Composition containing alkaline stabilizers for encapsulating creatine monohydrate for increased bioavailability

Abstract

Composition containing alkaline stabilizers (10) for encapsulating creatine hydrates, characterized by that the composition (10) for encapsulating creatine hydrates comprises a hydrogel encapsulation structure (11) and a plurality of creatine composition units (12), wherein each creatine composition unit (12) consists of a creatine monomer (121) and an alkaline stabilizer (122), wherein the hydrogel encapsulation structure (11) is capsule-shaped and has a three-dimensionally cross-linked gel matrix (11), wherein the creatine monomer (121) comprises 50-99.99% and the alkaline stabilizer comprises 0.01-50% of the creatine composition unit (12), wherein the creatine composition units (12) are encapsulated in the gel matrix (11); that the base material of the gel matrix (11) is selected from the group consisting of gum arabic, pectin, guar gum, locust bean gum, gellan gum, carrageenan, agar, xanthan gum, carboxymethylcellulose, gelatin, fucoidan, modified starch, starch, maltodextrin and poorly digestible maltodextrin; that the creatine monomer (121) is a variety of creatine molecules; and the alkaline stabilizer (122) consists of a variety of alkaline metal ions or their compounds.

Description

Technical field

[0001] The invention relates to a composition for encapsulating creatine hydrates, in particular a composition for encapsulating creatine hydrates which can prevent creatine from hydrolyzing to creatinine due to its instability. State of the art

[0002] Creatine is widely used in sports nutrition and offers benefits such as increased muscle energy storage, enhanced muscle strength, and accelerated recovery. However, creatine is extremely unstable in aqueous solutions and readily hydrolyzes to creatinine, leading to reduced absorption and potentially increased kidney strain. Conventional solutions such as microencapsulation and delayed-release dosing have limited efficacy or high production costs, making creatine stabilization challenging.

[0003] There is therefore an urgent need for a simple structure that can directly form a buffering mechanism with creatine to prolong its stability and improve its bioavailability. Object of the invention

[0004] The invention is based on the objective of creating a composition containing alkaline stabilizers for encapsulating creatine hydrates that can prevent creatine from decomposing to creatinine under acidic conditions (such as in an environment with gastric acids). Technical solution

[0005] This problem is solved according to the invention by a composition containing alkaline stabilizers for encapsulating creatine hydrates with the features of claim 1. Advantageous embodiments are the subject of the dependent claims.

[0006] The invention provides a composition containing alkaline stabilizers for encapsulating creatine hydrates. This composition comprises a hydrogel encapsulation structure and a plurality of creatine composition units, each consisting of a creatine monomer and an alkaline stabilizer. The hydrogel encapsulation structure has a three-dimensionally cross-linked gel matrix, wherein the creatine monomer comprises 50-99.99% and the alkaline stabilizer comprises 0.01-50% of the creatine composition unit. The creatine composition units are encapsulated within the gel matrix. The base material of the gel matrix is ​​selected from the group consisting of gum arabic, pectin, guar gum, locust bean gum, gellan gum, carrageenan, agar, xanthan gum, carboxymethylcellulose, gelatin, fucoidan, modified starch, starch, maltodextrin, and poorly digestible maltodextrin.The creatine monomer consists of a multitude of creatine molecules, and the alkaline stabilizer consists of a multitude of alkaline metal ions or their compounds.

[0007] Furthermore, the alkaline stabilizer is a natural substance or an alkaline stabilizing compound consisting of the group of phosphate, carbonate, bicarbonate, amino acid chelated minerals, hydroxide, oxide, sulfate, chloride, lactoferrin, heme, citric acid, lactate and organic acid salts and the group of sodium, calcium, magnesium, potassium, zinc, iron and chromium.

