack for removal, and as such also maintains the structural integrity of the cavity contents.

[0042] The cavitated film used for the lid of the push-through blister pack can be produced via a multi-layer extrusion casting process, resulting in approximately 1 to 7 layers. The lid can be considered a film or a layer, even if it contains multiple layers. In some embodiments, the base polymer can be modified with inorganic micro-additives such as, but not limited to, silica, talc, mica, titanium dioxide (TiO2), and non-stoichiometric silicon dioxide (SiO2). x , where x is a positive real number less than 2) are mixed to impart microcrystallineity to the polymer matrix and / or to act as the cavitation agent when the material is stretched.

[0043] In some embodiments, other incompatible polymeric materials, such as, but not limited to, cellulose, polypropylene, and polyethylene, may be included as a cavitation agent to introduce discontinuity into the continuous phase during the alignment process in the manufacture of the lid film. In some embodiments, the concentration of the cavitation agent may be approximately 1 to approximately 30 wt% based on the total weight of the tearable lid film. After mixing the film with the cavitation agent and extrusion, the material is aligned in at least one direction, but usually in both the machine and transverse directions. The stress exerted during the alignment process may facilitate the generation of discontinuities between the polymer components and the aforementioned micro-additives and cavitation agents.

[0044] In some embodiments, the lidding film may contain micro-cavities / micro-voids throughout the polymer matrix. The discontinuity within the polymer matrix, through micro-cavities, embedded microcrystalline particles within the matrix, or voids, or a combination thereof, promotes crack initiation when an external puncture force is applied to force the contents, e.g., a tablet, out of the blister pack. In some embodiments, other treatments, such as corona treatment to improve surface properties or coating to enhance the barrier and sealing properties of the lidding film, are incorporated into the film manufacturing process.

[0045] The present process produces a consistent product with respect to the puncture force required to rupture the micro-cavitated / microcrystalline push-through blister pack. As shown in Table 1, the average puncture force of 8 different samples with an approximately 250-micron PET blister layer and an approximately 25-micron PET lid film micro-cavitated by cavitation agents, according to the present disclosure, through which the medication is dispensed, is 32.07 N, with a low degree of variation between the highest puncture force value of 35.35 N and the lowest of 30.57 N. In comparison, a prior art aluminum lid film blister pack requires a considerably higher average puncture force of 58.20 N, but also exhibits greater variance in product consistency / quality, as indicated by the larger standard deviation between the samples. Table 1 Penetrating force (N) Sample number new foil lid 25-micron aluminum foil lid 1 31,20 58,15 2 33,61 52,26 3 31,71 63,66 4 35,35 62,46 5 31,75 61,12 6 30,57 56,53 7 31,63 52,13 8 30,75 59,26 Average 32,07 58,20 Standard deviation 1,51 4,07

[0046] The blister pack can be a single-material or single-component plastic device. In some embodiments, minor proportions or residual amounts of materials other than the plastic may be included in the film or blister side, and in recycling applications, these proportions are adjusted so as not to alter the recyclability characteristics of the blister pack (lid film and blister side). The blister pack can be manufactured to consist of the same plastic or class of plastic (e.g., the grades described herein). The blister pack can be manufactured to consist substantially of the same plastic or class of plastic (e.g., the grades described herein), with the aim of achieving a recyclable structure (in single-stream or dual-stream recycling). The blister pack can be recycled chemically, mechanically, energetically, or in any other way.Theoretically, the blister packaging can be placed in a plastic or paper container, or it can have attachments that can be easily detached or removed. These are in addition to the blister packaging. For the sake of clarity, in this paragraph, "blister packaging" refers to the embodiments described herein for illustrative purposes. In some embodiments, the blister packaging may contain minor amounts of other components in quantities of less than approximately 10% of the total weight of the blister packaging.

[0047] The discontinuities or irregularities intended to be included in the polymer matrix of the lid film may be present throughout the lid film, in a certain selected area of ​​the lid film, or randomly distributed throughout the lid film when it is manufactured.

[0048] The tearable substrate or lid film may be visually clear enough to allow identification of the contents or product located within the cavity between the substrate or film and the blister layer. The lid film may also be translucent, opaque, or colored, depending on product specifications or safety requirements. In some embodiments, the lid film may be opaque or colored to preserve the photosensitive / photoreactive properties of the cavity contents. In some embodiments, the lid film may be free of additives other than cavitation agents, plasticizers, or other materials that affect the translucency or color of the lid film. In some embodiments, an opaque or colored lid may be included as a child-resistant packaging feature. The transparency, translucency, or opacity may depend on visible artifacts of the microcavities.

