Bioabsorbable composite membrane containing polylactic acid, plasma-rich fibrin and growth hormones

Abstract

Bioabsorbable composite membrane, including: ◯ A PLA base layer. ◯ PRF, which is integrated into the PLA layer. ◯ Growth hormones that are embedded or adsorbed on the membrane.

Description

SCOPE OF THE INVENTION

[0001] The present disclosure relates to a bioabsorbable composite membrane for biomedical applications. This membrane, which contains polylactic acid (PLA), plasma-rich fibrin (PRF), and growth hormones, was specifically developed for use in tissue regeneration, wound healing, and guided tissue engineering. BACKGROUND OF THE INVENTION

[0002] The growing demand for advanced regenerative materials has highlighted the limitations of existing bioresorbable membranes, which are often unable to combine sustained biological activity with structural support. PRF and growth hormone have demonstrated regenerative potential, but their use alone is limited due to their limited duration of activity and the lack of a supporting scaffold.

[0003] The integration of PLA with PRF and growth hormones into a single composite structure solves these problems. This innovative membrane provides temporary mechanical support, controlled biodegradability, and sustained release of bioactive molecules, making it a superior alternative for tissue engineering and healing applications.

[0004] The invention thus offers an efficient solution to overcome the shortcomings of existing methods while delivering excellent results in tissue regeneration and healing. SUMMARY OF THE INVENTION

[0005] The present invention discloses a composite bioabsorbable membrane comprising: ◯ Polylactic acid (PLA): A biodegradable polymer that provides structural integrity and controlled degradation. ◯ Plasma-rich fibrin (PRF): A patient-derived fibrin matrix loaded with growth factors. ◯ Growth hormones: Bioactive molecules such as insulin-like growth factor (IGF-1) or epidermal growth factor (EGF) to promote cell activity and healing.

[0006] The membrane is manufactured using advanced techniques that ensure uniform distribution of PRF and growth hormones. It is tailored for applications in wound healing, periodontal regeneration, orthopedic tissue engineering, and much more. DETAILED DESCRIPTION OF THE INVENTION 1. Composition:

[0007] The bioabsorbable composite membrane contains the following components: a. Polylactic acid (PLA): • Serves as primary scaffolding material. • Provides structural stability and is broken down into lactic acid for biocompatibility. b. Plasma Rich Fibrin (PRF): • PRF is isolated from the patient's blood and provides a natural reservoir of growth factors such as VEGF, PDGF and TGF-β. c. Growth hormones: • Embedded growth hormones such as IGF-1 or EGF increase cellular activities such as angiogenesis, fibroblast proliferation and collagen synthesis. 2. Features:

[0008] The composite membrane has the following properties: • Mechanical strength: Provides support for tissue regeneration. • Controlled biodegradability: Decomposes in sync with healing. • Sustained release: Releases growth factors gradually over time. • Biocompatibility: Integrates seamlessly into biological tissue. 3. Applications:

[0009] The membrane is versatile, with applications in: • Wound healing: Promotes angiogenesis and epithelialization. • Periodontal regeneration: Functions as a guided tissue regeneration membrane. • Orthopedic tissue engineering: Promotes bone healing in fractures and defects. • Soft tissue repair: Helps in the healing of hernias and tendon injuries.

Claims

[1] Bioabsorbable composite membrane comprising: ◯ A PLA base layer. ◯ PRF integrated into the PLA layer. ◯ Growth hormones embedded or adsorbed on the membrane. [2] The membrane according to claim 1, wherein the PLA layer is made to have a porous structure. [3] The membrane of claim 1, wherein PRF is derived from autologous blood. [4] The membrane of claim 1, wherein the growth hormones contain IGF-1 or EGF. [5] The membrane of claim 1, wherein the degradation rate of PLA is consistent with the timing of tissue healing.