[0008] The composition according to the invention, containing alkaline stabilizers, for encapsulating creatine hydrates is characterized by the following: The hydrogel encapsulation structure forms a polymer network that provides a control mechanism for physical support and slow release, wherein the alkaline stabilizers and the creatine monomers effect weak chelation or ion adsorption, which further results in the creatine molecules being converted to creatinine at a consistently slower rate in an acidic environment. The creatine composition units are encapsulated in the hydrogel encapsulation structure such that the creatine monomers and the alkaline stabilizers are present together within the hydrogel encapsulation structure, thereby forming microscale regions with a stable creatine distribution, thus increasing the stability and bioavailability of creatine in a gastric acid environment.The alkaline stabilizers have a high buffering capacity and can immediately adjust the pH in an acidic environment, preventing creatine from hydrolyzing to creatinine. Therefore, the creatine hydrate encapsulation formulation, consisting of creatine monomers and alkaline stabilizers, can improve water dispersibility, reduce sedimentation, and increase bioavailability. Brief description of the drawings Fig. Figure 1 shows a perspective view of a composition according to the invention containing alkaline stabilizers for encapsulating creatine hydrates. Fig. Figure 2 shows a schematic representation of the structure of the composition according to the invention. Fig. Figure 3 shows a schematic representation of the ratio of the components of a first embodiment of the composition according to the invention. Fig. Figure 4 shows a schematic representation of the ratio of the components of a second embodiment of the composition according to the invention. Fig. Figure 5 shows a schematic representation of the ratio of the components of a third embodiment of the composition according to the invention. Fig. Figure 6 shows an illustration of the physical appearance of the newly formed creatine structure in the solubility test according to the invention. Fig. Figure 7 shows an illustration of the physical appearance of pure creatine in the solubility test according to the invention. Fig. Figure 8 shows a perspective view of spherical compositions for encapsulating creatine hydrates. Detailed description of preferred embodiments

[0009] The following section explains the tasks, features, and advantages of the present invention in more detail with reference to exemplary embodiments and the accompanying drawings. However, the invention is not limited to the description of these exemplary embodiments and their representation in the accompanying drawings.

[0010] As in Fig. 1, Fig. 2 to Fig. As shown in Figure 3, the invention relates to a composition 10 containing alkaline stabilizers for encapsulating creatine hydrates, which composition has a hydrogel encapsulation structure 11 and a plurality of creatine composition units 12, wherein each creatine composition unit 12 consists of a creatine monomer 121 and an alkaline stabilizer 122, wherein the hydrogel encapsulation structure 11 has a three-dimensionally cross-linked gel matrix 111, wherein the creatine monomer 121 has a proportion of 50-99.99% and the alkaline stabilizer 122 has a proportion of 0.01-50% of the creatine composition unit 12, wherein the creatine composition units 12 are encapsulated in the gel matrix 111.

[0011] The base material of the gel matrix 111 is selected from the group consisting of gum arabic, pectin, guar gum, locust bean gum, gellan gum, carrageenan, agar, xanthan gum, carboxymethylcellulose, gelatin, fucoidan, modified starch, starch, maltodextrin and poorly digestible maltodextrin.

[0012] Creatine monomer 121 consists of a large number of creatine molecules.

[0013] The alkaline stabilizer 122 consists of a variety of alkaline metal ions or their compounds.

[0014] According to the invention, the hydrogel encapsulation structure 11 forms a polymer network that provides a control mechanism for physical support and slow release, wherein the alkaline stabilizers 122 and the creatine monomers 121 effect weak chelation or ion adsorption, which further results in the creatine molecules being converted to creatinine at a consistently slower rate in an acidic environment. The creatine composition units 12 are encapsulated in the hydrogel encapsulation structure 11 such that the creatine monomers 121 and the alkaline stabilizers 122 are present together within the hydrogel encapsulation structure 11, thereby forming microscale regions with a stable creatine distribution, thus increasing the stability and bioavailability of creatine in a gastric acid environment.