[0049] By selectively adding additional non-tearable layers over the primary push-through lid film, thereby making it difficult for children to open, the blister pack can be made child-resistant. Preferably, the blister pack can be designed to be child-resistant and senior-friendly, in accordance with the guidance or requirements of an agency or authority such as the Food and Drug Administration (FDA) or the European Medicines Agency (EMA).

[0050] Preferably, after the lid has been bonded to the cavity side (layer), the resulting structure (and / or the lid side) does not undergo any further processing and / or requires no such processing to be functional. For example, the blister pack does not require any additional curing or mechanical application to provide push-through medication. In some embodiments, the blister pack is designed to have peelable openings. Preferably, the substrate and the lid are bonded in such a way that they cannot be opened by peeling when used by the user, such as by having a bond strength of at least 0.30 kg / cm. Preferably, the opened blister pack can still consist of one piece (e.g., no peeled-off lids or parts) to make it easier and more convenient for a user to use and recycle the blister pack.

[0051] It should be understood that variations, clarifications, or modifications are planned. Applications of the technology to other, unmentioned areas are also being considered.

[0052] Thus, any sequence(s) and / or temporal order of steps in various processes or procedures described herein are descriptive and should not be interpreted as restrictive, except where such a conclusion could be generally drawn from the context and description. Accordingly, it should be understood that although various processes or procedures or combinations or sequences of operations are shown and described as being in a sequence or temporal order, they are not necessarily restricted to being carried out in any particular sequence or order.It should be understood that claims with fewer restrictions, broader claims such as claims without limitation to a certain feature or process step in the attached claims or in the description, clarifications to the claim features, different combinations and alternative implementations based on the description, or different applications are also conceived by the embodiments of the present disclosure.

[0053] It should be understood that combinations of the described features or steps are intended, even if they are not directly described together or in the same context.

[0054] The expressions and words used herein are addressed to ordinary professionals in this field of technology, and their meaning will be understood from the terminology used in this field or can reasonably be interpreted based on the usual meaning of such words, in conjunction with expert knowledge in this field of technology. This includes an understanding of implicit features, such as multiple possibilities, which can be understood by a person with ordinary expertise using a reasonable or primary approach.

[0055] The terms "may" or "can" (or similar expressions) are sometimes used herein to communicate that embodiments of the disclosure include the described features, attributes, or characteristics, but are not necessarily limited to that feature, attribute, or characteristic. This does not mean that the use of "is" or "are" (or similar expressions) is used to communicate that embodiments of the present disclosure are limited to that feature, attribute, or characteristic.

[0056] The present disclosure is not limited to the specific examples described in this application, which are intended to illustrate various aspects. Many modifications and examples can be devised without deviating from its concept and scope, as those skilled in the art will recognize. Functionally equivalent methods and devices within the scope of the disclosure, in addition to those listed herein, will be apparent to those skilled in the art from the preceding description. Such modifications and examples may fall within the scope of the attached claims. It should also be understood that the terminology used herein serves only to describe specific examples and is not intended to be limiting.

[0057] With regard to the use of essentially any plural and / or singular expressions herein, experts in this field would understand plural-to-singular and / or singular-to-plural.

[0058] While various aspects and examples have been revealed herein, experts will recognize other aspects and examples. The various aspects and examples revealed herein are for illustrative purposes only and are not intended to be limiting. QUOTES INCLUDED IN THE DESCRIPTION

[0000] This list of documents cited by the applicant was automatically generated and is included solely for the reader's convenience. The list is not part of the German patent or utility model application. The DPMA accepts no liability for any errors or omissions. Cited patent literature

[0000] US 63 / 386,156

[0001] US 8,986,591

[0032]