[0015] Furthermore, the alkaline stabilizers 122 have a high buffering capacity and can immediately adjust the pH value in an acidic environment to prevent creatine from hydrolyzing to creatinine. Thus, the composition 10 for encapsulating creatine hydrates, consisting of creatine monomers 121 and alkaline stabilizers 122, can improve water dispersibility, reduce sedimentation, and increase bioavailability.

[0016] Furthermore, the alkaline stabilizer 122 is a natural substance or an alkaline stabilizing compound consisting of the group of phosphate, carbonate, bicarbonate, amino acid chelated minerals, hydroxide, oxide, sulfate, chloride, lactoferrin, heme, citric acid, lactate and organic acid salts and the group of sodium, calcium, magnesium, potassium, zinc, iron and chromium.

[0017] In the composition according to the invention, containing alkaline stabilizers for encapsulating creatine hydrates, the hydrogel encapsulation structure 11 has a proportion of 1-3% of the composition 10 for encapsulating creatine hydrates and the creatine composition units 12 have a proportion of 97-99% of the same.

[0018] In the first embodiment in Fig. 3. The hydrogel encapsulation structure 11 is gum arabic, and the hydrogel encapsulation structure 11 comprises 2% of the composition 10 for encapsulating creatine hydrates. The creatine monomers 121 are creatine monohydrates, and the creatine monomers 121 comprise 97.5% of the composition 10 for encapsulating creatine hydrates. The alkaline stabilizers 122 are marine magnesium, and the alkaline stabilizers 122 comprise 0.5% of the composition 10 for encapsulating creatine hydrates.

[0019] In the second embodiment in Fig. 4. The hydrogel encapsulation structure 11 is gum arabic, and the hydrogel encapsulation structure 11 comprises 1.5% of the composition 10 for encapsulating creatine hydrates. The creatine monomers 121 are creatine monohydrates, and the creatine monomers 121 comprise 97% of the composition 10 for encapsulating creatine hydrates. The alkaline stabilizers 122 are magnesium glycinate, and the alkaline stabilizers 122 comprise 1.5% of the composition 10 for encapsulating creatine hydrates.

[0020] In the third embodiment in Fig. In the hydrogel encapsulation structure 11, the hydrogel encapsulation structure 11 is gum arabic, and the hydrogel encapsulation structure 11 comprises 2% of the composition 10 for encapsulating creatine hydrates. The creatine monomers 121 are creatine monohydrates, and the creatine monomers 121 comprise 97% of the composition 10 for encapsulating creatine hydrates. The alkaline stabilizers 122 are magnesium oxide, and the alkaline stabilizers 122 comprise 1% of the composition 10 for encapsulating creatine hydrates.

[0021] Fig. Figure 6 shows an illustration of the physical appearance of the composition 10 according to the invention, formed from creatine, for encapsulating creatine hydrates in the solubility test, wherein the composition 10 has high solubility and is clear. Fig. Figure 7 shows an illustration of the physical appearance of pure creatine in the solubility test, where pure creatine has a low solubility and sedimentation occurs due to the low solubility.

[0022] As in Fig. As shown in Figure 1, the hydrogel encapsulation structure 11 of the composition 10 according to the invention is capsule-shaped.

[0023] As in Fig. As shown in Figure 8, the hydrogel encapsulation structure 11 of the composition 10 according to the invention is spherical.

[0024] In the composition 10 according to the invention, the hydrogel encapsulation structure 11 is designed in a disc shape.

[0025] Although the present invention has been described in detail with reference to exemplary embodiments, it is obvious to those skilled in the art that the invention is not limited to these exemplary embodiments, but rather that modifications are possible such that individual features can be omitted or different combinations of features can be implemented without exceeding the scope of protection of the appended claims. The disclosure of the present invention includes all combinations of the individual features presented. Reference symbol list 10. Composition for the encapsulation of creatine monohydrate 11 Hydrogel encapsulation structure 111 Gel matrix 12 creatine composition units 121 Creatine monomer 122 alkaline stabilizer

Claims

A composition (10) containing alkaline stabilizers for encapsulating creatine hydrates, characterized in that the composition (10) for encapsulating creatine hydrates comprises a hydrogel encapsulation structure (11) and a plurality of creatine composition units (12), wherein each creatine composition unit (12) consists of a creatine monomer (121) and an alkaline stabilizer (122), wherein the hydrogel encapsulation structure (11) is capsule-shaped and has a three-dimensionally cross-linked gel matrix (11), wherein the creatine monomer (121) comprises 50-99.99% and the alkaline stabilizer comprises 0.01-50% of the creatine composition unit (12), wherein the creatine composition units (12) are encapsulated in the gel matrix (11);that the base material of the gel matrix (11) is selected from the group consisting of gum arabic, pectin, guar gum, locust bean gum, gellan gum, carrageenan, agar, xanthan gum, carboxymethylcellulose, gelatin, fucoidan, modified starch, starch, maltodextrin and poorly digestible maltodextrin; that the creatine monomer (121) is a variety of creatine molecules; and that the alkaline stabilizer (122) is a variety of alkaline metal ions or their compounds. A composition (10) containing alkaline stabilizers for encapsulating creatine hydrates, characterized in that the composition (10) for encapsulating creatine hydrates comprises a hydrogel encapsulation structure (11) and a plurality of creatine composition units (12), wherein each creatine composition unit (12) consists of a creatine monomer (121) and an alkaline stabilizer (122), wherein the hydrogel encapsulation structure (11) is spherically shaped and has a three-dimensionally cross-linked gel matrix (11), wherein the creatine monomer (121) comprises 50-99.99% and the alkaline stabilizer comprises 0.01-50% of the creatine composition unit (12), wherein the creatine composition units (12) are encapsulated in the gel matrix (11);that the base material of the gel matrix (11) is selected from the group consisting of gum arabic, pectin, guar gum, locust bean gum, gellan gum, carrageenan, agar, xanthan gum, carboxymethylcellulose, gelatin, fucoidan, modified starch, starch, maltodextrin and poorly digestible maltodextrin; that the creatine monomer (121) is a variety of creatine molecules; and that the alkaline stabilizer (122) is a variety of alkaline metal ions or their compounds. A composition (10) containing alkaline stabilizers for encapsulating creatine hydrates, characterized in that the composition (10) for encapsulating creatine hydrates comprises a hydrogel encapsulation structure (11) and a plurality of creatine composition units (12), wherein each creatine composition unit (12) consists of a creatine monomer (121) and an alkaline stabilizer (122), wherein the hydrogel encapsulation structure (11) is disc-shaped and has a three-dimensionally cross-linked gel matrix (11), wherein the creatine monomer (121) comprises 50-99.99% and the alkaline stabilizer comprises 0.01-50% of the creatine composition unit (12), wherein the creatine composition units (12) are encapsulated in the gel matrix (11);that the base material of the gel matrix (11) is selected from the group consisting of gum arabic, pectin, guar gum, locust bean gum, gellan gum, carrageenan, agar, xanthan gum, carboxymethylcellulose, gelatin, fucoidan, modified starch, starch, maltodextrin and poorly digestible maltodextrin; that the creatine monomer (121) is a variety of creatine molecules; and that the alkaline stabilizer (122) is a variety of alkaline metal ions or their compounds. Composition according to one of the preceding claims, characterized in that the alkaline stabilizer (122) is a natural substance or an alkaline stabilizing compound consisting of the group consisting of phosphate, carbonate, bicarbonate, amino acid chelated minerals, hydroxide, oxide, sulfate, chloride, lactoferrin, heme, citric acid, lactate and organic acid salts and the group consisting of sodium, calcium, magnesium, potassium, zinc, iron and chromium. Composition according to one of claims 1 to 3, characterized in that the hydrogel encapsulation structure (11) comprises a proportion of 1-3% of the composition (10) for encapsulating creatine hydrates and the creatine composition units (12) comprise a proportion of 97-99% of the same.

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