Claims

A plastic push-through blister pack comprising: a tearable plastic lid film or substrate; and a blister layer formed over the tearable plastic lid film or substrate, whereby a cavity remains between the tearable plastic lid layer and the layer forming the blister cavity, wherein the cavity is configured to contain a product, and wherein the tearable plastic lid film has micro cavities, micro-crystallinity, or a combination of both. Blister packaging according to claim 1, wherein the tearable lid film and the blister layer are made of the same thermoplastic or of the same class. Blister packaging according to claim 2, wherein the same plastic or that of the same class is selected such that the entire blister packaging is recyclable. Blister packaging according to claim 2, wherein the plastic push-through blister packaging is made of a single plastic. Blister packaging according to claim 1, wherein the tearable lid film is made of a thermoplastic material. Blister packaging according to claim 1, wherein the blister layer is formed from a thermoplastic material. Blister packaging according to claim 5, wherein the material used for the tearable lid film is BOPET (biaxially oriented polyethylene terephthalate). Blister packaging according to claim 1, wherein both the blister layer and the tearable lid film are made of a polymer selected from the group consisting of PET (polyethylene terephthalate), PVC (polyvinyl chloride), PE (polyethylene), PP (polypropylene), PETG (polyethylene terephthalate glycol) and a combination thereof. Blister packaging according to claim 1, wherein an additive is added to introduce micro-crystallinity into the tearable lid film. Blister packaging according to claim 9, wherein the additive is an inorganic micro-additive selected from the group consisting of silica, talc, mica, titanium dioxide (TiO2), non-stoichiometric silicon dioxide (SiOx) and a combination thereof. Blister packaging according to claim 1, wherein a cavitation agent for producing a cavitated film is added to the tearable lid film. Blister packaging according to claim 11, wherein a base polymer used as a continuous phase of the cavitated film is selected from PET, PVC, PE, PETG, PS (polystyrene) and a combination thereof. Blister packaging according to claim 11, wherein the cavitation agent is an incompatible polymer selected from the group consisting of cellulose, starch, polyketones, polyesters, polycarbonates, polysulfones, polypropylene, cycloolefins, polyethylene and a combination thereof. Blister packaging according to claim 11, wherein the concentration of the cavitating agent is between about 1 and about 30 wt.% based on the total weight of the tearable lid film. Blister packaging according to claim 1, wherein the blister layer comprises more than one layer. Blister packaging according to claim 1, wherein the tearable substrate comprises more than one layer. Plastic push-through blister packaging, producible by: providing a tear-off lid film and a blister layer; thermoforming the blister layer, leaving a cavity between the tear-off lid film and the blister layer; and extruding the tear-off lid film to seal onto the blister layer, wherein the tear-off lid film has micro cavities, micro-crystallinity or a combination of both. Plastic push-through blister packaging according to claim 17, wherein the tearable lid film and the blister layer are made of the same thermoplastic or of the same class, making the blister packaging recyclable. Plastic push-through blister packaging according to claim 17, wherein the plastic push-through blister packaging is made of a single plastic. Plastic push-through blister packaging according to claim 17, wherein the tearable lid film is coated or laminated with another polymer layer to act as a sealing layer to the blister film. Plastic push-through blister packaging according to claim 17, wherein the additive is added to impart micro-crystallinity or micro-crystallinity to the tearable lid film. Plastic push-through blister packaging according to claim 17, wherein an additional polymeric, inorganic or metallic layer is layered onto the tearable lid film to improve barrier properties. Thermoformable film for pharmaceutical blister packaging, comprising more than one layer, wherein the film has a total thickness of between 100 µm and 500 µm, and wherein the film comprises polypropylene. Thermoformable film according to claim 23, wherein the film has a total thickness of between 200 µm and 400 µm. Thermoformable film according to claim 24, wherein the film has a total thickness of between 250 µm and 300 µm. Thermoformable film according to claim 23, wherein the film instead consists of its single layer. Lid film for pharmaceutical blister packs, comprising more than one layer, wherein the film has an additional coating on a non-sealing area of ​​the film, and wherein the film comprises polypropylene. Blister packaging for pharmaceutical products, comprising: a thermoformable film according to one of claims 23 to 26, and a lid film according to claim 27, wherein the thermoformable film and the lid film together form cavities for accommodating pharmaceutical products. Blister packaging according to claim 28, wherein the thermoformable film and the lid film comprise polypropylene. Blister packaging according to claim 28 or 29, wherein the thermoformable film forms the cavities for the pharmaceuticals. Blister packaging according to one of claims 28 to 30, wherein the blister packaging is designed to form a push-through package by tearing the lid film.

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